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Centre for Misfolding Diseases

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  • Currently displaying 21 - 40 of 2720 publications
A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents.
RP Kreiser, AK Wright, LR Sasser, DJ Rinauro, JM Gabriel, CM Hsu, JA Hurtado, TL McKenzie, S Errico, JA Albright, L Richardson, VA Jaffett, DE Riegner, LT Nguyen, K LeForte, M Zasloff, JE Hollows, F Chiti, M Vendruscolo, R Limbocker
– ACS Chem Neurosci
(2022)
13,
1219
Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2
V Denninger, CK Xu, G Meisl, AS Morgunov, S Fiedler, A Ilsley, M Emmenegger, AY Malik, MA Piziorska, MM Schneider, SRA Devenish, V Kosmoliaptsis, A Aguzzi, H Fiegler, TPJ Knowles
– ACS Infectious Diseases
(2022)
8,
790
Single Mutation on Trastuzumab Modulates the Stability of Antibody–Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry
X Ferhati, E Jiménez-Moreno, EA Hoyt, G Salluce, M Cabeza-Cabrerizo, CD Navo, I Compañón, P Akkapeddi, MJ Matos, N Salaverri, P Garrido, A Martínez, V Laserna, TV Murray, G Jiménez-Osés, P Ravn, GJL Bernardes, F Corzana
– Journal of the American Chemical Society
(2022)
144,
5284
Surface interaction patches link non-specific binding and phase separation of antibodies
H Ausserwöger, G Krainer, T Welsh, T Sneideris, M Schneider, G Invernizzi, T Herling, N Lorenzen, T Knowles
(2022)
The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation.
S Cogo, FY Ho, E Tosoni, JE Tomkins, I Tessari, L Iannotta, TJ Montine, C Manzoni, PA Lewis, L Bubacco, M-C Chartier Harlin, J-M Taymans, A Kortholt, J Nichols, L Cendron, L Civiero, E Greggio
– Brain research
(2022)
1778,
147781
Chaperones Skp and SurA dynamically expand unfolded OmpX and synergistically disassemble oligomeric aggregates.
N Chamachi, A Hartmann, MQ Ma, A Svirina, G Krainer, M Schlierf
– Proceedings of the National Academy of Sciences of the United States of America
(2022)
119,
e2118919119
Tie-lines reveal interactions driving heteromolecular condensate formation
D Qian, T Welsh, N Erkamp, S Qamar, J Nixon-Abell, G Krainer, PS George-Hyslop, T Michaels, T Knowles
(2022)
The pathological G51D mutation in alpha-synuclein oligomers confers distinct structural attributes and cellular toxicity
CK Xu, M Castellana-Cruz, SW Chen, Z Du, G Meisl, A Levin, B Mannini, LS Itzhaki, TPJ Knowles, CM Dobson, N Cremades, JR Kumita
– Molecules
(2022)
27,
1293
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
C Xu, M Castellana-Cruz, S Chen, Z Du, G Meisl, A Levin, B Mannini, L Itzhaki, T Knowles, C Dobson, N Cremades, J Kumita
– Molecules
(2022)
27,
1293
Sustainable Production of Reduced Phosphorus Compounds: Mechanochemical Hydride Phosphorylation Using Condensed Phosphates as a Route to Phosphite
F Zhai, T Xin, MB Geeson, CC Cummins
– ACS Central Science
(2022)
8,
332
Simultaneous fractionation and characterization of pre-fibrillar aggregates in solution with single-molecule microfluidics
EA Andrzejewska, G Krainer, CK Xu, R Jacquat, MM Schneider, W Arter, TPJ Knowles
– Biophysical Journal
(2022)
121,
353a
Mechanism of secondary nucleation from the direct observation of A beta 42 aggregation at the single fibril level
MR Zimmermann, SC Bera, G Meisl, S Dasadhikari, S Ghosh, S Linse, K Garai, TPJ Knowles
– Biophysical Journal
(2022)
121,
443a
Hsc70 mediated disaggregation of alpha-synuclein fibrils
MM Schneider, S Gautam, TW Herling, G Krainer, E Andrzejewska, A Bracher, CM Dobson, U Hartl, TP Knowles
– Biophysical Journal
(2022)
121,
22
Using microscopy techniques to structurally characterise TDP-43 inclusions present in mammalian cell models
NS Matharu, CW Chung, JR Kumita, GS Kaminski, TP Knowles
– Biophysical Journal
(2022)
121,
268A
Universal lab-on-a-chip microfluidic spray deposition for bulk and single-molecule analytical methods on surfaces
AM Miller, SKR Chia, T Hakala, Z Toprakcioglu, M Vendruscolo, FS Ruggeri, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2022)
121,
351A
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for effectiveness of glycoconjugate vaccine candidates
G Lopes Bernardes, F carboni, A kitowski, C Sorieul, D Veggi, M Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, M Romano, R Adamo
– Chemical Science
(2022)
The C-terminal tail of alpha-synuclein protects against aggregate replication but is critical for oligomerization
A Farzadfard, JN Pedersen, G Meisl, AK Somavarapu, P Alam, L Goksøyr, MA Nielsen, AF Sander, TPJ Knowles, JS Pedersen, DE Otzen
– Communications Biology
(2022)
5,
123
Multiphase condensates from a kinetically arrested phase transition
N Erkamp, T Sneideris, H Ausserwöger, D Qian, S Qamar, J Nixon-Abell, PS George-Hyslop, J Schmit, D Weitz, TPJ Knowles
(2022)
Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration
S Fiedler, S Devenish, A Morgunov, A Ilsley, F Ricci, M Emmenegger, V Kosmoliaptsis, E Theel, J Mills, A Sholukh, A Aguzzi, A Iwasaki, A Lynn, T Knowles
(2022)
Nanofluidic Traps by Two-Photon Fabrication for Extended Detection of Single Macromolecules and Colloids in Solution
O Vanderpoorten, AN Babar, G Krainer, RPB Jacquat, PK Challa, Q Peter, Z Toprakcioglu, CK Xu, UF Keyser, JJ Baumberg, CF Kaminski, TPJ Knowles
– ACS Applied Nano Materials
(2022)
5,
1995