Centre for Misfolding Diseases

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  • Currently displaying 181 - 200 of 2403 publications
Author(s)
Publication title
Journal Name
Publication year
AIntibody: an experimentally validated in silico antibody discovery design challenge
MF Erasmus, L Spector, F Ferrara, R DiNiro, TJ Pohl, K Perea-Schmittle, W Wang, PM Tessier, C Richardson, L Turner, S Kumar, D Bedinger, P Sormanni, ML Fernández-Quintero, AB Ward, JR Loeffler, OM Swanson, CM Deane, MIJ Raybould, A Evers, C Sellmann, S Bachas, J Ruffolo, HG Nastri, K Ramesh, J Sørensen, R Croasdale-Wood, O Hijano, C Leal-Lopes, M Shahsavarian, Y Qiu, P Marcatili, E Vernet, R Akbar, S Friedensohn, R Wagner, VB Kurella, S Malhotra, S Kumar, P Kidger, JC Almagro, E Furfine, M Stanton, CP Graff, SD Villalba, F Tomszak, AAR Teixeira, E Hopkins, M Dovner, S D'Angelo, ARM Bradbury
Nat Biotechnol
(2024)
42
(doi: 10.1038/s41587-024-02469-9)
Non‐natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity
A Guerreiro, I Compañón, FS Lazaris, C Labão-Almeida, P Oroz, M Ghirardello, MC Marques, F Corzana, GJL Bernardes
Angewandte Chemie International Edition
(2024)
63
(doi: 10.1002/anie.202411009)
Oxidation-sensitive cysteines drive IL-38 amyloid formation.
A Diaz-Barreiro, G Cereghetti, FG Ortega Sánchez, J Tonacini, D Talabot-Ayer, S Kieffer-Jaquinod, VM Kissling, A Huard, C Swale, TPJ Knowles, Y Couté, M Peter, A Francés-Monerris, G Palmer
Cell reports
(2024)
43
(doi: 10.1016/j.celrep.2024.114940)
Synapsin condensation is governed by sequence-encoded molecular grammars.
C Hoffmann, KM Ruff, I Edu, M Kyung Shinn, J Tromm, M King, A Pant, H Ausserwoeger, J Morgan, T Knowles, RV Pappu, D Milovanovic
(2024)
(doi: 10.1101/2024.08.03.606464)
Small Molecule RNA Degraders
J Bonet-Aleta, T Maehara, BA Craig, GJL Bernardes
Angew Chem Int Ed Engl
(2024)
63
(doi: 10.1002/anie.202412925)
Serine phosphorylation mimics of Aβ form distinct, non-cross-seeding fibril morphs
K Sanagavarapu, G Meisl, V Lattanzi, K Bernfur, B Frohm, U Olsson, TPJ Knowles, A Malmendal, S Linse
Chem Sci
(2024)
15
(doi: 10.1039/d3sc06343g)
Biomolecular Condensates are Characterized by Interphase Electric Potentials.
AE Posey, A Bremer, NA Erkamp, A Pant, TPJ Knowles, Y Dai, T Mittag, RV Pappu
J Am Chem Soc
(2024)
146
(doi: 10.1021/jacs.4c08946)
244 (PB232): Pharmacologic inhibition of YTHDC1 biomolecular condensates as a novel approach to targeting L-MYC driven small cell lung cancer
R Centore, M Charles, M Arora, Y Chen, M Watson, C Kelley, M Czekalska, M Rebmann, M Ghandi, J Cattin, N Bharatham, P Radhakrishnan, A Howarth, W Arter, S Qamar, K Saar, A Seeber, M Kulander, T Knowles, S Arora
European Journal of Cancer
(2024)
211
(doi: 10.1016/j.ejca.2024.114762)
Aggregation of the amyloid-β peptide (Aβ40) within condensates generated through liquid-liquid phase separation
OM Morris, Z Toprakcioglu, A Röntgen, M Cali, TPJ Knowles, M Vendruscolo
Scientific Reports
(2024)
14
(doi: 10.1038/s41598-024-72265-7)
A rapid in vivo pipeline to identify small molecule inhibitors of amyloid aggregation.
M Kamal, J Knox, RI Horne, OS Tiwari, AR Burns, D Han, D Levy, D Laor Bar-Yosef, E Gazit, M Vendruscolo, PJ Roy
Nature communications
(2024)
15
(doi: 10.1038/s41467-024-52480-6)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
(2024)
(doi: 10.1101/2024.09.23.614536)
Designed endocytosis-inducing proteins degrade targets and amplify signals.
B Huang, M Abedi, G Ahn, B Coventry, I Sappington, C Tang, R Wang, T Schlichthaerle, JZ Zhang, Y Wang, I Goreshnik, CW Chiu, A Chazin-Gray, S Chan, S Gerben, A Murray, S Wang, J O'Neill, L Yi, R Yeh, A Misquith, A Wolf, LM Tomasovic, DI Piraner, MJ Duran Gonzalez, NR Bennett, P Venkatesh, M Ahlrichs, C Dobbins, W Yang, X Wang, DD Sahtoe, D Vafeados, R Mout, S Shivaei, L Cao, L Carter, L Stewart, JB Spangler, KT Roybal, PJ Greisen, X Li, GJL Bernardes, CR Bertozzi, D Baker
Nature
(2024)
638
(doi: 10.1038/s41586-024-07948-2)
Mechanical Profiling of Biopolymer Condensates through Acoustic Trapping.
K Nakajima, T Sneideris, LL Good, NA Erkamp, H Ogi, TPJ Knowles
(2024)
(doi: 10.1101/2024.09.16.613217)
Single-molecule digital sizing of proteins in solution.
G Krainer, RPB Jacquat, MM Schneider, TJ Welsh, J Fan, QAE Peter, EA Andrzejewska, G Šneiderienė, MA Czekalska, H Ausserwoeger, L Chai, WE Arter, KL Saar, TW Herling, TM Franzmann, V Kosmoliaptsis, S Alberti, FU Hartl, SF Lee, TPJ Knowles
Nature communications
(2024)
15
(doi: 10.1038/s41467-024-50825-9)
A human neuronal model of sporadic Alzheimer’s disease induced by FBXO2 downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairment
AG Díaz, A Possenti, GA Urrutia, Y Bian, S Kedia, D Boeken, CM Lim, D Licastro, B Mannini, D Klenerman, M Vendruscolo
(2024)
(doi: 10.1101/2024.09.01.610673)
TNF⍺-driven Aβ aggregation, synaptic dysfunction and hypermetabolism in human iPSC-derived cortical neurons
AG Díaz, E Belli, B Mannini, GA Urrutia, M Vendruscolo
(2024)
(doi: 10.1101/2024.08.30.610594)
Unraveling the Structure and Dynamics of Ac-PHF6-NH2 Tau Segment Oligomers.
I Stroganova, Z Toprakcioglu, H Willenberg, TPJ Knowles, AM Rijs
ACS Chem Neurosci
(2024)
15
(doi: 10.1021/acschemneuro.4c00404)
Surface effects on functional amyloid formation.
AJ Dear, G Meisl, CG Taylor, UC Palmiero, SN Stubbe, Q Liu, P Arosio, S Linse, TPJ Knowles, M Andreasen
Nanoscale
(2024)
16
(doi: 10.1039/d4nr01496k)
Proximity-driven site-specific cyclization of phage-displayed peptides
L Brown, AV Vidal, AL Dias, T Rodrigues, A Sigurdardottir, T Journeaux, S O'Brien, TV Murray, P Ravn, M Papworth, GJL Bernardes
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-51610-4)
Formation of Nano brillar Self-Healing Hydrogels using Antimicrobial Peptides
EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
ACS Applied Materials & Interfaces
(2024)
16
(doi: 10.1021/acsami.4c11542)
Yusuf Hamied Department of Chemistry
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