Centre for Misfolding Diseases

Publications

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  • Currently displaying 1201 - 1220 of 2453 publications
Author(s)
Publication title
Journal Name
Publication year
A general reaction network unifies the aggregation behaviour of the A$β$42 peptide and its variants
G Meisl, X Yang, CM Dobson, S Linse, TPJ Knowles
(2016)
(doi: 10.1039/C7SC00215G)
Analysis of the length distribution of amyloid fibrils by centrifugal sedimentation.
P Arosio, T Cedervall, TPJ Knowles, S Linse
Analytical biochemistry
(2016)
504
(doi: 10.1016/j.ab.2016.03.015)
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation.
P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, J Johansson, M Vendruscolo, CM Dobson, TPJ Knowles
Nat Commun
(2016)
7
(doi: 10.1038/ncomms10948)
Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain*
D Bonetti, C Camilloni, L Visconti, S Longhi, M Brunori, M Vendruscolo, S Gianni
The Journal of biological chemistry
(2016)
291
(doi: 10.1074/jbc.m116.721126)
Amyloid‑β and α‑Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing
JT Pedersen, SW Chen, CB Borg, S Ness, JM Bahl, NHH Heegaard, CM Dobson, L Hemmingsen, N Cremades, K Teilum
Journal of the American Chemical Society
(2016)
138
(doi: 10.1021/jacs.5b13577)
Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.
D Pinotsi, CH Michel, AK Buell, RF Laine, P Mahou, CM Dobson, CF Kaminski, GS Kaminski Schierle
Proc Natl Acad Sci U S A
(2016)
113
(doi: 10.1073/pnas.1516546113)
Quantitative thermophoretic study of disease-related protein aggregates
M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, D Braun, AK Buell
Scientific Reports
(2016)
6
(doi: 10.1038/srep22829)
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov
Journal of cell science
(2016)
129
(doi: 10.1242/jcs.180737)
Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.
P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles
Analytical chemistry
(2016)
88
(doi: 10.1021/acs.analchem.5b02930)
An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation.
EV Yates, G Meisl, TPJ Knowles, CM Dobson
The Journal of Physical Chemistry B
(2016)
120
(doi: 10.1021/acs.jpcb.5b09663)
A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding
LD Cabrita, AME Cassaignau, HMM Launay, CA Waudby, T Wlodarski, C Camilloni, M-E Karyadi, AL Robertson, X Wang, AS Wentink, L Goodsell, CA Woolhead, M Vendruscolo, CM Dobson, J Christodoulou
Nature Structural & Molecular Biology
(2016)
23
(doi: 10.1038/nsmb.3182)
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.
P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
ACS combinatorial science
(2016)
18
(doi: 10.1021/acscombsci.5b00129)
Oligomers of Heat-Shock Proteins: Structures That Don’t Imply Function
WM Jacobs, TPJ Knowles, D Frenkel
PLoS Comput Biol
(2016)
12
(doi: 10.1371/journal.pcbi.1004756)
Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein.
A Toto, C Camilloni, R Giri, M Brunori, M Vendruscolo, S Gianni
Scientific reports
(2016)
6
(doi: 10.1038/srep21994)
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman
Proceedings of the National Academy of Sciences
(2016)
113
(doi: 10.1073/pnas.1524128113)
Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation
E van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln
Physical review letters
(2016)
116
(doi: 10.1103/physrevlett.116.078101)
Construction of homogeneous antibody-drug conjugates using site-selective protein chemistry.
P Akkapeddi, S-A Azizi, AM Freedy, PMSD Cal, PMP Gois, GJL Bernardes
Chemical Science
(2016)
7
(doi: 10.1039/c6sc00170j)
Oligomers of heat-shock proteins: Structures that don't imply function
WM Jacobs, TPJ Knowles, D Frenkel
(2016)
(doi: 10.48550/arxiv.1508.07924)
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo
Science advances
(2016)
2
(doi: 10.1126/sciadv.1501244)
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids
MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, L Tosatto, M Kjaergaard, JS Beckwith, H Zetterberg, M Iljina, N Cremades, CM Dobson, NW Wood, D Klenerman
ACS Chem Neurosci
(2016)
7
(doi: 10.1021/acschemneuro.5b00324)
Yusuf Hamied Department of Chemistry
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