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Currently displaying 1101 - 1120 of 2474 publications

Silk micrococoons for protein stabilisation and molecular encapsulation.

U Shimanovich, FS Ruggeri, E De Genst, J Adamcik, TP Barros, D Porter, T Müller, R Mezzenga, CM Dobson, F Vollrath, C Holland, TPJ Knowles

Nature Communications

(2017)

8

15902

(doi: 10.1038/ncomms15902)

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis.

MA Hanspal, CM Dobson, JJ Yerbury, JR Kumita

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

(2017)

1863

2762

(doi: 10.1016/j.bbadis.2017.07.007)

The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases.

N Cremades, CM Dobson

Neurobiology of Disease

(2017)

109

178

(doi: 10.1016/j.nbd.2017.07.009)

Protein homeostasis of a metastable subproteome associated with Alzheimer's disease

R Kundra, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo

Proceedings of the National Academy of Sciences of the United States of America

(2017)

114

E5703

(doi: 10.1073/pnas.1618417114)

Nanobodies raised against monomeric α-synuclein inhibit fibril formation and destabilize toxic oligomeric species

D Klenerman, M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman

BMC Biol

(2017)

15

57

(doi: 10.1186/s12915-017-0390-6)

Measuring the prion-like character of tau by TIRF microscopy

F Kundel, B Falcon, L Hong, N Esteras, AJ Dear, AY Abramov, TPJ Knowles, M Goedert, D Klenerman

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46

S240

Single α-synuclein oligomers are hydrophobically distinct from mature fibrils

J-E Lee, MN Bongiovanni, M Rodrigues, CM Dobson, SF Lee, D Klenerman

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46

S348

Mechanisms of Amyloid-β 42 oligomer formation from kinetic analysis

TC Michaels, A Saric, HW Lazell, P Arosio, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46

S240

Single amyloid aggregates chemical and structural analysis by infrared nanospectroscopy

FS Ruggeri, J Habchi, C Sean, M Vendruscolo, TPJ Knowles

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46

S370

A microfluidic platform for quantitative protein studies

TW Herling, P Arosio, T Mueller, DJ O'Connell, MC Bauer, J Persson, U Weininger, S Linse, TPJ Knowles

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46

S345

Structural characterisation of the early events in the nucleation-condensation mechanism of folding

P Kukic, Y Pustovalova, C Camilloni, S Gianni, DM Korzhnev, M Vendruscolo

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46

S347

Evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils

M Tornquist, R Cukalevski, U Weininger, G Meisl, TPJ Knowles, T Leiding, M Akke, S Linse

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46

S242

Ultrasensitive measurement of Ca²⁺ influx into lipid vesicles induced by protein aggregates

P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TP Knowles, S Gandhi, CM Dobson, D Klenerman

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

(2017)

46

S237

Inverse electron demand Diels–Alder reactions in chemical biology

GJ Lopes Bernardes, BL Oliveira, Z Guo

Chem Soc Rev

(2017)

46

4895

(doi: 10.1039/c7cs00184c)

Amyloid-like Fibrils from an α‑Helical Transmembrane Protein

K Stroobants, JR Kumita, NJ Harris, DY Chirgadze, CM Dobson, PJ Booth, M Vendruscolo

Biochemistry

(2017)

56

3225

(doi: 10.1021/acs.biochem.7b00157)

Ultrasensitive Measurement of Ca²⁺ Influx into Lipid Vesicles Induced by Protein Aggregates

P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman

Angew Chem Int Ed Engl

(2017)

56

7750

(doi: 10.1002/anie.201700966)

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo

Science advances

(2017)

3

e1700488

(doi: 10.1126/sciadv.1700488)

Direct Conversion of an Enzyme from Native-like to Amyloid-like Aggregates within Inclusion Bodies.

F Elia, F Cantini, F Chiti, CM Dobson, F Bemporad

Biophysical journal

(2017)

112

2540

(doi: 10.1016/j.bpj.2017.05.011)

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.

A Munke, J Persson, T Weiffert, E De Genst, G Meisl, P Arosio, A Carnerup, CM Dobson, M Vendruscolo, TPJ Knowles, S Linse

Proceedings of the National Academy of Sciences of the United States of America

(2017)

114

6444

(doi: 10.1073/pnas.1700407114)

The Amyloid Phenomenon and Its Links with Human Disease

CM Dobson

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

(2017)

9

a023648

(doi: 10.1101/cshperspect.a023648)