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Centre for Misfolding Diseases

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  • Currently displaying 61 - 80 of 3133 publications
Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions.
M Kar, LT Vogel, G Chauhan, H Ausserwöger, TJ Welsh, AR Kamath, TPJ Knowles, AA Hyman, CAM Seidel, RV Pappu
Magnetoplasmonic gold nanorods for the sensitive and label-free detection of glutathione
Z Han, W Ali, T Mao, F Wang, X Wang
– Nanoscale advances
Targeted protein editing with an antibody-based system
O Rimon, J Konc, VR Chowdhury, G Bernardes, M Vendruscolo
Determination of the Structure and Dynamics of the Fuzzy Coat of an Amyloid Fibril of IAPP Using Cryo-Electron Microscopy
Z Faidon Brotzakis, T Löhr, S Truong, S Hoff, M Bonomi, M Vendruscolo
– Biochemistry
Ultrathin Twisted Stacked Gap‐Plasmon Metasurface with Giant and Tunable Shortwave Infrared Chirality
Z Han, F Wang, J Sun, X Wang, Z Tang
– Advanced Optical Materials
Single-molecule digital sizing of proteins in solution
G Krainer, RPB Jacquat, M Schneider, T Welsh, J Fan, Q Peter, E Andrzejewska, G Šneiderienė, M Czekalska, H Ausserwoeger, L Chai, W Arter, K Saar, T Herling, T Franzmann, V Kosmoliaptsis, S Alberti, F-U Hartl, S Lee, TPJ Knowles
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes.
S Errico, G Lucchesi, D Odino, EY Osman, R Cascella, L Neri, C Capitini, M Calamai, F Bemporad, C Cecchi, WA Kinney, D Barbut, A Relini, C Canale, G Caminati, R Limbocker, M Vendruscolo, M Zasloff, F Chiti
– J Med Chem
Self-replication of Aβ42 aggregates occurs on small and isolated fibril sites
S Curk, J Krausser, G Meisl, D Frenkel, S Linse, T Michaels, T Knowles, A Šarić
Amyloid formation as a protein phase transition
TCT Michaels, D Qian, A Šarić, M Vendruscolo, S Linse, TPJ Knowles
– Nature Reviews Physics
Positional influence on cellular transcriptional identity revealed through spatially segmented single-cell transcriptomics.
DB Morse, AM Michalowski, M Ceribelli, J De Jonghe, M Vias, D Riley, T Davies-Hill, T Voss, S Pittaluga, C Muus, J Liu, S Boyle, DA Weitz, JD Brenton, JD Buenrostro, TPJ Knowles, CJ Thomas
– Cell Syst
Amyloids and protein aggregation
S Linse, T Knowles
– Chemical science
Extracellular protein homeostasis: The dawning of a new age for human disease therapies?
MR Wilson, S Satapathy, M Vendruscolo
– Clinical and translational medicine
Dominant energetics in multi-component bio-molecular condensates
D Qian, H Ausserwoger, T Sneideris, M Farag, R Pappu, T Knowles
Formation of Protein Nanoparticles in Microdroplet Flow Reactors.
Q Zhang, Z Toprakcioglu, AK Jayaram, G Guo, X Wang, TPJ Knowles
– ACS nano
Fragment‐Merging Strategies with Known Pyrimidine Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis
T Kirkman, S Fun Tan, SM Chavez-Pacheco, A Hammer, C Abell, M Tosin, AG Coyne, MVB Dias
– ChemMedChem
De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
M Rebelo, C Tang, AR Coelho, C Labão-Almeida, MM Schneider, L Tatalick, P Ruivo, MP de Miranda, A Gomes, T Carvalho, MJ Walker, H Ausserwoeger, J Pedro Simas, M Veldhoen, TPJ Knowles, D-A Silva, D Shoultz, GJL Bernardes
– The Journal of infectious diseases
Thermodynamic and kinetic approaches for drug discovery to target protein misfolding and aggregation.
M Vendruscolo
– Expert opinion on drug discovery
Quantifying collective interactions in biomolecular phase separation
H Ausserwöger, D Qian, G Krainer, E de Csilléry, T Welsh, T Sneideris, T Franzmann, S Qamar, N Erkamp, J Nixon-Abell, M Kar, PS George-Hyslop, A Hyman, S Alberti, R Pappu, T Knowles
Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration.
S Koga, MA Metrick, LI Golbe, A Santambrogio, M Kim, AI Soto-Beasley, RL Walton, MC Baker, CF De Castro, M DeTure, D Russell, BA Navia, C Sandiego, OA Ross, M Vendruscolo, B Caughey, DW Dickson
– Acta neuropathologica communications
Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
– Angewandte Chemie