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  • Currently displaying 1 - 20 of 2982 publications
Amyloids and protein aggregation
S Linse, T Knowles
– Chemical Science
(2023)
(doi: 10.1039/d2sc90225g)
Condensate partitioning governs the mechanism of action of FUS phase separation modulators
H Ausserwoeger, D Qian, G Krainer, T Welsh, T Sneideris, T Franzmann, S Qamar, J Nixon-Abell, M Kar, P St George-Hyslop, A Hyman, S Alberti, R Pappu, T Knowles
(2023)
(doi: 10.1101/2023.05.31.543137)
α-Synuclein oligomers form by secondary nucleation
C Xu, G Meisl, E Andrzejewska, G Krainer, A Dear, MC Cruz, S Turi, R Jacquat, W Arter, M Vendruscolo, S Linse, TPJ Knowles
(2023)
(doi: 10.1101/2023.05.28.542651)
Towards sequence-based principles for protein phase separation predictions.
M Vendruscolo, M Fuxreiter
– Current Opinion in Chemical Biology
(2023)
75,
102317
(doi: 10.1016/j.cbpa.2023.102317)
Fragment merging strategies with known pyrimidine scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis
T Kirkman, SF Tan, SMC Pacheco, A Hammer, M Tosin, A Coyne, M Dias
– ChemMedChem
(2023)
e202300240
(doi: 10.1002/cmdc.202300240)
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains.
A Miller, J Wei, S Meehan, CM Dobson, ME Welland, D Klenerman, M Vendruscolo, FS Ruggeri, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2023)
120,
e2216234120
(doi: 10.1073/pnas.2216234120)
Theoretical and Data-Driven Approaches for Biomolecular Condensates
KL Saar, D Qian, LL Good, AS Morgunov, R Collepardo-Guevara, RB Best, TPJ Knowles
– Chemical Reviews
(2023)
(doi: 10.1021/acs.chemrev.2c00586)
High-grade serous ovarian carcinoma organoids as models of chromosomal instability.
M Vias, L Morrill Gavarró, CM Sauer, DA Sanders, AM Piskorz, D-L Couturier, S Ballereau, B Hernando, MP Schneider, J Hall, F Correia-Martins, F Markowetz, G Macintyre, JD Brenton
– Elife
(2023)
12,
e83867
(doi: 10.7554/elife.83867)
Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
– Angew Chem Int Ed Engl
(2023)
e202304449
(doi: 10.1002/anie.202304449)
Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
– Angewandte Chemie
(2023)
(doi: 10.1002/ange.202304449)
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C–C Bond Cleavage Reactions
GM Dal Forno, E Latocheski, A Beatriz Machado, J Becher, L Dunsmore, AL St John, BL Oliveira, CD Navo, G Jiménez-Osés, R Fior, JB Domingos, GJL Bernardes
– J Am Chem Soc
(2023)
145,
10790
(doi: 10.1021/jacs.3c01960)
Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules.
S Mikutis, M Rebelo, E Yankova, M Gu, C Tang, AR Coelho, M Yang, ME Hazemi, M Pires de Miranda, M Eleftheriou, M Robertson, GS Vassiliou, DJ Adams, JP Simas, F Corzana, JS Schneekloth, K Tzelepis, GJL Bernardes
– ACS Cent Sci
(2023)
9,
892
(doi: 10.1021/acscentsci.3c00015)
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases.
R Limbocker, N Cremades, R Cascella, PM Tessier, M Vendruscolo, F Chiti
– Accounts of chemical research
(2023)
(doi: 10.1021/acs.accounts.3c00045)
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference**
J El Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, I Fathoni, MVB Dias, EO Johnson, AG Coyne, V Mizrahi, TL Blundell, C Abell, C Spry
– Angewandte Chemie
(2023)
135,
(doi: 10.1002/ange.202300221)
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis
MM Katariya, M Snee, RB Tunnicliffe, ME Kavanagh, HIM Boshoff, CN Amadi, CW Levy, AW Munro, C Abell, D Leys, AG Coyne, KJ McLean
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2023)
29,
e202203868
(doi: 10.1002/chem.202203868)
Automated optimisation of solubility and conformational stability of antibodies and proteins
A Rosace, A Bennett, M Oeller, MM Mortensen, L Sakhnini, N Lorenzen, C Poulsen, P Sormanni
– Nat Commun
(2023)
14,
1937
(doi: 10.1038/s41467-023-37668-6)
Automated optimisation of solubility and conformational stability of antibodies and proteins
A Rosace, A Bennett, M Oeller, MM Mortensen, L Sakhnini, N Lorenzen, C Poulsen, P Sormanni
– Nature Communications
(2023)
14,
1937
(doi: 10.1038/s41467-023-37668-6)
Surface patches induce nonspecific binding and phase separation of antibodies.
H Ausserwöger, G Krainer, TJ Welsh, N Thorsteinson, E de Csilléry, T Sneideris, MM Schneider, T Egebjerg, G Invernizzi, TW Herling, N Lorenzen, TPJ Knowles
– Proc Natl Acad Sci U S A
(2023)
120,
e2210332120
(doi: 10.1073/pnas.2210332120)
FuzPred: a web server for the sequence-based prediction of the context-dependent binding modes of proteins.
A Hatos, JM Teixeira, S Barrera-Vilarmau, A Horvath, SCE Tosatto, M Vendruscolo, M Fuxreiter
– Nucleic acids research
(2023)
gkad214
(doi: 10.1093/nar/gkad214)
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins
G Agam, C Gebhardt, M Popara, R Mächtel, J Folz, B Ambrose, N Chamachi, SY Chung, TD Craggs, M de Boer, D Grohmann, T Ha, A Hartmann, J Hendrix, V Hirschfeld, CG Hübner, T Hugel, D Kammerer, H-S Kang, AN Kapanidis, G Krainer, K Kramm, EA Lemke, E Lerner, E Margeat, K Martens, J Michaelis, J Mitra, GG Moya Muñoz, RB Quast, NC Robb, M Sattler, M Schlierf, J Schneider, T Schröder, A Sefer, PS Tan, J Thurn, P Tinnefeld, J van Noort, S Weiss, N Wendler, N Zijlstra, A Barth, CAM Seidel, DC Lamb, T Cordes
– Nature methods
(2023)
20,
523
(doi: 10.1038/s41592-023-01807-0)

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