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Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 1954 publications
Determination of protein structural ensembles using cryo-electron microscopy
M Bonomi, M Vendruscolo
– Current Opinion in Structural Biology
(2019)
56,
37
(DOI: 10.1016/j.sbi.2018.10.006)
In vitro and in silico assessment of the developability of a designed monoclonal antibody library.
A-M Wolf Pérez, P Sormanni, JS Andersen, LI Sakhnini, I Rodriguez-Leon, JR Bjelke, AJ Gajhede, L De Maria, DE Otzen, M Vendruscolo, N Lorenzen
– mAbs
(2018)
(DOI: 10.1080/19420862.2018.1556082)
Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism.
C Bortolini, T Kartanas, D Copic, I Condado Morales, Y Zhang, PK Challa, Q Peter, T Jávorfi, R Hussain, M Dong, G Siligardi, TPJ Knowles, J Charmet
– Lab on a chip
(2018)
(DOI: 10.1039/c8lc00757h)
A synthetic enzyme built from DNA flips 107 lipids per second in biological membranes
A Ohmann, C-Y Li, C Maffeo, K Al Nahas, KN Baumann, K Göpfrich, J Yoo, UF Keyser, A Aksimentiev
– Nature Communications
(2018)
9,
2426
(DOI: 10.1038/s41467-018-04821-5)
Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.
FA Aprile, E Källstig, G Limorenko, M Vendruscolo, D Ron, C Hansen
– Sci Rep
(2018)
8,
11848
(DOI: 10.1038/s41598-018-29893-7)
Mechanobiology of Protein Droplets: Force Arises from Disorder.
TJ Welsh, Y Shen, A Levin, TPJ Knowles
– Cell
(2018)
175,
1457
(DOI: 10.1016/j.cell.2018.11.020)
Determination of Structural Ensembles of Proteins: Restraining vs Reweighting.
R Rangan, M Bonomi, GT Heller, A Cesari, G Bussi, M Vendruscolo
– Journal of chemical theory and computation
(2018)
(DOI: 10.1021/acs.jctc.8b00738)
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.
J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman
– Nano Letters
(2018)
(DOI: 10.1021/acs.nanolett.8b02916)
Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools.
L Shan, N Mody, P Sormani, KL Rosenthal, MM Damschroder, R Esfandiary
– Molecular pharmaceutics
(2018)
(DOI: 10.1021/acs.molpharmaceut.8b00867)
Quantifying Co-Oligomer Formation by α-Synuclein
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman
– ACS nano
(2018)
12,
10855
(DOI: 10.1021/acsnano.8b03575)
Statistical Mechanics of Globular Oligomer Formation by Protein Molecules.
AJ Dear, A Šarić, TCT Michaels, CM Dobson, TPJ Knowles
– J Phys Chem B
(2018)
(DOI: 10.1021/acs.jpcb.8b07805)
Direct Observation of Murine Prion Protein Replication in Vitro.
JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, R Bujdoso, D Klenerman
– Journal of the American Chemical Society
(2018)
140,
14789
(DOI: 10.1021/jacs.8b08311)
Third generation antibody discovery methods: in silico rational design.
P Sormanni, FA Aprile, M Vendruscolo
– Chem Soc Rev
(2018)
(DOI: 10.1039/c8cs00523k)
Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR.
C Pinto, D Mance, T Sinnige, M Daniëls, M Weingarth, M Baldus
– Nature Communications
(2018)
9,
4135
(DOI: 10.1038/s41467-018-06466-w)
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells
DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M-G Spillantini, D Klenerman, MH Horrocks
– ChemBioChem
(2018)
19,
2033
(DOI: 10.1002/cbic.201800209)
A bioinformatics approach to define the aggregation capacity of the myofiber proteome in inclusion body myositis
C Weihl, P Ciryam, A Guttsches, K Marcus, R Morimoto, M Vendruscolo, R Kley
– NEUROMUSCULAR DISORDERS
(2018)
28,
S77
(DOI: 10.1016/j.nmd.2018.06.188)
Observation of molecular self-assembly events in massively parallel microdroplet arrays.
Z Toprakcioglu, PK Challa, A Levin, TPJ Knowles
– Lab on a Chip
(2018)
18,
3303
(DOI: 10.1039/c8lc00862k)
SAR by kinetics for drug discovery in protein misfolding diseases.
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proc Natl Acad Sci U S A
(2018)
115,
10245
(DOI: 10.1073/pnas.1807884115)
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles
– Nature Communications
(2018)
9,
3890
(DOI: 10.1038/s41467-018-06345-4)
Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes.
Z Li, J Tuffin, IM Lei, FS Ruggeri, NS Lewis, EL Gill, T Savin, L Huleihel, SF Badylak, T Knowles, SC Satchell, GI Welsh, MA Saleem, YYS Huang
– Acta biomaterialia
(2018)
78,
111
(DOI: 10.1016/j.actbio.2018.08.010)

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