Centre for Misfolding Diseases

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  • Currently displaying 1441 - 1460 of 2508 publications
Author(s)
Publication title
Journal Name
Publication year
A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors
N Krall, F Pretto, W Decurtins, GJL Bernardes, CT Supuran, D Neri
Angew Chem Int Ed Engl
(2014)
53
(doi: 10.1002/anie.201310709)
Spatial Propagation of Protein Polymerization
SIA Cohen, L Rajah, CH Yoon, AK Buell, DA White, RA Sperling, M Vendruscolo, EM Terentjev, CM Dobson, DA Weitz, TPJ Knowles
Phys Rev Lett
(2014)
112
(doi: 10.1103/physrevlett.112.098101)
Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors
AJ Thompson, T-YD Tang, TW Herling, CRC Hak, S Mann, TPJ Knowles, MK Kuimova
Proceedings of SPIE--the International Society for Optical Engineering
(2014)
8947
(doi: 10.1117/12.2037851)
Dynamics and timekeeping in biological systems
CM Dobson
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83
(2014)
83
(doi: 10.1146/annurev-biochem-013014-102724)
Chemical kinetics for drug discovery to combat protein aggregation diseases
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Trends in Pharmacological Sciences
(2014)
35
(doi: 10.1016/j.tips.2013.12.005)
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.
N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen
J Am Chem Soc
(2014)
136
(doi: 10.1021/ja411577t)
Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide
B Bolognesi, SIA Cohen, P Aran Terol, EK Esbjörner, S Giorgetti, MF Mossuto, A Natalello, AC Brorsson, TPJ Knowles, CM Dobson, LM Luheshi
ACS Chemical Biology
(2014)
9
(doi: 10.1021/cb400616y)
The folding process of hen lysozyme: a perspective from the ‘new view’
A Matagne, CM Dobson
Cellular and molecular life sciences : CMLS
(2014)
54
(doi: 10.1007/s000180050165)
Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.
SE Kelly, G Meisl, PJE Rowling, SH McLaughlin, T Knowles, LS Itzhaki
Phys Chem Chem Phys
(2014)
16
(doi: 10.1039/c3cp54818j)
Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.
G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue
PLoS One
(2014)
9
(doi: 10.1371/journal.pone.0087133)
The dynamics of interleukin‐8 and its interaction with human CXC receptor I peptide
AA Kendrick, MJ Holliday, NG Isern, F Zhang, C Camilloni, C Huynh, M Vendruscolo, G Armstrong, EZ Eisenmesser
Protein Sci
(2014)
23
(doi: 10.1002/pro.2430)
Quantitative analysis of diffusive reactions at the solid-liquid interface in finite systems
TCT Michaels, AK Buell, EM Terentjev, TPJ Knowles
Journal of Physical Chemistry Letters
(2014)
5
(doi: 10.1021/jz4024833)
A conformational ensemble derived using NMR methyl chemical shifts reveals a mechanical clamping transition that gates the binding of the HU protein to DNA.
A Kannan, C Camilloni, AB Sahakyan, A Cavalli, M Vendruscolo
Journal of the American Chemical Society
(2014)
136
(doi: 10.1021/ja4105396)
Nanoscale spatially resolved infrared spectra from single microdroplets
T Müller, FS Ruggeri, AJ Kulik, U Shimanovich, TO Mason, TPJ Knowles, G Dietler
(2014)
(doi: 10.48550/arxiv.1401.8204)
Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.
TO Mason, DY Chirgadze, A Levin, L Adler-Abramovich, E Gazit, TPJ Knowles, AK Buell
ACS Nano
(2014)
2
(doi: 10.1021/nn404237f)
Determination of Primary Nucleation Mechanisms of α-Synuclein Amyloid Aggregation
FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, TPJ Knowles
BIOPHYSICAL JOURNAL
(2014)
106
Conformational Equilibrium between the Sub States of the Acidic Denatured State of ACBP Determined by NMR Chemical Shifts and Metadynamics
C Camilloni, M Vendruscolo
Biophysical Journal
(2014)
106
(doi: 10.1016/j.bpj.2013.11.2605)
Probing the Interaction Between α-Synuclein and Lipid Membranes by NMR Spectroscopy
G Fusco, CM Dobson
BIOPHYSICAL JOURNAL
(2014)
106
Proteome Metastability in Health, Aging, and Disease
P Ciryam, GG Tartaglia, RI Morimoto, CM Dobson, EP O'Brien, M Vendruscolo
Biophysical Journal
(2014)
106
(doi: 10.1016/j.bpj.2013.11.405)
Single-Molecule Characterisation of Alpha-Synuclein Oligomers
MH Horrocks, SF Lee, S Gandhi, M Iljina, L Tosatto, CM Dobson, D Klenerman
BIOPHYSICAL JOURNAL
(2014)
106
Yusuf Hamied Department of Chemistry
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