Centre for Misfolding Diseases

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  • Currently displaying 181 - 200 of 2400 publications
Author(s)
Publication title
Journal Name
Publication year
The diversity of SNCA transcripts in neurons, and its impact on antisense oligonucleotide therapeutics
JR Evans, EK Gustavsson, I Doykov, D Murphy, GS Virdi, J Lachica, A Röntgen, MH Murtada, CW Pang, H Macpherson, AI Wernick, CE Toomey, D Athauda, ML Choi, J Hardy, NW Wood, M Vendruscolo, K Mills, W Heywood, M Ryten, S Gandhi
(2024)
(doi: 10.1101/2024.05.30.596437)
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces
A Dear, D Thacker, S Wennmalm, L Ortigosa-Pascual, EA Andrzejewska, G Meisl, S Linse, T Knowles
ACS Chemical Neuroscience
(2024)
15
(doi: 10.1021/acschemneuro.4c00127)
An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions
G Cereghetti, VM Kissling, LM Koch, A Arm, CC Schmidt, Y Thüringer, N Zamboni, P Afanasyev, M Linsenmeier, C Eichmann, S Kroschwald, J Zhou, Y Cao, DM Pfizenmaier, T Wiegand, R Cadalbert, G Gupta, D Boehringer, TPJ Knowles, R Mezzenga, P Arosio, R Riek, M Peter
Developmental Cell
(2024)
59
(doi: 10.1016/j.devcel.2024.04.018)
Biomolecular condensates sustain pH gradients at equilibrium through charge neutralisation
H Ausserwöger, R Scrutton, C Fischer, T Sneideris, D Qian, E de Csilléry, I Baronaite, K Saar, A Białek, M Oeller, G Krainer, T Franzmann, S Wittmann, J Iglesias-Artola, G Invernizzi, A Hyman, S Alberti, N Lorenzen, T Knowles
(2024)
(doi: 10.1101/2024.05.23.595321)
Solutes unmask differences in clustering versus phase separation of FET proteins.
M Kar, LT Vogel, G Chauhan, S Felekyan, H Ausserwöger, TJ Welsh, F Dar, AR Kamath, TPJ Knowles, AA Hyman, CAM Seidel, RV Pappu
Nat Commun
(2024)
15
(doi: 10.1038/s41467-024-48775-3)
Polysaccharide functionalization reduces lipid vesicle stiffness
K Jahnke, M Pavlovic, W Xu, A Chen, TPJ Knowles, LR Arriaga, DA Weitz
Proceedings of the National Academy of Sciences of the United States of America
(2024)
121
(doi: 10.1073/pnas.2317227121)
Homogeneous multi-payload antibody–drug conjugates
T Journeaux, GJL Bernardes
Nat Chem
(2024)
16
(doi: 10.1038/s41557-024-01507-y)
Automated optimization of the solubility of a hyper-stable α-amylase
M Ali, M Greenig, M Oeller, M Atkinson, X Xu, P Sormanni
Open biology
(2024)
14
(doi: 10.1098/rsob.240014)
Automated optimization of the solubility of a hyper-stable α-amylase
M Ali, M Greenig, M Oeller, M Atkinson, X Xu, P Sormanni
Open Biology
(2024)
14
(doi: 10.1098/rsob.240014)
Kinetic models reveal the interplay of protein production and aggregation.
J Wei, G Meisl, A Dear, M Oosterhuis, R Melki, C Emanuelsson, S Linse, TPJ Knowles
Chemical Science
(2024)
15
(doi: 10.1039/d4sc00088a)
Pharmacological inhibition of α-synuclein aggregation within liquid condensates.
ST Dada, Z Toprakcioglu, MP Cali, A Röntgen, MC Hardenberg, OM Morris, LK Mrugalla, TPJ Knowles, M Vendruscolo
Nat Commun
(2024)
15
(doi: 10.1038/s41467-024-47585-x)
Maximum entropy determination of mammalian proteome dynamics.
AJ Dear, GA Garcia, G Meisl, GA Collins, TPJ Knowles, AL Goldberg
Proc Natl Acad Sci U S A
(2024)
121
(doi: 10.1073/pnas.2313107121)
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed.
AJ Dear, X Teng, SR Ball, J Lewin, RI Horne, D Clow, A Stevenson, N Harper, K Yahya, X Yang, SC Brewerton, J Thomson, TCT Michaels, S Linse, TPJ Knowles, J Habchi, G Meisl
Chem Sci
(2024)
15
(doi: 10.1039/d3sc05661a)
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
TL Chris Ng, M Hoare, J Maristany, E Wilde, T Sneideris, J Huertas, B Agbetiameh, M Furukawa, J Joseph, TPJ Knowles, R Collepardo-Guevara, L Itzhaki, J Kumita
(2024)
(doi: 10.1101/2024.04.16.589709)
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
Nature chemical biology
(2024)
20
(doi: 10.1038/s41589-024-01580-x)
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds
B Fu, E Brock, R Andrews, J Breiter, R Tian, C Toomey, J Lachica, T Lashley, M Ryten, N Wood, M Vendruscolo, S Gandhi, L Weiss, J Beckwith, S Lee
J Phys Chem B
(2024)
128
(doi: 10.1021/acs.jpcb.4c00174)
Selenium-silk microgels as antifungal and antibacterial agents
EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
Nanoscale horizons
(2024)
9
(doi: 10.1039/d3nh00385j)
Abstract 1657: Microfluidics-based screening platform identifies a novel therapeutic approach to targeting EML4-ALK driven cancers
RC Centore, M Watson, J Doh, J Cattin, C Sgambato, A Alex, J Sawant, P Radhakrishnan, J Cornish, A Howarth, N Bharatham, WE Arter, S Qamar, KL Saar, D Williamson, A Seeber, N Groenewegen, M Czekalska, T Kartanas, N Ermann, A Taher, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-1657)
Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer
RC Centore, M Charles, M Arora, Y Chen, M Watson, C Kelley, M Czekalska, M Rebmann, M Ghandi, J Cattin, N Bharatham, P Radhakrishnan, A Howarth, G Rudlaff, WE Arter, S Qamar, K Saar, D Williamson, A Seeber, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-3231)
Abstract 4891: Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools
KL Saar, M Rebmann, M Kanchwala, S Qamar, P Radhakrishnan, J Cornish, J Doh, J Cattin, A Rotem, M Ghandi, A Seeber, RC Centore, SA Teichmann, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-4891)
Yusuf Hamied Department of Chemistry
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