Centre for Misfolding Diseases

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  • Currently displaying 41 - 60 of 2517 publications
Author(s)
Publication title
Journal Name
Publication year
Rapid elongation drives the exceptionally fast aggregation of the most common localized human amyloid medin.
V Roy Chowdhury, RI Horne, MP Cali, Z Toprakcioglu, S Linse, M Vendruscolo
Communications Chemistry
(2026)
9
(doi: 10.1038/s42004-026-01950-7)
Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates.
L-T Deck, SN Pacheco, H Ausserwöger, D Frenkel, NA Erkamp, TPJ Knowles
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
(2026)
13
(doi: 10.1002/advs.202522585)
Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2
A Ramon, N Frassetto, H Zhao, X Xu, M Greenig, S Onuoha, P Sormanni
MAbs
(2026)
18
(doi: 10.1080/19420862.2026.2646361)
Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles
MK Karabova, A Del Ser-Badia, A Hedegaard, SJ Washer, Z Baykam, DP O'Brien, I Vendrell, SS Hester, R Fischer, E Johnson, CE Melia, TRS Matthews-Palmer, R Matadeen, A Santambrogio, MA Metrick, M Vendruscolo, S Keeling, KAX Cheam, WA McEwan, KS Kosik, TA Day, WS James, SA Cowley
Alzheimers Dement
(2026)
22
(doi: 10.1002/alz.71337)
Discovery of first-in-class YTHDC1 small molecule inhibitors for the treatment of MYC-driven cancers
RC Centore, M Charles, M Arora, M Rebmann, MJ Rawling, J Cattin, X Yang, E Batchelor, M Watson, N Bharatham, A Howarth, S Qamar, L Andraghetti, A Seeber, MG Kharas, S Cohen, M Kulander, T Knowles, S Arora
Cancer Research
(2026)
86
(doi: 10.1158/1538-7445.am2026-7101)
NPM1 Undergoes Salt‐Dependent Reentrant Phase Separation Driven by IDR Conformational Plasticity and Electrostatic Crosstalk
Y Zhen, Y Tan, Y Tang, T Sneideris, H Ausserwöger, J Wen, TPJ Knowles, S Perrett, G Wei, S Wu
Small (Weinheim an der Bergstrasse, Germany)
(2026)
22
(doi: 10.1002/smll.202514678)
Reversible peptide self-assembly enables sustained drug delivery with tuneable pharmacokinetics
TW Herling, J Wei, S Genapathy, C Rivera, M Persson, P Gennemark, D Workman, D Lundberg, E Bernard, H Bolt, MY Arteta, S Will, A Bak, D Hornigold, TPJ Knowles, ALG dos Santos
(2026)
(doi: 10.64898/2026.03.25.714189)
Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers.
H Yuan, Z Yang, C Yuan, S Shankar, A Levin, T Lv, Z Wang, W Sun, J Sitton, P-A Cazade, Y Dan, Y Tang, L Adler-Abramovich, Y Cao, S Rencus-Lazar, D Thompson, D Kurouski, TPJ Knowles, LJW Shimon, G Wei, B Xue, R Yang, E Gazit
Nature communications
(2026)
17
(doi: 10.1038/s41467-026-71043-5)
Systems-level organization of extracellular proteostasis
CM Gomes, M Vendruscolo
Science
(2026)
391
(doi: 10.1126/science.aed3712)
Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis
H Kiely-Collins, C Tang, MC Marques, L Butron, A Lamberti, N Bossons, F Offensperger, V Brennsteiner, B Sousa, L Carvalho, A Ferrer-Montiel, F Corzana, GE Winter, A Fernandez-Carvajal, GJL Bernardes
ACS Chemical Biology
(2026)
21
(doi: 10.1021/acschembio.5c00935)
Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner
M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede
Proc Natl Acad Sci U S A
(2026)
123
(doi: 10.1073/pnas.2532775123)
OmniBind: Proteome-Wide Promiscuity Predictions for Early-Stage Drug Screening
J Hanke, SP Ojeda, RW Cheong, LM Glasstetter, E Baker, H Lam, M Brezinova, A Louet, S Zhang, M Vendruscolo
(2026)
(doi: 10.64898/2026.03.17.712433)
The α-synuclein proteostasis network and its translational applications in Parkinson's disease
CM Lim, M Vendruscolo
Proceedings of the National Academy of Sciences
(2026)
123
(doi: 10.1073/pnas.2513317123)
Engineering armoured in vivo CAR T cells through targeted delivery and transient mRNA gating
K Hu, S Srivastava, B Ma, Y Yang, H Wang, M Mangolini, J Hayre, E Souster, R Karattil, A Ramon, M Greenig, P Sormanni, S Cordoba, S Onuoha
(2026)
(doi: 10.64898/2026.03.10.710759)
Reversibility and β-sheet formation are decoupled in tau condensate ageing
CM Fischer, IA Edu, T Šneideris, I Baronaite, Z Toprakcioglu, L-T Deck, D Qian, R Scrutton, L Dreyer, J Wen, DE Otzen, S Wu, S Perrett, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2026)
123
(doi: 10.1073/pnas.2522993123)
FuzDrop: sequence-based prediction of the propensity of proteins for liquid-liquid phase separation and aggregation.
M Vendruscolo, M Fuxreiter
Nature protocols
(2026)
21
(doi: 10.1038/s41596-025-01267-0)
Rational Design of Nanobodies Targeting LINGO‐1
A Röntgen, VR Chowdhury, A Ramon, M Greenig, X Xu, P Sormanni, M Vendruscolo
Applied Research
(2026)
5
(doi: 10.1002/appl.70071)
Correction to "Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay".
A Santambrogio, RI Horne, MA Metrick, NCT Gallagher, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
Journal of the American Chemical Society
(2026)
148
(doi: 10.1021/jacs.5c18723)
Toward a unified framework for determining conformational ensembles of disordered proteins.
H Ghafouri, P Kadeřávek, AM Melo, MC Aspromonte, P Bernadó, J Cortés, Z Dosztányi, G Erdős, M Feig, G Janson, K Lindorff-Larsen, FAA Mulder, P Nagy, R Pestell, D Piovesan, M Schiavina, B Schuler, N Sibille, G Tesei, P Tompa, M Vendruscolo, J Vondrasek, W Vranken, L Zidek, SCE Tosatto, AM Monzon
Nature Methods
(2026)
23
(doi: 10.1038/s41592-026-03003-2)
Structural Plausibility Without Binding Specificity: Limits of AI-Based Antibody-Antigen Structure Prediction Confidence Scores
E Smorodina, M Ali, KK Brumat, L Salicari, S Miklavc, A Kappassov, C Fu, P Sormanni, A de Marco, V Greiff
(2026)
(doi: 10.64898/2026.03.02.709004)
Yusuf Hamied Department of Chemistry
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