Centre for Misfolding Diseases

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  • Currently displaying 181 - 200 of 2336 publications
Author(s)
Publication title
Journal Name
Publication year
Sequence-based drug design using transformers
S Zhang, D Huo, R Horne, Y Qi, SP Ojeda, A Yan, M Vendruscolo
(2023)
(doi: 10.1101/2023.11.27.568880)
CryoENsemble - a Bayesian approach for reweighting biomolecular structural ensembles using heterogeneous cryo-EM maps
T Włodarski, J Streit, A Mitropoulou, L Cabrita, M Vendruscolo, J Christodoulou
(2023)
(doi: 10.1101/2023.11.21.567999)
Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses
IA Bermejo, A Guerreiro, A Eguskiza, N Martínez-Sáez, FS Lazaris, A Asín, VJ Somovilla, I Compañón, TK Raju, S Tadic, P Garrido, J García-Sanmartín, V Mangini, AS Grosso, F Marcelo, A Avenoza, JH Busto, F García-Martín, R Hurtado-Guerrero, JM Peregrina, GJL Bernardes, A Martínez, R Fiammengo, F Corzana
JACS Au
(2023)
4
(doi: 10.1021/jacsau.3c00587)
Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids.
M Oeller, RJD Kang, HL Bolt, AL Gomes Dos Santos, AL Weinmann, A Nikitidis, P Zlatoidsky, W Su, W Czechtizky, L De Maria, P Sormanni, M Vendruscolo
Nature communications
(2023)
14
(doi: 10.1038/s41467-023-42940-w)
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores
SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, M Castellana Cruz, Z Faidon Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo
Journal of the American Chemical Society
(2023)
145
(doi: 10.1021/jacs.3c09335)
Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides.
T Sneideris, NA Erkamp, H Ausserwöger, KL Saar, TJ Welsh, D Qian, K Katsuya-Gaviria, MLLY Johncock, G Krainer, A Borodavka, TPJ Knowles
Nature communications
(2023)
14
(doi: 10.1038/s41467-023-42374-4)
Linking modulation of bio-molecular phase behaviour with collective interactions
D Qian, H Ausserwoger, W Arter, R Scrutton, T Welsh, T Kartanas, N Ermann, S Qamar, C Fischer, T Sneideris, PS George-Hyslop, R Pappu, T Knowles
(2023)
(doi: 10.1101/2023.11.02.565376)
Merging the Isonitrile-Tetrazine (4+1) Cycloaddition and the Ugi Four-Component Reaction into a Single Multicomponent Process
Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres-Mozas, T Rodrigues, G Jiménez-Osés, GJL Bernardes
Angewandte Chemie International Edition
(2023)
62
(doi: 10.1002/anie.202311186)
Merging the Isonitrile‐Tetrazine (4+1) Cycloaddition and the Ugi Four‐Component Reaction into a Single Multicomponent Process
Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres‐Mozas, T Rodrigues, G Jiménez‐Osés, GJL Bernardes
Angewandte Chemie
(2023)
135
(doi: 10.1002/ange.202311186)
Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD-20 therapy
A Priddey, MXH Chen-Xu, DJ Cooper, S MacMillan, G Meisl, CK Xu, M Hosmillo, IG Goodfellow, R Kollyfas, R Doffinger, JR Bradley, II Mohorianu, R Jones, TPJ Knowles, R Smith, V Kosmoliaptsis
(2023)
(doi: 10.1101/2023.10.22.563481)
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
A Dear, X Teng, S Ball, J Lewin, R Horne, D Clow, N Harper, K Yahya, TCT Michaels, S Linse, T Knowles, X Yang, S Brewerton, J Thomson, J Habchi, G Meisl
(2023)
(doi: 10.1101/2023.10.20.563279)
Score-Based Generative Models for Designing Binding Peptide Backbones
JD Boom, M Greenig, P Sormanni, P Liò
(2023)
Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation.
CM Lim, A González Díaz, M Fuxreiter, FW Pun, A Zhavoronkov, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2023)
120
(doi: 10.1073/pnas.2300215120)
Multi-omic prediction of therapeutic targets for human diseases associated with protein phase separation
M Vendruscolo, C Lim, A González Díaz, M Fuxreiter, F Pun, A Zhavoronkov
Proceedings of the National Academy of Sciences of USA
(2023)
(doi: 10.1073/pnas.2300215120)
Pharmacological inhibition of α-synuclein aggregation within liquid condensates
M Vendruscolo, S Dada, Z Toprakcioglu, M Hardenberg, M Cali, L Mrugalla, O Morris, A Roentgen, T Knowles
(2023)
(doi: 10.21203/rs.3.rs-3174399/v1)
Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions
M Kar, LT Vogel, G Chauhan, H Ausserwöger, TJ Welsh, AR Kamath, TPJ Knowles, AA Hyman, CAM Seidel, RV Pappu
(2023)
(doi: 10.21203/rs.3.rs-3252197/v1)
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A
C Olivieri, Y Wang, C Walker, MV Subrahmanian, KN Ha, DA Bernlohr, J Gao, C Camilloni, M Vendruscolo, SS Taylor, G Veglia
bioRxiv
(2023)
4
(doi: 10.1101/2023.09.12.557419)
Ganglioside Lipids Inhibit the Aggregation of the Alzheimer’s Related Peptide Amyloid-β
Z Toprakcioglu, A Jayaram, T Knowles
(2023)
(doi: 10.1101/2023.09.10.556751)
Effects of Processing‐Induced Contamination on Organic Electronic Devices
D Simatos, IE Jacobs, I Dobryden, M Nguyen, A Savva, D Venkateshvaran, M Nikolka, J Charmet, LJ Spalek, M Gicevičius, Y Zhang, G Schweicher, DJ Howe, S Ursel, J Armitage, IB Dimov, U Kraft, W Zhang, M Alsufyani, I McCulloch, RM Owens, PM Claesson, TPJ Knowles, H Sirringhaus
Small Methods
(2023)
7
(doi: 10.1002/smtd.202300476)
Optimization of a small molecule inhibitor of secondary nucleation in a-synuclein aggregation
R Staats, ZF Brotzakis, S Chia, RI Horne, M Vendruscolo
Frontiers in molecular biosciences
(2023)
10
(doi: 10.3389/fmolb.2023.1155753)
Yusuf Hamied Department of Chemistry
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