Centre for Misfolding Diseases

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  • Currently displaying 1241 - 1260 of 2403 publications
Author(s)
Publication title
Journal Name
Publication year
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.
SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman
Nature communications
(2015)
6
(doi: 10.1038/ncomms8025)
The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution
Z Pietralik, JR Kumita, CM Dobson, M Kozak
Colloids and surfaces. B, Biointerfaces
(2015)
131
(doi: 10.1016/j.colsurfb.2015.04.042)
Preventing peptide and protein misbehavior
P Arosio, G Meisl, M Andreasen, TPJ Knowles
Proceedings of the National Academy of Sciences
(2015)
112
(doi: 10.1073/pnas.1505170112)
Investigating the mechanisms of amylolysis of starch granules by solution-state NMR
AJ Baldwin, DL Egan, FJ Warren, PD Barker, CM Dobson, PJ Butterworth, PR Ellis
Biomacromolecules
(2015)
16
(doi: 10.1021/acs.biomac.5b00190)
Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation
SW Chen, S Drakulic, E Deas, MM Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, GE De, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
Proceedings of the National Academy of Sciences
(2015)
112
(doi: 10.1073/pnas.1421204112.)
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
Proceedings of the National Academy of Sciences
(2015)
112
(doi: 10.1073/pnas.1421204112)
Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors.
A Loureiro, GJL Bernardes, U Shimanovich, MP Sárria, E Nogueira, A Preto, AC Gomes, A Cavaco-Paulo
Nanomedicine: Nanotechnology, Biology and Medicine
(2015)
11
(doi: 10.1016/j.nano.2015.02.022)
Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms.
P Kukic, HT Alvin Leung, F Bemporad, FA Aprile, JR Kumita, A De Simone, C Camilloni, M Vendruscolo
Structure (London, England : 1993)
(2015)
23
(doi: 10.1016/j.str.2014.12.020)
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.
SIA Cohen, P Arosio, J Presto, FR Kurudenkandy, H Biverstål, L Dolfe, C Dunning, X Yang, B Frohm, M Vendruscolo, J Johansson, CM Dobson, A Fisahn, TPJ Knowles, S Linse
Nature structural & molecular biology
(2015)
22
(doi: 10.1038/nsmb.2971)
The physical basis of protein misfolding disorders
TPJ Knowles, M Vendruscolo, CM Dobson
Physics Today
(2015)
68
(doi: 10.1063/pt.3.2719)
The s2D method: Simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins
P Sormanni, C Camilloni, P Fariselli, M Vendruscolo
Journal of Molecular Biology
(2015)
427
(doi: 10.1016/j.jmb.2014.12.007)
Chaperoned amyloid proteins for immune manipulation: α‐Synuclein/Hsp70 shifts immunity toward a modulatory phenotype
A Labrador-Garrido, M Cejudo-Guillén, R Klippstein, EJ De Genst, L Tomas-Gallardo, MM Leal, J Villadiego, JJ Toledo-Aral, CM Dobson, D Pozo, C Roodveldt
Immunity, Inflammation and Disease
(2015)
2
(doi: 10.1002/iid3.39)
Advances in chemical protein modification
O Boutureira, GJL Bernardes
Chem Rev
(2015)
115
(doi: 10.1021/cr500399p)
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, CM Dobson
Nature chemical biology
(2015)
11
(doi: 10.1038/NCHEMBIO.1750)
The CamSol method of rational design of protein mutants with enhanced solubility
P Sormanni, FA Aprile, M Vendruscolo
Journal of Molecular Biology
(2015)
427
(doi: 10.1016/j.jmb.2014.09.026)
Protein microgels from amyloid fibril networks
U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, S Linse, KS Åkerfeldt, CM Dobson, DA Weitz, TPJ Knowles
ACS Nano
(2015)
9
(doi: 10.1021/nn504869d)
Analysis of the hierarchical structure of the B. subtilis transcriptional regulatory network.
S Kumar, M Vendruscolo, A Singh, D Kumar, A Samal
Mol Biosyst
(2015)
11
(doi: 10.1039/c4mb00298a)
Structure of a low-population intermediate state in the release of an enzyme product.
A De Simone, FA Aprile, A Dhulesia, CM Dobson, M Vendruscolo
eLife
(2015)
4
(doi: 10.7554/elife.02777)
A contribution to the rational design of Ru(CO) 3 Cl 2 L complexes for in vivo delivery of CO
JD Seixas, MFA Santos, A Mukhopadhyay, AC Coelho, PM Reis, LF Veiros, AR Marques, N Penacho, AML Gonçalves, MJ Romão, GJL Bernardes, T Santos-Silva, CC Romão
Dalton transactions (Cambridge, England : 2003)
(2015)
44
(doi: 10.1039/c4dt02966f)
New insights into the mechanism of amyloid formation by alpha-synuclein
AK Buell, C Galvagnion, CM Dobson, TPJ Knowles
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2015)
44
Yusuf Hamied Department of Chemistry
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