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Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 3187 publications
Automated optimization of the solubility of a hyper-stable α-amylase
M Ali, M Greenig, M Oeller, M Atkinson, X Xu, P Sormanni
– Open Biology
(2024)
14,
240014
Pharmacological inhibition of α-synuclein aggregation within liquid condensates
ST Dada, Z Toprakcioglu, MP Cali, A Röntgen, MC Hardenberg, OM Morris, LK Mrugalla, TPJ Knowles, M Vendruscolo
– Nat Commun
(2024)
15,
3835
Automated optimisation of the solubility of a hyper-stable α-amylase
M Ali, M Greenig, M Oeller, M Atkinson, X Xu, P Sormanni
– Open Biology
(2024)
14,
240014
Maximum entropy determination of mammalian proteome dynamics.
AJ Dear, GA Garcia, G Meisl, GA Collins, TPJ Knowles, AL Goldberg
– Proc Natl Acad Sci U S A
(2024)
121,
e2313107121
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
AJ Dear, X Teng, SR Ball, J Lewin, RI Horne, D Clow, A Stevenson, N Harper, K Yahya, X Yang, SC Brewerton, J Thomson, TCT Michaels, S Linse, TPJ Knowles, J Habchi, G Meisl
– Chemical Science
(2024)
15,
7229
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
TLC Ng, MP Hoare, MJ Maristany, EJ Wilde, T Sneideris, J Huertas, BK Agbetiameh, M Furukawa, JA Joseph, TPJ Knowles, R Collepardo-Guevara, LS Itzhaki, JR Kumita
(2024)
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
– Nature chemical biology
(2024)
20,
634
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds
B Fu, E Brock, R Andrews, J Breiter, R Tian, C Toomey, J Lachica, T Lashley, M Ryten, N Wood, M Vendruscolo, S Gandhi, L Weiss, J Beckwith, S Lee
– The Journal of Physical Chemistry B
(2024)
128,
3585
Selenium-silk microgels as antifungal and antibacterial agents
EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
– Nanoscale Horiz
(2024)
9,
609
Dominance Analysis: A formalism to uncover dominant energetic contributions to biomolecular condensate formation in multicomponent systems
D Qian, H Ausserwoger, T Sneideris, M Farag, RV Pappu, TPJ Knowles
(2024)
The thermodynamics of neurodegenerative disease
G Meisl
– Biophysics reviews
(2024)
5,
011303
Design of amyloidogenic peptide traps
DD Sahtoe, EA Andrzejewska, HL Han, E Rennella, MM Schneider, G Meisl, M Ahlrichs, J Decarreau, H Nguyen, A Kang, P Levine, M Lamb, X Li, AK Bera, LE Kay, TPJ Knowles, D Baker
– Nature Chemical Biology
(2024)
1
Understanding Biology in the Age of Artificial Intelligence
E Lawrence, A El-Shazly, S Seal, CK Joshi, P Liò, S Singh, A Bender, P Sormanni, M Greenig
(2024)
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions
S Chia, RL Cataldi, FS Ruggeri, R Limbocker, I Condado-Morales, K Pisani, A Possenti, S Linse, TPJ Knowles, J Habchi, B Mannini, M Vendruscolo
– ACS Chemical Neuroscience
(2024)
15,
1125
Targeted protein editing with an antibody-based system
M Vendruscolo, O Rimon, J Konc, M Ali, VR Chowdhury, P Sormanni, G Bernardes
(2024)
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
DJ Rinauro, F Chiti, M Vendruscolo, R Limbocker
– Molecular Neurodegeneration
(2024)
19,
20
Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, R Tian, JS Beckwith, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
(2024)
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates.
B Bernardim, J Conde, T Hakala, JB Becher, M Canzano, AV Vasco, TPJ Knowles, J Cameron, GJL Bernardes
– Bioconjugate chemistry
(2024)
35,
132
Self-replication of Aβ42 aggregates occurs on small and isolated fibril sites
S Curk, J Krausser, G Meisl, D Frenkel, S Linse, TCT Michaels, TPJ Knowles, A Šarić
– Proc Natl Acad Sci U S A
(2024)
121,
e2220075121
Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms.
A Röntgen, Z Toprakcioglu, JE Tomkins, M Vendruscolo
– Proceedings of the National Academy of Sciences
(2024)
121,
e2313465121