Centre for Misfolding Diseases

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  • Currently displaying 1041 - 1060 of 2508 publications
Author(s)
Publication title
Journal Name
Publication year
Rapid Growth of Acetylated Aβ(16–20) into Macroscopic Crystals
C Bortolini, LH Klausen, SV Hoffmann, NC Jones, D Saadeh, Z Wang, TPJ Knowles, M Dong
ACS Nano
(2018)
12
(doi: 10.1021/acsnano.8b00448)
A rationally designed Hsp70 variant rescues the aggregation-associated toxicity of human IAPP in cultured pancreatic islet β-cells
MN Bongiovanni, FA Aprile, P Sormanni, M Vendruscolo
International Journal of Molecular Sciences
(2018)
(doi: 10.3390/ijms19051443)
Developing NMR methods for macromolecular machines: Measurement of residual dipolar couplings to probe dynamic regions of the ribosome
X Wang, JP Kirkpatrick, HMM Launay, A de Simone, D Häussinger, CM Dobson, M Vendruscolo, LD Cabrita, CA Waudby, J Christodoulou
(2018)
(doi: 10.1101/319251)
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Nature chemistry
(2018)
10
(doi: 10.1038/s41557-018-0031-x)
Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.
T Le Marchand, M de Rosa, N Salvi, BM Sala, LB Andreas, E Barbet-Massin, P Sormanni, A Barbiroli, R Porcari, C Sousa Mota, D de Sanctis, M Bolognesi, L Emsley, V Bellotti, M Blackledge, C Camilloni, G Pintacuda, S Ricagno
Nature Communications
(2018)
9
(doi: 10.1038/s41467-018-04078-y)
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.
S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop
Cell
(2018)
173
(doi: 10.1016/j.cell.2018.03.056)
Sustainable Polysulfides for Oil Spill Remediation: Repurposing Industrial Waste for Environmental Benefit
MJH Worthington, CJ Shearer, LJ Esdaile, JA Campbell, CT Gibson, SK Legg, Y Yin, NA Lundquist, JR Gascooke, IS Albuquerque, JG Shapter, GG Andersson, DA Lewis, GJL Bernardes, JM Chalker
Advanced Sustainable Systems
(2018)
2
(doi: 10.1002/adsu.201800024)
Parapred: antibody paratope prediction using convolutional and recurrent neural networks.
E Liberis, P Velickovic, P Sormanni, M Vendruscolo, P Liò
Bioinformatics (Oxford, England)
(2018)
34
(doi: 10.1093/bioinformatics/bty305)
Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy
M Bonomi, R Pellarin, M Vendruscolo
Biophys J
(2018)
114
(doi: 10.1016/j.bpj.2018.02.028)
Water‐Dispersible Polydopamine‐Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion
S Sieste, T Mack, CV Synatschke, C Schilling, C Meyer Zu Reckendorf, L Pendi, S Harvey, FS Ruggeri, TPJ Knowles, C Meier, DYW Ng, T Weil, B Knöll
Advanced Healthcare Materials
(2018)
7
(doi: 10.1002/adhm.201701485)
Biophotonics of Native Silk Fibrils.
U Shimanovich, D Pinotsi, K Shimanovich, N Yu, S Bolisetty, J Adamcik, R Mezzenga, J Charmet, F Vollrath, E Gazit, CM Dobson, GK Schierle, C Holland, CF Kaminski, TPJ Knowles
Macromolecular bioscience
(2018)
18
(doi: 10.1002/mabi.201700295)
Molecular determinants of the interaction of EGCG with ordered and disordered proteins
G Fusco, M Sanz-Hernandez, FS Ruggeri, M Vendruscolo, CM Dobson, A De Simone
Biopolymers
(2018)
109
(doi: 10.1002/bip.23117)
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.
F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, N Esteras, AY Abramov, TJP Knowles, M Goedert, D Klenerman
ACS Chem Neurosci
(2018)
9
(doi: 10.1021/acschemneuro.8b00094)
Correction to ‘Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species’
L-M Needham, J Weber, JWB Fyfe, OM Kabia, DT Do, E Klimont, Y Zhang, M Rodrigues, CM Dobson, S Gandhi, SE Bohndiek, TN Snaddon, SF Lee
Royal Society Open Science
(2018)
5
(doi: 10.1098/rsos.180308)
Artificial Intelligence Recognizes β-Lapachone as an Allosteric 5- Lipoxygenase Inhibitor
G Bernardes, T Rodrigues, M Werner, J Roth, EHG da Cruz, MC Marques, SA Lobo, A Koeberle, F Corzana, E N. da Silva Júnior, O Werz
(2018)
(doi: 10.26434/chemrxiv.6026795.v1)
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide
SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, M Vendruscolo, CM Dobson, AK Buell, TPJ Knowles, S Linse
Nature Chemistry
(2018)
10
(doi: 10.1038/s41557-018-0023-x)
The small heat shock protein Hsp27 binds -synuclein fibrils, preventing elongation and cytotoxicity
D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, D Klenerman, AM van Oijen, H Ecroyd
Journal of Biological Chemistry
(2018)
293
(doi: 10.1074/jbc.m117.813865)
Optical Structural Analysis of Individual α‐Synuclein Oligomers
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
Angewandte Chemie
(2018)
130
(doi: 10.1002/ange.201710779)
Chemo- and Regioselective Lysine Modification on Native Proteins
MJ Matos, BL Oliveira, N Martínez-Sáez, A Guerreiro, PMSD Cal, J Bertoldo, M Maneiro, E Perkins, J Howard, MJ Deery, JM Chalker, F Corzana, G Jiménez-Osés, GJL Bernardes
J Am Chem Soc
(2018)
140
(doi: 10.1021/jacs.7b12874)
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.
F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, SE Jackson, CM Dobson, D Klenerman
ACS chemical biology
(2018)
13
(doi: 10.1021/acschembio.7b01039)
Yusuf Hamied Department of Chemistry
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