Centre for Misfolding Diseases

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  • Currently displaying 41 - 60 of 2472 publications
Author(s)
Publication title
Journal Name
Publication year
BPS2026 – Cell-penetrating peptide-conjugated bovine serum albumin nanoparticles for efficient mRNA and siRNA loading and delivery
D Tu, T Sneideris, Y Ou, S Cai, Y Yao, H Yang, TPJ Knowles
Biophysical Journal
(2026)
125
(doi: 10.1016/j.bpj.2025.11.2147)
BPS2026 – Liquid-liquid phase separation modulates protein pathological aggregation
Y Shen, TP Knowles, DA Weitz, D Vigolo, T Li, D Ilhamsyah
Biophysical Journal
(2026)
125
(doi: 10.1016/j.bpj.2025.11.1782)
BPS2026 – Proteoglycan mimic-based microgel as 3D bioink for constructing high cell-laden scaffolds
S Xu, Y Chen, Y Li, R Zhan, Y Ou, D Tu, TPJ Knowles
Biophysical Journal
(2026)
125
(doi: 10.1016/j.bpj.2025.11.1028)
BPS2026 – Mechanistic insights into the liquid-liquid phase separation of Boc-protected amino acids from simulation and experiment
LL Good, SK Yorke, A Levin, Y Yao, RB Best, TP Knowles
Biophysical Journal
(2026)
125
(doi: 10.1016/j.bpj.2025.11.1166)
BPS2026 – Single-molecule microfluidic diffusional sizing
JJ Fan, R Jacquat, G Krainer, TPJ Knowles, SF Lee
Biophysical Journal
(2026)
125
(doi: 10.1016/j.bpj.2025.11.1026)
Molecularly specific solubilization of therapeutic antibodies
Z Han, NA Erkamp, R Scrutton, G Licari, O Predeina, A Evers, P Sormanni, TPJ Knowles
(2026)
(doi: 10.64898/2026.01.29.702671)
Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization
H Ausserwöger, R Scrutton, CM Fischer, T Sneideris, D Qian, E de Csilléry, I Baronaite, KL Saar, AZ Białek, M Oeller, G Krainer, TM Franzmann, S Wittmann, JM Iglesias-Artola, G Invernizzi, AA Hyman, S Alberti, N Lorenzen, TPJ Knowles
Nat Chem
(2026)
18
(doi: 10.1038/s41557-025-02039-9)
Microglial Activation and Alpha-Synuclein Oligomers Drive the Early Inflammatory Phase of Parkinson's Disease
C Toomey, J Evans, M Grant-Peters, J Beckwith, R Popovic, J Breiter, J Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, E Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, R Saleeb, H Lucas-Clarke, A Penverne, K D'sa, CW Pang, M Horrocks, M Vendruscolo, N Wood, S Lee, M Ryten, S Gandhi
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2026)
52
Flow behavior of a droplet in viscous fluids through asymmetric bifurcating microchannels
H Yang, TPJ Knowles
Physics of Fluids
(2026)
38
(doi: 10.1063/5.0309289)
Patch deconvolution for Fourier light-field microscopy.
B Fu, CL Jones, D Heraghty, S Yang, C O'Brien-Ball, V Junghans, H Yang, D Klenerman, TPJ Knowles, LE Weiss, RA Fernandes, SF Lee
Biophysical journal
(2026)
125
(doi: 10.1016/j.bpj.2026.01.034)
Oligomers mediate the spatial transmission of Aβ peptide aggregation
Q Peter, C Taylor, U Lapinska, J Wei, TCT Michaels, P Arosio, S Linse, TPJ Knowles
Communications Chemistry
(2026)
9
(doi: 10.1038/s42004-025-01837-z)
Abstract PR004: Targeting aberrant condensate formation in fusion-positive cancers with an integrated discovery platform
A Seeber, WE Arter, S Qamar, C Sgambato, A Alex, K Saar, J Doh, M Kulander, T Knowles, S Arora
Cancer Research
(2026)
86
(doi: 10.1158/1538-7445.fusionpositive26-pr004)
Biomaterials with droplet microfluidics
Y Ou, Z Han, S Cai, JR Heck, Z Toprakcioglu, Z Yu, DA Weitz, TPJ Knowles
Nature Reviews Bioengineering
(2026)
4
(doi: 10.1038/s44222-025-00389-0)
The NewroBus platform: engineered humanized anti-TfR1 nanobodies for efficient brain delivery.
T Yin, M Yesiltepe, S Metkar, A Ramon, M Greenig, P Sormanni, L D'Adamio
Cell Communication and Signaling Ccs
(2025)
24
(doi: 10.1186/s12964-025-02605-1)
SurfDiff: protein surface profiling for selective or broadly reactive epitope prioritisation in binder and immunogen design.
B Jedlitzke, O Wissett, TH Nguyen, E Ghedin, P Sormanni
bioRxiv
(2025)
(doi: 10.64898/2025.12.23.696170)
Deep Cervical Lymphatic-Venous Anastomosis in Dementia: A Prospective Clinical Study and Mechanistic Evaluation
C Tang, X Zheng, H Li, B Wang, Y Zheng, W Song, A Wu, L Xin, D Zhang, R Yang, S Du, P He, Y Li, L Wu, X Wang, Q Shi, GJL Bernardes
International journal of surgery (London, England)
(2025)
112
(doi: 10.1097/JS9.0000000000004561)
Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core
H Nadwa, ZF Brotzakis, A Santucci, D Braconi, M Vendruscolo
J Phys Chem Lett
(2025)
16
(doi: 10.1021/acs.jpclett.5c03467)
Controlled Self-Immolative Release of β-Lapachone via an Opti- mized para-Hydroxybenzyl Linker for Targeted Pancreatic Cancer Therapy
JB Becher, N Dutta, CD Navo, L Dunsmore, R Misteli, E Gil de Montes, GG Simpson, CC Alewine, G Jiménez-Osés, GJL Bernardes
J Am Chem Soc
(2025)
147
(doi: 10.1021/jacs.5c17598)
Single-molecule imaging of small aggregates of IAPP in type 2 diabetes serum with rationally-designed antibody-like scaffolds.
J Lin, YP Zhang, S Chia, D Klenerman, P Sormanni, M Vendruscolo
Chemical science
(2025)
17
(doi: 10.1039/d5sc01427a)
In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA
V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux
(2025)
(doi: 10.1101/2025.11.25.690368)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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