Centre for Misfolding Diseases

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  • Currently displaying 121 - 140 of 2486 publications
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Correction to: Modifying recombinant purple acid phosphatase using computational design (European Biophysics Journal, (2025), 10.1007/s00249-025-01779-3)
A Venkatramani, M Ali, O Predeina, JC Molloy, P Sormanni, EAH Hall
European Biophysics Journal
(2025)
(doi: 10.1007/s00249-025-01792-6)
Classification of Tauopathies from Human Brain Homogenates through Salt-Modulated Tau Amplification
A Santambrogio, MA Metrick, P Xu, S Koga, B Ghetti, DW Dickson, B Caughey, M Vendruscolo
(2025)
(doi: 10.1101/2025.08.05.25331458)
Berberine mitigates neurotoxicity of misfolded protein oligomers by interacting with the cell membrane and subsequent internalization, without altering their structure
S Errico, G Fani, M Gennari, A Mastricci, L Neri, D Odino, C Canale, A Relini, M Vendruscolo, B Mannini, F Chiti
International journal of biological macromolecules
(2025)
322
(doi: 10.1016/j.ijbiomac.2025.146398)
A Charge-Driven Strategy for Covalent Modification and Modula- tion of Biomolecular Condensates
Z Chen, L Liu, J Cattin, TPJ Knowles, GJL Bernardes
Journal of the American Chemical Society
(2025)
147
(doi: 10.1021/jacs.5c06625)
Diffusing protein binders to intrinsically disordered proteins
C Liu, K Wu, H Choi, HL Han, X Zhang, JL Watson, G Ahn, JZ Zhang, S Shijo, LL Good, CM Fischer, AK Bera, A Kang, E Brackenbrough, B Coventry, DR Hick, S Qamar, X Li, J Decarreau, SR Gerben, W Yang, I Goreshnik, D Vafeados, X Wang, M Lamb, A Murray, S Kenny, MS Bauer, AN Hoofnagle, P Zhu, TPJ Knowles, D Baker
Nature
(2025)
644
(doi: 10.1038/s41586-025-09248-9)
Kinetics of seeded protein aggregation: Theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
The Journal of Chemical Physics
(2025)
163
(doi: 10.1063/5.0273677)
Sequence-based virtual screening using transformers.
S Zhang, D Huo, RI Horne, Y Qi, S Pujalte Ojeda, A Yan, M Vendruscolo
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-61833-8)
A De Novo Luciferase Bioconjugate for the Cas13-Based Detection of Influenza A.
M Canzano, JL Harman, Y Méndez, A Quijano-Rubio, D-A Silva, GJL Bernardes
Jacs Au
(2025)
5
(doi: 10.1021/jacsau.5c00576)
Recruitment of Aβ into α‑Synuclein Condensates Catalyzes Primary Nucleation of α‑Synuclein Aggregation
OM Morris, A Röntgen, Z Toprakcioglu, M Cali, S Dada, M Vendruscolo
ACS central science
(2025)
11
(doi: 10.1021/acscentsci.5c00614)
Aβ42 promotes the aggregation of α-synuclein splice isoforms via heterogeneous nucleation
A Röntgen, Z Toprakcioglu, M Vendruscolo
FEBS Lett
(2025)
599
(doi: 10.1002/1873-3468.70118)
LuxSit Pro and sPro: Next-Generation Designed Luciferases for Bioluminescent Reporting and Complementation-Based Detection
R Vergara, J Wagner, P Kamalian, JL Harman, N Lara, ES Fischer, GJL Bernardes, A Quijano-Rubio, D-A Silva
(2025)
(doi: 10.1101/2025.07.21.665742)
Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesicles
MK Karabova, A del Ser-Badia, A Hedegaard, SJ Washer, Z Baykam, DP O’Brien, I Vendrell, SS Hester, R Fischer, E Johnson, CE Melia, TRS Matthews-Palmer, R Matadeen, A Santambrogio, MA Metrick, M Vendruscolo, S Keeling, KAX Cheam, WA McEwan, KS Kosik, TA Day, WS James, SA Cowley
(2025)
(doi: 10.1101/2025.07.17.664991)
Amyloid-β modulates the phase separation and aggregation of α-synuclein
A Röntgen, Z Toprakcioglu, O Morris, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2025)
(doi: 10.1073/pnas.2501987122)
Immunodiagnostic plasma amino acid residue biomarkers detect cancer early and predict treatment response
C Tang, P Corredeira, S Casimiro, Q Shi, Q Han, W Sukdao, A Cavaco, C Melo-Alvim, CO Matos, C Abreu, S Walsh, G Nogueira-Costa, L Ribeiro, R Sousa, AL Barradas, JE Fonseca, L Costa, EV Yates, GJL Bernardes
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-61685-2)
Modifying recombinant purple acid phosphatase using computational design.
A Venkatramani, M Ali, O Predeina, JC Molloy, P Sormanni, EAH Hall
European Biophysics Journal
(2025)
55
(doi: 10.1007/s00249-025-01779-3)
An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates.
LB Fallot, JR Pinc, JE Buselmeier, JC Palchak, SS Shroff, K Zang, DJ Rinauro, KM Bacon, M Nguyen, MC Schleck, AR Cornell, A Oshidar, DJ Darrell, JM Gabriel, AK Wright, LR Sasser, RP Kreiser, FJ Burpo, A Santambrogio, P Xu, RW Kubiak, J Loverde, VA Jaffett, JR Toole, D Barbut, M Zasloff, F Chiti, AJ Dear, M Vendruscolo, R Limbocker
Proc Natl Acad Sci U S A
(2025)
122
(doi: 10.1073/pnas.2417944122)
Targeted Protein Modification with an Antibody-Based System.
O Rimon, J Konc, I Černauskienė, M Ali, V Roy Chowdhury, P Sormanni, GJL Bernardes, M Vendruscolo
ACS Central Science
(2025)
11
(doi: 10.1021/acscentsci.5c00651)
Organic Carbon Monoxide Prodrugs Activated by Endogenous Reactive Oxygen Species for Targeted Delivery
I Cernauskiene, CD Navo, C Labão-Almeida, RS J Proctor, BH Gless, WT Khaw, C Tang, MM Muriel-Olaya, G Jiménez-Osés, GJL Bernardes
J Am Chem Soc
(2025)
147
(doi: 10.1021/jacs.5c05952)
Bright sorting yields drug-like anti-amyloid antibodies
B Li, P Sormanni
Trends in Pharmacological Sciences
(2025)
46
(doi: 10.1016/j.tips.2025.05.013)
Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules
A Stevenson, R Staats, AJ Dear, D Voderholzer, JE Dreier, G Meisl, R Guido, TPJ Knowles, C Galvagnion, AK Buell, M Vendruscolo, TCT Michaels
Proceedings of the National Academy of Sciences
(2025)
122
(doi: 10.1073/pnas.2422427122)
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