Centre for Misfolding Diseases

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  • Currently displaying 141 - 160 of 2456 publications
Author(s)
Publication title
Journal Name
Publication year
Quantifying temperature-induced changes in protein interactions and phase behavior using high-throughput droplet microfluidics
CM Fischer, H Ausserwoger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Quantifying and predicting antibody non-specificity in the clinical landscape: Microfluidics and machine learning
E de Csillery, H Ausserwoger, M Oeller, I Waibel, R Akbar, A Abrudan, G Krainer, G Invernizzi, P Arosio, N Lorenzen, T Knowles
BIOPHYSICAL JOURNAL
(2025)
123
Digital seed amplification quantifies the increase in seeding- competent aggregates in Parkinson's patients' CSF
A Levin, S Cai, H Ausserwoeger, G Meisl, D Qian, R Scrutton, IA Edu, G Krainer, T Sneideris, L Chai, W Arter, TP Knowles
BIOPHYSICAL JOURNAL
(2025)
124
Investigating the role of sequence patterning in the mixing of polymer dense phases
LL Good, TP Knowles, RB Best
BIOPHYSICAL JOURNAL
(2025)
124
Estimation of Ligand Binding Free Energy Using Multi-eGO.
B Stegani, E Scalone, FB Toplek, T Löhr, S Gianni, M Vendruscolo, R Capelli, C Camilloni
Journal of chemical information and modeling
(2024)
65
(doi: 10.1021/acs.jcim.4c01545)
G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability
IREA Trussina, A Hartmann, C Desroches Altamirano, J Natarajan, CM Fischer, M Aleksejczuk, H Ausserwöger, TPJ Knowles, M Schlierf, TM Franzmann, S Alberti
Mol Cell
(2024)
85
(doi: 10.1016/j.molcel.2024.11.039)
Liquid–liquid phase separation in hepatocellular carcinoma
J Xu, W Liu, Y Yao, TPJ Knowles, Z-G Zhang, Y-L Zhang
Frontiers in cell and developmental biology
(2024)
12
(doi: 10.3389/fcell.2024.1454587)
Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
Analytical Chemistry
(2024)
97
(doi: 10.1021/acs.analchem.4c04188)
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.
N Watamura, MS Foiani, S Bez, M Bourdenx, A Santambrogio, C Frodsham, E Camporesi, G Brinkmalm, H Zetterberg, S Patel, N Kamano, M Takahashi, J Rueda-Carrasco, L Katsouri, S Fowler, E Turkes, S Hashimoto, H Sasaguri, T Saito, AS Islam, S Benner, T Endo, K Kobayashi, C Ishida, M Vendruscolo, M Yamada, KE Duff, TC Saido
Nature Neuroscience
(2024)
28
(doi: 10.1038/s41593-024-01829-7)
Proteostasis Signatures in Human Diseases
CM Lim, M Vendruscolo
(2024)
(doi: 10.1101/2024.12.23.630032)
Immuno-moodulin is Differentially Expressed in T Cells and Plasma in Obsessive-Compulsive Disorder Patients
IA Blacksell, M Vismara, CM Lim, B Dell’Osso, S Pallanti, E Hollander, M Vendruscolo, C D’Addario, D Cooper, F D’Acquisto
(2024)
(doi: 10.1101/2024.12.16.628685)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
(2024)
(doi: 10.1101/2024.12.14.24318991)
Estimation of ligand binding free energy using multi-eGO.
B Stegani, E Scalone, F Bacic Toplek, T Lohr, S Gianni, M Vendruscolo, R Capelli, C Camilloni
(2024)
(doi: 10.26434/chemrxiv-2024-jcmgc-v2)
Detecting and Tracking β-Amyloid Oligomeric Forms and Dynamics In Vitro by a High-Sensitivity Fluorescent-Based Assay.
Y Zhao, O Brener, E Andrzejewska, J Wei, C Reiß, O Tietz, TPJ Knowles, FI Aigbirhio
ACS chemical neuroscience
(2024)
15
(doi: 10.1021/acschemneuro.4c00312)
Language Models for Molecular Dynamics
MH Murtada, ZF Brotzakis, M Vendruscolo
(2024)
(doi: 10.1101/2024.11.25.625337)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
T Knowles, Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, M Schneider, C Fischer, E Schoenmakers, N Schoenmakers
(2024)
(doi: 10.21203/rs.3.rs-5139555/v1)
Assessment of fine-tuned large language models for real-world chemistry and material science applications
J Van Herck, MV Gil, KM Jablonka, A Abrudan, AS Anker, M Asgari, B Blaiszik, A Buffo, L Choudhury, C Corminboeuf, H Daglar, AM Elahi, IT Foster, S Garcia, M Garvin, G Godin, LL Good, J Gu, N Xiao Hu, X Jin, T Junkers, S Keskin, TPJ Knowles, R Laplaza, M Lessona, S Majumdar, H Mashhadimoslem, RD McIntosh, SM Moosavi, B Mouriño, F Nerli, C Pevida, N Poudineh, M Rajabi-Kochi, KL Saar, F Hooriabad Saboor, M Sagharichiha, KJ Schmidt, J Shi, E Simone, D Svatunek, M Taddei, I Tetko, D Tolnai, S Vahdatifar, J Whitmer, DCF Wieland, R Willumeit-Römer, A Züttel, B Smit
Chemical science
(2024)
16
(doi: 10.1039/d4sc04401k)
The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway.
D Ghosh, F Torres, MM Schneider, D Ashkinadze, H Kadavath, Y Fleischmann, S Mergenthal, P Güntert, G Krainer, EA Andrzejewska, L Lin, J Wei, E Klotzsch, T Knowles, R Riek
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-54212-2)
A scale-invariant log-normal droplet size distribution below the transition concentration for protein phase separation
T Amico, S Dada, A Lazzari, A Trovato, M Vendruscolo, M Fuxreiter, A Maritan
eLife
(2024)
13
(doi: 10.7554/elife.94214.3)
A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation
T Amico, ST Dada, A Lazzari, M Brezinova, A Trovato, M Vendruscolo, M Fuxreiter, A Maritan
eLife
(2024)
13
(doi: 10.7554/eLife.94214)
Yusuf Hamied Department of Chemistry
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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