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Currently displaying 1 - 20 of 2491 publications

Errors in peptide synthesis are a source of discrepancies in Aβ42 studies

K Matulewska-Sobczuk, K Bernfur, D Thacker, J Wallerstein, E Stemme, A Dear, N Lindblom, EA Andrzejewska, C Šneiderienė, TPJ Knowles, G Gouras, U Olsson, S Linse, L Ortigosa-Pascual

(2026)

(doi: 10.64898/2026.07.30.741826)

Structure–Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers

S Errico, A Bigi, G Fani, M Ambrosino, E Galmiche, F Bemporad, M Vendruscolo, B Mannini, F Chiti

Journal of Medicinal Chemistry

(2026)

(doi: 10.1021/acs.jmedchem.6c01682)

Potent substoichiometric inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins

Y Zhang, HL Han, L Ortigosa-Pascual, UZ Miles, F Snow, D Tu, G Meisl, TJ Nott, H Laman, AC McShan, DD Sahtoe, TPJ Knowles

(2026)

(doi: 10.64898/2026.07.13.738012)

Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson’s disease brain tissue

A Röntgen, G Fusco, J Breiter, JS Beckwith, J Lachica, CE Toomey, J Singh, O Klementieva, S Gandhi, S Lee, A De Simone, Z Toprakcioglu, M Vendruscolo

(2026)

(doi: 10.64898/2026.07.05.736591)

Complex coacervation reshapes the aggregation landscape of tau

Z Han, P Xu, Y Ou, D Qian, Z Xiao, Y Wu, A Santambrogio, M Vendruscolo, TPJ Knowles

(2026)

(doi: 10.64898/2026.06.27.734011)

Postoperative changes in cervical hemodynamics and cognitive function following cervical lymphatic-venous surgery in Alzheimer's disease

X Zheng, C Tang, H Li, B Wang, Y Zheng, W Song, A Wu, L Xin, D Zhang, R Yang, S Du, P He, Y Li, L Wu, Q Shi, GJL Bernardes

Journal of Alzheimer's Disease

(2026)

112

1536

(doi: 10.1177/13872877261459037)

Editorial overview: Folding, binding and protein design.

J Christodoulou, M Vendruscolo

Current Opinion in Structural Biology

(2026)

103306

(doi: 10.1016/j.sbi.2026.103306)

Preserving Native Cellulose–Xylan Architecture Enables Structure–Property Control in Holocellulose Nanofibrils and High-Performance Sustainable Materials

PK Deralia, R Cresswell, Y Yoshimi, T Kuga, A Echevarría-Poza, P Howell, A Dickson, MJ Le Guen, E Wagner, ACS de Alcântara, CGT Batista, N Follain, A Miller, M Vendruscolo, SJ Hill, J Beaugrand, MS Skaf, DJ Cosgrove, SP Brown, JA Elliott, R Dupree, P Dupree

(2026)

(doi: 10.64898/2026.06.07.730583)

Dynamic Palladium Speciation Governs Prodrug Activation by Nanoparticles In Vitro and In Vivo

E Latocheski, GMD Forno, JP Agnes, J Konč, A Zanotto-Filho, GJL Bernardes, JB Domingos

Colloids and surfaces. B, Biointerfaces

(2026)

267

115902

(doi: 10.1016/j.colsurfb.2026.115902)

Size of Biomolecular Condensates Dictates Fate in Liquid–Solid Phase Transitions through Amorphous–Amyloid Competition

J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, Y Oshita, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama

Journal of the American Chemical Society

(2026)

148

23837

(doi: 10.1021/jacs.6c02816)

<i>In vitro</i> and <i>in vivo</i> inhibition of amyloid β aggregation by a Ru(II)-naphthalene diimide complex.

MA Tiburcio, MP Cali, LMB Pereira, AE Graminha, I Atienza-Navarro, M Vendruscolo, M Garcia-Alloza, RM Carlos

Dalton transactions (Cambridge, England : 2003)

(2026)

8304

(doi: 10.1039/d5dt02853a)

Many-body Interaction Competition Drives Reentrant Phase Transitions

J Qiao, RM Scrutton, D Qian, TPJ Knowles

(2026)

(doi: 10.64898/2026.05.26.727925)

Prediction of antibody non-specificity using protein language models and biophysical parameters.

LI Sakhnini, L Beltrame, S Fulle, P Sormanni, A Henriksen, N Lorenzen, M Vendruscolo, D Granata

Mabs

(2026)

2678000

(doi: 10.1080/19420862.2026.2678000)

Effects of PTMs on Tau Protein Aggregation: Insights from HCG and Atomistic MD Simulations

A Louet, J Stuke, L Pietrek, M Vendruscolo, G Hummer

(2026)

(doi: 10.64898/2026.05.22.727278)

Phosphorylation tunes strain-specific protein condensation during rotavirus replication organelle assembly

J Acker, X Wang, AJ Pardal, D Desirò, T Agarwal, A Colyer, A Tollervey, R Scrutton, C Haller, L Sherry, KL Saar, K Fominykh, MLLY Johncock, SH Chong, R Murray, J Terry, JD Schmit, AN Calabrese, TPJ Knowles, A Borodavka

The EMBO journal

(2026)

(doi: 10.1038/s44318-026-00814-z)

Does the sequence of a disordered protein encode small molecule binding paths?

A Louet, G Hummer, M Vendruscolo

(2026)

(doi: 10.64898/2026.05.20.726646)

Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2-deficient environments.

G Lopes Bernardes

Journal of Experimental Medicine (JEM)

(2026)

223

e20252133

(doi: 10.1084/jem.20252133)

Molecular origins of opalescence and phase separation in mAb formulations and their relation to aggregation

I Brakti, S Lenton, M Polimeni, H Ausserwöger, R Scrutton, A Henriksen, N Lorenzen, MN Pedersen, JS Marino, F Herranz-Trillo, AE Terry, TPJ Knowles, M Groenning, V Foderà

Communications Chemistry

(2026)

256

(doi: 10.1038/s42004-026-02056-w)

Tracer-free Contactless Acoustic Microrheometry Quantifies Viscoelastic Spectrum of Phase-separated Condensates

K Nakajima, T Yoshikawa, Y Suzuki, S Nakatani, K Adachi, N Nakamura, S Murayama, H Sakuta, N Yangisawa, NA Erkamp, T Sneideris, M Fukuyama, M Taniguchi, M Yanagisawa, H Ogi, TPJ Knowles

(2026)

(doi: 10.48550/arxiv.2605.11660)

In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA.

V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux

Science Advances

(2026)

eaee2110

(doi: 10.1126/sciadv.aee2110)

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