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Currently displaying 21 - 40 of 2432 publications

Transcript Identification Using Arrayed Hydrogels With TrapFISH (Adv. Mater. Technol. 18/2025)

DB Morse, Z Toprakcioglu, A Denduluri‐Marthi, JD Brenton, CJ Thomas, TPJ Knowles

Advanced Materials Technologies

(2025)

e70330

(doi: 10.1002/admt.70330)

Tumour-specific STING agonist synthesis via a two-component prodrug system

N-S Hsu, C Tang, RV Mendes, C Labão-Almeida, CV Dos Reis, AR Coelho, MC Marques, M Cabeza Cabrerizo, R Misteli, TPC Rooney, M Hyvönen, F Corzana, R Fior, GJL Bernardes

Nat Chem

(2025)

(doi: 10.1038/s41557-025-01930-9)

Decoupling liquid-liquid phase separation and opalescence from stress-induced aggregation in therapeutic mAb formulations

I Brakti, S Lenton, H Ausserwöger, R Scrutton, N Lorenzen, MN Pedersen, JS Marino, F Herranz-Trillo, AE Terry, TPJ Knowles, MG Jensen, V Foderà

(2025)

(doi: 10.1101/2025.08.29.672998)

Direct, high-throughput linking of single cell imaging and gene expression

CK Xu, G Meisl, N Moshkov, K Goda, A Shkarin, MF Schlögel, TP Knowles, L Mazutis, J Guck

(2025)

(doi: 10.1101/2025.09.01.672798)

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease

JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi

(2025)

(doi: 10.1101/2025.08.25.671921)

Rapid elongation drives the exceptionally fast aggregation of medin, the most common localized human amyloid

M Vendruscolo, VR Chowdhury, R Horne, M Cali, Z Toprakcioglu, S Linse

(2025)

(doi: 10.21203/rs.3.rs-6476074/v1)

Direct Observation of the Conformational Transitions in Tau and Their Correlation with Phase Behavior.

J Wen, Y Tang, T Sneideris, H Ausserwöger, L Hong, TPJ Knowles, S Perrett, G Wei, S Wu

JACS Au

(2025)

4268

(doi: 10.1021/jacsau.5c00625)

The role of N-terminal acetylation on biomolecular condensation

CG Oliveira, MTS Silva, E Kava, T Agarwal, G Cereghetti, EF Vicente, TPJ Knowles, AJ Costa-Filho, LFS Mendes

(2025)

(doi: 10.1101/2025.08.21.671499)

α-Synuclein driven cell susceptibility in Parkinson’s disease

JC Breiter, JS Beckwith, EE Brock, J Lachica, CE Toomey, B Fu, M Ryten, LE Weiss, NW Wood, S Gandhi, M Vendruscolo, SF Lee

(2025)

(doi: 10.1101/2025.08.19.670819)

Protein self-assembly in crowded environments

MCM Martens, Z Han, TPJ Knowles, R Tuinier, NA Erkamp

(2025)

(doi: 10.26434/chemrxiv-2025-zhb2l)

[2.2.1]Heterobicyclic Bromovinyl Sulfones for Thiol-Triggered Strategies in Linker Chemistry: Aza- vs Oxa-Norbornadienic Systems.

M Carranza, AT Carmona, C Maya, E Gil de Montes, AV Vasco, GJL Bernardes, AJ Moreno-Vargas

Bioconjug Chem

(2025)

2079

(doi: 10.1021/acs.bioconjchem.5c00371)

Spatial transmission of the Alzheimer’s amyloid beta peptide by secondary oligomers

T Knowles, Q Peter, C Taylor, U Lapinska, J Wei, T Michaels, P Arosio, S Linse

(2025)

(doi: 10.21203/rs.3.rs-7035767/v1)

Model Agnostic Conditioning of Boltzmann Generators for Peptide Cyclization

B du Pont, A Abrudan, R Scrutton, V Radenkovic, H Zhao, T Knowles

(2025)

(doi: 10.1101/2025.08.15.670426)

A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease

S-H Huang, MW Cotton, TPJ Knowles, D Klenerman, G Meisl

(2025)

(doi: 10.48550/arxiv.2508.15046)

Quantifying collective interactions in biomolecular phase separation.

H Ausserwöger, E de Csilléry, D Qian, G Krainer, TJ Welsh, T Sneideris, TM Franzmann, S Qamar, NA Erkamp, J Nixon-Abell, M Kar, P St George-Hyslop, AA Hyman, S Alberti, RV Pappu, TPJ Knowles

Nature communications

(2025)

7724

(doi: 10.1038/s41467-025-62437-y)

Current practices in the study of biomolecular condensates: a community comment.

S Alberti, P Arosio, RB Best, S Boeynaems, D Cai, R Collepardo-Guevara, GL Dignon, R Dimova, S Elbaum-Garfinkle, NL Fawzi, M Fuxreiter, AS Gladfelter, A Honigmann, A Jain, JA Joseph, TPJ Knowles, K Lasker, EA Lemke, K Lindorff-Larsen, R Lipowsky, J Mittal, S Mukhopadhyay, S Myong, RV Pappu, K Rippe, TA Shelkovnikova, AG Vecchiarelli, S Wegmann, H Zhang, M Zhang, C Zubieta, M Zweckstetter, D Dormann, T Mittag

Nature communications

(2025)

7730

(doi: 10.1038/s41467-025-62055-8)

Structure-based Generation of a Secondary Nucleation Inhibitor in α-Synuclein Aggregation Using a Conditional Diffusion Model

H Zhang, RI Horne, ZF Brotzakis, C Harris, P Liò, M Vendruscolo

(2025)

(doi: 10.1101/2025.08.16.670694)

Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders

MD Overath, ASH Rygaard, CP Jacobsen, V Brasas, O Morell, P Sormanni, TP Jenkins

(2025)

(doi: 10.1101/2025.08.14.670059)

Correction: Modifying recombinant purple acid phosphatase using computational design.

A Venkatramani, M Ali, O Predeina, JC Molloy, P Sormanni, EAH Hall

European Biophysics Journal

(2025)

(doi: 10.1007/s00249-025-01792-6)

Classification of Tauopathies from Human Brain Homogenates through Salt-Modulated Tau Amplification

A Santambrogio, MA Metrick, P Xu, S Koga, B Ghetti, DW Dickson, B Caughey, M Vendruscolo

(2025)

(doi: 10.1101/2025.08.05.25331458)

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