Centre for Misfolding Diseases

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  • Currently displaying 121 - 140 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
Correction to "Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform".
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
Anal Chem
(2025)
97
(doi: 10.1021/acs.analchem.5c00703)
Synapsin Condensation is Governed by Sequence-Encoded Molecular Grammars
C Hoffmann, KM Ruff, IA Edu, MK Shinn, JV Tromm, MR King, A Pant, H Ausserwöger, JR Morgan, TPJ Knowles, RV Pappu, D Milovanovic
J Mol Biol
(2025)
437
(doi: 10.1016/j.jmb.2025.168987)
Kinetics of Amyloid Oligomer Formation.
J Wei, G Meisl, AJ Dear, TCT Michaels, TPJ Knowles
Annu Rev Biophys
(2025)
54
(doi: 10.1146/annurev-biophys-080124-122953)
Liquid-solid coexistence at single fibril resolution during tau condensate ageing
MSR Sahu, J Wei, DA Weitz, TPJ Knowles, K Garai
(2025)
(doi: 10.1101/2025.02.06.636870)
Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils
S Bismut, MM Schneider, M Miyasaki, Y Feng, EJ Wilde, MD Gunawardena, TPJ Knowles, GSK Schierle, LS Itzhaki, JR Kumita
(2025)
(doi: 10.1101/2025.02.04.636406)
BPS2025 - Single-molecule investigation of liquid-liquid and liquid-solid phase separation of amyloid proteins
M Sahu, J Wei, KV Vinoth, TP Knowles, K Garai
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2208)
BPS2025 - Extracellular phase separation mediates the storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2943)
BPS2025 - Investigating α-synuclein liquid condensates transition to an irreversible aggregated state
IA Edu, A Levin, T Sneideris, CM Fischer, TPJ Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.489)
BPS2025 - Quantifying temperature-induced changes in protein interactions and phase behavior using high-throughput droplet microfluidics
CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.488)
BPS2025 - Investigating the role of sequence patterning in the mixing of polymer dense phases
LL Good, TP Knowles, RB Best
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.486)
BPS2025 - A mathematical model to quantify tau aggregation rates and determine molecular mechanisms from patient data
G Meisl, S-H Huang, A Quaegebeur, T Rittman, M Cotton, J Rowe, TP Knowles, D Klenerman
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2197)
BPS2025 - Sequence-encoded molecular grammar governs the formation of synaptic condensates
C Hoffmann, K Ruff, IA Edu, MK Shinn, JV Tromm, A Pant, H Ausserwöger, J Morgan, TP Knowles, RV Pappu, D Milovanovic
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2925)
BPS2025 - Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwöger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2003)
BPS2025 - Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.217)
BPS2025 - Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwöger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.377)
BPS2025 - Digital seed amplification quantifies the increase in seeding-competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2024.11.2683)
On the reversibility of amyloid fibril formation
T Pálmadóttir, J Getachew, L Ortigosa-Pascual, E Axell, J Wei, U Olsson, TPJ Knowles, S Linse
Biophys Rev (Melville)
(2025)
6
(doi: 10.1063/5.0236947)
Competing addition processes give distinct growth regimes in the assembly of 1D filaments
SA Akram, T Brown, S Whitelam, G Meisl, TPJ Knowles, JD Schmit
Biophysical Journal
(2025)
124
(doi: 10.1016/j.bpj.2025.01.018)
Lipid- induced condensate formation from the Alzheimer's Aβ peptide triggers amyloid aggregation
G Šneiderienė, A González Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
Proc Natl Acad Sci U S A
(2025)
122
(doi: 10.1073/pnas.2401307122)
Sustainable and Surfactant-Free Synthesis of Negatively Charged Acrylamide Nanogels for Biomedical Applications
D Mazzali, G Rath, A Röntgen, V Roy Chowdhury, M Vendruscolo, M Resmini
Macromolecules
(2025)
58
(doi: 10.1021/acs.macromol.4c02128)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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enquiries@ch.cam.ac.uk
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