Centre for Misfolding Diseases

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  • Currently displaying 181 - 200 of 2486 publications
Author(s)
Publication title
Journal Name
Publication year
Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups
BH Gless, E Jones, C Labão‐Almeida, C Tang, N Gottscheber, R Couto, GJL Bernardes
Angewandte Chemie
(2025)
137
(doi: 10.1002/ange.202502268)
Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups.
BH Gless, E Jones, C Labão-Almeida, C Tang, N Gottscheber, R Couto, GJL Bernardes
Angewandte Chemie (International ed. in English)
(2025)
64
(doi: 10.1002/anie.202502268)
Bifunctional Phagocytic Synapse Enhancers for Cancer Immunotherapy
V Sabatino, S Fleisch, C Tang, FM Müller, C Labão-Almeida, WT Khaw, S Hogan, DR Hicks, M Fontes, AR Coelho, W Yang, I Sarkar, D Shome, AV Vidal, M Cabeza-Cabrerizo, T Rohm, RM Reijmers, D Kaymak, F Gerster, D Baker, R Fior, G Hutter, GJL Bernardes
(2025)
(doi: 10.1101/2025.03.13.642658)
Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay
A Santambrogio, RI Horne, MA Metrick, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
(2025)
(doi: 10.1101/2025.03.09.642189)
Ganglioside Lipids Inhibit the Aggregation of the Alzheimer's Amyloid-β Peptide
Z Toprakcioglu, AK Jayaram, TPJ Knowles
RSC Chem Biol
(2025)
6
(doi: 10.1039/d4cb00189c)
The SpyBLI cell-free pipeline for the rapid quantification of binding kinetics from crude samples
O Predeina, M Atkinson, O Wissett, M Ali, C Visentin, S Ricagno, AH Keeble, MR Howarth, P Sormanni
(2025)
(doi: 10.1101/2025.03.06.641810)
Detection of protein oligomers with nanopores 
RI Horne, SE Sandler, M Vendruscolo, UF Keyser
Nature Reviews Chemistry
(2025)
9
(doi: 10.1038/s41570-025-00694-7)
PLUMED Tutorials: A collaborative, community-driven learning ecosystem.
GA Tribello, M Bonomi, G Bussi, C Camilloni, BI Armstrong, A Arsiccio, S Aureli, F Ballabio, M Bernetti, L Bonati, SGH Brookes, ZF Brotzakis, R Capelli, M Ceriotti, K-T Chan, P Cossio, S Dasetty, D Donadio, B Ensing, AL Ferguson, G Fraux, JD Gale, FL Gervasio, T Giorgino, NSM Herringer, GM Hocky, SE Hoff, M Invernizzi, O Languin-Cattoën, V Leone, V Limongelli, O Lopez-Acevedo, F Marinelli, P Febrer Martinez, M Masetti, S Mehdi, A Michaelides, MH Murtada, M Parrinello, PM Piaggi, A Pietropaolo, F Pietrucci, S Pipolo, C Pritchard, P Raiteri, S Raniolo, D Rapetti, V Rizzi, J Rydzewski, M Salvalaglio, C Schran, A Seal, A Shayesteh Zadeh, TFD Silva, V Spiwok, G Stirnemann, D Sucerquia, P Tiwary, O Valsson, M Vendruscolo, GA Voth, AD White, J Wu
J Chem Phys
(2025)
162
(doi: 10.1063/5.0251501)
Design of Protein Sequences with Precisely Tuned Kinetic Properties
ZF Brotzakis, M Vendruscolo, G Skretas
(2025)
(doi: 10.1101/2025.02.13.638027)
AlphaFold prediction of structural ensembles of disordered proteins.
ZF Brotzakis, S Zhang, MH Murtada, M Vendruscolo
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-56572-9)
Investigating a-synuclein liquid condensates transition to an irreversible aggregated state
IA Edu, A Levin, T Sneideris, CM Fischer, TPJ Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, T Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Quantifying temperature-induced changes in protein interactions and phase behavior using high-throughput droplet microfluidics
CM Fischer, H Ausserwoger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwoger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
BIOPHYSICAL JOURNAL
(2025)
124
BPS2025-SpringSaLaDpy: Python-based analysis and visualization of molecular clusters in 3D
HL Perone, A Chattaraj, ML Blinov, S Cai, H Ausserwoeger, G Meisl, T Sneideris, L Chai, W Arter, TP Knowles, Y Hamied
BIOPHYSICAL JOURNAL
(2025)
124
Investigating the role of sequence patterning in the mixing of polymer dense phases
LL Good, TP Knowles, RB Best
BIOPHYSICAL JOURNAL
(2025)
124
Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwoger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
BIOPHYSICAL JOURNAL
(2025)
123
Digital seed amplification quantifies the increase in seeding-competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Digital seed amplification quantifies the increase in seeding- competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Synapsin Condensation is Governed by Sequence-Encoded Molecular Grammars
C Hoffmann, KM Ruff, IA Edu, MK Shinn, JV Tromm, MR King, A Pant, H Ausserwöger, JR Morgan, TPJ Knowles, RV Pappu, D Milovanovic
Journal of Molecular Biology
(2025)
437
(doi: 10.1016/j.jmb.2025.168987)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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enquiries@ch.cam.ac.uk
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