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Currently displaying 1141 - 1160 of 2455 publications

Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.

JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, C Fletcher, M Koch, N Darvill, N Scull, A Escalera-Maurer, L Sefer, R Wenman, S Lambert, J Jean, Y Xu, B Turner, SG Kazarian, MR Chapman, D Bubeck, A de Simone, TPJ Knowles, SJ Matthews

Sci Rep

(2016)

24656

(doi: 10.1038/srep24656)

Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor

A Deckert, CA Waudby, T Wlodarski, AS Wentink, X Wang, JP Kirkpatrick, JFS Paton, C Camilloni, P Kukic, CM Dobson, M Vendruscolo, LD Cabrita, J Christodoulou

Proceedings of the National Academy of Sciences

(2016)

113

5012

(doi: 10.1073/pnas.1519124113)

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

V Kakkar, C Månsson, EP de Mattos, S Bergink, M van der Zwaag, MAWH van Waarde, NJ Kloosterhuis, R Melki, RTP van Cruchten, S Al-Karadaghi, P Arosio, CM Dobson, TPJ Knowles, GP Bates, JM van Deursen, S Linse, B van de Sluis, C Emanuelsson, HH Kampinga

Molecular Cell

(2016)

272

(doi: 10.1016/j.molcel.2016.03.017)

A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation

P Ciryam, R Kundra, R Freer, RI Morimoto, CM Dobson, M Vendruscolo

Proceedings of the National Academy of Sciences of the United States of America

(2016)

113

4753

(doi: 10.1073/pnas.1516604113)

A general reaction network unifies the aggregation behaviour of the A$β$42 peptide and its variants

G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles

(2016)

(doi: 10.1039/C7SC00215G)

A general reaction network unifies the aggregation behaviour of the A$\beta$42 peptide and its variants

G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles

(2016)

(doi: 10.48550/arxiv.1604.00828)

Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation.

P Arosio, T Cedervall, TPJ Knowles, S Linse

Analytical biochemistry

(2016)

504

(doi: 10.1016/j.ab.2016.03.015)

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, J Johansson, M Vendruscolo, CM Dobson, TPJ Knowles

Nature Communications

(2016)

10948

(doi: 10.1038/ncomms10948)

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing.

JT Pedersen, SW Chen, CB Borg, S Ness, JM Bahl, NHH Heegaard, CM Dobson, L Hemmingsen, N Cremades, K Teilum

J Am Chem Soc

(2016)

138

3966

(doi: 10.1021/jacs.5b13577)

Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain*

D Bonetti, C Camilloni, L Visconti, S Longhi, M Brunori, M Vendruscolo, S Gianni

Journal of Biological Chemistry

(2016)

291

10886

(doi: 10.1074/jbc.M116.721126)

Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.

D Pinotsi, CH Michel, AK Buell, RF Laine, P Mahou, CM Dobson, CF Kaminski, GS Kaminski Schierle

Proceedings of the National Academy of Sciences of the United States of America

(2016)

113

3815

(doi: 10.1073/pnas.1516546113)

Quantitative thermophoretic study of disease-related protein aggregates

M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, D Braun, AK Buell

Scientific reports

(2016)

22829

(doi: 10.1038/srep22829)

Ca2+ is a key factor in α-synuclein-induced neurotoxicity

PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov

Journal of Cell Science

(2016)

129

1792

(doi: 10.1242/jcs.180737)

Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.

P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles

Anal Chem

(2016)

3488

(doi: 10.1021/acs.analchem.5b02930)

An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation

EV Yates, G Meisl, TPJ Knowles, CM Dobson

The Journal of Physical Chemistry B

(2016)

120

2087

(doi: 10.1021/acs.jpcb.5b09663)

Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function

WM Jacobs, TPJ Knowles, D Frenkel

Plos Computational Biology

(2016)

e1004756

(doi: 10.1371/journal.pcbi.1004756)

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

LD Cabrita, AME Cassaignau, HMM Launay, CA Waudby, T Wlodarski, C Camilloni, M-E Karyadi, AL Robertson, X Wang, AS Wentink, L Goodsell, CA Woolhead, M Vendruscolo, CM Dobson, J Christodoulou

Nature Structural and Molecular Biology

(2016)

278

(doi: 10.1038/nsmb.3182)