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Currently displaying 41 - 60 of 2491 publications

Toward a unified framework for determining conformational ensembles of disordered proteins

H Ghafouri, P Kadeřávek, AM Melo, MC Aspromonte, P Bernadó, J Cortés, Z Dosztányi, G Erdős, M Feig, G Janson, K Lindorff-Larsen, FAA Mulder, P Nagy, R Pestell, D Piovesan, M Schiavina, B Schuler, N Sibille, G Tesei, P Tompa, M Vendruscolo, J Vondrasek, W Vranken, L Zidek, SCE Tosatto, AM Monzon

Nat Methods

(2026)

705

(doi: 10.1038/s41592-026-03003-2)

Correction to “Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay”

A Santambrogio, RI Horne, MA Metrick, NCT Gallagher, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo

Journal of the American Chemical Society

(2026)

148

12423

(doi: 10.1021/jacs.5c18723)

Rational Design of Nanobodies Targeting LINGO-1

A Röntgen, VR Chowdhury, A Ramon, M Greenig, X Xu, P Sormanni, M Vendruscolo

Applied Research

(2026)

e70071

(doi: 10.1002/appl.70071)

Structural Plausibility Without Binding Specificity: Limits of AI-Based Antibody-Antigen Structure Prediction Confidence Scores

E Smorodina, M Ali, KK Brumat, L Salicari, S Miklavc, A Kappassov, C Fu, P Sormanni, A de Marco, V Greiff

(2026)

(doi: 10.64898/2026.03.02.709004)

Scaling Relations of Multicomponent Phase Coexistence Boundaries

D Qian, J Acker, RM Scrutton, CM Fischer, S Qamar, T Sneideris, A Borodavka, TPJ Knowles

Prx Life

(2026)

013026

(doi: 10.1103/t2v5-49k4)

Proteoglycan mimic-based microgel as 3D bioink for constructing high cell-laden scaffolds

S Xu, Y Chen, Y Li, R Zhan, Y Ou, D Tu, TPJ Knowles

BIOPHYSICAL JOURNAL

(2026)

125

Liquid-liquid phase separation modulates protein pathological aggregation

Y Shen, TP Knowles, DA Weitz, D Vigolo, T Li, D Ilhamsyah

BIOPHYSICAL JOURNAL

(2026)

125

281a

BPS2026 – Nucleation kinetics reveals a distinct biological function space of biomolecular condensates

L-T Deck, SN Pacheco, H Ausserwöger, D Frenkel, NA Erkamp, TPJ Knowles

Biophysical Journal

(2026)

125

240a

(doi: 10.1016/j.bpj.2025.11.1572)

Mechanistic insights into the liquid-liquid phase separation of Boc-protected amino acids from simulation and experiment

LL Good, SK Yorke, A Levin, Y Yao, RB Best, TP Knowles

BIOPHYSICAL JOURNAL

(2026)

125

Cell-penetrating peptide-conjugated bovine serum albumin nanoparticles for efficient mRNA and siRNA loading and delivery

D Tu, T Sneideris, Y Ou, S Cai, Y Yao, H Yang, TPJ Knowles.

BIOPHYSICAL JOURNAL

(2026)

125

342a

Single-molecule microfluidic diffusional sizing

JJ Fan, R Jacquat, G Krainer, TPJ Knowles, SF Lee

BIOPHYSICAL JOURNAL

(2026)

125

Structural defects in amyloid-β fibrils drive secondary nucleation.

J Hu, T Scheidt, D Thacker, E Axell, E Stemme, U Łapińska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Šarić, JD Schmit, TPJ Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear

Nature communications

(2026)

1933

(doi: 10.1038/s41467-026-69377-1)

A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease

S-H Huang, MW Cotton, TPJ Knowles, D Klenerman, G Meisl

(2026)

(doi: 10.48550/arxiv.2508.15046)

A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease

S-H Huang, 黃士桓, MW Cotton, TPJ Knowles, D Klenerman, G Meisl

Prx Life

(2026)

013021

(doi: 10.1103/f9hz-xvpr)

Distinct mechanistic pathways of early tauopathy revealed by MAPT mutations.

MS Foiani, RS Nirujogi, N Watamura, S Bez, E Tsefou, A Santambrogio, S Patel, H Davies, C Goulbourne, N Fatima, T Birkle, E Camporesi, G Brinkmalm, H Zetterberg, M Wilkinson, SE Radford, NA Ranson, P Maglio-Cauhy, E Turkes, A Avdic-Belltheus, I Rawlinson, X Prebibaj, L Panti, D Gavriouchkina, M Blunskyte-Hendley, T Saido, M Vendruscolo, R Frank, M Bourdenx, KE Duff

bioRxiv

(2026)

(doi: 10.64898/2026.02.14.705716)

Classification of tauopathies from human brain homogenates through salt‐modulated tau amplification

A Santambrogio, MA Metrick, P Xu, NCT Gallagher, S Koga, B Ghetti, DW Dickson, B Caughey, M Vendruscolo

Alzheimer's & Dementia

(2026)

e71112

(doi: 10.1002/alz.71112)

Disulphide and sequence-encoded conformational priors guide nanobody structure prediction

M Ali, M Jaskolowski, M Greenig, TH Nguyen, M Crnogaj, E Smorodina, A Ramon, H Zhao, ML Fernández-Quintero, E Ghedin, V Greiff, P Sormanni

(2026)