Centre for Misfolding Diseases

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  • Currently displaying 21 - 40 of 2347 publications
Author(s)
Publication title
Journal Name
Publication year
Scaling relations of multicomponent phase coexistence boundaries
D Qian, J Acker, RM Scrutton, CM Fischer, S Qamar, T Sneideris, A Borodavka, TPJ Knowles
(2025)
(doi: 10.1101/2025.04.02.645070)
Serial amplification of tau filaments using Alzheimer’s brain homogenates and C322A or C322S recombinant tau
A Santambrogio, S Lövestam, MA Metrick, TS Lohr, P Xu, B Caughey, SHW Scheres, M Vendruscolo
(2025)
(doi: 10.1101/2025.03.29.646137)
Linking Aβ and tau in the amyloid cascade through the intersection of their proteostasis networks
CM Lim, J Hardy, M Vendruscolo
(2025)
(doi: 10.1101/2025.03.28.646065)
Structural defects in amyloid-β fibrils drive secondary nucleation
J Hu, TJ Scheidt, D Thacker, E Axell, E Stemme, U Lapinska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Saric, J Schmit, T Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear
(2025)
(doi: 10.1101/2025.03.31.646415)
Kinetics of seeded protein aggregation: theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
(2025)
(doi: 10.48550/arxiv.2503.20941)
Learning the rules of peptide self-assembly through data mining with large language models.
Z Yang, SK Yorke, TPJ Knowles, MJ Buehler
Sci Adv
(2025)
11
(doi: 10.1126/sciadv.adv1971)
IgCraft: A versatile sequence generation framework for antibody discovery and engineering
M Greenig, H Zhao, V Radenkovic, A Ramon, P Sormanni
(2025)
Natural aminosterols inhibit NMDA receptors with low nanomolar potency
G Fani, E Coppi, S Errico, F Cherchi, M Gennari, D Barbut, M Vendruscolo, M Zasloff, AM Pugliese, F Chiti
The FEBS journal
(2025)
(doi: 10.1111/febs.70072)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
Commun Biol
(2025)
8
(doi: 10.1038/s42003-025-07909-z)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-58142-5)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-58142-5)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
Communications Biology
(2025)
8
(doi: 10.1038/s42003-025-07909-z)
Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups
G Lopes Bernardes, B Gless, E Jones
Angewandte Chemie International Edition
(2025)
137
(doi: 10.1002/ange.202502268)
The α-Synuclein Proteostasis Network and its Translational Applications in Parkinson’s disease
CM Lim, M Vendruscolo
(2025)
(doi: 10.1101/2025.03.17.643594)
Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups.
BH Gless, E Jones, C Labão-Almeida, C Tang, N Gottscheber, R Couto, GJL Bernardes
Angew Chem Int Ed Engl
(2025)
64
(doi: 10.1002/anie.202502268)
Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups
BH Gless, E Jones, C Labão‐Almeida, C Tang, N Gottscheber, R Couto, GJL Bernardes
Angewandte Chemie
(2025)
137
(doi: 10.1002/ange.202502268)
Bifunctional Phagocytic Synapse Enhancers for Cancer Immunotherapy
V Sabatino, S Fleisch, C Tang, FM Müller, C Labão-Almeida, WT Khaw, S Hogan, DR Hicks, M Fontes, AR Coelho, W Yang, I Sarkar, D Shome, AV Vidal, M Cabeza-Cabrerizo, T Rohm, RM Reijmers, D Kaymak, F Gerster, D Baker, R Fior, G Hutter, GJL Bernardes
(2025)
(doi: 10.1101/2025.03.13.642658)
Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay
A Santambrogio, RI Horne, MA Metrick, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
(2025)
(doi: 10.1101/2025.03.09.642189)
Ganglioside lipids inhibit the aggregation of the Alzheimer's amyloid-β peptide
Z Toprakcioglu, AK Jayaram, TPJ Knowles
RSC Chem Biol
(2025)
6
(doi: 10.1039/d4cb00189c)
The SpyBLI cell-free pipeline for the rapid quantification of binding kinetics from crude samples
O Predeina, M Atkinson, O Wissett, M Ali, C Visentin, S Ricagno, AH Keeble, MR Howarth, P Sormanni
(2025)
(doi: 10.1101/2025.03.06.641810)
Yusuf Hamied Department of Chemistry
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