Centre for Misfolding Diseases

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  • Currently displaying 21 - 40 of 2403 publications
Author(s)
Publication title
Journal Name
Publication year
A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery
I Černauskienė, E Izquierdo‐García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes
Angewandte Chemie International Edition
(2025)
65
(doi: 10.1002/anie.202513808)
Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using deep docking
M Brezinova, ZF Brotzakis, RI Horne, V Roy Chowdhury, RC Gregory, Y Bian, A González Díaz, F Gentile, M Vendruscolo
Mol Syst Biol
(2025)
22
(doi: 10.1038/S44320-025-00159-5)
PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning.
SAH Jansen, LSA Dreyer, J van Basten, Y Yao, DE Otzen, TFA de Greef, TPJ Knowles, EW Meijer, NA Erkamp
ACS nano
(2025)
19
(doi: 10.1021/acsnano.5c07268)
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
(doi: 10.1101/2025.09.08.674880)
Droplet-based microfluidics uncovers hidden kinetic pathways of protein condensates: divergent routes to amyloids and amorphous aggregates.
J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama
(2025)
(doi: 10.26434/chemrxiv-2025-6xwcg-v2)
Kinetics of seeded protein aggregation: theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
(2025)
(doi: 10.48550/arxiv.2503.20941)
A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
Adv Sci (Weinh)
(2025)
13
(doi: 10.1002/advs.202511297)
α-Synuclein driven cell susceptibility in Parkinson’s disease
S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo
(2025)
(doi: 10.21203/rs.3.rs-7375981/v1)
Tau catalyzes amyloid-β aggregation in a fold-dependent manner
M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede
(2025)
(doi: 10.1101/2025.10.21.683640)
YTHDC1 inhibition as a therapeutic strategy with potent preclinical activity alone and in combination with BCL-2 inhibitors
RC Centore, M Charles, M Arora, M Rebmann, J Cattin, A Howarth, N Bharatham, M Rawling, P Radhakrishnan, S Qamar, M Watson, L Andraghetti, A Seeber, S Cohen, M Kulander, T Knowles, S Arora
Molecular Cancer Therapeutics
(2025)
24
(doi: 10.1158/1535-7163.TARG-25-B124)
Multi-state Protein Design with DynamicMPNN
A Abrudan, SP Ojeda, CK Joshi, M Greenig, F Engelberger, A Khmelinskaia, J Meiler, M Vendruscolo, TPJ Knowles
(2025)
(doi: 10.48550/arxiv.2507.21938)
Size of biomolecular condensates dictates fate in liquid–solid phase transitions through amorphous–amyloid competition
J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama
(2025)
(doi: 10.26434/chemrxiv-2025-6xwcg)
Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau
A Santambrogio, S Lövestam, MA Metrick, T Löhr, P Xu, NCT Gallagher, B Ghetti, B Caughey, SHW Scheres, M Vendruscolo
FEBS Lett
(2025)
599
(doi: 10.1002/1873-3468.70141)
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
Nat Biomed Eng
(2025)
(doi: 10.1038/s41551-025-01496-4)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St George-Hyslop, FS Ruggeri, T Knowles, M Vendruscolo
Communications chemistry
(2025)
8
(doi: 10.1038/s42004-025-01659-z)
Advances in Proximity-Assisted Bioconjugation.
M Canzano, GJL Bernardes
Accounts of chemical research
(2025)
58
(doi: 10.1021/acs.accounts.5c00368)
Optofluidic Waveguides for the Label-Free Study of Silk Protein Aggregates.
JR Heck, Z Toprakcioglu, TE Naegele, MH Frosz, TPJ Knowles, TG Euser
ACS Omega
(2025)
10
(doi: 10.1021/acsomega.5c07826)
Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease
S De, E Prescott, J Wei, E Garland, A Urbanek, F Capriglia, W Molenkamp, D Rhodes, L Heywood, A Schwartzentruber, E Stephen, R Hughes, O Bandmann, M Collins, S Linse, A Abelein, J Johansson, M Vendruscolo, J Highley, T Knowles, H Mortiboys
(2025)
(doi: 10.21203/rs.3.rs-7657706/v1)
Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease
EE Prescott, J Wei, EF Garland, A Urbanek, F Capriglia, WH Molenkamp, DP Rhodes, L Heywood, A Schwartzentruber, E Stephen, R Hughes, O Bandmann, MO Collins, S Linse, A Abelein, J Johansson, M Vendruscolo, JR Highly, TPJ Knowles, H Mortiboys, S De
(2025)
(doi: 10.1101/2025.09.17.676873)
Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay.
A Santambrogio, RI Horne, MA Metrick, NCT Gallagher, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
J Am Chem Soc
(2025)
147
(doi: 10.1021/jacs.5c12812)
Yusuf Hamied Department of Chemistry
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