Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 2517 publications
Author(s)
Publication title
Journal Name
Publication year
Single-Atom O/S/Se Substitution at the Glycosidic Linkage in Glycopeptide Cancer Vaccines Reveals Divergent Performance.
C Bretón, A Guerreiro, P Oroz, N Osés, I Ginés-Alcober, FJ Cañada, R Hurtado-Guerrero, JL Asensio, JM Peregrina, GJL Bernardes, F Corzana
Angew Chem Int Ed Engl
(2026)
(doi: 10.1002/anie.8540595)
Single‐Atom O/S/Se Substitution at the Glycosidic Linkage in Glycopeptide Cancer Vaccines Reveals Divergent Performance
C Bretón, A Guerreiro, P Oroz, N Osés, I Ginés‐Alcober, FJ Cañada, R Hurtado‐Guerrero, JL Asensio, JM Peregrina, GJL Bernardes, F Corzana
Angewandte Chemie International Edition
(2026)
(doi: 10.1002/ange.8540595)
Mechanistic Interpretability of Protein Language Models Reveals Encoded Structural and Functional Properties of Intrinsically Disordered Proteins
L Naworski, LL Good, R Scrutton, TPJ Knowles
(2026)
(doi: 10.64898/2026.09.10.750691)
Protein self-assembly in crowded environments.
MCM Martens, Z Han, RVM Freire, S Huisman, IK Voets, TPJ Knowles, R Tuinier, NA Erkamp
J Colloid Interface Sci
(2026)
727
(doi: 10.1016/j.jcis.2026.141573)
Mapping high resolution, multidimensional phase diagrams of near-physiological protein condensates
T Agarwal, T Sneideris, F Svara, K Jermakovs, H Coyle, S Qamar, E Kava, R Scrutton, N Pleschka, P Peres, G Cereghetti, E Andrzejewska, A Diaz-Barreiro, G Palmer, AJ Costa-Filho, G Krainer, TP Knowles, J Nixon-Abell
Nature Communications
(2026)
(doi: 10.1038/s41467-026-77696-6)
Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression
V Sabatino, C Tang, RC Acúrcio, AR Coelho, FM Müller, M Fontes, WT Khaw, C Labão-Almeida, DR Hicks, W Yang, A Vasco Vidal, I Sarkar, D Shome, M Cabeza-Cabrerizo, TV Rohm, S Fleisch, A Gerber, SA Hogan, F Gerster, D Kaymak, S Pantelyushin, J Vom Berg, L Li, RM Reijmers, R Fior, D Baker, HF Florindo, G Hutter, GJL Bernardes
Cancer Res
(2026)
(doi: 10.1158/0008-5472.can-25-5578)
Downregulation of FBXO2 is associated with Aβ aggregation, tau hyperphosphorylation and network impairment in human cortical neurons
M Vendruscolo, AG Diaz, A Possenti, G Urritia, Y Bian, S Kedia, D Boeken, C Lim, D Licastro, B Mannini, D Klenerman
(2026)
(doi: 10.21203/rs.3.rs-10790732/v1)
Melanin Suppresses Aβ Aggregation and Toxicity
A Röntgen, JL Heise, M Vendruscolo, Z Toprakcioglu
(2026)
(doi: 10.64898/2026.09.01.748646)
Quantifying molecular specificity in excipient-driven antibody solubilization.
Z Han, NA Erkamp, R Scrutton, G Licari, O Predeina, A Evers, P Sormanni, TPJ Knowles
mAbs
(2026)
18
(doi: 10.1080/19420862.2026.2722444)
Multimerization of a rationally designed nanobody for enhanced avidity toward Aβ42 oligomers.
M Nowinska, E Suh, C Mogilevsky, M Vendruscolo
Protein Sci
(2026)
35
(doi: 10.1002/pro.70754)
Mechanical Profiling of Biopolymer Condensates through Acoustic Trapping
K Nakajima, T Sneideris, NA Erkamp, LL Good, Y Hideshima, H Ogi, TPJ Knowles
PRX Life
(2026)
4
(doi: 10.1103/kl9v-5ywv)
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression (vol 7, pg 868, 2021)
J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, B Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, C Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes
ACS Central Science
(2026)
12
(doi: 10.1021/acscentsci.6c01291)
Systematic identification of pH-sensing amyloid core motifs reveals a widespread mechanism for reversible protein assembly upon stress
A Kovalenko, DM Pfizenmaier, C Wilson-Zbinden, F Uliana, I Krystkowiak, M Bonassera, CC Schmidt, P Afanasyev, T Cairoli, AD Gossert, T Agarwal, S Kroschwald, VL Bueno, G Cereghetti, T Knowles, N Davey, M Peter
(2026)
(doi: 10.64898/2026.08.11.744147)
Errors in peptide synthesis are a source of discrepancies in Aβ42 studies
K Matulewska-Sobczuk, K Bernfur, D Thacker, J Wallerstein, E Stemme, A Dear, N Lindblom, EA Andrzejewska, C Šneiderienė, TPJ Knowles, G Gouras, U Olsson, S Linse, L Ortigosa-Pascual
(2026)
(doi: 10.64898/2026.07.30.741826)
Structure-Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers
S Errico, A Bigi, G Fani, M Ambrosino, E Galmiche, F Bemporad, M Vendruscolo, B Mannini, F Chiti
Journal of medicinal chemistry
(2026)
69
(doi: 10.1021/acs.jmedchem.6c01682)
Potent substoichiometric inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins
Y Zhang, HL Han, L Ortigosa-Pascual, UZ Miles, F Snow, D Tu, G Meisl, TJ Nott, H Laman, AC McShan, DD Sahtoe, TPJ Knowles
(2026)
(doi: 10.64898/2026.07.13.738012)
Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson’s disease brain tissue
A Röntgen, G Fusco, J Breiter, JS Beckwith, J Lachica, CE Toomey, J Singh, O Klementieva, S Gandhi, S Lee, A De Simone, Z Toprakcioglu, M Vendruscolo
(2026)
(doi: 10.64898/2026.07.05.736591)
Proteoforms modulate the co-condensation of amyloid proteins
A Rontgen, Z Toprakcioglu, O Morris, M Vendruscolo
FEBS OPEN BIO
(2026)
16
Benchmarking and optimisation of human iPSC-based neuronal models for Alzheimer's disease
M Gennari, A Cinuzzi, ZW Terlikowska, M Vendruscolo, F Chiti, B Mannini
FEBS OPEN BIO
(2026)
16
Complex coacervation reshapes the aggregation landscape of tau
Z Han, P Xu, Y Ou, D Qian, Z Xiao, Y Wu, A Santambrogio, M Vendruscolo, TPJ Knowles
(2026)
(doi: 10.64898/2026.06.27.734011)
Yusuf Hamied Department of Chemistry
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