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Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 1843 publications
Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion.
S Sieste, T Mack, CV Synatschke, C Schilling, C Meyer Zu Reckendorf, L Pendi, S Harvey, FS Ruggeri, TPJ Knowles, C Meier, DYW Ng, T Weil, B Knöll
– Adv Healthc Mater
(2018)
e1701485
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.
F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, N Esteras, AY Abramov, TJP Knowles, M Goedert, D Klenerman
– ACS Chem Neurosci
(2018)
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding
F El Turk, E De Genst, T Guilliams, B Fauvet, M Hejjaoui, J Di Trani, A Chiki, A Mittermaier, M Vendruscolo, HA Lashuel, CM Dobson
– Protein Science
(2018)
Molecular determinants of the interaction of EGCG with ordered and disordered proteins
G Fusco, M Sanz-Hernandez, FS Ruggeri, M Vendruscolo, CM Dobson, A De Simone
– Biopolymers
(2018)
e23117
Ethanol Controls the Self-Assembly and Mesoscopic Properties of Human Insulin Amyloid Spherulites
V Vetri, F Piccirilli, J Krausser, G Buscarino, U Łapińska, B Vestergaard, A Zaccone, V Foderà
– J Phys Chem B
(2018)
122,
3101
Toxic HypF-N Oligomers Selectively Bind the Plasma Membrane to Impair Cell Adhesion Capability.
R Oropesa-Nuñez, S Keshavan, S Dante, A Diaspro, B Mannini, C Capitini, C Cecchi, M Stefani, F Chiti, C Canale
– Biophys J
(2018)
114,
1357
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide
SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, M Vendruscolo, CM Dobson, AK Buell, TPJ Knowles, S Linse
– Nature Chemistry
(2018)
10,
1
A structural ensemble modulation mechanism of small molecule binding to disordered proteins
GT Heller, M Bonomi, M Vendruscolo
– Journal of molecular biology
(2018)
Corneal Dystrophy Mutations Drive Pathogenesis by Targeting TGFBIp Stability and Solubility in a Latent Amyloid-forming Domain.
M Stenvang, NP Schafer, KG Malmos, A-MW Pérez, O Niembro, P Sormanni, RV Basaiawmoit, G Christiansen, M Andreasen, DE Otzen
– Journal of molecular biology
(2018)
430,
1116
Publisher Correction: The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris.
M Bonanomi, V Roffia, A De Palma, A Lombardi, FA Aprile, C Visentin, P Tortora, P Mauri, ME Regonesi
– Scientific reports
(2018)
8,
4285
Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices.
PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, JLP Benesch, TPJ Knowles
– Anal Chem
(2018)
90,
3849
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
– Annu Rev Phys Chem
(2018)
69,
273
TEMPORARY REMOVAL: Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, NW Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
– J Neurosci Methods
(2018)
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species
L-M Needham, J Weber, JWB Fyfe, OM Kabia, DT Do, E Klimont, Y Zhang, M Rodrigues, CM Dobson, S Ghandi, SE Bohndiek, TN Snaddon, SF Lee
– Royal Society open science
(2018)
5,
171399
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.
D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, D Klenerman, AM van Oijen, H Ecroyd
– J Biol Chem
(2018)
293,
4486
Biophotonics of Native Silk Fibrils.
U Shimanovich, D Pinotsi, K Shimanovich, N Yu, S Bolisetty, J Adamcik, R Mezzenga, J Charmet, F Vollrath, E Gazit, CM Dobson, GK Schierle, C Holland, CF Kaminski, TPJ Knowles
– Macromolecular Bioscience
(2018)
18,
e1700295
Microfluidic approaches for probing amyloid assembly and behaviour
TW Herling, A Levin, KL Saar, CM Dobson, TPJ Knowles
– Lab on a chip
(2018)
18,
999
Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2.
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, S Perrett
– Journal of the American Chemical Society
(2018)
140,
2493
Optical Structural Analysis of Individual α-Synuclein Oligomers.
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
– Angew Chem Int Ed Engl
(2018)
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.
H Gang, C Galvagnion, G Meisl, T Müller, M Pfammatter, AK Buell, A Levin, CM Dobson, B Mu, TPJ Knowles
– Anal Chem
(2018)
90,
3284