Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 2393 publications
Author(s)
Publication title
Journal Name
Publication year
Biomaterials with droplet microfluidics
JR Heck, Z Toprakcioglu, DA Weitz, TPJ Knowles
Nature Reviews Bioengineering
(2026)
(doi: 10.1038/s44222-025-00389-0)
Deep Cervical Lymphatic-Venous Anastomosis in Dementia: A Prospective Clinical Study and Mechanistic Evaluation
C Tang, X Zheng, H Li, B Wang, Y Zheng, W Song, A Wu, L Xin, D Zhang, R Yang, S Du, P He, Y Li, L Wu, X Wang, Q Shi, GJL Bernardes
Int J Surg
(2025)
(doi: 10.1097/js9.0000000000004561)
Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core.
H Nadwa, ZF Brotzakis, A Santucci, D Braconi, M Vendruscolo
J Phys Chem Lett
(2025)
16
(doi: 10.1021/acs.jpclett.5c03467)
Controlled Self-Immolative Release of β-Lapachone via an Optimized para-Hydroxybenzyl Linker for Targeted Pancreatic Cancer Therapy
JB Becher, N Dutta, CD Navo, L Dunsmore, R Misteli, E Gil de Montes, GG Simpson, CC Alewine, G Jiménez-Osés, GJL Bernardes
J Am Chem Soc
(2025)
147
(doi: 10.1021/jacs.5c17598)
Single-molecule imaging of small aggregates of IAPP in type 2 diabetes serum with rationally-designed antibody-like scaffolds.
J Lin, YP Zhang, S Chia, D Klenerman, P Sormanni, M Vendruscolo
Chem Sci
(2025)
(doi: 10.1039/d5sc01427a)
Mapping high resolution, multidimensional phase diagrams of physiological protein condensates
T Agarwal, T Sneideris, F Svara, K Jermakovs, H Coyle, S Qamar, E Kava, R Scrutton, N Pleschka, P Peres, G Cereghetti, E Andrzejewska, A Diaz-Barreiro, G Palmer, AJ Costa-Filho, G Krainer, TP Knowles, J Nixon-Abell
(2025)
(doi: 10.1101/2025.11.24.690258)
In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA
V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux
(2025)
(doi: 10.1101/2025.11.25.690368)
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity
SJ Resnick, S Qamar, P Krishna, V Korobeynikov, H Ausserwoger, A Miller, P Esposito, JA Varela, J Sheng, LH Huang, J Nixon-Abell, S Melore, CW Chung, NF Läubli, S Kapsiani, X Li, J Wang, N Zhang, MM Alam, AS Burguete, TC Swayne, Y Chen, Y-C Liao, NA Shneider, M Vendruscolo, TPJ Knowles, CF Kaminski, FS Ruggeri, GS Kaminski Schierle, P St George-Hyslop, A Chavez
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-65178-0)
The Liquid State of RIM1α and RBP Condensates is Maintained by Lipids
CM Fischer, Z Toprakcioglu, E de Csilléry, GS Kaminski Schierle, TPJ Knowles
ACS nano
(2025)
19
(doi: 10.1021/acsnano.5c07661)
Binding Paths: Describing Small Molecule Interactions with Disordered Proteins via Markov State Models
A Louet, G Hummer, M Vendruscolo
(2025)
(doi: 10.1101/2025.11.19.688850)
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding
Y-H Lee, T Saio, M Watabe, M Matsusaki, S Kanemura, Y Lin, T Mannen, T Kuramochi, Y Kamada, K Iuchi, M Tajiri, K Suzuki, Y Li, Y Heo, K Ishii, K Arai, K Ban, M Hashimoto, S Oshita, S Ninagawa, Y Hattori, H Kumeta, A Takeuchi, S Kajimoto, H Abe, E Mori, T Muraoka, T Nakabayashi, S Akashi, T Okiyoneda, M Vendruscolo, K Inaba, M Okumura
Nature Cell Biology
(2025)
27
(doi: 10.1038/s41556-025-01794-8)
A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery
I Černauskienė, E Izquierdo‐García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes
Angewandte Chemie
(2025)
138
(doi: 10.1002/ange.202513808)
A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery
I Černauskienė, E Izquierdo‐García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes
Angewandte Chemie International Edition
(2025)
(doi: 10.1002/anie.202513808)
Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using deep docking
M Brezinova, ZF Brotzakis, RI Horne, V Roy Chowdhury, RC Gregory, Y Bian, A González Díaz, F Gentile, M Vendruscolo
Mol Syst Biol
(2025)
22
(doi: 10.1038/S44320-025-00159-5)
PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning.
SAH Jansen, LSA Dreyer, J van Basten, Y Yao, DE Otzen, TFA de Greef, TPJ Knowles, EW Meijer, NA Erkamp
ACS Nano
(2025)
19
(doi: 10.1021/acsnano.5c07268)
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
(doi: 10.1101/2025.09.08.674880)
Kinetics of seeded protein aggregation: theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
(2025)
(doi: 10.48550/arxiv.2503.20941)
Droplet-based microfluidics uncovers hidden kinetic pathways of protein condensates: divergent routes to amyloids and amorphous aggregates.
J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama
(2025)
(doi: 10.26434/chemrxiv-2025-6xwcg-v2)
A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease.
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
Adv Sci (Weinh)
(2025)
13
(doi: 10.1002/advs.202511297)
Tau catalyzes amyloid-β aggregation in a fold-dependent manner
M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede
(2025)
(doi: 10.1101/2025.10.21.683640)
Yusuf Hamied Department of Chemistry
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