Centre for Misfolding Diseases

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  • Currently displaying 1281 - 1300 of 2523 publications
Author(s)
Publication title
Journal Name
Publication year
Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.
D Pinotsi, CH Michel, AK Buell, RF Laine, P Mahou, CM Dobson, CF Kaminski, GS Kaminski Schierle
Proc Natl Acad Sci U S A
(2016)
113
(doi: 10.1073/pnas.1516546113)
Ca2+ is a key factor in α-synuclein-induced neurotoxicity
PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov
J Cell Sci
(2016)
129
(doi: 10.1242/jcs.180737)
Quantitative thermophoretic study of disease-related protein aggregates.
M Wolff, JJ Mittag, TW Herling, ED Genst, CM Dobson, TPJ Knowles, D Braun, AK Buell
Scientific reports
(2016)
6
(doi: 10.1038/srep22829)
Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions.
P Arosio, K Hu, FA Aprile, T Müller, TPJ Knowles
Analytical Chemistry
(2016)
88
(doi: 10.1021/acs.analchem.5b02930)
Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing.
JT Pedersen, SW Chen, CB Borg, S Ness, JM Bahl, NHH Heegaard, CM Dobson, L Hemmingsen, N Cremades, K Teilum
J Am Chem Soc
(2016)
138
(doi: 10.1021/jacs.5b13577)
An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation
EV Yates, G Meisl, TPJ Knowles, CM Dobson
The journal of physical chemistry. B
(2016)
120
(doi: 10.1021/acs.jpcb.5b09663)
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
E Deas, N Cremades, PR Angelova, MHR Ludtmann, Z Yao, S Chen, MH Horrocks, B Banushi, D Little, MJ Devine, P Gissen, D Klenerman, CM Dobson, NW Wood, S Gandhi, AY Abramov
Antioxidants & Redox Signaling
(2016)
24
(doi: 10.1089/ars.2015.6343)
A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding.
LD Cabrita, AME Cassaignau, HMM Launay, CA Waudby, T Wlodarski, C Camilloni, M-E Karyadi, AL Robertson, X Wang, AS Wentink, L Goodsell, CA Woolhead, M Vendruscolo, CM Dobson, J Christodoulou
Nature Structural & Molecular Biology
(2016)
23
(doi: 10.1038/nsmb.3182)
A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.
P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
ACS Combinatorial Science
(2016)
18
(doi: 10.1021/acscombsci.5b00129)
Oligomers of Heat-Shock Proteins: Structures That Don't Imply Function
WM Jacobs, TPJ Knowles, D Frenkel
Plos Computational Biology
(2016)
12
(doi: 10.1371/journal.pcbi.1004756)
Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein
A Toto, C Camilloni, R Giri, M Brunori, M Vendruscolo, S Gianni
Scientific Reports
(2016)
6
(doi: 10.1038/srep21994)
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman
Proceedings of the National Academy of Sciences of the United States of America
(2016)
113
(doi: 10.1073/pnas.1524128113)
Structural Studies of the Oligomerization Process of Human Cystatin C Variants
Z Pietralik, M Murawska, A Szymanska, JR Kumita, CM Dobson, M Kozak
Biophysical Journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.205)
Consistent Treatment of Hydrophobicity in Protein Lattice Models Accounts for Cold Denaturation.
E van Dijk, P Varilly, TPJ Knowles, D Frenkel, S Abeln
Physical Review Letters
(2016)
116
(doi: 10.1103/physrevlett.116.078101)
Combining Single-Molecule Techniques with Microfluidics for Protein Analysis
C Taylor, T Knowles, D Klenerman
Biophysical Journal
(2016)
110
(doi: 10.1016/j.bpj.2015.11.1086)
Construction of homogeneous antibody-drug conjugates using site-selective protein chemistry.
P Akkapeddi, S-A Azizi, AM Freedy, PMSD Cal, PMP Gois, GJL Bernardes
Chem Sci
(2016)
7
(doi: 10.1039/c6sc00170j)
Oligomers of heat-shock proteins: Structures that don't imply function
WM Jacobs, TPJ Knowles, D Frenkel
(2016)
(doi: 10.48550/arxiv.1508.07924)
Neuroscience: An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Ab42 aggregates linked with Alzheimer's disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, SIA Cohen, MBD Müller, S Linse, EAA Nollen, CM Dobson, TPJ Knowles, M Vendruscolo
Science advances
(2016)
2
(doi: 10.1126/sciadv.1501244)
Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.
K-L Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles
Biophys J
(2016)
110
(doi: 10.1016/j.bpj.2015.11.3523)
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, L Tosatto, M Kjaergaard, JS Beckwith, H Zetterberg, M Iljina, N Cremades, CM Dobson, NW Wood, D Klenerman
ACS Chem Neurosci
(2016)
7
(doi: 10.1021/acschemneuro.5b00324)
Yusuf Hamied Department of Chemistry
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