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Currently displaying 1041 - 1060 of 2338 publications

A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.

P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo

ACS combinatorial science

(2016)

144

(doi: 10.1021/acscombsci.5b00129)

Oligomers of Heat-Shock Proteins: Structures That Don’t Imply Function

WM Jacobs, TPJ Knowles, D Frenkel

PLoS Comput Biol

(2016)

e1004756

(doi: 10.1371/journal.pcbi.1004756)

A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding

LD Cabrita, AME Cassaignau, HMM Launay, CA Waudby, T Wlodarski, C Camilloni, M-E Karyadi, AL Robertson, X Wang, AS Wentink, L Goodsell, CA Woolhead, M Vendruscolo, CM Dobson, J Christodoulou

Nature Structural & Molecular Biology

(2016)

278

(doi: 10.1038/nsmb.3182)

Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein

A Toto, C Camilloni, R Giri, M Brunori, M Vendruscolo, S Gianni

Sci Rep

(2016)

21994

(doi: 10.1038/srep21994)

Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.

E van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln

Phys Rev Lett

(2016)

116

078101

(doi: 10.1103/physrevlett.116.078101)

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman

Proceedings of the National Academy of Sciences

(2016)

113

e1206

(doi: 10.1073/pnas.1524128113)

Construction of homogeneous antibody-drug conjugates using site-selective protein chemistry

P Akkapeddi, S-A Azizi, AM Freedy, PMSD Cal, PMP Gois, GJL Bernardes

Chemical Science

(2016)

2954

(doi: 10.1039/c6sc00170j)

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo

Sci Adv

(2016)

e1501244

(doi: 10.1126/sciadv.1501244)

Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids

MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, L Tosatto, M Kjaergaard, JS Beckwith, H Zetterberg, M Iljina, N Cremades, CM Dobson, NW Wood, D Klenerman

ACS Chem Neurosci

(2016)

399

(doi: 10.1021/acschemneuro.5b00324)

Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.

K-L Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles

Biophysical journal

(2016)

110

555

(doi: 10.1016/j.bpj.2015.11.3523)

Structural Studies of the Oligomerization Process of Human Cystatin C Variants

Z Pietralik, M Murawska, A Szymanska, JR Kumita, CM Dobson, M Kozak

Biophysical Journal

(2016)

110

26a

(doi: 10.1016/j.bpj.2015.11.205)

Combining Single-Molecule Techniques with Microfluidics for Protein Analysis

C Taylor, T Knowles, D Klenerman

Biophysical Journal

(2016)

110

195a

(doi: 10.1016/j.bpj.2015.11.1086)

Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson's disease

E Deas, N Cremades, PR Angelova, MHR Ludtmann, Z Yao, S Chen, MH Horrocks, B Banushi, D Little, MJ Devine, P Gissen, D Klenerman, CM Dobson, NW Wood, S Gandhi, AY Abramov

Antioxidants & redox signaling

(2016)

376

(doi: 10.1089/ars.2015.6343)

Hamiltonian Dynamics of Protein Filament Formation

TCT Michaels, SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles

Phys Rev Lett

(2016)

116

038101

(doi: 10.1103/physrevlett.116.038101)