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Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 1613 publications
Thermodynamics of polypeptide supramolecular assembly in the short chain limit.
TO Mason, TCT Michaels, A Levin, CM Dobson, E Gazit, TPJ Knowles, AK Buell
– Journal of the American Chemical Society
(2017)
High quality-factor label-free single analyte detection with MEMS cantilevers integrated into microfluidic systems.
T Kartanas, V Ostanin, PK Challa, R Daly, J Charmet, TPJ Knowles
– Anal Chem
(2017)
Absolute Quantification of Amyloid Propagons by Digital Microfluidics.
M Pfammatter, M Andreasen, G Meisl, CG Taylor, J Adamcik, S Bolisetty, A Sanchez-Ferrer, D Klenerman, CM Dobson, R Mezzenga, TPJ Knowles, AA Aguzzi, S Hornemann
– Anal Chem
(2017)
Hierarchical biomolecular emulsions using 3-D microfluidics with uniform surface chemistry.
Z Toprakcioglu, A Levin, TPJ Knowles
– Biomacromolecules
(2017)
Integrative structure modeling with the Integrative Modeling Platform.
B Webb, S Viswanath, M Bonomi, R Pellarin, CH Greenberg, D Saltzberg, A Sali
– Protein Sci
(2017)
Kinetic constraints on self-assembly into closed supramolecular structures
TCT Michaels, MMJ Bellaiche, MF Hagan, TPJ Knowles
– Scientific reports
(2017)
7,
12295
Gradient-free determination of isoelectric points of proteins on chip.
U Łapińska, KL Saar, EV Yates, TW Herling, T Müller, PK Challa, CM Dobson, TPJ Knowles
– Physical chemistry chemical physics : PCCP
(2017)
19,
23060
Methods of probing the interactions between small molecules and disordered proteins.
GT Heller, FA Aprile, M Vendruscolo
– Cellular and Molecular Life Sciences
(2017)
74,
3225
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide
GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, M Vendruscolo
– Journal of molecular biology
(2017)
429,
2772
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress alpha-synuclein aggregation
FA Aprile, E Källstig, G Limorenko, M Vendruscolo, D Ron, C Hansen
– Scientific reports
(2017)
7,
9039
The molecular architecture of the yeast spindle pole body core determined by Bayesian integrative modeling
S Viswanath, M Bonomi, SJ Kim, VA Klenchin, KC Taylor, KC Yabut, NT Umbreit, HA Van Epps, J Meehl, MH Jones, D Russel, JA Velazquez-Muriel, M Winey, I Rayment, TN Davis, A Sali, EG Muller
– Molecular Biology of the Cell
(2017)
mbc.E17-06-0397
Rapid and accurate in silico solubility screening of a monoclonal antibody library.
P Sormanni, L Amery, S Ekizoglou, M Vendruscolo, B Popovic
– Scientific reports
(2017)
7,
8200
Sequential Release of Proteins from Structured Multishell Microcapsules
U Shimanovich, TCT Michaels, E De Genst, D Matak-Vinkovic, CM Dobson, TPJ Knowles
– Biomacromolecules
(2017)
Monomeric and fibrillar alpha-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of A beta 42 aggregates
S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
8005
Silk micrococoons for protein stabilisation and molecular encapsulation
U Shimanovich, FS Ruggeri, E De Genst, J Adamcik, TP Barros, D Porter, T Müller, R Mezzenga, CM Dobson, F Vollrath, C Holland, TPJ Knowles
– Nature Communications
(2017)
8,
15902
The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases.
N Cremades, CM Dobson
– Neurobiology of disease
(2017)
Protein homeostasis of a metastable subproteome associated with Alzheimer's disease
R Kundra, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E5703
Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species
M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman
– BMC biology
(2017)
15,
57
Self-assembled Protein Fibril-metal Oxide Nanocomposites
A Levin, TO Mason, TPJ Knowles, U Shimanovich
– Israel Journal of Chemistry
(2017)
57,
724
Ultrasensitive Measurement of Ca<sup>2+</sup> Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angew Chem Int Ed Engl
(2017)
56,
7750