Centre for Misfolding Diseases

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  • Currently displaying 81 - 100 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS Condensates
D Ilhamsyah, C Luong, S Qamar, P St George-Hyslop, J MacKay, LA Ju, TPJ Knowles, D Vigolo, Y Shen
(2025)
(doi: 10.1101/2025.06.03.657213)
Balancing Antigen Loading on Gold Nanoparticles: Implications for Future Cancer Vaccine Strategies.
M Ghirardello, A Guerreiro, C Bretón, I Compañón, J Zabalza, V Mangini, JM Peregrina, GJL Bernardes, F Corzana
Chemistry - A European Journal
(2025)
31
(doi: 10.1002/chem.202501286)
Molecular mechanisms of condensate modulation from energy-dominance analysis
D Qian, H Ausserwoger, WE Arter, RM Scrutton, TJ Welsh, T Kartanas, N Ermann, S Qamar, CM Fischer, T Sneideris, P St George-Hyslop, RV Pappu, TPJ Knowles
Physical Review Applied
(2025)
23
(doi: 10.1103/physrevapplied.23.064017)
Transcript Identification Using Arrayed Hydrogels with TrapFISH
DB Morse, Z Toprakcioglu, A Denduluri‐Marthi, JD Brenton, CJ Thomas, TPJ Knowles
Advanced Materials Technologies
(2025)
10
(doi: 10.1002/admt.202401953)
Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core
H Nadwa, ZF Brotzakis, A Santucci, D Braconi, M Vendruscolo
(2025)
(doi: 10.1101/2025.05.27.656333)
Phosphorylation enables allosteric control of a viral condensate.
J Acker, X Wang, D Desirò, T Agarwal, A Colyer, C Haller, R Scrutton, L Sherry, KL Saar, R Murray, K Fominykh, SH Chong, JD Schmit, AN Calabrese, TPJ Knowles, A Borodavka
bioRxiv
(2025)
(doi: 10.1101/2025.05.24.655949)
Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases.
S Carra, B Fabian, H Taghavi, E Milanetti, V Giliberti, G Ruocco, J Shepherd, M Vendruscolo, M Fuxreiter
Mol Aspects Med
(2025)
103
(doi: 10.1016/j.mam.2025.101369)
Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases.
T Yin, A Ramon, M Greenig, P Sormanni, L D'Adamio
mAbs
(2025)
17
(doi: 10.1080/19420862.2025.2498164)
High-throughput Screening of the Mechanical Properties of Peptide Assemblies
SK Yorke, Z Yang, A Levin, A Ray, JO Boamah, TPJ Knowles, MJ Buehler
(2025)
(doi: 10.48550/arxiv.2505.08850)
High-throughput Screening of the Mechanical Properties of Peptide Assemblies.
SK Yorke, Z Yang, A Levin, A Ray, JO Boamah, TPJ Knowles, MJ Buehler
ArXiv
(2025)
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro
NS Lewis, S Zedlitz, H Ausserwöger, PM McCall, L Hubatsch, M Nousch, M Ruer-Gruß, C Hoege, F Jülicher, CR Eckmann, TPJ Knowles, AA Hyman
Proc Natl Acad Sci U S A
(2025)
122
(doi: 10.1073/pnas.2412218122)
An Expanded View of RNA Modification with Carbohydrate-Based Metabolic Probes
ME Hazemi, MB Geeson, FM Müller, S Mikutis, AJ Enright, GJL Bernardes
Jacs Au
(2025)
5
(doi: 10.1021/jacsau.5c00249)
The thermodynamic hypothesis of protein aggregation.
M Vendruscolo
Mol Aspects Med
(2025)
103
(doi: 10.1016/j.mam.2025.101364)
Prediction of Antibody Non-Specificity using Protein Language Models and Biophysical Parameters
LI Sakhnini, L Beltrame, S Fulle, P Sormanni, A Henriksen, N Lorenzen, M Vendruscolo, D Granata
(2025)
(doi: 10.1101/2025.04.28.650927)
A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner.
S Dasadhikari, S Ghosh, S Pal, TPJ Knowles, K Garai
Communications chemistry
(2025)
8
(doi: 10.1038/s42004-025-01524-z)
Rational design of single-domain antibodies targeting the central nervous system neurite outgrowth inhibitor Nogo-A
VR Chowdhury, A Röntgen, M Greenig, YM Gómez, SP Spiegel, M Nowinska, A Ramon, P Sormanni, A Chan, M Vendruscolo
Applied Research
(2025)
4
(doi: 10.1002/appl.70012)
Abstract 453: Discovery of potent, selective, and orally bioavailable small molecule inhibitors of YTHDC1 for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, P Radhakrishanan, A Howarth, S Qamar, L Andraghetti, M Kulander, T Knowles, MG Kharas, S Arora
Cancer Research
(2025)
85
(doi: 10.1158/1538-7445.AM2025-453)
Aggregation of α-synuclein splice isoforms through a phase separation pathway
A Roentgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
Science advances
(2025)
11
(doi: 10.1126/sciadv.adq5396)
Design and sustainability of polypeptide material systems
SK Yorke, Z Yang, EG Wiita, A Kamada, TPJ Knowles, MJ Buehler
Nature Reviews Materials
(2025)
10
(doi: 10.1038/s41578-025-00793-3)
Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates
NA Erkamp, M Farag, Y Qiu, D Qian, T Sneideris, T Wu, TJ Welsh, H Ausserwöger, TJ Krug, G Chauhan, DA Weitz, MD Lew, TPJ Knowles, RV Pappu
Nat Commun
(2025)
16
(doi: 10.1038/s41467-025-58736-z)
Yusuf Hamied Department of Chemistry
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