Centre for Misfolding Diseases

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  • Currently displaying 1321 - 1340 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
Mean-field master equation formalism for biofilament growth
TCT Michaels, TPJ Knowles
American Journal of Physics
(2014)
82
(doi: 10.1119/1.4870004)
Curative properties of noninternalizing antibody-drug conjugates based on maytansinoids.
E Perrino, M Steiner, N Krall, GJL Bernardes, F Pretto, G Casi, D Neri
Cancer Research
(2014)
74
(doi: 10.1158/0008-5472.CAN-13-2990)
Determination of the individual roles of the linker residues in the interdomain motions of calmodulin using NMR chemical shifts
P Kukic, C Camilloni, A Cavalli, M Vendruscolo
Biophysical Journal
(2014)
426
(doi: 10.1016/j.jmb.2014.02.002)
ChemInform Abstract: Protein Micro‐ and Nano‐Capsules for Biomedical Applications
U Shimanovich, GJL Bernardes, TPJ Knowles, A Cavaco‐Paulo
ChemInform
(2014)
45
(doi: 10.1002/chin.201418286)
Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies.
J Wacker, R Rönicke, M Westermann, M Wulff, KG Reymann, CM Dobson, U Horn, DC Crowther, LM Luheshi, M Fändrich
Acta Neuropathologica Communications
(2014)
2
(doi: 10.1186/2051-5960-2-43)
Rare Individual Amyloid‑β Oligomers Act on Astrocytes to Initiate Neuronal Damage
P Narayan, KM Holmström, D-H Kim, DJ Whitcomb, MR Wilson, P St George-Hyslop, NW Wood, CM Dobson, K Cho, AY Abramov, D Klenerman
Biochemistry
(2014)
53
(doi: 10.1021/bi401606f)
Density-Gradient-Free Microfluidic Centrifugation for Analytical and Preparative Separation of Nanoparticles
P Arosio, T Müller, L Mahadevan, TPJ Knowles
Nano Lett
(2014)
14
(doi: 10.1021/nl404771g)
New opportunities for tensor-free calculations of residual dipolar couplings for the study of protein dynamics
R Montalvao, C Camilloni, A De Simone, M Vendruscolo
Journal of Biomolecular NMR
(2014)
58
(doi: 10.1007/s10858-013-9801-3)
Nucleation-conversion-polymerization reactions of biological macromolecules with prenucleation clusters
GA Garcia, SIA Cohen, CM Dobson, TPJ Knowles
Physical Review E
(2014)
89
(doi: 10.1103/PhysRevE.89.032712)
A small-molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors.
N Krall, F Pretto, W Decurtins, GJL Bernardes, CT Supuran, D Neri
Angew Chem Int Ed Engl
(2014)
53
(doi: 10.1002/anie.201310709)
Spatial Propagation of Protein Polymerization
SIA Cohen, L Rajah, CH Yoon, AK Buell, DA White, RA Sperling, M Vendruscolo, EM Terentjev, CM Dobson, DA Weitz, TPJ Knowles
Physical review letters
(2014)
112
(doi: 10.1103/physrevlett.112.098101)
Quantitative sensing of microviscosity in protocells and amyloid materials using fluorescence lifetime imaging of molecular rotors
AJ Thompson, T-YD Tang, TW Herling, CRC Hak, S Mann, TPJ Knowles, MK Kuimova
SPIE Proceedings
(2014)
8947
(doi: 10.1117/12.2037851)
Dynamics and Timekeeping in Biological Systems
CM Dobson
Annual Review of Biochemistry
(2014)
83
(doi: 10.1146/annurev-biochem-013014-102724)
Chemical kinetics for drug discovery to combat protein aggregation diseases
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Trends in Pharmacological Sciences
(2014)
35
(doi: 10.1016/j.tips.2013.12.005)
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation
N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen
J Am Chem Soc
(2014)
136
(doi: 10.1021/ja411577t)
Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide
B Bolognesi, SIA Cohen, P Aran Terol, EK Esbjörner, S Giorgetti, MF Mossuto, A Natalello, AC Brorsson, TPJ Knowles, CM Dobson, LM Luheshi
ACS Chemical Biology
(2014)
9
(doi: 10.1021/cb400616y)
The folding process of hen lysozyme: a perspective from the 'new view'.
A Matagne, CM Dobson
Cellular and molecular life sciences : CMLS
(2014)
54
(doi: 10.1007/s000180050165)
Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.
SE Kelly, G Meisl, PJE Rowling, SH McLaughlin, T Knowles, LS Itzhaki
Physical Chemistry Chemical Physics
(2014)
16
(doi: 10.1039/c3cp54818j)
Targeting the intrinsically disordered structural ensemble of a-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease
G Tóth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, J-C Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, S-S Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue
PLoS One
(2014)
9
(doi: 10.1371/journal.pone.0087133)
The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide.
AA Kendrick, MJ Holliday, NG Isern, F Zhang, C Camilloni, C Huynh, M Vendruscolo, G Armstrong, EZ Eisenmesser
Protein Sci
(2014)
23
(doi: 10.1002/pro.2430)
Yusuf Hamied Department of Chemistry
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