Centre for Misfolding Diseases

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  • Currently displaying 101 - 120 of 2400 publications
Author(s)
Publication title
Journal Name
Publication year
BPS2025 - Digital seed amplification quantifies the increase in seeding-competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2683)
BPS2025 - Investigating α-synuclein liquid condensates transition to an irreversible aggregated state
IA Edu, A Levin, T Sneideris, CM Fischer, TPJ Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.489)
BPS2025 - Sequence-encoded molecular grammar governs the formation of synaptic condensates
C Hoffmann, K Ruff, IA Edu, MK Shinn, JV Tromm, A Pant, H Ausserwöger, J Morgan, TP Knowles, RV Pappu, D Milovanovic
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2925)
BPS2025 - Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.217)
On the reversibility of amyloid fibril formation
T Pálmadóttir, J Getachew, L Ortigosa-Pascual, E Axell, J Wei, U Olsson, TPJ Knowles, S Linse
Biophysics Reviews
(2025)
6
(doi: 10.1063/5.0236947)
Competing addition processes give distinct growth regimes in the assembly of 1D filaments
SA Akram, T Brown, S Whitelam, G Meisl, TPJ Knowles, JD Schmit
Biophys J
(2025)
124
(doi: 10.1016/j.bpj.2025.01.018)
Lipid-induced condensate formation from the Alzheimer's Aβ peptide triggers amyloid aggregation
G Šneiderienė, A González Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2025)
122
(doi: 10.1073/pnas.2401307122)
Sustainable and Surfactant-Free Synthesis of Negatively Charged Acrylamide Nanogels for Biomedical Applications.
D Mazzali, G Rath, A Röntgen, V Roy Chowdhury, M Vendruscolo, M Resmini
Macromolecules
(2025)
58
(doi: 10.1021/acs.macromol.4c02128)
Structural commonalities determined by physicochemical principles in the complex polymorphism of the amyloid state of proteins
S Errico, G Fani, S Ventura, J Schymkowitz, F Rousseau, A Trovato, M Vendruscolo, F Bemporad, F Chiti
Biochem J
(2025)
482
(doi: 10.1042/BCJ20240602)
Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments
M Milanesi, ZF Brotzakis, M Vendruscolo
Science Advances
(2025)
11
(doi: 10.1126/sciadv.adr7008)
Transforming an ATP-dependent enzyme into a dissipative, self-assembling system.
Y Li, J Zhu, Z Zhang, J Wei, F Wang, G Meisl, TPJ Knowles, EH Egelman, FA Tezcan
Nat Chem Biol
(2025)
21
(doi: 10.1038/s41589-024-01811-1)
Prediction of protein biophysical traits from limited data: a case study on nanobody thermostability through NanoMelt
A Ramon, M Ni, O Predeina, R Gaffey, P Kunz, S Onuoha, P Sormanni
mAbs
(2025)
17
(doi: 10.1080/19420862.2024.2442750)
Digestibility and enteric release achieved with microencapsulates made from emulsion-templated plant proteins
LW Browning, H Wang, JW Taylor, P Wilde, M Rodriguez-Garcia, LAM Holland, TPJ Knowles
Sustainable Food Technology
(2025)
3
(doi: 10.1039/d4fb00375f)
Estimation of Ligand Binding Free Energy Using Multi-eGO.
B Stegani, E Scalone, FB Toplek, T Löhr, S Gianni, M Vendruscolo, R Capelli, C Camilloni
J Chem Inf Model
(2024)
65
(doi: 10.1021/acs.jcim.4c01545)
G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability
IREA Trussina, A Hartmann, C Desroches Altamirano, J Natarajan, CM Fischer, M Aleksejczuk, H Ausserwöger, TPJ Knowles, M Schlierf, TM Franzmann, S Alberti
Molecular cell
(2024)
85
(doi: 10.1016/j.molcel.2024.11.039)
Liquid–liquid phase separation in hepatocellular carcinoma
J Xu, W Liu, Y Yao, TPJ Knowles, Z-G Zhang, Y-L Zhang
Frontiers in cell and developmental biology
(2024)
12
(doi: 10.3389/fcell.2024.1454587)
Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
Anal Chem
(2024)
97
(doi: 10.1021/acs.analchem.4c04188)
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.
N Watamura, MS Foiani, S Bez, M Bourdenx, A Santambrogio, C Frodsham, E Camporesi, G Brinkmalm, H Zetterberg, S Patel, N Kamano, M Takahashi, J Rueda-Carrasco, L Katsouri, S Fowler, E Turkes, S Hashimoto, H Sasaguri, T Saito, AS Islam, S Benner, T Endo, K Kobayashi, C Ishida, M Vendruscolo, M Yamada, KE Duff, TC Saido
Nat Neurosci
(2024)
28
(doi: 10.1038/s41593-024-01829-7)
Proteostasis Signatures in Human Diseases
C Lim, M Vendruscolo
(2024)
(doi: 10.1101/2024.12.23.630032)
Immuno-moodulin is Differentially Expressed in T Cells and Plasma in Obsessive-Compulsive Disorder Patients
IA Blacksell, M Vismara, CM Lim, B Dell’Osso, S Pallanti, E Hollander, M Vendruscolo, C D’Addario, D Cooper, F D’Acquisto
(2024)
(doi: 10.1101/2024.12.16.628685)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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