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Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 2159 publications
The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State.
M Runfola, A De Simone, M Vendruscolo, CM Dobson, G Fusco
– Sci Rep
(2020)
10,
204
(DOI: 10.1038/s41598-019-57023-4)
Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy.
FS Ruggeri, B Mannini, R Schmid, M Vendruscolo, TPJ Knowles
– Nature Communications
(2020)
11,
2945
(DOI: 10.1038/s41467-020-16728-1)
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition.
Y Shen, FS Ruggeri, D Vigolo, A Kamada, S Qamar, A Levin, C Iserman, S Alberti, PS George-Hyslop, TPJ Knowles
– Nature Nanotechnology
(2020)
1
(DOI: 10.1038/s41565-020-0731-4)
Probing the unfolded protein response in long-lived naked mole-rats
Z Du, S Chakrabarti, Y Kulaberoglu, ESJ Smith, CM Dobson, LS Itzhaki, JR Kumita
– Biochemical and Biophysical Research Communications
(2020)
529,
1151
(DOI: 10.1016/j.bbrc.2020.06.118)
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation.
P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, M Vendruscolo, S Linse, D Klenerman, TPJ Knowles, CM Dobson
– Nature structural & molecular biology
(2020)
1
(DOI: 10.1038/s41594-020-0471-z)
Single-molecule confinement with uniform electrodynamic nanofluidics.
S Ghosh, N Karedla, I Gregor
– Lab on a Chip
(2020)
(DOI: 10.1039/d0lc00398k)
A microfluidic strategy for the detection of membrane protein interactions
Y Zhang, TW Herling, S Kreida, QAE Peter, T Kartanas, S Törnroth-Horsefield, S Linse, TPJ Knowles
– Lab on a chip
(2020)
(DOI: 10.1039/d0lc00205d)
Continuous Flow Reactors from Microfluidic Compartmentalization of Enzymes within Inorganic Microparticles.
TA Hakala, F Bialas, Z Toprakcioglu, B Bräuer, KN Baumann, A Levin, GJL Bernardes, CFW Becker, TPJ Knowles
– ACS Applied Materials & Interfaces
(2020)
12,
32951
(DOI: 10.1021/acsami.0c09226)
Templating S100A9 amyloids on A beta fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses
J Pansieri, IA Iashchishyn, H Fakhouri, L Ostojić, M Malisauskas, G Musteikyte, V Smirnovas, MM Schneider, T Scheidt, CK Xu, G Meisl, TPJ Knowles, E Gazit, R Antoine, LA Morozova-Roche
– Chemical Science
(2020)
11,
7031
(DOI: 10.1039/c9sc05905a)
Half a century of amyloids: past, present and future
PC Ke, R Zhou, LC Serpell, R Riek, TPJ Knowles, HA Lashuel, E Gazit, IW Hamley, TP Davis, M Fändrich, DE Otzen, MR Chapman, CM Dobson, DS Eisenberg, R Mezzenga
– Chemical Society Reviews
(2020)
49,
5473
(DOI: 10.1039/c9cs00199a)
Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-beta Oligomers
R Limbocker, B Mannini, R Cataldi, S Chhangur, AK Wright, RP Kreiser, JA Albright, S Chia, J Habchi, P Sormanni, JR Kumita, FS Ruggeri, CM Dobson, F Chiti, FA Aprile, M Vendruscolo
– International journal of molecular sciences
(2020)
21,
4542
(DOI: 10.3390/ijms21124542)
Multidimensional protein characterisation using microfluidic post-column analysis.
T Scheidt, T Kartanas, Q Peter, MM Schneider, KL Saar, T Müller, PK Challa, A Levin, S Devenish, TPJ Knowles
– Lab Chip
(2020)
20,
2663
(DOI: 10.1039/d0lc00219d)
Identification of on- and off-pathway oligomers in amyloid fibril formation
AJ Dear, G Meisl, A Saric, TCT Michaels, M Kjaergaard, S Linse, TPJ Knowles
– Chemical Science
(2020)
11,
6236
(DOI: 10.1039/c9sc06501f)
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.
FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo
– Proc Natl Acad Sci U S A
(2020)
117,
13509
(DOI: 10.1073/pnas.1919464117)
Comparative characterisation of non-monodisperse gold nanoparticle populations by X-ray scattering and electron microscopy.
Y Yang, S Liao, Z Luo, R Qi, N Mac Fhionnlaoich, F Stellacci, S Guldin
– Nanoscale
(2020)
12,
12007
(DOI: 10.1039/c9nr09481d)
Microfluidic Templating of Spatially Inhomogeneous Protein Microgels.
Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles
– Small (Weinheim an der Bergstrasse, Germany)
(2020)
e2000432
(DOI: 10.1002/smll.202000432)
Rapid Generation of Protein Condensate Phase Diagrams Using Combinatorial Droplet Microfluidics
W Arter, R Qi, G Krainer, T Welsh, Y Xu, PS George-Hyslop, S Alberti, TPJ Knowles
(2020)
(DOI: 10.1101/2020.06.04.132308)
Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases.
T Sinnige, K Stroobants, CM Dobson, M Vendruscolo
– Quarterly Reviews of Biophysics
(2020)
49,
e22
(DOI: 10.1017/S0033583520000025)
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
E Kelmer Sacramento, JM Kirkpatrick, M Mazzetto, M Baumgart, A Bartolome, S Di Sanzo, C Caterino, M Sanguanini, N Papaevgeniou, M Lefaki, D Childs, S Bagnoli, E Terzibasi Tozzini, D Di Fraia, N Romanov, PH Sudmant, W Huber, N Chondrogianni, M Vendruscolo, A Cellerino, A Ori
– Mol Syst Biol
(2020)
16,
e9596
(DOI: 10.15252/msb.20209596)
Direct digital sensing of proteins in solution through single-molecule optofluidics
G Krainer, K Saar, W Arter, RPB Jacquat, Q Peter, P Challa, C Taylor, D Klenerman, TPJ Knowles
(2020)
(DOI: 10.1101/2020.05.24.113498)

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