Centre for Misfolding Diseases

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  • Currently displaying 101 - 120 of 2393 publications
Author(s)
Publication title
Journal Name
Publication year
Natural aminosterols inhibit NMDA receptors with low nanomolar potency
G Fani, E Coppi, S Errico, F Cherchi, M Gennari, D Barbut, M Vendruscolo, M Zasloff, AM Pugliese, F Chiti
The FEBS Journal
(2025)
292
(doi: 10.1111/febs.70072)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
Communications Biology
(2025)
8
(doi: 10.1038/s42003-025-07909-z)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-58142-5)
The α-Synuclein Proteostasis Network and its Translational Applications in Parkinson’s disease
CM Lim, M Vendruscolo
(2025)
(doi: 10.1101/2025.03.17.643594)
Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups
BH Gless, E Jones, C Labão‐Almeida, C Tang, N Gottscheber, R Couto, GJL Bernardes
Angewandte Chemie
(2025)
137
(doi: 10.1002/ange.202502268)
Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups.
BH Gless, E Jones, C Labão-Almeida, C Tang, N Gottscheber, R Couto, GJL Bernardes
Angew Chem Int Ed Engl
(2025)
64
(doi: 10.1002/anie.202502268)
Bifunctional Phagocytic Synapse Enhancers for Cancer Immunotherapy
V Sabatino, S Fleisch, C Tang, FM Müller, C Labão-Almeida, WT Khaw, S Hogan, DR Hicks, M Fontes, AR Coelho, W Yang, I Sarkar, D Shome, AV Vidal, M Cabeza-Cabrerizo, T Rohm, RM Reijmers, D Kaymak, F Gerster, D Baker, R Fior, G Hutter, GJL Bernardes
(2025)
(doi: 10.1101/2025.03.13.642658)
Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay
A Santambrogio, RI Horne, MA Metrick, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
(2025)
(doi: 10.1101/2025.03.09.642189)
Ganglioside lipids inhibit the aggregation of the Alzheimer's amyloid-β peptide
Z Toprakcioglu, AK Jayaram, TPJ Knowles
RSC Chem Biol
(2025)
6
(doi: 10.1039/d4cb00189c)
The SpyBLI cell-free pipeline for the rapid quantification of binding kinetics from crude samples
O Predeina, M Atkinson, O Wissett, M Ali, C Visentin, S Ricagno, AH Keeble, MR Howarth, P Sormanni
(2025)
(doi: 10.1101/2025.03.06.641810)
Detection of protein oligomers with nanopores 
RI Horne, SE Sandler, M Vendruscolo, UF Keyser
Nat Rev Chem
(2025)
9
(doi: 10.1038/s41570-025-00694-7)
PLUMED Tutorials: A collaborative, community-driven learning ecosystem
GA Tribello, M Bonomi, G Bussi, C Camilloni, BI Armstrong, A Arsiccio, S Aureli, F Ballabio, M Bernetti, L Bonati, SGH Brookes, ZF Brotzakis, R Capelli, M Ceriotti, K-T Chan, P Cossio, S Dasetty, D Donadio, B Ensing, AL Ferguson, G Fraux, JD Gale, FL Gervasio, T Giorgino, NSM Herringer, GM Hocky, SE Hoff, M Invernizzi, O Languin-Cattoën, V Leone, V Limongelli, O Lopez-Acevedo, F Marinelli, P Febrer Martinez, M Masetti, S Mehdi, A Michaelides, MH Murtada, M Parrinello, PM Piaggi, A Pietropaolo, F Pietrucci, S Pipolo, C Pritchard, P Raiteri, S Raniolo, D Rapetti, V Rizzi, J Rydzewski, M Salvalaglio, C Schran, A Seal, A Shayesteh Zadeh, TFD Silva, V Spiwok, G Stirnemann, D Sucerquia, P Tiwary, O Valsson, M Vendruscolo, GA Voth, AD White, J Wu
Journal of Chemical Physics
(2025)
162
(doi: 10.1063/5.0251501)
Design of Protein Sequences with Precisely Tuned Kinetic Properties
ZF Brotzakis, M Vendruscolo, G Skretas
(2025)
(doi: 10.1101/2025.02.13.638027)
AlphaFold prediction of structural ensembles of disordered proteins.
ZF Brotzakis, S Zhang, MH Murtada, M Vendruscolo
Nature communications
(2025)
16
(doi: 10.1038/s41467-025-56572-9)
Synapsin Condensation is Governed by Sequence-Encoded Molecular Grammars
C Hoffmann, KM Ruff, IA Edu, MK Shinn, JV Tromm, MR King, A Pant, H Ausserwöger, JR Morgan, TPJ Knowles, RV Pappu, D Milovanovic
Journal of molecular biology
(2025)
437
(doi: 10.1016/j.jmb.2025.168987)
Correction to "Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform".
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
Anal Chem
(2025)
97
(doi: 10.1021/acs.analchem.5c00703)
Kinetics of Amyloid Oligomer Formation
J Wei, G Meisl, AJ Dear, TCT Michaels, TPJ Knowles
Annual review of biophysics
(2025)
54
(doi: 10.1146/annurev-biophys-080124-122953)
Liquid-solid coexistence at single fibril resolution during tau condensate ageing
MSR Sahu, J Wei, DA Weitz, TPJ Knowles, K Garai
(2025)
(doi: 10.1101/2025.02.06.636870)
Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils
S Bismut, MM Schneider, M Miyasaki, Y Feng, EJ Wilde, MD Gunawardena, TPJ Knowles, GSK Schierle, LS Itzhaki, JR Kumita
(2025)
(doi: 10.1101/2025.02.04.636406)
BPS2025 - Investigating α-synuclein liquid condensates transition to an irreversible aggregated state
IA Edu, A Levin, T Sneideris, CM Fischer, TPJ Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.489)
Yusuf Hamied Department of Chemistry
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