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Centre for Misfolding Diseases


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  • Currently displaying 1 - 20 of 2192 publications
Formation of distinct prion protein amyloid fibrils under identical experimental conditions
M Ziaunys, T Sneideris, V Smirnovas
– Sci Rep
The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State
M Runfola, A De Simone, M Vendruscolo, CM Dobson, G Fusco
– Scientific Reports
Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy.
FS Ruggeri, B Mannini, R Schmid, M Vendruscolo, TPJ Knowles
– Nature Communications
Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution
WE Arter, CK Xu, M Castellana-Cruz, TW Herling, G Krainer, KL Saar, JR Kumita, CM Dobson, TPJ Knowles
– Nano letters
Phase Transition and Crystallization Kinetics of a Supramolecular System in a Microfluidic Platform
D Cohen-Gerassi, ZA Arnon, T Guterman, A Levin, M Ghosh, M Aviv, D Levy, TPJ Knowles, Y Shacham-Diamand, L Adler-Abramovich
– Chemistry of Materials
The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils
D Thacker, K Sanagavarapu, B Frohm, G Meisl, TPJ Knowles, S Linse
– Proceedings of the National Academy of Sciences of the United States of America
Self-Replication of Prion Protein Fragment 89-230 Amyloid Fibrils Accelerated by Prion Protein Fragment 107-143 Aggregates
T Sneideris, M Ziaunys, BK-Y Chu, RP-Y Chen, V Smirnovas
– International Journal of Molecular Sciences
An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase
AE Conicella, R Huang, ZA Ripstein, A Nguyen, E Wang, T Löhr, P Schuck, M Vendruscolo, JL Rubinstein, LE Kay
– Proceedings of the National Academy of Sciences
Direct measurement of lipid membrane disruption connects kinetics and toxicity of A beta 42 aggregation
P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, M Vendruscolo, S Linse, D Klenerman, TPJ Knowles, CM Dobson
– Nat Struct Mol Biol
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition
Y Shen, FS Ruggeri, D Vigolo, A Kamada, S Qamar, A Levin, C Iserman, S Alberti, PS George-Hyslop, TPJ Knowles
– Nat Nanotechnol
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease.
T Ikenoue, FA Aprile, P Sormanni, FS Ruggeri, M Perni, GT Heller, CP Haas, C Middel, R Limbocker, B Mannini, TCT Michaels, TPJ Knowles, CM Dobson, M Vendruscolo
– Scientific reports
Biomimetic peptide self-assembly for functional materials
A Levin, TA Hakala, L Schnaider, GJL Bernardes, E Gazit, TPJ Knowles
– Nature Reviews Chemistry
Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors.
TCT Michaels, A Šarić, G Meisl, GT Heller, S Curk, P Arosio, S Linse, CM Dobson, M Vendruscolo, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
Probing the unfolded protein response in long-lived naked mole-rats.
Z Du, S Chakrabarti, Y Kulaberoglu, ESJ Smith, CM Dobson, LS Itzhaki, JR Kumita
– Biochemical and biophysical research communications
SDS-induced multi-stage unfolding of a small globular protein through different denatured states revealed by single-molecule fluorescence
G Krainer, A Hartmann, V Bogatyr, J Nielsen, M Schlierf, DE Otzen
– Chemical Science
A prion-like domain in ELF3 functions as a thermosensor inArabidopsis
J-H Jung, AD Barbosa, S Hutin, JR Kumita, M Gao, D Derwort, CS Silva, X Lai, E Pierre, F Geng, S-B Kim, S Baek, C Zubieta, KE Jaeger, PA Wigge
– Nature
Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers.
M Chrabąszczewska, AK Sieradzan, S Rodziewicz-Motowidło, A Grubb, CM Dobson, JR Kumita, M Kozak
– Int J Mol Sci
Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils.
J Yang, AJ Dear, Q-Q Yao, Z Liu, CM Dobson, TPJ Knowles, S Wu, S Perrett
– Nanoscale
Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism
T Sinnige, G Meisl, T Michaels, M Vendruscolo, TPJ Knowles, R Morimoto
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, SW Chen, J Habchi, A Bigi, RP Kreiser, AK Wright, JA Albright, T Kartanas, JR Kumita, N Cremades, M Zasloff, C Cecchi, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Communications biology