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Currently displaying 1121 - 1140 of 2338 publications

The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation

R Cukalevski, X Yang, G Meisl, U Weininger, K Bernfur, B Frohm, TPJ Knowles, S Linse

Chem Sci

(2015)

4215

(doi: 10.1039/c4sc02517b)

Widespread proteome remodeling and aggregation in aging C. elegans

DM Walther, P Kasturi, M Zheng, S Pinkert, G Vecchi, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo, M Mann, FU Hartl

Cell

(2015)

161

919

(doi: 10.1016/j.cell.2015.03.032)

Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation

E Lira-Navarrete, M de Las Rivas, I Compañón, MC Pallarés, Y Kong, J Iglesias-Fernández, GJL Bernardes, JM Peregrina, C Rovira, P Bernadó, P Bruscolini, H Clausen, A Lostao, F Corzana, R Hurtado-Guerrero

Nat Commun

(2015)

6937

(doi: 10.1038/ncomms7937)

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.

SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman

Nature Communications

(2015)

7025

(doi: 10.1038/ncomms8025)

The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution

Z Pietralik, JR Kumita, CM Dobson, M Kozak

Colloids and Surfaces B Biointerfaces

(2015)

131

(doi: 10.1016/j.colsurfb.2015.04.042)

Preventing peptide and protein misbehavior.

P Arosio, G Meisl, M Andreasen, TPJ Knowles

Proc Natl Acad Sci U S A

(2015)

112

5267

(doi: 10.1073/pnas.1505170112)

Investigating the mechanisms of amylolysis of starch granules by solution-state NMR.

AJ Baldwin, DL Egan, FJ Warren, PD Barker, CM Dobson, PJ Butterworth, PR Ellis

Biomacromolecules

(2015)

1614

(doi: 10.1021/acs.biomac.5b00190)

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades

Proc Natl Acad Sci U S A

(2015)

112

e1994

(doi: 10.1073/pnas.1421204112)

Structure of a Single-Chain Fv Bound to the 17 N-Terminal Residues of Huntingtin Provides Insights into Pathogenic Amyloid Formation and Suppression

E De Genst, DY Chirgadze, FAC Klein, DC Butler, D Matak-Vinković, Y Trottier, JS Huston, A Messer, CM Dobson

Journal of Molecular Biology

(2015)

427

2166

(doi: 10.1016/j.jmb.2015.03.021)

Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation

SW Chen, S Drakulic, E Deas, MM Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, GE De, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades

Proceedings of the National Academy of Sciences

(2015)

112

E1994

(doi: 10.1073/pnas.1421204112.)

Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors

A Loureiro, GJL Bernardes, U Shimanovich, MP Sárria, E Nogueira, A Preto, AC Gomes, A Cavaco-Paulo

Nanomedicine

(2015)

1077

(doi: 10.1016/j.nano.2015.02.022)

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms.

P Kukic, HT Alvin Leung, F Bemporad, FA Aprile, JR Kumita, A De Simone, C Camilloni, M Vendruscolo

Structure

(2015)

745

(doi: 10.1016/j.str.2014.12.020)

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.

SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstål, L Dolfe, C Dunning, X Yang, B Frohm, M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse

Nature Structural and Molecular Biology

(2015)

207

(doi: 10.1038/nsmb.2971)

The physical basis of protein misfolding disorders

TPJ Knowles, M Vendruscolo, CM Dobson

Physics Today

(2015)

(doi: 10.1063/pt.3.2719)

The s2D method: Simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins

P Sormanni, C Camilloni, P Fariselli, M Vendruscolo

Journal of Molecular Biology

(2015)

427

982

(doi: 10.1016/j.jmb.2014.12.007)

Advances in Chemical Protein Modification

O Boutureira, GJL Bernardes

Chemical reviews

(2015)

115

2174

(doi: 10.1021/cr500399p)

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.

SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstal, L Dolfe, C Dunning, X Yang, B Frohm, M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse

Nat Struct Mol Biol

(2015)

207

(doi: 10.1038/nsmb.2971)