Centre for Misfolding Diseases

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  • Currently displaying 41 - 60 of 2521 publications
Author(s)
Publication title
Journal Name
Publication year
The role of N-terminal acetylation on biomolecular condensation.
C G Oliveira, MTS Silva, E Kava, T Agarwal, G Cereghetti, E F Vicente, TPJ Knowles, AJ Costa-Filho, LFS Mendes
Communications Chemistry
(2026)
9
(doi: 10.1038/s42004-026-01975-y)
Spatially patterned, spectral single-molecule microscopy
JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, Y Zhang, AM Santos, SJ Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, SF Lee
(2026)
(doi: 10.64898/2026.04.08.715690)
Microglia as transcriptional pacemakers of neuronal aging heterogeneity across individuals
CM Lim, M Vendruscolo
(2026)
(doi: 10.64898/2026.04.05.716624)
Rapid elongation drives the exceptionally fast aggregation of the most common localized human amyloid medin
V Roy Chowdhury, RI Horne, MP Cali, Z Toprakcioglu, S Linse, M Vendruscolo
Commun Chem
(2026)
9
(doi: 10.1038/s42004-026-01950-7)
Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates
L-T Deck, SN Pacheco, H Ausserwöger, D Frenkel, NA Erkamp, TPJ Knowles
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
(2026)
13
(doi: 10.1002/advs.202522585)
Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2
A Ramon, N Frassetto, H Zhao, X Xu, M Greenig, S Onuoha, P Sormanni
Mabs
(2026)
18
(doi: 10.1080/19420862.2026.2646361)
Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles
MK Karabova, A Del Ser-Badia, A Hedegaard, SJ Washer, Z Baykam, DP O'Brien, I Vendrell, SS Hester, R Fischer, E Johnson, CE Melia, TRS Matthews-Palmer, R Matadeen, A Santambrogio, MA Metrick, M Vendruscolo, S Keeling, KAX Cheam, WA McEwan, KS Kosik, TA Day, WS James, SA Cowley
Alzheimer S and Dementia
(2026)
22
(doi: 10.1002/alz.71337)
Discovery of first-in-class YTHDC1 small molecule inhibitors for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, MJ Rawling, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, A Howarth, S Qamar, L Andraghetti, A Seeber, MG Kharas, S Cohen, M Kulander, T Knowles, S Arora
Cancer Research
(2026)
86
(doi: 10.1158/1538-7445.am2026-7101)
NPM1 Undergoes Salt-Dependent Reentrant Phase Separation Driven by IDR Conformational Plasticity and Electrostatic Crosstalk
Y Zhen, Y Tan, Y Tang, T Sneideris, H Ausserwöger, J Wen, TPJ Knowles, S Perrett, G Wei, S Wu
Small (Weinheim an der Bergstrasse, Germany)
(2026)
22
(doi: 10.1002/smll.202514678)
Reversible peptide self-assembly enables sustained drug delivery with tuneable pharmacokinetics
TW Herling, J Wei, S Genapathy, C Rivera, M Persson, P Gennemark, D Workman, D Lundberg, E Bernard, H Bolt, MY Arteta, S Will, A Bak, D Hornigold, TPJ Knowles, ALG dos Santos
(2026)
(doi: 10.64898/2026.03.25.714189)
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers
H Yuan, Z Yang, C Yuan, S Shankar, A Levin, T Lv, Z Wang, W Sun, J Sitton, P-A Cazade, Y Dan, Y Tang, L Adler-Abramovich, Y Cao, S Rencus-Lazar, D Thompson, D Kurouski, TPJ Knowles, LJW Shimon, G Wei, B Xue, R Yang, E Gazit
Nature Communications
(2026)
17
(doi: 10.1038/s41467-026-71043-5)
Systems-level organization of extracellular proteostasis
CM Gomes, M Vendruscolo
Science (New York, N.Y.)
(2026)
391
(doi: 10.1126/science.aed3712)
Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis
H Kiely-Collins, C Tang, MC Marques, L Butron, A Lamberti, N Bossons, F Offensperger, V Brennsteiner, B Sousa, L Carvalho, A Ferrer-Montiel, F Corzana, GE Winter, A Fernandez-Carvajal, GJL Bernardes
ACS Chemical Biology
(2026)
21
(doi: 10.1021/acschembio.5c00935)
Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner.
M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede
Proceedings of the National Academy of Sciences of the United States of America
(2026)
123
(doi: 10.1073/pnas.2532775123)
OmniBind: Proteome-Wide Promiscuity Predictions for Early-Stage Drug Screening
J Hanke, SP Ojeda, RW Cheong, LM Glasstetter, E Baker, H Lam, M Brezinova, A Louet, S Zhang, M Vendruscolo
(2026)
(doi: 10.64898/2026.03.17.712433)
The α-synuclein proteostasis network and its translational applications in Parkinson's disease
CM Lim, M Vendruscolo
Proc Natl Acad Sci U S A
(2026)
123
(doi: 10.1073/pnas.2513317123)
Engineering armoured in vivo CAR T cells through targeted delivery and transient mRNA gating
K Hu, S Srivastava, B Ma, Y Yang, H Wang, M Mangolini, J Hayre, E Souster, R Karattil, A Ramon, M Greenig, P Sormanni, S Cordoba, S Onuoha
(2026)
(doi: 10.64898/2026.03.10.710759)
Reversibility and β-sheet formation are decoupled in tau condensate ageing
CM Fischer, IA Edu, T Šneideris, I Baronaite, Z Toprakcioglu, L-T Deck, D Qian, R Scrutton, L Dreyer, J Wen, DE Otzen, S Wu, S Perrett, TPJ Knowles
Proceedings of the National Academy of Sciences
(2026)
123
(doi: 10.1073/pnas.2522993123)
FuzDrop: sequence-based prediction of the propensity of proteins for liquid-liquid phase separation and aggregation.
M Vendruscolo, M Fuxreiter
Nat Protoc
(2026)
21
(doi: 10.1038/s41596-025-01267-0)
Toward a unified framework for determining conformational ensembles of disordered proteins.
H Ghafouri, P Kadeřávek, AM Melo, MC Aspromonte, P Bernadó, J Cortés, Z Dosztányi, G Erdős, M Feig, G Janson, K Lindorff-Larsen, FAA Mulder, P Nagy, R Pestell, D Piovesan, M Schiavina, B Schuler, N Sibille, G Tesei, P Tompa, M Vendruscolo, J Vondrasek, W Vranken, L Zidek, SCE Tosatto, AM Monzon
Nature methods
(2026)
23
(doi: 10.1038/s41592-026-03003-2)
Yusuf Hamied Department of Chemistry
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