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Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 1890 publications
A synthetic enzyme built from DNA flips 10<sup>7</sup>lipids per second in biological membranes
A Ohmann, C-Y Li, C Maffeo, K Al Nahas, KN Baumann, K Göpfrich, J Yoo, UF Keyser, A Aksimentiev
– Nature Communications
(2018)
9,
2426
Secondary nucleation in amyloid formation.
M Törnquist, TCT Michaels, K Sanagavarapu, X Yang, G Meisl, SIA Cohen, TPJ Knowles, S Linse
– Chemical communications (Cambridge, England)
(2018)
Oligomer diversity during the aggregation of the repeat-region of tau
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman
– ACS Chemical Neuroscience
(2018)
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson
– ACS Chem Biol
(2018)
Determination of Polypeptide Conformation with Nanoscale Resolution in Water.
G Ramer, FS Ruggeri, A Levin, TPJ Knowles, A Centrone
– ACS Nano
(2018)
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils.
JWP Brown, G Meisl, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion
– Chemical communications (Cambridge, England)
(2018)
Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.
FS Ruggeri, F Benedetti, TPJ Knowles, HA Lashuel, S Sekatskii, G Dietler
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
Enhancing the resolution of micro free flow electrophoresis through spatially controlled sample injection.
KL Saar, T Müller, J Charmet, PK Challa, TPJ Knowles
– Anal Chem
(2018)
Reversible inhibition of the ClpP protease via an N-terminal conformational switch.
S Vahidi, ZA Ripstein, M Bonomi, T Yuwen, MF Mabanglo, JB Juravsky, K Rizzolo, A Velyvis, WA Houry, M Vendruscolo, JL Rubinstein, LE Kay
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers
DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, JR Kumita, H Ecroyd, CM Dobson, D Klenerman, MR Wilson
– Cell Rep
(2018)
23,
3492
On the role of sidechain size and charge in the aggregation of A
X Yang, G Meisl, B Frohm, E Thulin, TPJ Knowles, S Linse
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
E5849
Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry.
R Fassler, N Edinger, O Rimon, D Reichmann
– Journal of visualized experiments : JoVE
(2018)
(DOI: 10.3791/57806)
Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils
Y Song, TCT Michaels, Q Ma, Z Liu, H Yuan, S Takayama, TPJ Knowles, HC Shum
– Nature Communications
(2018)
9,
2110
Cooperative Assembly of Hsp70 Subdomain Clusters
MA Wright, FA Aprile, MMJ Bellaiche, TCT Michaels, T Müller, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Biochemistry
(2018)
57,
3641
Reaction rate theory for supramolecular kinetics: application to protein aggregation
TCT Michaels, LX Liu, S Curk, PG Bolhuis, A Šarić, TPJ Knowles
– Molecular Physics
(2018)
1
A method for partitioning the information contained in a protein sequence between its structure and function.
A Possenti, M Vendruscolo, C Camilloni, G Tiana
– Proteins
(2018)
Rapid Growth of Acetylated Aβ(16-20) into Macroscopic Crystals.
C Bortolini, LH Klausen, SV Hoffmann, NC Jones, D Saadeh, Z Wang, TPJ Knowles, M Dong
– ACS Nano
(2018)
Stochastic calculus of protein filament formation under spatial confinement
TCT Michaels, AJ Dear, TPJ Knowles
– NEW JOURNAL OF PHYSICS
(2018)
20,
ARTN 055007
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.
MN Bongiovanni, FA Aprile, P Sormanni, M Vendruscolo
– International journal of molecular sciences
(2018)
19,
ARTN 1443
Single-Molecule Light-Sheet Imaging of Suspended T Cells
A Ponjavic, J McColl, AR Carr, AM Santos, K Kulenkampff, A Lippert, SJ Davis, D Klenerman, SF Lee
– Biophys J
(2018)
114,
2200