Centre for Misfolding Diseases

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  • Currently displaying 1261 - 1280 of 2453 publications
Author(s)
Publication title
Journal Name
Publication year
Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies
M Pickhardt, EM Mandelkow, E Mandelkow
Current medicinal chemistry
(2015)
12
(doi: 10.2174/156720501209151019104951)
Targeting disordered proteins with small molecules using entropy.
GT Heller, P Sormanni, M Vendruscolo
Trends in biochemical sciences
(2015)
40
(doi: 10.1016/j.tibs.2015.07.004)
An N-Acetyl Cysteine Ruthenium Tricarbonyl Conjugate Enables Simultaneous Release of CO and Ablation of Reactive Oxygen Species
JD Seixas, M Chaves-Ferreira, D Montes-Grajales, AM Gonçalves, AR Marques, LM Saraiva, J Olivero-Verbel, CC Romão, GJL Bernardes
Chemistry (Weinheim an der Bergstrasse, Germany)
(2015)
21
(doi: 10.1002/chem.201502474)
Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study
R Collepardo-Guevara, G Portella, M Vendruscolo, D Frenkel, T Schlick, M Orozco
J Am Chem Soc
(2015)
137
(doi: 10.1021/jacs.5b04086)
Alzheimer’s disease: addressing a twenty-first century plague
CM Dobson
Rendiconti Lincei. Scienze Fisiche e Naturali
(2015)
26
(doi: 10.1007/s12210-015-0453-y)
Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α‑Synuclein Oligomers
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, M Dalla Serra, TPJ Knowles, CM Dobson, D Klenerman
Analytical chemistry
(2015)
87
(doi: 10.1021/acs.analchem.5b01811)
Peptide Anchor for Folate-Targeted Liposomal Delivery
E Nogueira, IC Mangialavori, A Loureiro, NG Azoia, MP Sárria, P Nogueira, J Freitas, J Härmark, U Shimanovich, A Rollett, G Lacroix, GJL Bernardes, G Guebitz, H Hebert, A Moreira, AM Carmo, JPFC Rossi, AC Gomes, A Preto, A Cavaco-Paulo
Biomacromolecules
(2015)
16
(doi: 10.1021/acs.biomac.5b00823)
A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate
FA Aprile, P Sormanni, M Vendruscolo
Biochemistry
(2015)
54
(doi: 10.1021/acs.biochem.5b00459)
Force generation by the growth of amyloid aggregates
TW Herling, GA Garcia, TCT Michaels, W Grentz, J Dean, U Shimanovich, H Gang, T Müller, B Kav, EM Terentjev, CM Dobson, TPJ Knowles
Proceedings of the National Academy of Sciences
(2015)
112
(doi: 10.1073/pnas.1417326112)
Dynamics of protein aggregation and oligomer formation governed by secondary nucleation.
TCT Michaels, HW Lazell, P Arosio, TPJ Knowles
The Journal of chemical physics
(2015)
143
(doi: 10.1063/1.4927655)
Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody
N Martínez-Sáez, J Castro-Lõpez, J Valero-González, D Madariaga, I Compañõn, VJ Somovilla, M Salvadõ, JL Asensio, J Jiménez-Barbero, A Avenoza, JH Busto, GJL Bernardes, JM Peregrina, R Hurtado-Guerrero, F Corzana
Angewandte Chemie International Edition
(2015)
54
(doi: 10.1002/anie.201502813)
Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation
AJ Thompson, TW Herling, M Kubánková, A Vyšniauskas, TPJ Knowles, MK Kuimova
J Phys Chem B
(2015)
119
(doi: 10.1021/acs.jpcb.5b05099)
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins.
P Sormanni, FA Aprile, M Vendruscolo
Proceedings of the National Academy of Sciences
(2015)
112
(doi: 10.1073/pnas.1422401112)
Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy
Y Pustovalova, P Kukic, M Vendruscolo, DM Korzhnev
Biochemistry
(2015)
54
(doi: 10.1021/acs.biochem.5b00345)
Size controlled protein nanoemulsions for active targeting of folate receptor positive cells.
A Loureiro, E Nogueira, NG Azoia, MP Sárria, AS Abreu, U Shimanovich, A Rollett, J Härmark, H Hebert, G Guebitz, GJL Bernardes, A Preto, AC Gomes, A Cavaco-Paulo
Colloids and Surfaces B Biointerfaces
(2015)
135
(doi: 10.1016/j.colsurfb.2015.06.073)
Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution
KD Brewer, T Bacaj, A Cavalli, C Camilloni, JD Swarbrick, J Liu, A Zhou, P Zhou, N Barlow, J Xu, AB Seven, EA Prinslow, R Voleti, D Häussinger, AMJJ Bonvin, DR Tomchick, M Vendruscolo, B Graham, TC Südhof, J Rizo
Nature Structural and Molecular Biology
(2015)
22
(doi: 10.1038/nsmb.3035)
89 Constructing free energy landscapes of RNAs at atomic resolution and characterisation of their excited states.
AN Borkar, P Vallurupalli, C Camilloni, LE Kay, M Vendruscolo
Journal of Biomolecular Structure and Dynamics
(2015)
33 Suppl 1
(doi: 10.1080/07391102.2015.1032706)
Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies.
AR Wyatt, JR Kumita, NE Farrawell, CM Dobson, MR Wilson
Plos One
(2015)
10
(doi: 10.1371/journal.pone.0130036)
Constructing free energy landscapes of RNAs at atomic resolution and characterisation of their excited states
PNA Okai, E Agustin, MR Miller, J Sheng, M Royzen
Journal of Biomolecular Structure and Dynamics
(2015)
33
(doi: 10.1080/07391102.2015.1032703)
Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression
E De Genst, DY Chirgadze, FAC Klein, DC Butler, D Matak-Vinković, Y Trottier, JS Huston, A Messer, CM Dobson
Journal of Molecular Biology
(2015)
427
(doi: 10.1016/j.jmb.2015.03.021)
Yusuf Hamied Department of Chemistry
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