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Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 2498 publications
Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis.
PR Lindstedt, RJ Taylor, GJL Bernardes, M Vendruscolo
– ACS chemical neuroscience
(2021)
acschemneuro.0c00761
A kinetic ensemble of the Alzheimer’s Aβ peptide
T Löhr, K Kohlhoff, GT Heller, C Camilloni, M Vendruscolo
– Nature Computational Science
(2021)
1,
71
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
R Cataldi, S Chia, K Pisani, FS Ruggeri, CK Xu, T Šneideris, M Perni, S Sarwat, P Joshi, JR Kumita, S Linse, J Habchi, TPJ Knowles, B Mannini, CM Dobson, M Vendruscolo
– Communications Biology
(2021)
4,
19
Observation of an α-1synuclein liquid droplet state and its maturation into Lewy body-like assemblies
MC Hardenberg, T Sinnige, S Casford, S Dada, C Poudel, EA Robinson, M Fuxreiter, C Kaminksi, GS Kaminski-Schierle, EAA Nollen, CM Dobson, M Vendruscolo
– J Mol Cell Biol
(2021)
mjaa075-
Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions (vol 16, pg 3586, 2020)
Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GJL Bernardes, TPJ Knowles
– Soft matter
(2021)
17,
201
A method of incorporating rate constants as kinetic constraints in molecular dynamics simulations
ZF Brotzakis, M Vendruscolo, PG Bolhuis
– Proc Natl Acad Sci U S A
(2020)
118,
e2012423118
Interactions of α-synuclein oligomers with lipid membranes.
G Musteikytė, AK Jayaram, CK Xu, M Vendruscolo, G Krainer, TPJ Knowles
– Biochim Biophys Acta Biomembr
(2020)
183536
Environmental Control of Amyloid Polymorphism by Modulation of Hydrodynamic Stress.
J Zhou, L Venturelli, L Keiser, SK Sekatskii, F Gallaire, S Kasas, G Longo, TPJ Knowles, FS Ruggeri, G Dietler
– ACS nano
(2020)
acsnano.0c07570
Screening of small molecules using the inhibition of oligomer formation in alpha-synuclein aggregation as a selection parameter
R Staats, TCT Michaels, P Flagmeier, S Chia, RI Horne, J Habchi, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Communications Chemistry
(2020)
3,
191
Engineering mono- and multi-valent inhibitors on a modular scaffold
A Diamante, PK Chaturbedy, PJE Rowling, JR Kumita, RS Eapen, SH McLaughlin, MDL Roche, A Perez-Riba, LS Itzhaki
– Chemical Science
(2020)
Physical mechanisms of amyloid nucleation on fluid membranes
J Krausser, TPJ Knowles, A Šarić
– Proc Natl Acad Sci U S A
(2020)
117,
33090
New solution for fast axial scanning in fluorescence microscopy
W Zong
– Light: Science & Applications
(2020)
9,
199
Widespread occurrence of the droplet state of proteins in the human proteome
M Hardenberg, A Horvath, V Ambrus, M Fuxreiter, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2020)
117,
33254
Evolution of Conformation, Nanomechanics, and Infrared Nanospectroscopy of Single Amyloid Fibrils Converting into Microcrystals
J Adamcik, FS Ruggeri, JT Berryman, A Zhang, TPJ Knowles, R Mezzenga
– Advanced Science
(2020)
8,
2002182
In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry.
VFC Ferreira, BL Oliveira, A D'Onofrio, CM Farinha, L Gano, A Paulo, GJL Bernardes, F Mendes
– Bioconjugate Chemistry
(2020)
32,
121
Sequence determinants for the aggregation and cytotoxicity of proteins within condensates generated by liquid-liquid phase separation
M Vendruscolo, M Fuxreiter
(2020)
Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates.
N Ahmed, UA Friedrich, P Sormanni, P Ciryam, NS Altman, B Bukau, G Kramer, EP O'Brien
– Journal of molecular biology
(2020)
432,
166696
A Computational and Experimental Investigation of the Origin of Selectivity in the Chiral Phosphoric Acid Catalyzed Enantioselective Minisci Reaction.
K Ermanis, AC Colgan, RSJ Proctor, BW Hadrys, RJ Phipps, JM Goodman
– Journal of the American Chemical Society
(2020)
142,
21091
Effect of Ionic Strength on Thioflavin-T Affinity to Amyloid Fibrils and Its Fluorescence Intensity
K Mikalauskaite, M Ziaunys, T Sneideris, V Smirnovas
– International Journal of Molecular Sciences
(2020)
21,
8916
Structural and dynamics analysis of intrinsically disordered proteins by high-speed atomic force microscopy.
N Kodera, D Noshiro, SK Dora, T Mori, J Habchi, D Blocquel, A Gruet, M Dosnon, E Salladini, C Bignon, Y Fujioka, T Oda, NN Noda, M Sato, M Lotti, M Mizuguchi, S Longhi, T Ando
– Nat Nanotechnol
(2020)
1