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Centre for Misfolding Diseases

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  • Currently displaying 41 - 60 of 3040 publications
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins.
G Agam, C Gebhardt, M Popara, R Mächtel, J Folz, B Ambrose, N Chamachi, SY Chung, TD Craggs, M de Boer, D Grohmann, T Ha, A Hartmann, J Hendrix, V Hirschfeld, CG Hübner, T Hugel, D Kammerer, H-S Kang, AN Kapanidis, G Krainer, K Kramm, EA Lemke, E Lerner, E Margeat, K Martens, J Michaelis, J Mitra, GG Moya Muñoz, RB Quast, NC Robb, M Sattler, M Schlierf, J Schneider, T Schröder, A Sefer, PS Tan, J Thurn, P Tinnefeld, J van Noort, S Weiss, N Wendler, N Zijlstra, A Barth, CAM Seidel, DC Lamb, T Cordes
– Nature methods
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
– bioRxiv
Sequence-based prediction of the solubility of peptides containing non-natural amino acids
M Oeller, R Kang, H Bolt, AGD Santos, A Weinmann, A Nikitidis, P Zlatoidsky, W Su, W Czechtizky, L De Maria, P Sormanni, M Vendruscolo
α-synuclein oligomers displace monomeric α-synuclein from lipid membranes
G Šneiderienė, M Czekalska, C Xu, A Jayaram, G Krainer, W Arter, Q Peter, M Castellana-Cruz, K Saar, A Levin, T Mueller, S Fiedler, S Devenish, H Fiegler, J Kumita, T Knowles
Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α‑Synuclein Secondary Nucleation
RI Horne, MH Murtada, D Huo, ZF Brotzakis, RC Gregory, A Possenti, S Chia, M Vendruscolo
– Journal of chemical theory and computation
AlphaFold Prediction of Structural Ensembles of Disordered Proteins
F Brotzakis, S Zhang, M Vendruscolo
Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform
NA Erkamp, M Oeller, T Sneideris, H Ausserwoger, A Levin, TJ Welsh, R Qi, D Qian, N Lorenzen, H Zhu, P Sormanni, M Vendruscolo, TPJ Knowles
– Analytical Chemistry
Kinetic Analysis Reveals the Role of Secondary Nucleation in Regenerated Silk Fibroin Self-Assembly
A Kamada, Z Toprakcioglu, TPJ Knowles
– Biomacromolecules
Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target
VM Howieson, J Zeng, J Kloehn, C Spry, C Marchetti, M Lunghi, E Varesio, A Soper, AG Coyne, C Abell, GG van Dooren, KJ Saliba
– Int J Parasitol Drugs Drug Resist
Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference.
J El Bakali, M Blaszczyk, JC Evans, JA Boland, WJ McCarthy, I Fathoni, MVB Dias, EO Johnson, AG Coyne, V Mizrahi, TL Blundell, C Abell, C Spry
– Angewandte Chemie - International Edition
Modulating Nucleic Acid Phase Transitions as a Mechanism of Action for Cell-Penetrating Antimicrobial Peptides
T Sneideris, N Erkamp, H Ausserwöger, K Saar, T Welsh, D Qian, M Johncock, G Krainer, A Borodavka, T Knowles
Nanopore Detection Using Supercharged Polypeptide Molecular Carriers.
X Wang, T-M Thomas, R Ren, Y Zhou, P Zhang, J Li, S Cai, K Liu, AP Ivanov, A Herrmann, JB Edel
– Journal of the American Chemical Society
Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum
MM Schneider, T Scheidt, AJ Priddey, CK Xu, M Hu, G Meisl, SRA Devenish, CM Dobson, V Kosmoliaptsis, TPJ Knowles
– Biosensors & bioelectronics
Sequence-based prediction of the solubility of peptides containing non-natural amino acids
M Oeller, R Kang, H Bolt, A Gomes dos Santos, A Langborg Weinmann, A Nikitidis, P Zlatoidsky, W Su, W Czechtizky, L De Maria, P Sormanni, M Vendruscolo
Farewell to single-well: An automated single-molecule FRET platform for high-content, multiwell plate screening of biomolecular conformations and dynamics
A Hartmann, K Sreenivasa, M Schenkel, N Chamachi, P Schake, G Krainer, M Schlierf
Single-Molecule Sizing through Nanocavity Confinement
RPB Jacquat, G Krainer, QAE Peter, AN Babar, O Vanderpoorten, CK Xu, TJ Welsh, CF Kaminski, UF Keyser, JJ Baumberg, TPJ Knowles
– Nano Lett
Extracellular protein homeostasis in neurodegenerative diseases
MR Wilson, S Satapathy, M Vendruscolo
– Nature reviews. Neurology
Spontaneous nucleation and fast aggregate-dependent proliferation of & alpha;-synuclein aggregates within liquid condensates at neutral pH
ST Dada, MC Hardenberg, Z Toprakcioglu, LK Mrugalla, MP Cali, MO McKeon, E Klimont, TCT Michaels, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of USA
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes.
T Bhardwaj, K Gadhave, SK Kapuganti, P Kumar, ZF Brotzakis, KU Saumya, N Nayak, A Kumar, R Joshi, B Mukherjee, A Bhardwaj, KG Thakur, N Garg, M Vendruscolo, R Giri
– Nat Commun
Selenium Silk Nanostructured Films with Antifungal and Antibacterial Activity.
Z Toprakcioglu, EG Wiita, AK Jayaram, RC Gregory, TPJ Knowles
– ACS Appl Mater Interfaces