Centre for Misfolding Diseases

Publications

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  • Currently displaying 961 - 980 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species.
L-M Needham, J Weber, JWB Fyfe, OM Kabia, DT Do, E Klimont, Y Zhang, M Rodrigues, CM Dobson, S Ghandi, SE Bohndiek, TN Snaddon, SF Lee
Royal Society Open Science
(2018)
5
(doi: 10.1098/rsos.171399)
Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease
S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1253)
Molecular Mechanism of AB42 Peptide-Fibril Adsorption
MMJ Bellaiche, TPJ Knowles, RB Best
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1165)
Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1246)
2-Photon Lithography for Nanofluidic Lab-on-Chip Devices
O Vanderpoorten, PK Challa, Q Peter, J Charmet, N Curry, TPJ Knowles, CF Kaminski
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.3716)
Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Perrett, S Wu
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.3693)
Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates
R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.2382)
Principles of Protein Structural Ensemble Determination
M Vendruscolo
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.2149)
Optical structural analysis of individual α-synuclein oligomers
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
Angew Chem Int Ed Engl
(2018)
57
(doi: 10.1002/anie.201710779)
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein–Lipid Interactions
H Gang, C Galvagnion, G Meisl, T Müller, M Pfammatter, AK Buell, A Levin, CM Dobson, B Mu, TPJ Knowles
Anal Chem
(2018)
90
(doi: 10.1021/acs.analchem.7b04820)
Third generation antibody discovery methods:in silicorational design
P Sormanni, FA Aprile, M Vendruscolo
Chemical Society Reviews
(2018)
47
(doi: 10.1039/c8cs00523k)
Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans
T Sinnige, RF Laine, KY Ma, AJ Haack, P Gaida, N Curry, M Perni, EAA Nollen, CM Dobson, M Vendruscolo, GSK Schierle, CF Kaminski
BIOPHYSICAL JOURNAL
(2018)
114
Systematic Development of Small Molecules to Inhibit Specific Steps of α-Synuclein Aggregation in Parkinson's Disease
R Staats, P Flagmeier, M Vendruscolo
BIOPHYSICAL JOURNAL
(2018)
114
On-chip measurements of protein unfolding from direct observations of micron-scale diffusion
Y Zhang, EV Yates, L Hong, KL Saar, G Meisl, CM Dobson, TPJ Knowles
Chemical Science
(2018)
9
(doi: 10.1039/c7sc04331g)
Microfluidic Diffusional Sizing Enables Characterisation of Protein-Protein Interactions Under Native Conditions
S Devenish, C Thorne, T Scheidt, J Carozza, P Arosio, Y Zhang, A Buell, T Mueller, A Lynn, J Faherty, M Wright, M Butz, T Knowles
PROTEIN SCIENCE
(2018)
27
On-Chip Measurements of Membrane Protein Interactions
Y Zhang, T Knowles, S Linse
PROTEIN SCIENCE
(2018)
27
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils
JWP Brown, G Meisl, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion
Chemical Communications
(2018)
54
(doi: 10.1039/c8cc03002b)
Development of Antibody‐Directed Therapies: Quo Vadis?
T Rodrigues, GJL Bernardes
Angewandte Chemie International Edition
(2018)
57
(doi: 10.1002/anie.201712185)
A silicon‐labelled amino acid suitable for late‐stage fluorination and unexpected oxidative cleavage reactions in the preparation of a key intermediate in the Strecker synthesis
KR Scroggie, LJ Alcock, MJ Matos, GJL Bernardes, MV Perkins, JM Chalker
Peptide Science
(2018)
110
(doi: 10.1002/pep2.24069)
Glaucoma as a protein misfolding disease: an investigation of its metastable proteome
P Joshi, M Vendruscolo
JOURNAL OF ALZHEIMERS DISEASE
(2018)
64
Yusuf Hamied Department of Chemistry
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