Centre for Misfolding Diseases

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  • Currently displaying 1261 - 1280 of 2484 publications
Author(s)
Publication title
Journal Name
Publication year
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, L Tosatto, M Kjaergaard, JS Beckwith, H Zetterberg, M Iljina, N Cremades, CM Dobson, NW Wood, D Klenerman
ACS Chem Neurosci
(2016)
7
(doi: 10.1021/acschemneuro.5b00324)
Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.
K-L Saar, EV Yates, T Müller, S Saunier, CM Dobson, TPJ Knowles
Biophys J
(2016)
110
(doi: 10.1016/j.bpj.2015.11.3523)
Hamiltonian Dynamics of Protein Filament Formation
TCT Michaels, SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Physical Review Letters
(2016)
116
(doi: 10.1103/PhysRevLett.116.038101)
Effect of molecular chaperones on aberrant protein oligomers in vitro: super-versus sub-stoichiometric chaperone concentrations.
S Cappelli, A Penco, B Mannini, R Cascella, MR Wilson, H Ecroyd, X Li, JN Buxbaum, CM Dobson, C Cecchi, A Relini, F Chiti
Biol Chem
(2016)
397
(doi: 10.1515/hsz-2015-0250)
Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide.
G Meisl, X Yang, B Frohm, TPJ Knowles, S Linse
Scientific reports
(2016)
6
(doi: 10.1038/srep18728)
Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
D Montes-Grajales, GJL Bernardes, J Olivero-Verbel
Chem Res Toxicol
(2016)
29
(doi: 10.1021/acs.chemrestox.5b00342)
Molecular mechanisms of protein aggregation from global fitting of kinetic models.
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
Nature protocols
(2016)
11
(doi: 10.1038/nprot.2016.010)
A kinetic model of the aggregation of α-synuclein provides insights into prion-like spreading
M Iljina, G Garcia, MH Horrocks, L Tosatto, M Choi, S Gandhi, T Knowles, D Klenerman
PRION
(2016)
10
Microfluidic devices fabricated using soft lithography for the study of protein structures using synchrotron radiation circular dichroism
J Charmet, C Bortolini, D Copic, IC Morales, Y Zhang, PK Challa, T Jávorfi, R Hussain, G Siligardi, TPJ Knowles
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2016
(2016)
Metainference: A Bayesian inference method for heterogeneous systems.
M Bonomi, C Camilloni, A Cavalli, M Vendruscolo
Science advances
(2016)
2
(doi: 10.1126/sciadv.1501177)
Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurements.
P Kukic, P Lundström, C Camilloni, J Evenäs, M Akke, M Vendruscolo
Biochemistry
(2015)
55
(doi: 10.1021/acs.biochem.5b00961)
Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions.
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, DA White, TW Herling, EJ De Genst, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
ACS Nano
(2015)
10
(doi: 10.1021/acsnano.5b04713)
Using Pseudocontact Shifts and Residual Dipolar Couplings as Exact NMR Restraints for the Determination of Protein Structural Ensembles
C Camilloni, M Vendruscolo
Biochemistry
(2015)
54
(doi: 10.1021/acs.biochem.5b01138)
Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice
E Nogueira, F Lager, D Le Roux, P Nogueira, J Freitas, C Charvet, G Renault, A Loureiro, CR Almeida, A Ohradanova-Repic, C Machacek, GJL Bernardes, A Moreira, H Stockinger, M Burnet, AM Carmo, AC Gomes, A Preto, G Bismuth, A Cavaco-Paulo
J Biomed Nanotechnol
(2015)
11
(doi: 10.1166/jbn.2015.2170)
Site-selective protein-modification chemistry for basic biology and drug development.
N Krall, FP da Cruz, O Boutureira, GJL Bernardes
Nat Chem
(2015)
8
(doi: 10.1038/NCHEM.2393)
Consistent treatment of hydrophobicity in protein lattice models accounts for cold denaturation
E van Dijk, P Varilly, T Knowles, D Frenkel, S Abeln
(2015)
(doi: 10.48550/arxiv.1511.06590)
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman
Sci Rep
(2015)
5
(doi: 10.1038/srep16696)
N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42
O Szczepankiewicz, B Linse, G Meisl, E Thulin, B Frohm, C Sala Frigerio, MT Colvin, AC Jacavone, RG Griffin, T Knowles, DM Walsh, S Linse
J Am Chem Soc
(2015)
137
(doi: 10.1021/jacs.5b07849)
Parmbsc1: a refined force field for DNA simulations.
I Ivani, PD Dans, A Noy, A Pérez, I Faustino, A Hospital, J Walther, P Andrio, R Goñi, A Balaceanu, G Portella, F Battistini, JL Gelpí, C González, M Vendruscolo, CA Laughton, SA Harris, DA Case, M Orozco
Nature Methods
(2015)
13
(doi: 10.1038/nmeth.3658)
Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins.
FN Newby, A De Simone, M Yagi-Utsumi, X Salvatella, CM Dobson, M Vendruscolo
Biochemistry
(2015)
54
(doi: 10.1021/acs.biochem.5b00670)
Yusuf Hamied Department of Chemistry
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