Centre for Misfolding Diseases

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  • Currently displaying 1461 - 1480 of 2523 publications
Author(s)
Publication title
Journal Name
Publication year
Chemical kinetics for drug discovery to combat protein aggregation diseases
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Trends in Pharmacological Sciences
(2014)
35
(doi: 10.1016/j.tips.2013.12.005)
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation
N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen
J Am Chem Soc
(2014)
136
(doi: 10.1021/ja411577t)
Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide
B Bolognesi, SIA Cohen, P Aran Terol, EK Esbjörner, S Giorgetti, MF Mossuto, A Natalello, AC Brorsson, TPJ Knowles, CM Dobson, LM Luheshi
ACS Chemical Biology
(2014)
9
(doi: 10.1021/cb400616y)
The folding process of hen lysozyme: A perspective from the 'new view'
A Matagne, CM Dobson
Cellular and Molecular Life Sciences
(2014)
54
(doi: 10.1007/s000180050165)
Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.
SE Kelly, G Meisl, PJE Rowling, SH McLaughlin, T Knowles, LS Itzhaki
Physical chemistry chemical physics : PCCP
(2014)
16
(doi: 10.1039/c3cp54818j)
Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease
G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue
PloS one
(2014)
9
(doi: 10.1371/journal.pone.0087133)
The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide
AA Kendrick, MJ Holliday, NG Isern, F Zhang, C Camilloni, C Huynh, M Vendruscolo, G Armstrong, EZ Eisenmesser
Protein Science
(2014)
23
(doi: 10.1002/pro.2430)
Quantitative Analysis of Diffusive Reactions at the Solid-Liquid Interface in Finite Systems
TCT Michaels, AK Buell, EM Terentjev, TPJ Knowles
The journal of physical chemistry letters
(2014)
5
(doi: 10.1021/jz4024833)
A conformational ensemble derived using NMR methyl chemical shifts reveals a mechanical clamping transition that gates the binding of the HU protein to dna
A Kannan, C Camilloni, AB Sahakyan, A Cavalli, M Vendruscolo
Journal of the American Chemical Society
(2014)
136
(doi: 10.1021/ja4105396)
Nanoscale spatially resolved infrared spectra from single microdroplets
T Müller, FS Ruggeri, AJ Kulik, U Shimanovich, TO Mason, TPJ Knowles, G Dietler
(2014)
(doi: 10.48550/arxiv.1401.8204)
Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.
TO Mason, DY Chirgadze, A Levin, L Adler-Abramovich, E Gazit, TPJ Knowles, AK Buell
ACS nano
(2014)
8
(doi: 10.1021/nn404237f)
Proteome Metastability in Health, Aging, and Disease
P Ciryam, GG Tartaglia, RI Morimoto, CM Dobson, EP O'Brien, M Vendruscolo
Biophysical Journal
(2014)
106
(doi: 10.1016/j.bpj.2013.11.405)
Determination of Primary Nucleation Mechanisms of α-Synuclein Amyloid Aggregation
FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, TPJ Knowles
BIOPHYSICAL JOURNAL
(2014)
106
Probing the Interaction Between α-Synuclein and Lipid Membranes by NMR Spectroscopy
G Fusco, CM Dobson
BIOPHYSICAL JOURNAL
(2014)
106
MD Simulations of Intrinsically Disordered Proteins with Replica-Averaged Chemical Shift Restraints
B Fu, P Kukic, C Camilloni, M Vendruscolo
Biophysical Journal
(2014)
106
(doi: 10.1016/j.bpj.2013.11.2714)
Elucidating the Structural Basis of α-Synuclein Fibrillation using Small Camelid Nanobodies
FE Turk, G Tomba, E De Genst, T Guillams, P Kukic, M Vendruscolo, C Dobson
Biophysical Journal
(2014)
106
(doi: 10.1016/j.bpj.2013.11.1512)
Studying Distribution and Aggregation of TDP-43 in Mammalian Cells: A Comparison between Fluorescent Protein and Tetracysteine Labelling Strategies
JSW Ng, TP Barros, EK Esbjörner, LM Luheshi, JR Kumita, CM Dobson
Biophysical Journal
(2014)
106
(doi: 10.1016/j.bpj.2013.11.2599)
Conformational Equilibrium between the Sub States of the Acidic Denatured State of ACBP Determined by NMR Chemical Shifts and Metadynamics
C Camilloni, M Vendruscolo
Biophysical Journal
(2014)
106
(doi: 10.1016/j.bpj.2013.11.2605)
Structural and Mechanistic Analyses of the Effects of Small Compounds on Amyloid Beta Self-Assembly
J Habchi, P Joshi, A Spilotros, D Svergun, M Vendruscolo
BIOPHYSICAL JOURNAL
(2014)
106
Amyloid β-Protein: The Influence of Intrinsic and Extrinsic Factors on Fibril Formation
R Cukalevski, X Yang, S Cohen, B Boland, B Frohm, E Thulin, D Walsh, T Knowles, S Linse
Biophysical Journal
(2014)
106
(doi: 10.1016/j.bpj.2013.11.3778)
Yusuf Hamied Department of Chemistry
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