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Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 2049 publications
Trodusquemine enhances A beta(42) aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nat Commun
(2019)
10,
225
(DOI: 10.1038/s41467-018-07699-5)
Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis
MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles
– Analyst
(2019)
(DOI: 10.1039/c9an00382g)
Programmable On-Chip Artificial Cell Producing Post-Translationally Modified Ubiquitinated Protein.
S Zilberzwige-Tal, A Levin, Z Toprakcioglu, TPJ Knowles, E Gazit, J Elbaz
– Small
(2019)
e1901780
(DOI: 10.1002/smll.201901780)
Determination of protein structural ensembles using cryo-electron microscopy
M Bonomi, M Vendruscolo
– Current Opinion in Structural Biology
(2018)
56,
37
(DOI: 10.1016/j.sbi.2018.10.006)
Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response.
T Sinnige, P Ciryam, S Casford, CM Dobson, M de Bono, M Vendruscolo
– PloS one
(2019)
14,
e0217746
(DOI: 10.1371/journal.pone.0217746)
Defining α-synuclein species responsible for Parkinson disease phenotypes in mice.
JM Froula, M Castellana-Cruz, NM Anabtawi, JD Camino, SW Chen, DR Thrasher, J Freire, AA Yazdi, S Fleming, CM Dobson, JR Kumita, N Cremades, LA Volpicelli-Daley
– Journal of Biological Chemistry
(2019)
jbc.RA119.007743
(DOI: 10.1074/jbc.ra119.007743)
Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation.
C Torrini, RJ Cubero, E Dirkx, L Braga, H Ali, G Prosdocimo, MI Gutierrez, C Collesi, D Licastro, L Zentilin, M Mano, S Zacchigna, M Vendruscolo, M Marsili, A Samal, M Giacca
– Cell reports
(2019)
27,
2759
(DOI: 10.1016/j.celrep.2019.05.005)
The toxicity of misfolded protein oligomers is independent of their secondary structure
M Vivoli Vega, R Cascella, SW Chen, G Fusco, A De Simone, CM Dobson, C Cecchi, F Chiti
– ACS Chemical Biology
(2019)
acschembio.9b00324
(DOI: 10.1021/acschembio.9b00324)
Effects of alpha-tubulin acetylation on microtubule structure and stability
L Eshun-Wilson, R Zhang, D Portran, MV Nachury, DB Toso, T Löhr, M Vendruscolo, M Bonomi, JS Fraser, E Nogales
– Proc Natl Acad Sci U S A
(2019)
116,
10366
(DOI: 10.1073/pnas.1900441116)
Whole genome experimental maps of DNA G-quadruplexes in multiple species
G Marsico, VS Chambers, AB Sahakyan, P McCauley, JM Boutell, M Di Antonio, S Balasubramanian
– Nucleic Acids Research
(2019)
47,
3862
(DOI: 10.1093/nar/gkz179)
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies
R Cascella, M Perni, SW Chen, G Fusco, C Cecchi, M Vendruscolo, F Chiti, CM Dobson, A De Simone
– ACS Chem Biol
(2019)
acschembio.9b00312
(DOI: 10.1021/acschembio.9b00312)
Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in
C Huang, S Wagner-Valladolid, AD Stephens, R Jung, C Poudel, T Sinnige, MC Lechler, N Schlörit, M Lu, RF Laine, CH Michel, M Vendruscolo, CF Kaminski, GS Kaminski Schierle, DC David
– eLife
(2019)
8,
ARTN e43059
(DOI: 10.7554/elife.43059)
Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming.
N Ahmed, P Sormanni, P Ciryam, M Vendruscolo, CM Dobson, EP O'Brien
– Scientific reports
(2019)
9,
6256
(DOI: 10.1038/s41598-019-42348-x)
Biophysical Techniques in Structural Biology.
CM Dobson
– Annu Rev Biochem
(2019)
88,
annurev-biochem-013118-111947
(DOI: 10.1146/annurev-biochem-013118-111947)
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions.
P Kukic, GM Lo Piccolo, MO Nogueira, DI Svergun, M Vendruscolo, IC Felli, R Pierattelli
– Sci Rep
(2019)
9,
5822
(DOI: 10.1038/s41598-019-41925-4)
Determination of the structural ensemble of the molten globule state of a protein by computer simulations
M Shimizu, Y Kajikawa, K Kuwajima, CM Dobson, Y Okamoto
– Proteins: Structure, Function and Bioinformatics
(2019)
prot.25688
(DOI: 10.1002/prot.25688)
Different soluble aggregates of A beta 42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
– Nature communications
(2019)
10,
1541
(DOI: 10.1038/s41467-019-09477-3)
The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS
JJ Yerbury, L Ooi, IP Blair, P Ciryam, CM Dobson, M Vendruscolo
– Neuroscience Letters
(2019)
704,
89
(DOI: 10.1016/j.neulet.2019.04.001)
Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates
T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio
– Sci Adv
(2019)
5,
eaau3112
(DOI: 10.1126/sciadv.aau3112)
The Amyloid Phenomenon and Its Significance in Biology and Medicine.
CM Dobson, TPJ Knowles, M Vendruscolo
– Cold Spring Harb Perspect Biol
(2019)
a033878
(DOI: 10.1101/cshperspect.a033878)

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