Centre for Misfolding Diseases

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  • Currently displaying 21 - 40 of 2509 publications
Author(s)
Publication title
Journal Name
Publication year
Effects of PTMs on Tau Protein Aggregation: Insights from HCG and Atomistic MD Simulations
A Louet, J Stuke, L Pietrek, M Vendruscolo, G Hummer
(2026)
(doi: 10.64898/2026.05.22.727278)
Phosphorylation tunes strain-specific protein condensation during rotavirus replication organelle assembly.
J Acker, X Wang, AJ Pardal, D Desirò, T Agarwal, A Colyer, A Tollervey, R Scrutton, C Haller, L Sherry, KL Saar, K Fominykh, MLLY Johncock, SH Chong, R Murray, J Terry, JD Schmit, AN Calabrese, TPJ Knowles, A Borodavka
The EMBO journal
(2026)
45
(doi: 10.1038/s44318-026-00814-z)
Does the sequence of a disordered protein encode small molecule binding paths?
A Louet, G Hummer, M Vendruscolo
(2026)
(doi: 10.64898/2026.05.20.726646)
Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2–deficient environments
G Lopes Bernardes
Journal of Experimental Medicine
(2026)
223
(doi: 10.1084/jem.20252133)
Molecular origins of opalescence and phase separation in mAb formulations and their relation to aggregation
I Brakti, S Lenton, M Polimeni, H Ausserwöger, R Scrutton, A Henriksen, N Lorenzen, MN Pedersen, JS Marino, F Herranz-Trillo, AE Terry, TPJ Knowles, M Groenning, V Foderà
Commun Chem
(2026)
9
(doi: 10.1038/s42004-026-02056-w)
Tracer-free Contactless Acoustic Microrheometry Quantifies Viscoelastic Spectrum of Phase-separated Condensates
K Nakajima, T Yoshikawa, Y Suzuki, S Nakatani, K Adachi, N Nakamura, S Murayama, H Sakuta, N Yangisawa, NA Erkamp, T Sneideris, M Fukuyama, M Taniguchi, M Yanagisawa, H Ogi, TPJ Knowles
(2026)
(doi: 10.48550/arxiv.2605.11660)
In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA.
V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux
Science Advances
(2026)
12
(doi: 10.1126/sciadv.aee2110)
Glutathione-Responsive Fragmentation of Heteronorbornadiene-Based Thiovinyl Sulfones in Glioma Cells.
M Carranza, AT Carmona, E Gil de Montes, Y Méndez, I Černauskienė, GJL Bernardes, AJ Moreno-Vargas
Bioconjug Chem
(2026)
37
(doi: 10.1021/acs.bioconjchem.5c00581)
The role of N-terminal acetylation on biomolecular condensation.
C G Oliveira, MTS Silva, E Kava, T Agarwal, G Cereghetti, E F Vicente, TPJ Knowles, AJ Costa-Filho, LFS Mendes
Commun Chem
(2026)
9
(doi: 10.1038/s42004-026-01975-y)
Spatially patterned, spectral single-molecule microscopy
JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, Y Zhang, AM Santos, S Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, S Lee
(2026)
(doi: 10.64898/2026.04.08.715690)
Microglia as transcriptional pacemakers of neuronal aging heterogeneity across individuals
CM Lim, M Vendruscolo
(2026)
(doi: 10.64898/2026.04.05.716624)
Rapid elongation drives the exceptionally fast aggregation of the most common localized human amyloid medin.
V Roy Chowdhury, RI Horne, MP Cali, Z Toprakcioglu, S Linse, M Vendruscolo
Commun Chem
(2026)
9
(doi: 10.1038/s42004-026-01950-7)
Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2.
A Ramon, N Frassetto, H Zhao, X Xu, M Greenig, S Onuoha, P Sormanni
Mabs
(2026)
18
(doi: 10.1080/19420862.2026.2646361)
Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates
L-T Deck, SN Pacheco, H Ausserwöger, D Frenkel, NA Erkamp, TPJ Knowles
Advanced Science
(2026)
13
(doi: 10.1002/advs.202522585)
Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles
MK Karabova, A Del Ser-Badia, A Hedegaard, SJ Washer, Z Baykam, DP O'Brien, I Vendrell, SS Hester, R Fischer, E Johnson, CE Melia, TRS Matthews-Palmer, R Matadeen, A Santambrogio, MA Metrick, M Vendruscolo, S Keeling, KAX Cheam, WA McEwan, KS Kosik, TA Day, WS James, SA Cowley
Alzheimers Dement
(2026)
22
(doi: 10.1002/alz.71337)
Discovery of first-in-class YTHDC1 small molecule inhibitors for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, MJ Rawling, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, A Howarth, S Qamar, L Andraghetti, A Seeber, MG Kharas, S Cohen, M Kulander, T Knowles, S Arora
Cancer Research
(2026)
86
(doi: 10.1158/1538-7445.am2026-7101)
NPM1 Undergoes Salt-Dependent Reentrant Phase Separation Driven by IDR Conformational Plasticity and Electrostatic Crosstalk
Y Zhen, Y Tan, Y Tang, T Sneideris, H Ausserwöger, J Wen, TPJ Knowles, S Perrett, G Wei, S Wu
Small (Weinheim an der Bergstrasse, Germany)
(2026)
22
(doi: 10.1002/smll.202514678)
Reversible peptide self-assembly enables sustained drug delivery with tuneable pharmacokinetics
TW Herling, J Wei, S Genapathy, C Rivera, M Persson, P Gennemark, D Workman, D Lundberg, E Bernard, H Bolt, MY Arteta, S Will, A Bak, D Hornigold, TPJ Knowles, ALG dos Santos
(2026)
(doi: 10.64898/2026.03.25.714189)
Systems-level organization of extracellular proteostasis.
CM Gomes, M Vendruscolo
Science
(2026)
391
(doi: 10.1126/science.aed3712)
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers.
H Yuan, Z Yang, C Yuan, S Shankar, A Levin, T Lv, Z Wang, W Sun, J Sitton, P-A Cazade, Y Dan, Y Tang, L Adler-Abramovich, Y Cao, S Rencus-Lazar, D Thompson, D Kurouski, TPJ Knowles, LJW Shimon, G Wei, B Xue, R Yang, E Gazit
Nat Commun
(2026)
17
(doi: 10.1038/s41467-026-71043-5)
Yusuf Hamied Department of Chemistry
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