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Centre for Misfolding Diseases

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  • Currently displaying 61 - 80 of 2956 publications
Protein condensation diseases: therapeutic opportunities.
M Vendruscolo, M Fuxreiter
– Nature Communications
(2022)
13,
5550
(DOI: 10.1038/s41467-022-32940-7)
An antibody scanning method for the detection of alpha-synuclein oligomers in the serum of Parkinson's disease patients
K Kulenkampff, D Emin, R Staats, YP Zhang, L Sakhnini, A Kouli, O Rimon, E Lobanova, CH Williams-Gray, FA Aprile, P Sormanni, D Klenerman, M Vendruscolo
– Chem Sci
(2022)
13,
13815
(DOI: 10.1039/d2sc00066k)
Influence of denaturants on amyloid β42 aggregation kinetics
T Weiffert, G Meisl, S Curk, R Cukalevski, A Šarić, TPJ Knowles, S Linse
– Front Neurosci
(2022)
16,
943355
(DOI: 10.3389/fnins.2022.943355)
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman
– Nature Communications
(2022)
13,
5512
(DOI: 10.1038/s41467-022-33252-6)
Small soluble alpha-synuclein aggregates are the toxic species in Parkinson's disease
D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman
– Nature Communications
(2022)
13,
5512
(DOI: 10.1038/s41467-022-33252-6)
Effects of N-terminal Acetylation on the Aggregation of Disease-related α-synuclein Variants
R Bell, M Castellana-Cruz, A Nene, RJ Thrush, CK Xu, JR Kumita, M Vendruscolo
– Journal of molecular biology
(2022)
435,
167825
(DOI: 10.1016/j.jmb.2022.167825)
Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins
S Cogo, JE Tomkins, N Vavouraki, V Giusti, F Forcellato, C Franchin, I Tessari, G Arrigoni, L Cendron, C Manzoni, L Civiero, PA Lewis, E Greggio
– Neurobiology of disease
(2022)
174,
105858
(DOI: 10.1016/j.nbd.2022.105858)
Quantitative analysis of protein liquid-liquid phase separation
R Qi
(2022)
A chip-based supersonic microfluidic nebulizer for efficient sample introduction into inductively coupled plasma - Mass spectrometry.
E Mavrakis, Z Toprakcioglu, N Lydakis-Simantiris, TPJ Knowles, SA Pergantis
– Analytica chimica acta
(2022)
1229,
340342
(DOI: 10.1016/j.aca.2022.340342)
Bayesian Approaches for the Mechanistic Analysis of Protein Aggregation Kinetics
M Zimmermann
(2022)
(DOI: 10.17863/CAM.92162)
High-grade serous ovarian carcinoma organoids as models of chromosomal instability
M Vias, L Morrill Gavarró, C Sauer, D Sanders, A Piskorz, D-L Couturier, S Ballereau, B Hernando, J Hall, F Correia-Martins, F Markowetz, G Macintyre, J Brenton
(2022)
(DOI: 10.1101/2022.09.01.506155)
Misfolded protein oligomers induce an increase of intracellular Ca 2+ causing an escalation of reactive oxidative species
G Fani, CE La Torre, R Cascella, C Cecchi, M Vendruscolo, F Chiti
– Cellular and molecular life sciences : CMLS
(2022)
79,
500
(DOI: 10.1007/s00018-022-04513-w)
Protein and Peptide Solubility - In Silico and In Vitro Approaches
M Oeller
(2022)
(DOI: 10.17863/CAM.93911)
Analytical Solution to the Flory-Huggins Model
D Qian, TCT Michaels, TPJ Knowles
– J Phys Chem Lett
(2022)
13,
7853
(DOI: 10.1021/acs.jpclett.2c01986)
Development of potent inhibitors by fragment‐linking strategies
EV Bedwell, WJ McCarthy, AG Coyne, C Abell
– Chemical Biology & Drug Design
(2022)
100,
469
(DOI: 10.1111/cbdd.14120)
Uncovering the universality of self-replication in protein aggregation and its link to disease.
G Meisl, CK Xu, JD Taylor, TCT Michaels, A Levin, D Otzen, D Klenerman, S Matthews, S Linse, M Andreasen, TPJ Knowles
– Science advances
(2022)
8,
eabn6831
(DOI: 10.1126/sciadv.abn6831)
A conformational switch controlling the toxicity of the prion protein
K Frontzek, M Bardelli, A Senatore, A Henzi, RR Reimann, S Bedir, M Marino, R Hussain, S Jurt, G Meisl, M Pedotti, F Mazzola, G Siligardi, O Zerbe, M Losa, T Knowles, A Lakkaraju, C Zhu, P Schwarz, S Hornemann, MG Holt, L Simonelli, L Varani, A Aguzzi
– Nature Structural and Molecular Biology
(2022)
29,
831
(DOI: 10.1038/s41594-022-00814-7)
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates
R Bell, RJ Thrush, M Castellana-Cruz, M Oeller, R Staats, A Nene, P Flagmeier, CK Xu, S Satapathy, C Galvagnion, MR Wilson, CM Dobson, JR Kumita, M Vendruscolo
– Biochemistry
(2022)
61,
1743
(DOI: 10.1021/acs.biochem.2c00104)
Photochemical Alkene Hydrophosphination with Bis(trichlorosilyl)phosphine
MB Geeson, K Tanaka, R Taakili, R Benhida, CC Cummins
– Journal of the American Chemical Society
(2022)
144,
14452
(DOI: 10.1021/jacs.2c05248)
Chemical and Enzymatic Methods for Post-Translational Protein-Protein Conjugation
RJ Taylor, MB Geeson, T Journeaux, GJL Bernardes
– Journal of the American Chemical Society
(2022)
144,
14404
(DOI: 10.1021/jacs.2c00129)

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