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Centre for Misfolding Diseases

Publications

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  • Currently displaying 21 - 40 of 1620 publications
Silk micrococoons for protein stabilisation and molecular encapsulation
U Shimanovich, FS Ruggeri, E De Genst, J Adamcik, TP Barros, D Porter, T Müller, R Mezzenga, CM Dobson, F Vollrath, C Holland, TPJ Knowles
– Nature Communications
(2017)
8,
15902
The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases.
N Cremades, CM Dobson
– Neurobiology of disease
(2017)
Protein homeostasis of a metastable subproteome associated with Alzheimer's disease
R Kundra, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E5703
Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species
M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman
– BMC biology
(2017)
15,
57
Self-assembled Protein Fibril-metal Oxide Nanocomposites
A Levin, TO Mason, TPJ Knowles, U Shimanovich
– Israel Journal of Chemistry
(2017)
57,
724
Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.
R Kundra, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E5703
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angew Chem Int Ed Engl
(2017)
56,
7750
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Sci Adv
(2017)
3,
e1700488
Direct Conversion of an Enzyme from Native-like to Amyloid-like Aggregates within Inclusion Bodies
F Elia, F Cantini, F Chiti, CM Dobson, F Bemporad
– Biophys J
(2017)
112,
2540
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.
A Munke, J Persson, T Weiffert, E De Genst, G Meisl, P Arosio, A Carnerup, CM Dobson, M Vendruscolo, TPJ Knowles, S Linse
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
6444
The Amyloid Phenomenon and Its Links with Human Disease
CM Dobson
– COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2017)
9,
ARTN a023648
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
F Chiti, CM Dobson
– Annual Review of Biochemistry
(2017)
86,
27
Amyloid-like Fibrils from an α-Helical Transmembrane Protein
K Stroobants, JR Kumita, NJ Harris, DY Chirgadze, CM Dobson, PJ Booth, M Vendruscolo
– Biochemistry
(2017)
56,
3225
Structural basis of synaptic vesicle assembly promoted by alpha-synuclein (vol 7, 12563, 2016)
G Fusco, T Pape, AD Stephens, P Mahou, AR Costa, CF Kaminski, GSK Schierle, M Vendruscolo, G Veglia, CM Dobson, A De Simone
– Nature Communications
(2017)
8,
15667
Flow cytometric measurement of the cellular propagation of TDP-43 aggregation.
R Zeineddine, DR Whiten, NE Farrawell, L McAlary, MA Hanspal, JR Kumita, MR Wilson, JJ Yerbury
– Prion
(2017)
11,
195
The rnf168 paralog rnf169 defines a new class of ubiquitylated histone reader involved in the response to dna damage
J Kitevski-LeBlanc, A Fradet-Turcotte, P Kukic, MD Wilson, G Portella, T Yuwen, S Panier, S Duan, MD Canny, H van Ingen, CH Arrowsmith, JL Rubinstein, M Vendruscolo, D Durocher, LE Kay
– eLife
(2017)
6,
ARTN e23872
Structural Characterization of the Early Events in the Nucleation-Condensation Mechanism in a Protein Folding Process
P Kukic, Y Pustovalova, C Camilloni, S Gianni, DM Korzhnev, M Vendruscolo
– Journal of the American Chemical Society
(2017)
139,
6899
Emergence and evolution of an interaction between intrinsically disordered proteins
G Hultqvist, E Åberg, C Camilloni, GN Sundell, E Andersson, J Dogan, CN Chi, M Vendruscolo, P Jemth
– eLife
(2017)
6,
ARTN e16059
Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS
P Ciryam, IA Lambert-Smith, DM Bean, R Freer, F Cid, GG Tartaglia, DN Saunders, MR Wilson, SG Oliver, RI Morimoto, CM Dobson, M Vendruscolo, G Favrin, JJ Yerbury
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E3935
Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers.
P Varilly, AP Willard, JB Kirkegaard, TPJ Knowles, D Chandler
– The Journal of chemical physics
(2017)
146,
135102