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Currently displaying 1341 - 1360 of 2338 publications

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers

B Mannini, R Cascella, M Zampagni, M van Waarde-Verhagen, S Meehan, C Roodveldt, S Campioni, M Boninsegna, A Penco, A Relini, HH Kampinga, CM Dobson, MR Wilson, C Cecchi, F Chiti

Proceedings of the National Academy of Sciences

(2012)

109

12479

(doi: 10.1073/pnas.1117799109)

Nanobodies as structural probes of protein misfolding and fibril formation.

E De Genst, CM Dobson

Methods in molecular biology (Clifton, N.J.)

(2012)

911

533

(doi: 10.1007/978-1-61779-968-6_34)

Rapid distinction of intracellular and extracellular proteins using NMR diffusion measurements

CA Waudby, MD Mantle, LD Cabrita, LF Gladden, CM Dobson, J Christodoulou

Journal of the American Chemical Society

(2012)

134

11312

(doi: 10.1021/ja304912c)

Generation of carbon monoxide releasing molecules (CO-RMs) as drug candidates for the treatment of acute liver injury: Targeting of CO-RMs to the liver

AR Marques, L Kromer, DJ Gallo, N Penacho, SS Rodrigues, JD Seixas, GJL Bernardes, PM Reis, SL Otterbein, RA Ruggieri, ASG Gonçalves, AML Gonçalves, MND Matos, I Bento, LE Otterbein, WA Blättler, CC Romão

Organometallics

(2012)

5810

(doi: 10.1021/om300360c)

Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings.

RW Montalvao, A De Simone, M Vendruscolo

J Biomol NMR

(2012)

281

(doi: 10.1007/s10858-012-9644-3)

Trigger factor slows Co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions

EP O'Brien, J Christodoulou, M Vendruscolo, CM Dobson

Journal of the American Chemical Society

(2012)

134

10920

(doi: 10.1021/ja302305u)

Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format

K Zuberbühler, G Casi, GJL Bernardes, D Neri

Chem Commun (Camb)

(2012)

7100

(doi: 10.1039/c2cc32412a)

Selenium-Enhanced Electron Microscopic Imaging of Different Aggregate Forms of a Segment of the Amyloid β Peptide in Cells

EK McGuire, M Motskin, B Bolognesi, SD Bergin, TPJ Knowles, J Skepper, LM Luheshi, DW McComb, CM Dobson, AE Porter

ACS Nano

(2012)

4740

(doi: 10.1021/nn204859e)

Characterizing Intermolecular Interactions That Initiate Native-Like Protein Aggregation

F Bemporad, A De Simone, F Chiti, CM Dobson

Biophysical Journal

(2012)

102

2595

(doi: 10.1016/j.bpj.2012.03.057)

Prediction of variable translation rate effects on cotranslational protein folding.

EP O'Brien, M Vendruscolo, CM Dobson

Nature communications

(2012)

868

(doi: 10.1038/ncomms1850)

Direct observation of the interconversion of normal and toxic forms of α-synuclein

N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, M Sandal, RW Clarke, P Dunne, FA Aprile, CW Bertoncini, NW Wood, TPJ Knowles, CM Dobson, D Klenerman

Cell

(2012)

149

1048

(doi: 10.1016/j.cell.2012.03.037)