Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 2525 publications
Author(s)
Publication title
Journal Name
Publication year
Diffusion-Model-Guided Identification of a Candidate α-Synuclein Aggregation Inhibitor under Secondary-Nucleation-Dominated Conditions
H Zhang, RI Horne, ZF Brotzakis, C Harris, P Liò, M Vendruscolo
The Journal of Physical Chemistry Letters
(2026)
(doi: 10.1021/acs.jpclett.6c02433)
PED in 2027: integrating experimental and predicted protein conformational ensembles at scale
AM Monzon, H Ghafouri, XA Castro, S Khezrian, MC Aspromonte, K Singla, S Barethiya, P Bernadó, M Bonomi, J Chen, T Cordeiro, J Cortés, S De Castro, R Emenecker, M Feig, JD Forman-Kay, T Head-Gordon, A Holehouse, G Janson, K Lindorff-Larsen, ZH Liu, S Longhi, M Pajkos, P Robustelli, S Rodriguez, V Schnapka, N Sibille, M Vendruscolo, SCE Tosatto
Nucleic Acids Res
(2026)
(doi: 10.1093/nar/gkag1048)
Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression
V Sabatino, C Tang, RC Acúrcio, AR Coelho, FM Müller, M Fontes, WT Khaw, C Labão-Almeida, DR Hicks, W Yang, A Vasco Vidal, I Sarkar, D Shome, M Cabeza-Cabrerizo, TV Rohm, S Fleisch, A Gerber, SA Hogan, F Gerster, D Kaymak, S Pantelyushin, J Vom Berg, L Li, RM Reijmers, R Fior, D Baker, HF Florindo, G Hutter, GJL Bernardes
Cancer Res
(2026)
(doi: 10.1158/0008-5472.can-25-5578)
Zatom-2: Multitask Pretraining on Atomistic Data for Generative Modeling across Domains
M Cretu, A Abrudan, A Panescu, T Perez, R Anand, NB Erichson, MW Mahoney, S Blau, J Jacobson, R Gómez-Bombarelli, R Ying, T Knowles, P Liò, A Morehead
(2026)
Protein rheostasis: quality control in metastable proteomes
M Vendruscolo
Philos Trans R Soc Lond B Biol Sci
(2026)
381
(doi: 10.1098/rstb.2025.0279)
Binding without Docking: Small-Molecule Binding Paths on Disordered Proteins.
A Louet, G Hummer, M Vendruscolo
J Am Chem Soc
(2026)
148
(doi: 10.1021/jacs.6c05891)
Charge-driven remodelling of monomeric Tau determines its phase behaviour
Y Oktaviandie, Z Han, K Stott, TPJ Knowles
(2026)
(doi: 10.64898/2026.09.21.752903)
Single-Atom O/S/Se Substitution at the Glycosidic Linkage in Glycopeptide Cancer Vaccines Reveals Divergent Performance
C Bretón, A Guerreiro, P Oroz, N Osés, I Ginés‐Alcober, FJ Cañada, R Hurtado‐Guerrero, JL Asensio, JM Peregrina, GJL Bernardes, F Corzana
Angewandte Chemie
(2026)
(doi: 10.1002/ange.8540595)
Single-Atom O/S/Se Substitution at the Glycosidic Linkage in Glycopeptide Cancer Vaccines Reveals Divergent Performance.
C Bretón, A Guerreiro, P Oroz, N Osés, I Ginés-Alcober, FJ Cañada, R Hurtado-Guerrero, JL Asensio, JM Peregrina, GJL Bernardes, F Corzana
Angew Chem Int Ed Engl
(2026)
(doi: 10.1002/anie.8540595)
Mechanistic Interpretability of Protein Language Models Reveals Encoded Structural and Functional Properties of Intrinsically Disordered Proteins.
L Naworski, LL Good, R Scrutton, TPJ Knowles
(2026)
(doi: 10.64898/2026.09.10.750691)
Protein self-assembly in crowded environments
MCM Martens, Z Han, RVM Freire, S Huisman, IK Voets, TPJ Knowles, R Tuinier, NA Erkamp
J Colloid Interface Sci
(2026)
727
(doi: 10.1016/j.jcis.2026.141573)
Mapping high resolution, multidimensional phase diagrams of near-physiological protein condensates
T Agarwal, T Sneideris, F Svara, K Jermakovs, H Coyle, S Qamar, E Kava, R Scrutton, N Pleschka, P Peres, G Cereghetti, E Andrzejewska, A Diaz-Barreiro, G Palmer, AJ Costa-Filho, G Krainer, TP Knowles, J Nixon-Abell
Nat Commun
(2026)
17
(doi: 10.1038/s41467-026-77696-6)
Downregulation of FBXO2 is associated with Aβ aggregation, tau hyperphosphorylation and network impairment in human cortical neurons
M Vendruscolo, AG Diaz, A Possenti, G Urritia, Y Bian, S Kedia, D Boeken, C Lim, D Licastro, B Mannini, D Klenerman
(2026)
(doi: 10.21203/rs.3.rs-10790732/v1)
Melanin Suppresses Aβ Aggregation and Toxicity
A Röntgen, JL Heise, M Vendruscolo, Z Toprakcioglu
(2026)
(doi: 10.64898/2026.09.01.748646)
Quantifying molecular specificity in excipient-driven antibody solubilization
Z Han, NA Erkamp, R Scrutton, G Licari, O Predeina, A Evers, P Sormanni, TPJ Knowles
MAbs
(2026)
18
(doi: 10.1080/19420862.2026.2722444)
Multimerization of a rationally designed nanobody for enhanced avidity toward Aβ42 oligomers.
M Nowinska, E Suh, C Mogilevsky, M Vendruscolo
Protein Science
(2026)
35
(doi: 10.1002/pro.70754)
Mechanical Profiling of Biopolymer Condensates through Acoustic Trapping
K Nakajima, T Sneideris, NA Erkamp, LL Good, Y Hideshima, H Ogi, TPJ Knowles
Prx Life
(2026)
4
(doi: 10.1103/kl9v-5ywv)
Correction to "Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression".
J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, S H Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes
ACS Central Science
(2026)
12
(doi: 10.1021/acscentsci.6c01291)
Systematic identification of pH-sensing amyloid core motifs reveals a widespread mechanism for reversible protein assembly upon stress
A Kovalenko, DM Pfizenmaier, C Wilson-Zbinden, F Uliana, I Krystkowiak, M Bonassera, CC Schmidt, P Afanasyev, T Cairoli, AD Gossert, T Agarwal, S Kroschwald, VL Bueno, G Cereghetti, T Knowles, N Davey, M Peter
(2026)
(doi: 10.64898/2026.08.11.744147)
Errors in peptide synthesis are a source of discrepancies in Aβ42 studies
K Matulewska-Sobczuk, K Bernfur, D Thacker, J Wallerstein, E Stemme, A Dear, N Lindblom, EA Andrzejewska, C Šneiderienė, TPJ Knowles, G Gouras, U Olsson, S Linse, L Ortigosa-Pascual
(2026)
(doi: 10.64898/2026.07.30.741826)
Yusuf Hamied Department of Chemistry
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