Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 2490 publications
Author(s)
Publication title
Journal Name
Publication year
Errors in peptide synthesis are a source of discrepancies in Aβ42 studies
K Matulewska-Sobczuk, K Bernfur, D Thacker, J Wallerstein, E Stemme, A Dear, N Lindblom, EA Andrzejewska, C Šneiderienė, TPJ Knowles, G Gouras, U Olsson, S Linse, L Ortigosa-Pascual
(2026)
(doi: 10.64898/2026.07.30.741826)
Structure–Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers
S Errico, A Bigi, G Fani, M Ambrosino, E Galmiche, F Bemporad, M Vendruscolo, B Mannini, F Chiti
Journal of Medicinal Chemistry
(2026)
(doi: 10.1021/acs.jmedchem.6c01682)
Potent substoichiometric inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins
Y Zhang, HL Han, L Ortigosa-Pascual, UZ Miles, F Snow, D Tu, G Meisl, TJ Nott, H Laman, AC McShan, DD Sahtoe, TPJ Knowles
(2026)
(doi: 10.64898/2026.07.13.738012)
Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson’s disease brain tissue
A Röntgen, G Fusco, J Breiter, JS Beckwith, J Lachica, CE Toomey, J Singh, O Klementieva, S Gandhi, S Lee, AD Simone, Z Toprakcioglu, M Vendruscolo
(2026)
(doi: 10.64898/2026.07.05.736591)
Complex coacervation reshapes the aggregation landscape of tau
Z Han, P Xu, Y Ou, D Qian, Z Xiao, Y Wu, A Santambrogio, M Vendruscolo, TPJ Knowles
(2026)
(doi: 10.64898/2026.06.27.734011)
Postoperative Changes in Cervical Hemodynamics and Cognitive Function Following Cervical Lymphatic-Venous Surgery in Alzheimer’s Disease
X Zheng, C Tang, H Li, B Wang, Y Zheng, W Song, A Wu, L Xin, D Zhang, R Yang, S Du, P He, Y Li, L Wu, Q Shi, GJL Bernardes
Journal of Alzheimer's Disease
(2026)
112
(doi: 10.1177/13872877261459037)
Editorial overview: Folding, binding and protein design.
J Christodoulou, M Vendruscolo
Current Opinion in Structural Biology
(2026)
99
(doi: 10.1016/j.sbi.2026.103306)
Preserving Native Cellulose–Xylan Architecture Enables Structure–Property Control in Holocellulose Nanofibrils and High-Performance Sustainable Materials
PK Deralia, R Cresswell, Y Yoshimi, T Kuga, A Echevarría-Poza, P Howell, A Dickson, MJ Le Guen, E Wagner, ACS de Alcântara, CGT Batista, N Follain, A Miller, M Vendruscolo, SJ Hill, J Beaugrand, MS Skaf, DJ Cosgrove, SP Brown, JA Elliott, R Dupree, P Dupree
(2026)
(doi: 10.64898/2026.06.07.730583)
Dynamic Palladium Speciation Governs Prodrug Activation by Nanoparticles In Vitro and In Vivo
E Latocheski, GMD Forno, JP Agnes, J Konč, A Zanotto-Filho, GJL Bernardes, JB Domingos
Colloids and surfaces. B, Biointerfaces
(2026)
267
(doi: 10.1016/j.colsurfb.2026.115902)
Size of Biomolecular Condensates Dictates Fate in Liquid-Solid Phase Transitions through Amorphous-Amyloid Competition
J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, Y Oshita, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama
Journal of the American Chemical Society
(2026)
148
(doi: 10.1021/jacs.6c02816)
In vitro and in vivo inhibition of amyloid β aggregation by a Ru( ii )–naphthalene diimide complex
MA Tiburcio, MP Cali, LMB Pereira, AE Graminha, I Atienza-Navarro, M Vendruscolo, M Garcia-Alloza, RM Carlos
Dalton Transactions
(2026)
55
(doi: 10.1039/d5dt02853a)
Many-body Interaction Competition Drives Reentrant Phase Transitions
J Qiao, RM Scrutton, D Qian, TPJ Knowles
(2026)
(doi: 10.64898/2026.05.26.727925)
Prediction of antibody non-specificity using protein language models and biophysical parameters.
LI Sakhnini, L Beltrame, S Fulle, P Sormanni, A Henriksen, N Lorenzen, M Vendruscolo, D Granata
MAbs
(2026)
18
(doi: 10.1080/19420862.2026.2678000)
Phosphorylation tunes strain-specific protein condensation during rotavirus replication organelle assembly
J Acker, X Wang, AJ Pardal, D Desirò, T Agarwal, A Colyer, A Tollervey, R Scrutton, C Haller, L Sherry, KL Saar, K Fominykh, MLLY Johncock, SH Chong, R Murray, J Terry, JD Schmit, AN Calabrese, TPJ Knowles, A Borodavka
The EMBO journal
(2026)
45
(doi: 10.1038/s44318-026-00814-z)
Effects of PTMs on Tau Protein Aggregation: Insights from HCG and Atomistic MD Simulations
A Louet, J Stuke, L Pietrek, M Vendruscolo, G Hummer
(2026)
(doi: 10.64898/2026.05.22.727278)
Does the sequence of a disordered protein encode small molecule binding paths?
A Louet, G Hummer, M Vendruscolo
(2026)
(doi: 10.64898/2026.05.20.726646)
Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2-deficient environments
G Lopes Bernardes
The Journal of experimental medicine
(2026)
223
(doi: 10.1084/jem.20252133)
Tracer-free Contactless Acoustic Microrheometry Quantifies Viscoelastic Spectrum of Phase-separated Condensates
K Nakajima, T Yoshikawa, Y Suzuki, S Nakatani, K Adachi, N Nakamura, S Murayama, H Sakuta, N Yangisawa, NA Erkamp, T Sneideris, M Fukuyama, M Taniguchi, M Yanagisawa, H Ogi, TPJ Knowles
(2026)
(doi: 10.48550/arxiv.2605.11660)
Molecular origins of opalescence and phase separation in mAb formulations and their relation to aggregation.
I Brakti, S Lenton, M Polimeni, H Ausserwöger, R Scrutton, A Henriksen, N Lorenzen, MN Pedersen, JS Marino, F Herranz-Trillo, AE Terry, TPJ Knowles, M Groenning, V Foderà
Commun Chem
(2026)
9
(doi: 10.1038/s42004-026-02056-w)
In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA
V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux
Sci Adv
(2026)
12
(doi: 10.1126/sciadv.aee2110)
Yusuf Hamied Department of Chemistry
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