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Centre for Misfolding Diseases

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  • Currently displaying 41 - 60 of 3295 publications
Hierarchical Protofilament Intertwining Rules the Formation of Mixed-Curvature Amyloid Polymorphs
J Zhou, S Assenza, M Tatli, J Tian, IM Ilie, EL Starostin, A Caflisch, TPJ Knowles, G Dietler, FS Ruggeri, H Stahlberg, SK Sekatskii, R Mezzenga
– Adv Sci (Weinh)
(2024)
11,
2402740
A Fragment‐Based Competitive 19F LB‐NMR Platform For Hotspot‐Directed Ligand Profiling
W McCarthy, S Thomas, T Olaleye, J Boland, RA Floto, G Williams, T Blundell, A Coyne, C Abell
– Angewandte Chemie (International ed. in English)
(2024)
63,
e202406846
The Cystic Fibrosis Transmembrane Regulator Controls Tolerogenic Responses to Food Allergens in Mice and Humans
M Emmenegger, C Zografou, Y Dai, LR Hoyt, R Gudneppanavar, A Chincisan, H Rehrauer, FJ Noé, N Zajac, G Meisl, MM Schneider, H Nguyen, K Höpker, TPJ Knowles, M Sospedra, R Martin, AM Ring, S Leeds, SC Eisenbarth, ME Egan, EM Bruscia, A Aguzzi
(2024)
The role of shear forces in primary and secondary nucleation of amyloid fibrils
E Axell, J Hu, M Lindberg, AJ Dear, L Ortigosa-Pascual, EA Andrzejewska, G Šneiderienė, D Thacker, TPJ Knowles, E Sparr, S Linse
– Proceedings of the National Academy of Sciences
(2024)
121,
e2322572121
Electrolyte‐gated organic field‐effect transistors with high operational stability and lifetime in practical electrolytes
D Simatos, M Nikolka, J Charmet, LJ Spalek, Z Toprakcioglu, IE Jacobs, IB Dimov, G Schweicher, MJ Lee, CM Fernández-Posada, DJ Howe, TA Hakala, LWY Roode, V Pecunia, TP Sharp, W Zhang, M Alsufyani, I McCulloch, TPJ Knowles, H Sirringhaus
– SmartMat
(2024)
Electrolyte‐gated organic field‐effect transistors with high operational stability and lifetime in practical electrolytes
D Simatos, M Nikolka, J Charmet, LJ Spalek, Z Toprakcioglu, IE Jacobs, IB Dimov, G Schweicher, MJ Lee, CM Fernández‐Posada, DJ Howe, TA Hakala, LWY Roode, V Pecunia, TP Sharp, W Zhang, M Alsufyani, I McCulloch, TPJ Knowles, H Sirringhaus
– SmartMat
(2024)
e1291
Biomolecular condensates with complex architectures via controlled nucleation
NA Erkamp, MAM Verwiel, D Qian, T Sneideris, FA Spaepen, DA Weitz, JCM van Hest, TPJ Knowles
– Nature Chemical Engineering
(2024)
1,
430
Identification of high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using Deep Docking
M Vendruscolo, M Brezinova, F Brotzakis, R Horne, VR Chowdhury, R Gregory, F Gentile
(2024)
Stimulating Creativity Through Cognitive Symmetry Breaking: Tagorean Theory of Sustainable Human Development
S Ghosh
(2024)
Nanomedicine Targeting Cuproplasia in Cancer: Labile Copper Sequestration Using Polydopamine Particles Blocks Tumor Growth In Vivo through Altering Metabolism and Redox Homeostasis
J Bonet-Aleta, M Encinas-Gimenez, M Oi, AT Pezacki, V Sebastian, A de Martino, A Martín-Pardillos, P Martin-Duque, JL Hueso, CJ Chang, J Santamaria
– ACS Applied Materials & Interfaces
(2024)
16,
29844
The diversity of SNCA transcripts in neurons, and its impact on antisense oligonucleotide therapeutics
JR Evans, EK Gustavsson, I Doykov, D Murphy, GS Virdi, J Lachica, A Röntgen, MH Murtada, CW Pang, H Macpherson, AI Wernick, CE Toomey, D Athauda, ML Choi, J Hardy, NW Wood, M Vendruscolo, K Mills, W Heywood, M Ryten, S Gandhi
(2024)
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces.
A Dear, D Thacker, S Wennmalm, L Ortigosa-Pascual, EA Andrzejewska, G Meisl, S Linse, T Knowles
– ACS Chem Neurosci
(2024)
15,
2296
Solutes unmask differences in clustering versus phase separation of FET proteins
M Kar, LT Vogel, G Chauhan, S Felekyan, H Ausserwöger, TJ Welsh, F Dar, AR Kamath, TPJ Knowles, AA Hyman, CAM Seidel, RV Pappu
– Nature communications
(2024)
15,
4408
An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions
G Cereghetti, VM Kissling, LM Koch, A Arm, CC Schmidt, Y Thüringer, N Zamboni, P Afanasyev, M Linsenmeier, C Eichmann, S Kroschwald, J Zhou, Y Cao, DM Pfizenmaier, T Wiegand, R Cadalbert, G Gupta, D Boehringer, TPJ Knowles, R Mezzenga, P Arosio, R Riek, M Peter
– Developmental Cell
(2024)
59,
1876
Biomolecular condensates sustain pH gradients at equilibrium driven by charge neutralisation
H Ausserwöger, R Scrutton, T Sneideris, C Fischer, D Qian, E de Csilléry, K Saar, A Białek, M Oeller, G Krainer, T Franzmann, S Wittmann, J Iglesias-Artola, G Invernizzi, A Hyman, S Alberti, N Lorenzen, T Knowles
(2024)
Polysaccharide functionalization reduces lipid vesicle stiffness
K Jahnke, M Pavlovic, W Xu, A Chen, TPJ Knowles, LR Arriaga, DA Weitz
– Proceedings of the National Academy of Sciences
(2024)
121,
e2317227121
Homogeneous multi-payload antibody–drug conjugates
T Journeaux, GJL Bernardes
– Nature chemistry
(2024)
16,
854
Automated optimization of the solubility of a hyper-stable α-amylase
M Ali, M Greenig, M Oeller, M Atkinson, X Xu, P Sormanni
– Open Biology
(2024)
14,
240014
Automated optimisation of the solubility of a hyper-stable α-amylase
M Ali, M Greenig, M Oeller, M Atkinson, X Xu, P Sormanni
– Open Biol
(2024)
14,
240014
Quantum Control of Nonlinear Dynamics in Confined Fluids
V Johny, S Contera, S Ghosh
(2024)