Centre for Misfolding Diseases

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  • Currently displaying 41 - 60 of 2462 publications
Author(s)
Publication title
Journal Name
Publication year
Proteoglycan mimic-based microgel as 3D bioink for constructing high cell-laden scaffolds
S Xu, Y Chen, Y Li, R Zhan, Y Ou, D Tu, TPJ Knowles
BIOPHYSICAL JOURNAL
(2026)
125
The NewroBus platform: engineered humanized anti-TfR1 nanobodies for efficient brain delivery.
T Yin, M Yesiltepe, S Metkar, A Ramon, M Greenig, P Sormanni, L D'Adamio
Cell communication and signaling : CCS
(2025)
24
(doi: 10.1186/s12964-025-02605-1)
SurfDiff: protein surface profiling for selective or broadly reactive epitope prioritisation in binder and immunogen design
B Jedlitzke, O Wissett, TH Nguyen, E Ghedin, P Sormanni
bioRxiv
(2025)
(doi: 10.64898/2025.12.23.696170)
Deep Cervical Lymphatic-Venous Anastomosis in Dementia: A Prospective Clinical Study and Mechanistic Evaluation
C Tang, X Zheng, H Li, B Wang, Y Zheng, W Song, A Wu, L Xin, D Zhang, R Yang, S Du, P He, Y Li, L Wu, X Wang, Q Shi, GJL Bernardes
International journal of surgery (London, England)
(2025)
(doi: 10.1097/js9.0000000000004561)
Controlled Self-Immolative Release of β-Lapachone via an Optimized para-Hydroxybenzyl Linker for Targeted Pancreatic Cancer Therapy
JB Becher, N Dutta, CD Navo, L Dunsmore, R Misteli, E Gil de Montes, GG Simpson, CC Alewine, G Jiménez-Osés, GJL Bernardes
Journal of the American Chemical Society
(2025)
147
(doi: 10.1021/jacs.5c17598)
Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core
H Nadwa, ZF Brotzakis, A Santucci, D Braconi, M Vendruscolo
The journal of physical chemistry letters
(2025)
16
(doi: 10.1021/acs.jpclett.5c03467)
Single-molecule imaging of small aggregates of IAPP in type 2 diabetes serum with rationally-designed antibody-like scaffolds
J Lin, YP Zhang, S Chia, D Klenerman, P Sormanni, M Vendruscolo
Chemical Science
(2025)
17
(doi: 10.1039/d5sc01427a)
Mapping high resolution, multidimensional phase diagrams of physiological protein condensates
T Agarwal, T Sneideris, F Svara, K Jermakovs, H Coyle, S Qamar, E Kava, R Scrutton, N Pleschka, P Peres, G Cereghetti, E Andrzejewska, A Diaz-Barreiro, G Palmer, AJ Costa-Filho, G Krainer, TP Knowles, J Nixon-Abell
(2025)
(doi: 10.1101/2025.11.24.690258)
In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA
V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux
(2025)
(doi: 10.1101/2025.11.25.690368)
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.
SJ Resnick, S Qamar, P Krishna, V Korobeynikov, H Ausserwoger, A Miller, P Esposito, JA Varela, J Sheng, LH Huang, J Nixon-Abell, S Melore, CW Chung, NF Läubli, S Kapsiani, X Li, J Wang, N Zhang, MM Alam, AS Burguete, TC Swayne, Y Chen, Y-C Liao, NA Shneider, M Vendruscolo, TPJ Knowles, CF Kaminski, FS Ruggeri, GS Kaminski Schierle, P St George-Hyslop, A Chavez
Nature communications
(2025)
16
(doi: 10.1038/s41467-025-65178-0)
The Liquid State of RIM1α and RBP Condensates is Maintained by Lipids.
CM Fischer, Z Toprakcioglu, E de Csilléry, GS Kaminski Schierle, TPJ Knowles
ACS Nano
(2025)
19
(doi: 10.1021/acsnano.5c07661)
Binding Paths: Describing Small Molecule Interactions with Disordered Proteins via a Markov State Model
A Louet, G Hummer, M Vendruscolo
(2025)
(doi: 10.1101/2025.11.19.688850)
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding
Y-H Lee, T Saio, M Watabe, M Matsusaki, S Kanemura, Y Lin, T Mannen, T Kuramochi, Y Kamada, K Iuchi, M Tajiri, K Suzuki, Y Li, Y Heo, K Ishii, K Arai, K Ban, M Hashimoto, S Oshita, S Ninagawa, Y Hattori, H Kumeta, A Takeuchi, S Kajimoto, H Abe, E Mori, T Muraoka, T Nakabayashi, S Akashi, T Okiyoneda, M Vendruscolo, K Inaba, M Okumura
Nature cell biology
(2025)
27
(doi: 10.1038/s41556-025-01794-8)
A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery
I Černauskienė, E Izquierdo‐García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes
Angewandte Chemie
(2025)
138
(doi: 10.1002/ange.202513808)
A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery
I Černauskienė, E Izquierdo‐García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes
Angewandte Chemie International Edition
(2025)
65
(doi: 10.1002/anie.202513808)
Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using deep docking
M Brezinova, ZF Brotzakis, RI Horne, V Roy Chowdhury, RC Gregory, Y Bian, A González Díaz, F Gentile, M Vendruscolo
Molecular Systems Biology
(2025)
22
(doi: 10.1038/s44320-025-00159-5)
PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning
SAH Jansen, LSA Dreyer, J van Basten, Y Yao, DE Otzen, TFA de Greef, TPJ Knowles, EW Meijer, NA Erkamp
ACS Nano
(2025)
19
(doi: 10.1021/acsnano.5c07268)
Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2
A Ramon, N Frassetto, H Zhao, X Xu, M Greenig, S Onuoha, P Sormanni
(2025)
(doi: 10.1101/2025.10.31.685806)
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
(doi: 10.1101/2025.09.08.674880)
Kinetics of seeded protein aggregation: theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
(2025)
(doi: 10.48550/arxiv.2503.20941)
Yusuf Hamied Department of Chemistry
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