Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 2400 publications
Author(s)
Publication title
Journal Name
Publication year
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue.
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
Nat Biomed Eng
(2025)
(doi: 10.1038/s41551-025-01496-4)
Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau
A Santambrogio, S Lövestam, MA Metrick, T Löhr, P Xu, NCT Gallagher, B Ghetti, B Caughey, SHW Scheres, M Vendruscolo
FEBS Letters
(2025)
(doi: 10.1002/1873-3468.70141)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St George-Hyslop, FS Ruggeri, TPJ Knowles, M Vendruscolo
Communications Chemistry
(2025)
8
(doi: 10.1038/s42004-025-01659-z)
Advances in Proximity-Assisted Bioconjugation
M Canzano, GJL Bernardes
Acc Chem Res
(2025)
58
(doi: 10.1021/acs.accounts.5c00368)
Optofluidic waveguides for the label-free study of silk protein aggregates
JR Heck, Z Toprakcioglu, TE Naegele, MH Frosz, TPJ Knowles, TG Euser
ACS Omega
(2025)
10
(doi: 10.1021/acsomega.5c07826)
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
(doi: 10.1101/2025.09.08.674880)
Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay.
A Santambrogio, RI Horne, MA Metrick, NCT Gallagher, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
J Am Chem Soc
(2025)
147
(doi: 10.1021/jacs.5c12812)
Tumor-Specific STING Agonist Synthesis via a Two-Component Prodrug System
N-S Hsu, C Tang, RV Mendes, C Labão-Almeida, CV Dos Reis, AR Coelho, MC Marques, M Cabeza Cabrerizo, R Misteli, TPC Rooney, M Hyvönen, F Corzana, R Fior, GJL Bernardes
Nature Chemistry
(2025)
(doi: 10.1038/s41557-025-01930-9)
Direct, high-throughput linking of single cell imaging and gene expression
C Xu, G Meisl, N Moshkov, K Goda, A Shkarin, M Schlögel, TPJ Knowles, L Mazutis, J Guck
(2025)
(doi: 10.1101/2025.09.01.672798)
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
J Evans, M Grant-Peters, J Beckwith, C Toomey, R Popovic, J Breiter, J Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, E Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, R Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, M Horrocks, M Vendruscolo, N Wood, S Lee, M Ryten, S Gandhi
(2025)
(doi: 10.1101/2025.08.25.671921)
Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior.
J Wen, Y Tang, T Sneideris, H Ausserwöger, L Hong, TPJ Knowles, S Perrett, G Wei, S Wu
JACS Au
(2025)
5
(doi: 10.1021/jacsau.5c00625)
Rapid elongation drives the exceptionally fast aggregation of medin, the most common localized human amyloid
M Vendruscolo, VR Chowdhury, R Horne, M Cali, Z Toprakcioglu, S Linse
(2025)
(doi: 10.21203/rs.3.rs-6476074/v1)
α-Synuclein driven cell susceptibility in Parkinson’s disease
J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo, S Lee
(2025)
(doi: 10.1101/2025.08.19.670819)
[2.2.1]Heterobicyclic Bromovinyl Sulfones for Thiol-Triggered Strategies in Linker Chemistry: Aza- vs Oxa-Norbornadienic Systems
M Carranza, AT Carmona, C Maya, E Gil de Montes, AV Vasco, GJL Bernardes, AJ Moreno-Vargas
Bioconjug Chem
(2025)
36
(doi: 10.1021/acs.bioconjchem.5c00371)
Spatial transmission of the Alzheimer’s amyloid beta peptide by secondary oligomers
T Knowles, Q Peter, C Taylor, U Lapinska, J Wei, T Michaels, P Arosio, S Linse
(2025)
(doi: 10.21203/rs.3.rs-7035767/v1)
Model Agnostic Conditioning of Boltzmann Generators for Peptide Cyclization
B du Pont, A Abrudan, R Scrutton, V Radenkovic, H Zhao, T Knowles
(2025)
(doi: 10.1101/2025.08.15.670426)
Current practices in the study of biomolecular condensates: a community comment
S Alberti, P Arosio, RB Best, S Boeynaems, D Cai, R Collepardo-Guevara, GL Dignon, R Dimova, S Elbaum-Garfinkle, NL Fawzi, M Fuxreiter, AS Gladfelter, A Honigmann, A Jain, JA Joseph, TPJ Knowles, K Lasker, EA Lemke, K Lindorff-Larsen, R Lipowsky, J Mittal, S Mukhopadhyay, S Myong, RV Pappu, K Rippe, TA Shelkovnikova, AG Vecchiarelli, S Wegmann, H Zhang, M Zhang, C Zubieta, M Zweckstetter, D Dormann, T Mittag
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-62055-8)
Quantifying collective interactions in biomolecular phase separation.
H Ausserwöger, E de Csilléry, D Qian, G Krainer, TJ Welsh, T Sneideris, TM Franzmann, S Qamar, NA Erkamp, J Nixon-Abell, M Kar, P St George-Hyslop, AA Hyman, S Alberti, RV Pappu, TPJ Knowles
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-62437-y)
Structure-based Generation of a Secondary Nucleation Inhibitor in α-Synuclein Aggregation Using a Conditional Diffusion Model
H Zhang, R Horne, Z Faidon Brotzakis, C Harris, P Liò, M Vendruscolo
(2025)
(doi: 10.1101/2025.08.16.670694)
Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders
MD Overath, ASH Rygaard, CP Jacobsen, V Brasas, O Morell, P Sormanni, TP Jenkins
(2025)
(doi: 10.1101/2025.08.14.670059)
Yusuf Hamied Department of Chemistry
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