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Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 2732 publications
Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants.
M Emmenegger, S Fiedler, SD Brugger, SRA Devenish, AS Morgunov, A Ilsley, F Ricci, AY Malik, T Scheier, L Batkitar, L Madrigal, M Rossi, G Meisl, AK Lynn, L Saleh, A von Eckardstein, TPJ Knowles, A Aguzzi
– iScience
(2022)
25,
104766
Uncovering the universality of self-replication in protein aggregation and its link to disease
G Meisl, CK Xu, JD Taylor, TCT Michaels, A Levin, D Otzen, D Klenerman, S Matthews, S Linse, M Andreasen, TPJ Knowles
– Science Advances
(2022)
8,
eabn6831
A conformational switch controlling the toxicity of the prion protein.
K Frontzek, M Bardelli, A Senatore, A Henzi, RR Reimann, S Bedir, M Marino, R Hussain, S Jurt, G Meisl, M Pedotti, F Mazzola, G Siligardi, O Zerbe, M Losa, T Knowles, A Lakkaraju, C Zhu, P Schwarz, S Hornemann, MG Holt, L Simonelli, L Varani, A Aguzzi
– Nature Structural & Molecular Biology
(2022)
29,
831
The N-terminal acetylation of α-synuclein slows down its aggregation process and alters the morphology of the resulting aggregates
R Bell, RJ Thrush, M Castellana-Cruz, M Oeller, R Staats, A Nene, P Flagmeier, CK Xu, S Satapathy, C Galvagnion, MR Wilson, CM Dobson, JR Kumita, M Vendruscolo
– Biochemistry
(2022)
Chemical and Enzymatic Methods for Post-Translational Protein–Protein Conjugation
RJ Taylor, MB Geeson, T Journeaux, GJL Bernardes
– Journal of the American Chemical Society
(2022)
ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy.
C Olivieri, GC Li, Y Wang, M V S, C Walker, J Kim, C Camilloni, A De Simone, M Vendruscolo, DA Bernlohr, SS Taylor, G Veglia
– Science Advances
(2022)
8,
eabo0696
Adsorption free energy predicts amyloid protein nucleation rates.
Z Toprakcioglu, A Kamada, TCT Michaels, M Xie, J Krausser, J Wei, A Saric, M Vendruscolo, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2022)
119,
e2109718119
Are casein micelles extracellular condensates formed by liquid‐liquid phase separation?
A Horvath, M Fuxreiter, M Vendruscolo, C Holt, JA Carver
– FEBS Letters
(2022)
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
H Mikolajek, M Weckener, ZF Brotzakis, J Huo, EV Dalietou, A Le Bas, P Sormanni, PJ Harrison, PN Ward, S Truong, L Moynie, DK Clare, M Dumoux, J Dormon, C Norman, N Hussain, V Vogirala, RJ Owens, M Vendruscolo, JH Naismith
– Proc Natl Acad Sci U S A
(2022)
119,
e2205412119
DNA–Liposome Hybrid Carriers for Triggered Cargo Release
KN Baumann, T Schröder, PS Ciryam, D Morzy, P Tinnefeld, TPJ Knowles, S Hernández-Ainsa
– ACS Applied Bio Materials
(2022)
π‑Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation
RJ Taylor, M Aguilar Rangel, MB Geeson, P Sormanni, M Vendruscolo, GJL Bernardes
– Journal of the American Chemical Society
(2022)
144,
13026
Injectable Granular Hydrogels as Colloidal Assembly Microreactors for Customized Structural Colored Objects.
J Zhang, Y Qin, Y Ou, Y Shen, B Tang, X Zhang, Z Yu
– Angewandte Chemie International Edition
(2022)
e202206339
Structure specific amyloid precipitation in biofluids
M Rodrigues, P Bhattacharjee, A Brinkmalm, DT Do, CM Pearson, S De, A Ponjavic, JA Varela, K Kulenkampff, I Baudrexel, D Emin, FS Ruggeri, JE Lee, AR Carr, TPJ Knowles, H Zetterberg, TN Snaddon, S Gandhi, SF Lee, D Klenerman
– Nat Chem
(2022)
1
Recent Advances in Microgels: From Biomolecules to Functionality.
Y Xu, H Zhu, A Denduluri, Y Ou, NA Erkamp, R Qi, Y Shen, TPJ Knowles
– Small
(2022)
e2200180
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.
M Kar, F Dar, TJ Welsh, LT Vogel, R Kühnemuth, A Majumdar, G Krainer, TM Franzmann, S Alberti, CAM Seidel, TPJ Knowles, AA Hyman, RV Pappu
– Proceedings of the National Academy of Sciences
(2022)
119,
e2202222119
Amyloid seeding assays for the selective amplification of tau aggregates from human brain homogenates
M Metrick
(2022)
Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease.
G Meisl, TPJ Knowles, D Klenerman
– Frontiers in neuroscience
(2022)
16,
909861
Controlled masking and targeted release of redox-cycling ortho-quinones via a C-C bond-cleaving 1,6-elimination
L Dunsmore, CD Navo, J Becher, EG de Montes, A Guerreiro, E Hoyt, L Brown, V Zelenay, S Mikutis, J Cooper, I Barbieri, S Lawrinowitz, E Siouve, E Martin, PR Ruivo, T Rodrigues, FP da Cruz, O Werz, G Vassiliou, P Ravn, G Jiménez-Osés, GJL Bernardes
– Nature chemistry
(2022)
14,
754
Aging can transform single-component protein condensates into multiphase architectures.
A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
– Proceedings of the National Academy of Sciences
(2022)
119,
e2119800119
Uncovering the universality of self-replication in protein aggregation and its link to disease
G Meisl, C Xu, J Taylor, TCT Michaels, A Levin, DE Otzen, D Klenerman, S Matthews, S Linse, M Andreasen, T Knowles
(2022)