Centre for Misfolding Diseases

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  • Currently displaying 61 - 80 of 2426 publications
Author(s)
Publication title
Journal Name
Publication year
DropFit: Determination of the Critical Concentration for Protein Liquid-Liquid Phase Separation.
M Brezinova, ST Dada, M Fuxreiter, M Vendruscolo
J Mol Biol
(2025)
437
(doi: 10.1016/j.jmb.2025.169294)
Microfluidics for protein interaction studies: current methods, challenges, and future perspectives.
MM Schneider, TPJ Knowles, S Keller, G Krainer
Eur Biophys J
(2025)
(doi: 10.1007/s00249-025-01763-x)
DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS Condensates
D Ilhamsyah, C Luong, S Qamar, P St George-Hyslop, J MacKay, LA Ju, TPJ Knowles, D Vigolo, Y Shen
(2025)
(doi: 10.1101/2025.06.03.657213)
Molecular mechanisms of condensate modulation from energy-dominance analysis
D Qian, H Ausserwoger, WE Arter, RM Scrutton, TJ Welsh, T Kartanas, N Ermann, S Qamar, CM Fischer, T Sneideris, P St George-Hyslop, RV Pappu, TPJ Knowles
Physical Review Applied
(2025)
23
(doi: 10.1103/PhysRevApplied.23.064017)
Balancing Antigen Loading on Gold Nanoparticles: Implications for Future Cancer Vaccine Strategies
M Ghirardello, A Guerreiro, C Bretón, I Compañón, J Zabalza, V Mangini, JM Peregrina, GJL Bernardes, F Corzana
Chemistry – A European Journal
(2025)
31
(doi: 10.1002/chem.202501286)
Transcript Identification Using Arrayed Hydrogels with TrapFISH
DB Morse, Z Toprakcioglu, A Denduluri‐Marthi, JD Brenton, CJ Thomas, TPJ Knowles
Advanced Materials Technologies
(2025)
10
(doi: 10.1002/admt.202401953)
Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core
H Nadwa, ZF Brotzakis, A Santucci, D Braconi, M Vendruscolo
(2025)
(doi: 10.1101/2025.05.27.656333)
Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases.
S Carra, B Fabian, H Taghavi, E Milanetti, V Giliberti, G Ruocco, J Shepherd, M Vendruscolo, M Fuxreiter
Molecular Aspects of Medicine
(2025)
103
(doi: 10.1016/j.mam.2025.101369)
Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils.
S Bismut, MM Schneider, M Miyasaki, Y Feng, EJ Wilde, MD Gunawardena, TPJ Knowles, GS Kaminski Schierle, LS Itzhaki, JR Kumita
Protein Science
(2025)
34
(doi: 10.1002/pro.70150)
Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases
T Yin, A Ramon, M Greenig, P Sormanni, L D'Adamio
MAbs
(2025)
17
(doi: 10.1080/19420862.2025.2498164)
High-throughput Screening of the Mechanical Properties of Peptide Assemblies
SK Yorke, Z Yang, A Levin, A Ray, JO Boamah, TPJ Knowles, MJ Buehler
(2025)
(doi: 10.48550/arxiv.2505.08850)
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro.
NS Lewis, S Zedlitz, H Ausserwöger, PM McCall, L Hubatsch, M Nousch, M Ruer-Gruß, C Hoege, F Jülicher, CR Eckmann, TPJ Knowles, AA Hyman
Proceedings of the National Academy of Sciences
(2025)
122
(doi: 10.1073/pnas.2412218122)
An Expanded View of RNA Modification with Carbohydrate-Based Metabolic Probes.
ME Hazemi, MB Geeson, FM Müller, S Mikutis, AJ Enright, GJL Bernardes
JACS Au
(2025)
5
(doi: 10.1021/jacsau.5c00249)
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates.
TLC Ng, MP Hoare, MJ Maristany, EJ Wilde, T Sneideris, J Huertas, BK Agbetiameh, M Furukawa, JA Joseph, TPJ Knowles, R Collepardo-Guevara, LS Itzhaki, JR Kumita
Chemical Science
(2025)
16
(doi: 10.1039/d5sc00903k)
The thermodynamic hypothesis of protein aggregation
M Vendruscolo
Molecular Aspects of Medicine
(2025)
103
(doi: 10.1016/j.mam.2025.101364)
Prediction of Antibody Non-Specificity using Protein Language Models and Biophysical Parameters
LI Sakhnini, L Beltrame, S Fulle, P Sormanni, A Henriksen, N Lorenzen, M Vendruscolo, D Granata
(2025)
(doi: 10.1101/2025.04.28.650927)
A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner.
S Dasadhikari, S Ghosh, S Pal, TPJ Knowles, K Garai
Communications Chemistry
(2025)
8
(doi: 10.1038/s42004-025-01524-z)
Rational Design of Single‐Domain Antibodies Targeting the Central Nervous System Neurite Outgrowth Inhibitor Nogo‐A
VR Chowdhury, A Röntgen, M Greenig, YM Gómez, SP Spiegel, M Nowinska, A Ramon, P Sormanni, A Chan, M Vendruscolo
Applied Research
(2025)
4
(doi: 10.1002/appl.70012)
Discovery of potent, selective, and orally bioavailable small molecule inhibitors of YTHDC1 for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, P Radhakrishanan, A Howarth, S Qamar, L Andraghetti, M Kulander, T Knowles, MG Kharas, S Arora
Cancer Research
(2025)
85
(doi: 10.1158/1538-7445.am2025-453)
Aggregation of α-Synuclein Splice Isoforms through a Phase Separation Pathway
A Roentgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
Science Advances
(2025)
11
(doi: 10.1126/sciadv.adq5396)
Yusuf Hamied Department of Chemistry
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