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Currently displaying 61 - 80 of 2471 publications

In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA

V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux

(2025)

(doi: 10.1101/2025.11.25.690368)

Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.

SJ Resnick, S Qamar, P Krishna, V Korobeynikov, H Ausserwoger, A Miller, P Esposito, JA Varela, J Sheng, LH Huang, J Nixon-Abell, S Melore, CW Chung, NF Läubli, S Kapsiani, X Li, J Wang, N Zhang, MM Alam, AS Burguete, TC Swayne, Y Chen, Y-C Liao, NA Shneider, M Vendruscolo, TPJ Knowles, CF Kaminski, FS Ruggeri, GS Kaminski Schierle, P St George-Hyslop, A Chavez

Nat Commun

(2025)

10285

(doi: 10.1038/s41467-025-65178-0)

The Liquid State of RIM1α and RBP Condensates is Maintained by Lipids.

CM Fischer, Z Toprakcioglu, E de Csilléry, GS Kaminski Schierle, TPJ Knowles

ACS nano

(2025)

40789

(doi: 10.1021/acsnano.5c07661)

Binding Paths: Describing Small Molecule Interactions with Disordered Proteins via a Markov State Model

A Louet, G Hummer, M Vendruscolo

(2025)

(doi: 10.1101/2025.11.19.688850)

Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding

Y-H Lee, T Saio, M Watabe, M Matsusaki, S Kanemura, Y Lin, T Mannen, T Kuramochi, Y Kamada, K Iuchi, M Tajiri, K Suzuki, Y Li, Y Heo, K Ishii, K Arai, K Ban, M Hashimoto, S Oshita, S Ninagawa, Y Hattori, H Kumeta, A Takeuchi, S Kajimoto, H Abe, E Mori, T Muraoka, T Nakabayashi, S Akashi, T Okiyoneda, M Vendruscolo, K Inaba, M Okumura

Nat Cell Biol

(2025)

1952

(doi: 10.1038/s41556-025-01794-8)

A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery

I Černauskienė, E Izquierdo‐García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes

Angewandte Chemie International Edition

(2025)

e13808

(doi: 10.1002/anie.202513808)

A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery

I Černauskienė, E Izquierdo‐García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes

Angewandte Chemie

(2025)

138

e13808

(doi: 10.1002/ange.202513808)

Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using deep docking.

M Brezinova, ZF Brotzakis, RI Horne, V Roy Chowdhury, RC Gregory, Y Bian, A González Díaz, F Gentile, M Vendruscolo

Mol Syst Biol

(2025)

(doi: 10.1038/S44320-025-00159-5)

PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning.

SAH Jansen, LSA Dreyer, J van Basten, Y Yao, DE Otzen, TFA de Greef, TPJ Knowles, EW Meijer, NA Erkamp

ACS nano

(2025)

38981

(doi: 10.1021/acsnano.5c07268)

Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2

A Ramon, N Frassetto, H Zhao, X Xu, M Greenig, S Onuoha, P Sormanni

(2025)

(doi: 10.1101/2025.10.31.685806)

Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal

MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl

(2025)

(doi: 10.1101/2025.09.08.674880)

Kinetics of seeded protein aggregation: theory and application

AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse

(2025)

(doi: 10.48550/arxiv.2503.20941)

Droplet-based microfluidics uncovers hidden kinetic pathways of protein condensates: divergent routes to amyloids and amorphous aggregates.

J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama

(2025)

(doi: 10.26434/chemrxiv-2025-6xwcg-v2)

BLOSUM Is All You Learn Generative Antibody Models Reflect Evolutionary Priors

T Uçar, P Sormanni

(2025)

(doi: 10.1101/2025.10.26.684652)

A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease.

S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl

Advanced Science

(2025)

e11297

(doi: 10.1002/advs.202511297)

YTHDC1 inhibition as a therapeutic strategy with potent preclinical activity alone and in combination with BCL-2 inhibitors

RC Centore, M Charles, M Arora, M Rebmann, J Cattin, A Howarth, N Bharatham, M Rawling, P Radhakrishnan, S Qamar, M Watson, L Andraghetti, A Seeber, S Cohen, M Kulander, T Knowles, S Arora

Molecular Cancer Therapeutics

(2025)

B124

(doi: 10.1158/1535-7163.TARG-25-B124)

Tau catalyzes amyloid-β aggregation in a fold-dependent manner

M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede

(2025)

(doi: 10.1101/2025.10.21.683640)