Centre for Misfolding Diseases

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  • Currently displaying 1141 - 1160 of 2403 publications
Author(s)
Publication title
Journal Name
Publication year
Structural Effects of Two Camelid Nanobodies Directed to Distinct C‑Terminal Epitopes on α‑Synuclein
F El-Turk, FN Newby, E De Genst, T Guilliams, T Sprules, A Mittermaier, CM Dobson, M Vendruscolo
Biochemistry
(2016)
55
(doi: 10.1021/acs.biochem.6b00149)
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov
Development
(2016)
143
(doi: 10.1242/dev.139345)
Amyloid fibrils as building blocks for natural and artificial functional materials
TPJ Knowles, R Mezzenga
Advanced Materials
(2016)
28
(doi: 10.1002/adma.201505961)
A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions
TW Herling, DJ O'Connell, MC Bauer, J Persson, U Weininger, TPJ Knowles, S Linse
Biophysical Journal
(2016)
110
(doi: 10.1016/j.bpj.2016.03.038)
Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability
C Camilloni, BM Sala, P Sormanni, R Porcari, A Corazza, M De Rosa, S Zanini, A Barbiroli, G Esposito, M Bolognesi, V Bellotti, M Vendruscolo, S Ricagno
Sci Rep
(2016)
6
(doi: 10.1038/srep25559)
Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism.
CLL Pham, A Rey, V Lo, M Soulès, Q Ren, G Meisl, TPJ Knowles, AH Kwan, M Sunde
Scientific Reports
(2016)
6
(doi: 10.1038/srep25288)
Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.
JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, C Fletcher, M Koch, N Darvill, N Scull, A Escalera-Maurer, L Sefer, R Wenman, S Lambert, J Jean, Y Xu, B Turner, SG Kazarian, MR Chapman, D Bubeck, A de Simone, TPJ Knowles, SJ Matthews
Scientific reports
(2016)
6
(doi: 10.1038/srep24656)
Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor
A Deckert, CA Waudby, T Wlodarski, AS Wentink, X Wang, JP Kirkpatrick, JFS Paton, C Camilloni, P Kukic, CM Dobson, M Vendruscolo, LD Cabrita, J Christodoulou
Proceedings of the National Academy of Sciences
(2016)
113
(doi: 10.1073/pnas.1519124113)
The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model
V Kakkar, C Månsson, EP de Mattos, S Bergink, M van der Zwaag, MAWH van Waarde, NJ Kloosterhuis, R Melki, RTP van Cruchten, S Al-Karadaghi, P Arosio, CM Dobson, TPJ Knowles, GP Bates, JM van Deursen, S Linse, B van de Sluis, C Emanuelsson, HH Kampinga
Mol Cell
(2016)
62
(doi: 10.1016/j.molcel.2016.03.017)
A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation
P Ciryam, R Kundra, R Freer, RI Morimoto, CM Dobson, M Vendruscolo
Proceedings of the National Academy of Sciences
(2016)
113
(doi: 10.1073/pnas.1516604113)
A general reaction network unifies the aggregation behaviour of the A$β$42 peptide and its variants
G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles
(2016)
(doi: 10.1039/C7SC00215G)
A general reaction network unifies the aggregation behaviour of the A$\beta$42 peptide and its variants
G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles
(2016)
(doi: 10.48550/arxiv.1604.00828)
Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation.
P Arosio, T Cedervall, TPJ Knowles, S Linse
Anal Biochem
(2016)
504
(doi: 10.1016/j.ab.2016.03.015)
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation
P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, J Johansson, M Vendruscolo, CM Dobson, TPJ Knowles
Nature Communications
(2016)
7
(doi: 10.1038/ncomms10948)
Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain.
D Bonetti, C Camilloni, L Visconti, S Longhi, M Brunori, M Vendruscolo, S Gianni
Journal of Biological Chemistry
(2016)
291
(doi: 10.1074/jbc.m116.721126)
Amyloid‑β and α‑Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing
JT Pedersen, SW Chen, CB Borg, S Ness, JM Bahl, NHH Heegaard, CM Dobson, L Hemmingsen, N Cremades, K Teilum
J Am Chem Soc
(2016)
138
(doi: 10.1021/jacs.5b13577)
Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.
D Pinotsi, CH Michel, AK Buell, RF Laine, P Mahou, CM Dobson, CF Kaminski, GS Kaminski Schierle
Proc Natl Acad Sci U S A
(2016)
113
(doi: 10.1073/pnas.1516546113)
Quantitative thermophoretic study of disease-related protein aggregates
M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, D Braun, AK Buell
Sci Rep
(2016)
6
(doi: 10.1038/srep22829)
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov
Journal of Cell Science
(2016)
129
(doi: 10.1242/jcs.180737)
Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions
P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles
Analytical Chemistry
(2016)
88
(doi: 10.1021/acs.analchem.5b02930)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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enquiries@ch.cam.ac.uk
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