Centre for Misfolding Diseases

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  • Currently displaying 981 - 1000 of 2508 publications
Author(s)
Publication title
Journal Name
Publication year
Automated Behavioral Analysis of Large <em>C. elegans</em> Populations Using a Wide Field-of-view Tracking Platform
M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson
Journal of Visualized Experiments
(2018)
(doi: 10.3791/58643-v)
Quantifying Co-Oligomer Formation by α‑Synuclein
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman
ACS Nano
(2018)
12
(doi: 10.1021/acsnano.8b03575)
Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells.
GJ Lopes Bernardes
Angew Chem Int Ed Engl
(2018)
130
(doi: 10.1002/anie.201811338)
Modular pore-forming immunotoxins with caged cytotoxicity tailored by directed evolution
NL Mutter, M Soskine, G Huang, IS Albuquerque, GJL Bernardes, G Maglia
ACS Chemical Biology
(2018)
13
(doi: 10.1021/acschembio.8b00720)
Determination of Structural Ensembles of Proteins: Restraining vs Reweighting.
R Rangan, M Bonomi, GT Heller, A Cesari, G Bussi, M Vendruscolo
Journal of chemical theory and computation
(2018)
14
(doi: 10.1021/acs.jctc.8b00738)
Cisplatin-Triggered Bioorthogonal Decaging of Amide Bonds for Targeted-Drug Activation in vivo
B Stenton, B Oliveira, J Conde, M Negrão, M Godinho Ferreira, R Fior, G Bernardes
(2018)
(doi: 10.26434/chemrxiv.7327904.v1)
Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools.
L Shan, N Mody, P Sormani, KL Rosenthal, MM Damschroder, R Esfandiary
Mol Pharm
(2018)
15
(doi: 10.1021/acs.molpharmaceut.8b00867)
On-Chip Measurements of Membrane Protein Interactions
Y Zhang, T Knowles, S Linse
PROTEIN SCIENCE
(2018)
27
Microfluidic Diffusional Sizing Enables Characterisation of Protein-Protein Interactions Under Native Conditions
S Devenish, C Thorne, T Scheidt, J Carozza, P Arosio, Y Zhang, A Buell, T Mueller, A Lynn, J Faherty, M Wright, M Butz, T Knowles
PROTEIN SCIENCE
(2018)
27
Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling.
M Bonomi, S Hanot, CH Greenberg, A Sali, M Nilges, M Vendruscolo, R Pellarin
Structure
(2018)
27
(doi: 10.1016/j.str.2018.09.011)
Automated behavioral analysis of large c. Elegans populations using a wide field-of-view tracking platform
M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson
Journal of visualized experiments : JoVE
(2018)
2018
(doi: 10.3791/58643)
Posttranslational Chemical Mutagenesis: To Reveal the Role of Noncatalytic Cysteine Residues in Pathogenic Bacterial Phosphatases.
JB Bertoldo, H Terenzi, S Hüttelmaier, GJL Bernardes
Biochemistry
(2018)
57
(doi: 10.1021/acs.biochem.8b00639)
Statistical Mechanics of Globular Oligomer Formation by Protein Molecules
AJ Dear, A Šarić, TCT Michaels, CM Dobson, TPJ Knowles
J Phys Chem B
(2018)
122
(doi: 10.1021/acs.jpcb.8b07805)
Direct Observation of Murine Prion Protein Replication in Vitro.
JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, R Bujdoso, D Klenerman
J Am Chem Soc
(2018)
140
(doi: 10.1021/jacs.8b08311)
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.
DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M-G Spillantini, D Klenerman, MH Horrocks
ChemBioChem
(2018)
19
(doi: 10.1002/cbic.201800209)
INFLAMMATORY MYOPATHIES P.160A bioinformatics approach to define the aggregation capacity of the myofiber proteome in inclusion body myositis
C Weihl, P Ciryam, A Guttsches, K Marcus, R Morimoto, M Vendruscolo, R Kley
Neuromuscular Disorders
(2018)
28
(doi: 10.1016/j.nmd.2018.06.188)
SAR by kinetics for drug discovery in protein misfolding diseases.
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Proceedings of the National Academy of Sciences
(2018)
115
(doi: 10.1073/pnas.1807884115)
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles
Nat Commun
(2018)
9
(doi: 10.1038/s41467-018-06345-4)
Solution Fibre Spinning Technique for the Fabrication of Tuneable Decellularised Matrix-Laden Fibres and Fibrous Micromembranes
Z Li, J Tuffin, IM Lei, FS Ruggeri, NS Lewis, EL Gill, T Savin, L Huleihel, SF Badylak, T Knowles, SC Satchell, GI Welsh, MA Saleem, YYS Huang
Acta biomaterialia
(2018)
78
(doi: 10.1016/j.actbio.2018.08.010)
Determination of the conformational states of strychnine in solution using NMR residual dipolar couplings in a tensor-free approach
G Tomba, C Camilloni, M Vendruscolo
Methods
(2018)
148
(doi: 10.1016/j.ymeth.2018.07.005)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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