Centre for Misfolding Diseases

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  • Currently displaying 1161 - 1180 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
Oligomers of Heat-Shock Proteins: Structures That Don’t Imply Function
WM Jacobs, TPJ Knowles, D Frenkel
PLOS Computational Biology
(2016)
12
(doi: 10.1371/journal.pcbi.1004756)
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.
P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
ACS Combinatorial Science
(2016)
18
(doi: 10.1021/acscombsci.5b00129)
A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding.
LD Cabrita, AME Cassaignau, HMM Launay, CA Waudby, T Wlodarski, C Camilloni, M-E Karyadi, AL Robertson, X Wang, AS Wentink, L Goodsell, CA Woolhead, M Vendruscolo, CM Dobson, J Christodoulou
Nat Struct Mol Biol
(2016)
23
(doi: 10.1038/nsmb.3182)
Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein
A Toto, C Camilloni, R Giri, M Brunori, M Vendruscolo, S Gianni
Scientific reports
(2016)
6
(doi: 10.1038/srep21994)
Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.
E van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln
Physical review letters
(2016)
116
(doi: 10.1103/physrevlett.116.078101)
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman
Proc Natl Acad Sci U S A
(2016)
113
(doi: 10.1073/pnas.1524128113)
Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry
P Akkapeddi, S-A Azizi, AM Freedy, PMSD Cal, PMP Gois, GJL Bernardes
Chemical science
(2016)
7
(doi: 10.1039/c6sc00170j)
Neuroscience: An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Ab42 aggregates linked with Alzheimer's disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo
Science advances
(2016)
2
(doi: 10.1126/sciadv.1501244)
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, L Tosatto, M Kjaergaard, JS Beckwith, H Zetterberg, M Iljina, N Cremades, CM Dobson, NW Wood, D Klenerman
ACS chemical neuroscience
(2016)
7
(doi: 10.1021/acschemneuro.5b00324)
Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.
K-L Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles
Biophysical journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.3523)
Structural Studies of the Oligomerization Process of Human Cystatin C Variants
Z Pietralik, M Murawska, A Szymanska, JR Kumita, CM Dobson, M Kozak
Biophysical Journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.205)
Combining Single-Molecule Techniques with Microfluidics for Protein Analysis
C Taylor, T Knowles, D Klenerman
Biophysical Journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.1086)
Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson's disease
E Deas, N Cremades, PR Angelova, MHR Ludtmann, Z Yao, S Chen, MH Horrocks, B Banushi, D Little, MJ Devine, P Gissen, D Klenerman, CM Dobson, NW Wood, S Gandhi, AY Abramov
Antioxid Redox Signal
(2016)
24
(doi: 10.1089/ars.2015.6343)
Hamiltonian Dynamics of Protein Filament Formation
TCT Michaels, SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Physical review letters
(2016)
116
(doi: 10.1103/physrevlett.116.038101)
Effect of molecular chaperones on aberrant protein oligomers in vitro: super-versus sub-stoichiometric chaperone concentrations
S Cappelli, A Penco, B Mannini, R Cascella, MR Wilson, H Ecroyd, X Li, JN Buxbaum, CM Dobson, C Cecchi, A Relini, F Chiti
Biological chemistry
(2016)
397
(doi: 10.1515/hsz-2015-0250)
Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide.
G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse
Sci Rep
(2016)
6
(doi: 10.1038/srep18728)
Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
D Montes-Grajales, GJL Bernardes, J Olivero-Verbel
Chemical research in toxicology
(2016)
29
(doi: 10.1021/acs.chemrestox.5b00342)
Molecular mechanisms of protein aggregation from global fitting of kinetic models
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
Nature Protocols
(2016)
11
(doi: 10.1038/nprot.2016.010)
Microfluidic devices fabricated using soft lithography for the study of protein structures using synchrotron radiation circular dichroism
J Charmet, C Bortolini, D Copic, IC Morales, Y Zhang, PK Challa, T Jávorfi, R Hussain, G Siligardi, TPJ Knowles
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2016
(2016)
A kinetic model of the aggregation of α-synuclein provides insights into prion-like spreading
M Iljina, G Garcia, MH Horrocks, L Tosatto, M Choi, S Gandhi, T Knowles, D Klenerman
PRION
(2016)
10
Yusuf Hamied Department of Chemistry
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