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  • Currently displaying 1 - 20 of 2699 publications
The Impact of Activity‐based Protein Profiling in Malaria Drug Discovery
LAR Carvalho, GJL Bernardes
– ChemMedChem
(2022)
e202200174
(DOI: 10.1002/cmdc.202200174)
Structural insights into TRPV2 activation by small molecules
RA Pumroy, AD Protopopova, TC Fricke, IU Lange, FM Haug, PT Nguyen, PN Gallo, BB Sousa, G Lopes Bernardes, V Yarov-Yarovoy, A Leffler, VY Moiseenkova-Bell
– Nature Communications
(2022)
13,
(DOI: 10.1038/s41467-022-30083-3)
Structural insights into TRPV2 activation by small molecules
RA Pumroy, AD Protopopova, TC Fricke, IU Lange, FM Haug, PT Nguyen, PN Gallo, BB Sousa, GJL Bernardes, V Yarov-Yarovoy, A Leffler, VY Moiseenkova-Bell
– Nat Commun
(2022)
13,
2334
(DOI: 10.1038/s41467-022-30083-3)
Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols.
AC Colgan, RSJ Proctor, DC Gibson, P Chuentragool, ASK Lahdenperä, K Ermanis, RJ Phipps
– Angew Chem Int Ed Engl
(2022)
e202200266
(DOI: 10.1002/anie.202200266)
Micromechanics of soft materials using microfluidics
Y Xu, H Zhu, Y Shen, APM Guttenplan, KL Saar, Y Lu, D Vigolo, LS Itzhaki, TPJ Knowles
– MRS Bulletin
(2022)
47,
1
(DOI: 10.1557/s43577-022-00279-5)
A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents
RP Kreiser, AK Wright, LR Sasser, DJ Rinauro, JM Gabriel, CM Hsu, JA Hurtado, TL McKenzie, S Errico, JA Albright, L Richardson, VA Jaffett, DE Riegner, LT Nguyen, K LeForte, M Zasloff, JE Hollows, F Chiti, M Vendruscolo, R Limbocker
– ACS Chemical Neuroscience
(2022)
13,
1219
(DOI: 10.1021/acschemneuro.1c00840)
Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2 br
V Denninger, CK Xu, G Meisl, AS Morgunov, S Fiedler, A Ilsley, M Emmenegger, AY Malik, MA Piziorska, MM Schneider, SRA Devenish, V Kosmoliaptsis, A Aguzzi, H Fiegler, TPJ Knowles
– ACS Infect Dis
(2022)
8,
790
(DOI: 10.1021/acsinfecdis.1c00486)
Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry
X Ferhati, E Jiménez-Moreno, EA Hoyt, G Salluce, M Cabeza-Cabrerizo, CD Navo, I Compañón, P Akkapeddi, MJ Matos, N Salaverri, P Garrido, A Martínez, V Laserna, TV Murray, G Jiménez-Osés, P Ravn, GJL Bernardes, F Corzana
– J Am Chem Soc
(2022)
144,
5284
(DOI: 10.1021/jacs.1c07675)
Surface interaction patches link non-specific binding and phase separation of antibodies
H Ausserwöger, G Krainer, T Welsh, T Sneideris, M Schneider, G Invernizzi, T Herling, N Lorenzen, T Knowles
(2022)
(DOI: 10.1101/2022.03.07.483238)
The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation.
S Cogo, FY Ho, E Tosoni, JE Tomkins, I Tessari, L Iannotta, TJ Montine, C Manzoni, PA Lewis, L Bubacco, M-C Chartier Harlin, J-M Taymans, A Kortholt, J Nichols, L Cendron, L Civiero, E Greggio
– Brain Research
(2022)
1778,
147781
(DOI: 10.1016/j.brainres.2022.147781)
Chaperones Skp and SurA dynamically expand unfolded OmpX and synergistically disassemble oligomeric aggregates.
N Chamachi, A Hartmann, MQ Ma, A Svirina, G Krainer, M Schlierf
– Proceedings of the National Academy of Sciences
(2022)
119,
e2118919119
(DOI: 10.1073/pnas.2118919119)
Tie-lines reveal interactions driving heteromolecular condensate formation
D Qian, T Welsh, N Erkamp, S Qamar, J Nixon-Abell, G Krainer, PS George-Hyslop, T Michaels, T Knowles
(2022)
(DOI: 10.1101/2022.02.22.481401)
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
C Xu, M Castellana-Cruz, S Chen, Z Du, G Meisl, A Levin, B Mannini, L Itzhaki, T Knowles, C Dobson, N Cremades, J Kumita
– Molecules
(2022)
27,
1293
(DOI: 10.3390/molecules27041293)
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.
CK Xu, M Castellana-Cruz, SW Chen, Z Du, G Meisl, A Levin, B Mannini, LS Itzhaki, TPJ Knowles, CM Dobson, N Cremades, JR Kumita
– Molecules
(2022)
27,
1293
(DOI: 10.3390/molecules27041293)
Sustainable Production of Reduced Phosphorus Compounds: Mechanochemical Hydride Phosphorylation Using Condensed Phosphates as a Route to Phosphite
F Zhai, T Xin, MB Geeson, CC Cummins
– ACS Cent Sci
(2022)
8,
332
(DOI: 10.1021/acscentsci.1c01381)
Simultaneous fractionation and characterization of pre-fibrillar aggregates in solution with single-molecule microfluidics
EA Andrzejewska, G Krainer, CK Xu, R Jacquat, MM Schneider, W Arter, TPJ Knowles
– Biophysical Journal
(2022)
121,
353a
(DOI: 10.1016/j.bpj.2021.11.1003)
Hsc70 mediated disaggregation of α-synuclein fibrils
MM Schneider, S Gautam, TW Herling, G Krainer, E Andrzejewska, A Bracher, CM Dobson, U Hartl, TP Knowles
– Biophysical Journal
(2022)
121,
22a
(DOI: 10.1016/j.bpj.2021.11.2605)
Using microscopy techniques to structurally characterise TDP-43 inclusions present in mammalian cell models
NS Matharu, CW Chung, JR Kumita, GS Kaminski, TP Knowles
– Biophysical Journal
(2022)
121,
268A
(DOI: 10.1016/j.bpj.2021.11.1401)
Mechanism of secondary nucleation from the direct observation of A beta 42 aggregation at the single fibril level
MR Zimmermann, SC Bera, G Meisl, S Dasadhikari, S Ghosh, S Linse, K Garai, TPJ Knowles
– Biophysical Journal
(2022)
121,
443a
(DOI: 10.1016/j.bpj.2021.11.556)
The C-terminal tail of alpha-synuclein protects against aggregate replication but is critical for oligomerization
A Farzadfard, JN Pedersen, G Meisl, AK Somavarapu, P Alam, L Goksøyr, MA Nielsen, AF Sander, TPJ Knowles, JS Pedersen, DE Otzen
– Commun Biol
(2022)
5,
123
(DOI: 10.1038/s42003-022-03059-8)

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