Centre for Misfolding Diseases

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  • Currently displaying 141 - 160 of 2339 publications
Author(s)
Publication title
Journal Name
Publication year
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed.
AJ Dear, X Teng, SR Ball, J Lewin, RI Horne, D Clow, A Stevenson, N Harper, K Yahya, X Yang, SC Brewerton, J Thomson, TCT Michaels, S Linse, TPJ Knowles, J Habchi, G Meisl
Chem Sci
(2024)
15
(doi: 10.1039/d3sc05661a)
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
TL Chris Ng, M Hoare, J Maristany, E Wilde, T Sneideris, J Huertas, B Agbetiameh, M Furukawa, J Joseph, TPJ Knowles, R Collepardo-Guevara, L Itzhaki, J Kumita
(2024)
(doi: 10.1101/2024.04.16.589709)
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
Nature Chemical Biology
(2024)
20
(doi: 10.1038/s41589-024-01580-x)
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.
B Fu, E Brock, R Andrews, J Breiter, R Tian, C Toomey, J Lachica, T Lashley, M Ryten, N Wood, M Vendruscolo, S Gandhi, L Weiss, J Beckwith, S Lee
The Journal of Physical Chemistry B
(2024)
128
(doi: 10.1021/acs.jpcb.4c00174)
Selenium-silk microgels as antifungal and antibacterial agents
EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
Nanoscale Horizons
(2024)
9
(doi: 10.1039/d3nh00385j)
Abstract 3231: Pharmacological inhibition of the m6A RNA reader, YTHDC1, as a novel approach to targeting biomolecular condensates in cancer
RC Centore, M Charles, M Arora, Y Chen, M Watson, C Kelley, M Czekalska, M Rebmann, M Ghandi, J Cattin, N Bharatham, P Radhakrishnan, A Howarth, G Rudlaff, WE Arter, S Qamar, K Saar, D Williamson, A Seeber, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-3231)
Abstract 4891: Discovery of novel biomolecular condensate drug targets in oncology using in silico predictive tools
KL Saar, M Rebmann, M Kanchwala, S Qamar, P Radhakrishnan, J Cornish, J Doh, J Cattin, A Rotem, M Ghandi, A Seeber, RC Centore, SA Teichmann, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-4891)
Abstract 1657: Microfluidics-based screening platform identifies a novel therapeutic approach to targeting EML4-ALK driven cancers
RC Centore, M Watson, J Doh, J Cattin, C Sgambato, A Alex, J Sawant, P Radhakrishnan, J Cornish, A Howarth, N Bharatham, WE Arter, S Qamar, KL Saar, D Williamson, A Seeber, N Groenewegen, M Czekalska, T Kartanas, N Ermann, A Taher, T Knowles, S Arora
Cancer Research
(2024)
84
(doi: 10.1158/1538-7445.am2024-1657)
Design of amyloidogenic peptide traps
DD Sahtoe, EA Andrzejewska, HL Han, E Rennella, MM Schneider, G Meisl, M Ahlrichs, J Decarreau, H Nguyen, A Kang, P Levine, M Lamb, X Li, AK Bera, LE Kay, TPJ Knowles, D Baker
Nat Chem Biol
(2024)
20
(doi: 10.1038/s41589-024-01578-5)
Understanding Biology in the Age of Artificial Intelligence
E Lawrence, A El-Shazly, S Seal, CK Joshi, P Liò, S Singh, A Bender, P Sormanni, M Greenig
(2024)
Fabrication of gradient hydrogels using a thermophoretic approach in microfluidics.
A Kosmidis Papadimitriou, SW Chong, Y Shen, OS Lee, TPJ Knowles, LM Grover, D Vigolo
Biofabrication
(2024)
16
(doi: 10.1088/1758-5090/ad2b05)
A Relationship Between Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions
S Chia, RL Cataldi, FS Ruggeri, R Limbocker, I Condado-Morales, K Pisani, A Possenti, S Linse, TPJ Knowles, J Habchi, B Mannini, M Vendruscolo
ACS Chem Neurosci
(2024)
15
(doi: 10.1021/acschemneuro.3c00718)
Targeted protein editing with an antibody-based system
M Vendruscolo, O Rimon, J Konc, M Ali, VR Chowdhury, P Sormanni, G Bernardes
(2024)
(doi: 10.21203/rs.3.rs-3947849/v1)
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases.
DJ Rinauro, F Chiti, M Vendruscolo, R Limbocker
Molecular Neurodegeneration
(2024)
19
(doi: 10.1186/S13024-023-00651-2)
Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue
R Andrews, B Fu, C Toomey, J Breiter, J Lachica, R Tian, J Beckwith, L-M Needham, G Chant, C Loiseau, A Deconfin, K Baspin, P Magill, Z Jaunmuktane, O Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, N Wood, L Weiss, S Gandhi, S Lee
(2024)
(doi: 10.1101/2024.02.17.580698)
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates.
B Bernardim, J Conde, T Hakala, JB Becher, M Canzano, AV Vasco, TPJ Knowles, J Cameron, GJL Bernardes
Bioconjugate chemistry
(2024)
35
(doi: 10.1021/acs.bioconjchem.3c00478)
Self-replication of Aβ42 aggregates occurs on small and isolated fibril sites
S Curk, J Krausser, G Meisl, D Frenkel, S Linse, TCT Michaels, TPJ Knowles, A Šarić
Proceedings of the National Academy of Sciences of the United States of America
(2024)
121
(doi: 10.1073/pnas.2220075121)
Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms
A Röntgen, Z Toprakcioglu, JE Tomkins, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2024)
121
(doi: 10.1073/pnas.2313465121)
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils
A Miller, S Chia, E Klimont, TPJ Knowles, M Vendruscolo, FS Ruggeri
Commun Biol
(2024)
7
(doi: 10.1038/s42003-024-05858-7)
Temperature-induced changes in protein interactions control RNA recruitment to G3BP1 condensates
C Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, T Knowles
(2024)
(doi: 10.1101/2024.02.02.578543)
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