Centre for Misfolding Diseases

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  • Currently displaying 1421 - 1440 of 2523 publications
Author(s)
Publication title
Journal Name
Publication year
Interaction of the Molecular Chaperone DNAJB6 with Growing Arnyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation
C Månsson, P Arosio, R Hussein, HH Kampinga, RM Hashem, WC Boelens, CM Dobson, TPJ Knowles, S Linse, C Emanuelsson
Journal of Biological Chemistry
(2014)
289
(doi: 10.1074/jbc.M114.595124)
Equilibrium simulations of proteins using molecular fragment replacement and NMR chemical shifts.
W Boomsma, P Tian, J Frellsen, J Ferkinghoff-Borg, T Hamelryck, K Lindorff-Larsen, M Vendruscolo
Proc Natl Acad Sci U S A
(2014)
111
(doi: 10.1073/pnas.1404948111)
NMR characterization of the conformational fluctuations of the human lymphocyte function‐associated antigen‐1 I‐domain
HTA Leung, P Kukic, C Camilloni, F Bemporad, A De Simone, FA Aprile, JR Kumita, M Vendruscolo
Protein Science
(2014)
23
(doi: 10.1002/pro.2538)
Antibodies and protein misfolding: From structural research tools to therapeutic strategies.
E De Genst, A Messer, CM Dobson
Biochimica Et Biophysica Acta Proteins and Proteomics
(2014)
1844
(doi: 10.1016/j.bbapap.2014.08.016)
The physical chemistry of the amyloid phenomenon: Thermodynamics and kinetics of fi lamentous protein aggregation
AK Buell, CM Dobson, TPJ Knowles
Essays in biochemistry
(2014)
56
(doi: 10.1042/BSE0560011)
Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity
B Mannini, E Mulvihill, C Sgromo, R Cascella, R Khodarahmi, M Ramazzotti, CM Dobson, C Cecchi, F Chiti
ACS chemical biology
(2014)
9
(doi: 10.1021/cb500505m)
Highlights from the 49th EUCHEM Conference on Stereochemistry, Bürgenstock, Switzerland, May 2014.
GJL Bernardes, AL Lawrence
Chemical Communications
(2014)
50
(doi: 10.1039/c4cc90250e)
Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain.
F Blombach, H Launay, APL Snijders, V Zorraquino, H Wu, B de Koning, SJJ Brouns, TJG Ettema, C Camilloni, A Cavalli, M Vendruscolo, MJ Dickman, LD Cabrita, A La Teana, D Benelli, P Londei, J Christodoulou, J van der Oost
Biochemical Journal
(2014)
462
(doi: 10.1042/bj20131474)
Carbon-monoxide-releasing molecules for the delivery of therapeutic CO in vivo.
S García-Gallego, GJL Bernardes
Angewandte Chemie International Edition
(2014)
53
(doi: 10.1002/anie.201311225)
Easyworm: an open-source software tool to determine the mechanical properties of worm-like chains.
G Lamour, JB Kirkegaard, H Li, TP Knowles, J Gsponer
Source Code for Biology and Medicine
(2014)
9
(doi: 10.1186/1751-0473-9-16)
Amyloid Beta Peptide Aβ40 and Aβ42 Form Separate Fibrils in Binary Mixtures
X Yang, R Cukalevski, G Meisl, B Frohm, T Knowles, S Linse
PROTEIN SCIENCE
(2014)
23
Cyclophilin a catalyzes proline isomerization by an electrostatic handle mechanism
C Camilloni, AB Sahakyan, MJ Holliday, NG Isern, F Zhang, EZ Eisenmesser, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2014)
111
(doi: 10.1073/pnas.1404220111)
Statistical Mechanics of the Denatured State of a Protein Using Replica-Averaged Metadynamics
C Camilloni, M Vendruscolo
J Am Chem Soc
(2014)
136
(doi: 10.1021/ja5027584)
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.
G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse, TPJ Knowles
Proc Natl Acad Sci U S A
(2014)
111
(doi: 10.1073/pnas.1401564111)
A tensor-free method for the structural and dynamical refinement of proteins using residual dipolar couplings.
C Camilloni, M Vendruscolo
J Phys Chem B
(2014)
119
(doi: 10.1021/jp5021824)
Self-assembly of amyloid fibrils that display active enzymes
X Zhou, A Entwistle, H Zhang, AP Jackson, TO Mason, U Shimanovich, TPJ Knowles, AT Smith, EB Sawyer, S Perrett
ChemCatChem
(2014)
6
(doi: 10.1002/cctc.201402125)
Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization.
TCT Michaels, TPJ Knowles
The Journal of chemical physics
(2014)
140
(doi: 10.1063/1.4880121)
ALMOST: An all atom molecular simulation toolkit for protein structure determination
B Fu, AB Sahakyan, C Camilloni, GG Tartaglia, E Paci, A Caflisch, M Vendruscolo, A Cavalli
Journal of Computational Chemistry
(2014)
35
(doi: 10.1002/jcc.23588)
Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour.
G Fusco, A De Simone, T Gopinath, V Vostrikov, M Vendruscolo, CM Dobson, G Veglia
Nature communications
(2014)
5
(doi: 10.1038/ncomms4827)
The amyloid state and its association with protein misfolding diseases.
TPJ Knowles, M Vendruscolo, CM Dobson
Nature reviews. Molecular cell biology
(2014)
15
(doi: 10.1038/nrm3810)
Yusuf Hamied Department of Chemistry
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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