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Currently displaying 1061 - 1080 of 2338 publications

Characterizing the free energy landscape of intrinsically disordered proteins by metadynamics simulation and experiments

D Granata, G Zerze, J Mittal, M Vendruscolo, A Laio

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2016)

252

A kinetic model of the aggregation of α-synuclein provides insights into prion-like spreading

M Iljina, G Garcia, MH Horrocks, L Tosatto, M Choi, S Gandhi, T Knowles, D Klenerman

PRION

(2016)

S63

Metainference: A Bayesian inference method for heterogeneous systems.

M Bonomi, C Camilloni, A Cavalli, M Vendruscolo

Science advances

(2016)

e1501177

(doi: 10.1126/sciadv.1501177)

Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurements.

P Kukic, P Lundström, C Camilloni, J Evenäs, M Akke, M Vendruscolo

Biochemistry

(2015)

(doi: 10.1021/acs.biochem.5b00961)

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions

P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, DA White, TW Herling, EJ De Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles

ACS Nano

(2015)

333

(doi: 10.1021/acsnano.5b04713)

Using Pseudocontact Shifts and Residual Dipolar Couplings as Exact NMR Restraints for the Determination of Protein Structural Ensembles

C Camilloni, M Vendruscolo

Biochemistry

(2015)

7470

(doi: 10.1021/acs.biochem.5b01138)

Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice

E Nogueira, F Lager, D Le Roux, P Nogueira, J Freitas, C Charvet, G Renault, A Loureiro, CR Almeida, A Ohradanova-Repic, C Machacek, GJL Bernardes, A Moreira, H Stockinger, M Burnet, AM Carmo, AC Gomes, A Preto, G Bismuth, A Cavaco-Paulo

J Biomed Nanotechnol

(2015)

2243

(doi: 10.1166/jbn.2015.2170)

Site-selective protein-modification chemistry for basic biology and drug development

N Krall, FP da Cruz, O Boutureira, GJL Bernardes

Nat Chem

(2015)

102

(doi: 10.1038/nchem.2393)

Consistent treatment of hydrophobicity in protein lattice models accounts for cold denaturation

E van Dijk, P Varilly, T Knowles, D Frenkel, S Abeln

(2015)

(doi: 10.48550/arxiv.1511.06590)

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.

L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman

Scientific Reports

(2015)

16696

(doi: 10.1038/srep16696)

N‑Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

O Szczepankiewicz, B Linse, G Meisl, E Thulin, B Frohm, C Sala Frigerio, MT Colvin, AC Jacavone, RG Griffin, T Knowles, DM Walsh, S Linse

Journal of the American Chemical Society

(2015)

137

14673

(doi: 10.1021/jacs.5b07849)

Parmbsc1: a refined force field for DNA simulations.

I Ivani, PD Dans, A Noy, A Pérez, I Faustino, A Hospital, J Walther, P Andrio, R Goñi, A Balaceanu, G Portella, F Battistini, JL Gelpí, C González, M Vendruscolo, CA Laughton, SA Harris, DA Case, M Orozco

Nat Methods

(2015)

(doi: 10.1038/NMETH.3658)

Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins

FN Newby, A De Simone, M Yagi-Utsumi, X Salvatella, CM Dobson, M Vendruscolo

Biochemistry

(2015)

6876

(doi: 10.1021/acs.biochem.5b00670)

Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide.

P Aran Terol, JR Kumita, SC Hook, CM Dobson, EK Esbjörner

Biochemical and biophysical research communications

(2015)

468

696

(doi: 10.1016/j.bbrc.2015.11.018)

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation.

R Zeineddine, JF Pundavela, L Corcoran, EM Stewart, D Do-Ha, M Bax, G Guillemin, KL Vine, DM Hatters, H Ecroyd, CM Dobson, BJ Turner, L Ooi, MR Wilson, NR Cashman, JJ Yerbury

Molecular Neurodegeneration

(2015)

(doi: 10.1186/s13024-015-0053-4)

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.

T Murakami, S Qamar, JQ Lin, GSK Schierle, E Rees, A Miyashita, AR Costa, RB Dodd, FTS Chan, CH Michel, D Kronenberg-Versteeg, Y Li, S-P Yang, Y Wakutani, W Meadows, RR Ferry, L Dong, GG Tartaglia, G Favrin, W-L Lin, DW Dickson, M Zhen, D Ron, G Schmitt-Ulms, PE Fraser, NA Shneider, C Holt, M Vendruscolo, CF Kaminski, P St George-Hyslop

Neuron

(2015)

678

(doi: 10.1016/j.neuron.2015.10.030)