Centre for Misfolding Diseases

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  • Currently displaying 1381 - 1400 of 2489 publications
Author(s)
Publication title
Journal Name
Publication year
Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)).
KA Ganzinger, P Narayan, SS Qamar, L Weimann, RT Ranasinghe, A Aguzzi, CM Dobson, J McColl, P St George-Hyslop, D Klenerman
Chembiochem : a European journal of chemical biology
(2014)
15
(doi: 10.1002/cbic.201402377)
Cysteine-selective reactions for antibody conjugation
PMSD Cal, GJL Bernardes, PMP Gois
Angewandte Chemie International Edition
(2014)
53
(doi: 10.1002/anie.201405702)
Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein.
S Gianni, C Camilloni, R Giri, A Toto, D Bonetti, A Morrone, P Sormanni, M Brunori, M Vendruscolo
Proceedings of the National Academy of Sciences
(2014)
111
(doi: 10.1073/pnas.1405233111)
Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein
H Takahashi, N Adachi, T Shirafuji, S Danno, T Ueyama, M Vendruscolo, AN Shuvaev, T Sugimoto, T Seki, D Hamada, K Irie, H Hirai, N Sakai, N Saito
Human molecular genetics
(2014)
24
(doi: 10.1093/hmg/ddu472)
Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation
C Månsson, P Arosio, R Hussein, HH Kampinga, RM Hashem, WC Boelens, CM Dobson, TPJ Knowles, S Linse, C Emanuelsson
Journal of Biological Chemistry
(2014)
289
(doi: 10.1074/jbc.M114.595124)
Equilibrium simulations of proteins using molecular fragment replacement and NMR chemical shifts.
W Boomsma, P Tian, J Frellsen, J Ferkinghoff-Borg, T Hamelryck, K Lindorff-Larsen, M Vendruscolo
Proc Natl Acad Sci U S A
(2014)
111
(doi: 10.1073/pnas.1404948111)
NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain.
HTA Leung, P Kukic, C Camilloni, F Bemporad, A De Simone, FA Aprile, JR Kumita, M Vendruscolo
Protein Science
(2014)
23
(doi: 10.1002/pro.2538)
Antibodies and protein misfolding: From structural research tools to therapeutic strategies.
E De Genst, A Messer, CM Dobson
Biochimica et Biophysica Acta
(2014)
1844
(doi: 10.1016/j.bbapap.2014.08.016)
The physical chemistry of the amyloid phenomenon: Thermodynamics and kinetics of fi lamentous protein aggregation
AK Buell, CM Dobson, TPJ Knowles
Essays in Biochemistry
(2014)
56
(doi: 10.1042/bse0560011)
Highlights from the 49th EUCHEM Conference on Stereochemistry, Bürgenstock, Switzerland, May 2014.
GJL Bernardes, AL Lawrence
Chem Commun (Camb)
(2014)
50
(doi: 10.1039/c4cc90250e)
Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity
B Mannini, E Mulvihill, C Sgromo, R Cascella, R Khodarahmi, M Ramazzotti, CM Dobson, C Cecchi, F Chiti
ACS Chem Biol
(2014)
9
(doi: 10.1021/cb500505m)
Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain
F Blombach, H Launay, APL Snijders, V Zorraquino, H Wu, B de Koning, SJJ Brouns, TJG Ettema, C Camilloni, A Cavalli, M Vendruscolo, MJ Dickman, LD Cabrita, A La Teana, D Benelli, P Londei, J Christodoulou, J van der Oost
The Biochemical journal
(2014)
462
(doi: 10.1042/BJ20131474)
Carbon-monoxide-releasing molecules for the delivery of therapeutic CO in vivo.
S García-Gallego, GJL Bernardes
Angew Chem Int Ed Engl
(2014)
53
(doi: 10.1002/anie.201311225)
Easyworm: An open-source software tool to determine the mechanical properties of worm-like chains
G Lamour, JB Kirkegaard, H Li, TP Knowles, J Gsponer
Source Code Biol Med
(2014)
9
(doi: 10.1186/1751-0473-9-16)
Amyloid Beta Peptide Aβ40 and Aβ42 Form Separate Fibrils in Binary Mixtures
X Yang, R Cukalevski, G Meisl, B Frohm, T Knowles, S Linse
PROTEIN SCIENCE
(2014)
23
Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism
C Camilloni, AB Sahakyan, MJ Holliday, NG Isern, F Zhang, EZ Eisenmesser, M Vendruscolo
Proc Natl Acad Sci U S A
(2014)
111
(doi: 10.1073/pnas.1404220111)
Statistical mechanics of the denatured state of a protein using replica-averaged metadynamics.
C Camilloni, M Vendruscolo
J Am Chem Soc
(2014)
136
(doi: 10.1021/ja5027584)
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.
G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse, TPJ Knowles
Proceedings of the National Academy of Sciences
(2014)
111
(doi: 10.1073/pnas.1401564111)
The amyloid state and its association with protein misfolding diseases (vol 15, pg 384, 2014)
TPJ Knowles, M Vendruscolo, CM Dobson
Nature Reviews Molecular Cell Biology
(2014)
15
(doi: 10.1038/nrm3826)
Self-assembly of amyloid fibrils that display active enzymes
X Zhou, A Entwistle, H Zhang, AP Jackson, TO Mason, U Shimanovich, TPJ Knowles, AT Smith, EB Sawyer, S Perrett
Chemcatchem
(2014)
6
(doi: 10.1002/cctc.201402125)
Yusuf Hamied Department of Chemistry
Lensfield Road
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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