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Currently displaying 81 - 100 of 3276 publications

Imaging Aβ aggregation by liquid-phase transmission electron microscopy

G Ing, S Acosta-Gutiérrez, M Vendruscolo, G Battaglia, L Ruiz-Pérez

(2024)

(doi: 10.1101/2024.01.29.577710)

Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments

M Vendruscolo, M Milanesi, F Brotzakis

(2024)

(doi: 10.21203/rs.3.rs-3847495/v1)

Improving Antibody Humanness Prediction using Patent Data

T Ucar, A Ramon, D Oglic, R Croasdale-Wood, T Diethe, P Sormanni

(2024)

(link to publication)

Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity

RI Horne, J Wilson-Godber, A González Díaz, ZF Brotzakis, S Seal, RC Gregory, A Possenti, S Chia, M Vendruscolo

– Journal of chemical information and modeling

(2024)

64,

590

(doi: 10.1021/acs.jcim.3c01777)

Site-selective peptide functionalisation mediated via vinyl-triazine linchpins

JD Sydenham, H Seki, S Krajcovicova, L Zeng, T Schober, T Deingruber, DR Spring

– Chemical Communications

(2024)

60,

706

(doi: 10.1039/d3cc05213c)

Assessing antibody and nanobody nativeness for hit selection and humanization with AbNatiV

A Ramon, M Ali, M Atkinson, A Saturnino, K Didi, C Visentin, S Ricagno, X Xu, M Greenig, P Sormanni

– Nature Machine Intelligence

(2024)

(doi: 10.1038/s42256-023-00778-3)

The Alzheimer’s Aβ peptide forms biomolecular condensates that trigger amyloid aggregation

G Šneiderienė, AG Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles

(2024)

(doi: 10.1101/2024.01.14.575549)

Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1.

G Lopes Bernardes

– ChemBioChem

(2024)

25,

e202300736

(doi: 10.1002/cbic.202300736)

Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments

M Milanesi, F Brotzakis, M Vendruscolo

(2024)

(doi: 10.1101/2024.01.08.574772)

Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy

A Priddey, MXH Chen-Xu, DJ Cooper, S MacMillan, G Meisl, CK Xu, M Hosmillo, IG Goodfellow, R Kollyfas, R Doffinger, JR Bradley, II Mohorianu, R Jones, TPJ Knowles, R Smith, V Kosmoliaptsis

– Front Immunol

(2024)

14,

1296148

(doi: 10.3389/fimmu.2023.1296148)

Small Molecules and Their Conjugates with Peptides: Chemical Strategies to Tackle Resistant Bacteria

T Deingruber

(2024)

(doi: 10.17863/CAM.109582)

Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms

S Mikutis, S Lawrinowitz, C Kretzer, L Dunsmore, L Sketeris, T Rodrigues, O Werz, GJL Bernardes

– ACS Chem Biol

(2023)

19,

217

(doi: 10.1021/acschembio.3c00725)

Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates

A Miller, Z Toprakcioglu, S Qamar, P St. George-Hyslop, S Ruggeri, T Knowles, M Vendruscolo

(2023)

(doi: 10.1101/2023.12.21.572955)

Aggregation of the Amyloid-β Peptide (Aβ40) within Condensates Generated through Liquid-Liquid Phase Separation

O Morris, Z Toprakcioglu, A Röntgen, M Cali, T Knowles, M Vendruscolo

(2023)

(doi: 10.1101/2023.12.23.573169)

Monoclonal antibodies targeting cytotoxic α-synuclein oligomers: molecular properties and diagnostic potential

D Otzen, J Nielsen, J Lauritsen, J Pedersen, J Nowak, M Bendtsen, G Kleijwegt, M Schneider, G Krainer, T Knowles, L Goksøyr, P Khalifé, S Kaalund, S Aznar, M Kjærgaard, M Nielsen, F Sander, M Romero-Ramos

(2023)

(doi: 10.21203/rs.3.rs-3778118/v1)

Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors

R Chandra, RI Horne, M Vendruscolo

– J Chem Theory Comput

(2023)

20,

469

(doi: 10.1021/acs.jctc.3c01224)

RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds

B Fu, E Brock, R Andrews, J Breiter, R Tian, C Toomey, J Lachica, T Lashley, M Ryten, N Wood, M Vendruscolo, S Gandhi, L Weiss, J Beckwith, S Lee

(2023)