Centre for Misfolding Diseases

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  • Currently displaying 101 - 120 of 2473 publications
Author(s)
Publication title
Journal Name
Publication year
Spatial transmission of the Alzheimer’s amyloid beta peptide by secondary oligomers
T Knowles, Q Peter, C Taylor, U Lapinska, J Wei, T Michaels, P Arosio, S Linse
(2025)
(doi: 10.21203/rs.3.rs-7035767/v1)
Model Agnostic Conditioning of Boltzmann Generators for Peptide Cyclization
B du Pont, A Abrudan, R Scrutton, V Radenkovic, H Zhao, T Knowles
(2025)
(doi: 10.1101/2025.08.15.670426)
Current practices in the study of biomolecular condensates: a community comment.
S Alberti, P Arosio, RB Best, S Boeynaems, D Cai, R Collepardo-Guevara, GL Dignon, R Dimova, S Elbaum-Garfinkle, NL Fawzi, M Fuxreiter, AS Gladfelter, A Honigmann, A Jain, JA Joseph, TPJ Knowles, K Lasker, EA Lemke, K Lindorff-Larsen, R Lipowsky, J Mittal, S Mukhopadhyay, S Myong, RV Pappu, K Rippe, TA Shelkovnikova, AG Vecchiarelli, S Wegmann, H Zhang, M Zhang, C Zubieta, M Zweckstetter, D Dormann, T Mittag
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-62055-8)
Quantifying collective interactions in biomolecular phase separation.
H Ausserwöger, E de Csilléry, D Qian, G Krainer, TJ Welsh, T Sneideris, TM Franzmann, S Qamar, NA Erkamp, J Nixon-Abell, M Kar, P St George-Hyslop, AA Hyman, S Alberti, RV Pappu, TPJ Knowles
Nature communications
(2025)
16
(doi: 10.1038/s41467-025-62437-y)
Structure-based Generation of a Secondary Nucleation Inhibitor in α-Synuclein Aggregation Using a Conditional Diffusion Model
H Zhang, RI Horne, ZF Brotzakis, C Harris, P Liò, M Vendruscolo
(2025)
(doi: 10.1101/2025.08.16.670694)
Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders
MD Overath, ASH Rygaard, CP Jacobsen, V Brasas, O Morell, P Sormanni, TP Jenkins
(2025)
(doi: 10.1101/2025.08.14.670059)
Correction: Modifying recombinant purple acid phosphatase using computational design
A Venkatramani, M Ali, O Predeina, JC Molloy, P Sormanni, EAH Hall
European biophysics journal : EBJ
(2025)
(doi: 10.1007/s00249-025-01792-6)
Classification of Tauopathies from Human Brain Homogenates through Salt-Modulated Tau Amplification
A Santambrogio, MA Metrick, P Xu, S Koga, B Ghetti, DW Dickson, B Caughey, M Vendruscolo
(2025)
(doi: 10.1101/2025.08.05.25331458)
Berberine mitigates neurotoxicity of misfolded protein oligomers by interacting with the cell membrane and subsequent internalization, without altering their structure
S Errico, G Fani, M Gennari, A Mastricci, L Neri, D Odino, C Canale, A Relini, M Vendruscolo, B Mannini, F Chiti
International Journal of Biological Macromolecules
(2025)
322
(doi: 10.1016/j.ijbiomac.2025.146398)
A Charge-Driven Strategy for Covalent Modification and Modulation of Biomolecular Condensates
Z Chen, L Liu, J Cattin, TPJ Knowles, GJL Bernardes
J Am Chem Soc
(2025)
147
(doi: 10.1021/jacs.5c06625)
Diffusing protein binders to intrinsically disordered proteins
C Liu, K Wu, H Choi, HL Han, X Zhang, JL Watson, G Ahn, JZ Zhang, S Shijo, LL Good, CM Fischer, AK Bera, A Kang, E Brackenbrough, B Coventry, DR Hick, S Qamar, X Li, J Decarreau, SR Gerben, W Yang, I Goreshnik, D Vafeados, X Wang, M Lamb, A Murray, S Kenny, MS Bauer, AN Hoofnagle, P Zhu, TPJ Knowles, D Baker
Nature
(2025)
644
(doi: 10.1038/s41586-025-09248-9)
Kinetics of seeded protein aggregation: Theory and application.
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
The Journal of Chemical Physics
(2025)
163
(doi: 10.1063/5.0273677)
A De Novo Luciferase Bioconjugate for the Cas13-based Detection of Influenza A
M Canzano, JL Harman, Y Méndez, A Quijano-Rubio, D-A Silva, GJL Bernardes
JACS Au
(2025)
5
(doi: 10.1021/jacsau.5c00576)
Sequence-based virtual screening using transformers.
S Zhang, D Huo, RI Horne, Y Qi, S Pujalte Ojeda, A Yan, M Vendruscolo
Nature communications
(2025)
16
(doi: 10.1038/S41467-025-61833-8)
Recruitment of Aβ into α‑Synuclein Condensates Catalyzes Primary Nucleation of α‑Synuclein Aggregation.
OM Morris, A Röntgen, Z Toprakcioglu, M Cali, S Dada, M Vendruscolo
ACS central science
(2025)
11
(doi: 10.1021/acscentsci.5c00614)
Aβ42 promotes the aggregation of α-synuclein splice isoforms via heterogeneous nucleation
A Röntgen, Z Toprakcioglu, M Vendruscolo
FEBS Lett
(2025)
599
(doi: 10.1002/1873-3468.70118)
LuxSit Pro and sPro: Next-Generation Designed Luciferases for Bioluminescent Reporting and Complementation-Based Detection
R Vergara, J Wagner, P Kamalian, JL Harman, N Lara, ES Fischer, GJL Bernardes, A Quijano-Rubio, D-A Silva
(2025)
(doi: 10.1101/2025.07.21.665742)
Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesicles
MK Karabova, A del Ser-Badia, A Hedegaard, SJ Washer, Z Baykam, DP O’Brien, I Vendrell, SS Hester, R Fischer, E Johnson, CE Melia, TRS Matthews-Palmer, R Matadeen, A Santambrogio, MA Metrick, M Vendruscolo, S Keeling, KAX Cheam, WA McEwan, KS Kosik, TA Day, WS James, SA Cowley
(2025)
(doi: 10.1101/2025.07.17.664991)
Immunodiagnostic plasma amino acid residue biomarkers detect cancer early and predict treatment response
C Tang, P Corredeira, S Casimiro, Q Shi, Q Han, W Sukdao, A Cavaco, C Melo-Alvim, CO Matos, C Abreu, S Walsh, G Nogueira-Costa, L Ribeiro, R Sousa, AL Barradas, JE Fonseca, L Costa, EV Yates, GJL Bernardes
Nature communications
(2025)
16
(doi: 10.1038/s41467-025-61685-2)
Amyloid-β modulates the phase separation and aggregation of α-synuclein
A Röntgen, Z Toprakcioglu, O Morris, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2025)
(doi: 10.1073/pnas.2501987122)
Yusuf Hamied Department of Chemistry
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