Centre for Misfolding Diseases

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  • Currently displaying 141 - 160 of 2400 publications
Author(s)
Publication title
Journal Name
Publication year
Small Molecule RNA Degraders
J Bonet-Aleta, T Maehara, BA Craig, GJL Bernardes
Angewandte Chemie International Edition
(2024)
63
(doi: 10.1002/anie.202412925)
Serine phosphorylation mimics of Aβ form distinct, non-cross-seeding fibril morphs
K Sanagavarapu, G Meisl, V Lattanzi, K Bernfur, B Frohm, U Olsson, TPJ Knowles, A Malmendal, S Linse
Chemical science
(2024)
15
(doi: 10.1039/d3sc06343g)
Biomolecular Condensates are Characterized by Interphase Electric Potentials.
AE Posey, A Bremer, NA Erkamp, A Pant, TPJ Knowles, Y Dai, T Mittag, RV Pappu
Journal of the American Chemical Society
(2024)
146
(doi: 10.1021/jacs.4c08946)
Aggregation of the amyloid-β peptide (Aβ40) within condensates generated through liquid-liquid phase separation
OM Morris, Z Toprakcioglu, A Röntgen, M Cali, TPJ Knowles, M Vendruscolo
Scientific reports
(2024)
14
(doi: 10.1038/s41598-024-72265-7)
A rapid in vivo pipeline to identify small molecule inhibitors of amyloid aggregation
M Kamal, J Knox, RI Horne, OS Tiwari, AR Burns, D Han, D Levy, D Laor Bar-Yosef, E Gazit, M Vendruscolo, PJ Roy
Nature communications
(2024)
15
(doi: 10.1038/s41467-024-52480-6)
Designed endocytosis-inducing proteins degrade targets and amplify signals
B Huang, M Abedi, G Ahn, B Coventry, I Sappington, C Tang, R Wang, T Schlichthaerle, JZ Zhang, Y Wang, I Goreshnik, CW Chiu, A Chazin-Gray, S Chan, S Gerben, A Murray, S Wang, J O'Neill, L Yi, R Yeh, A Misquith, A Wolf, LM Tomasovic, DI Piraner, MJ Duran Gonzalez, NR Bennett, P Venkatesh, M Ahlrichs, C Dobbins, W Yang, X Wang, DD Sahtoe, D Vafeados, R Mout, S Shivaei, L Cao, L Carter, L Stewart, JB Spangler, KT Roybal, PJ Greisen, X Li, GJL Bernardes, CR Bertozzi, D Baker
Nature
(2024)
638
(doi: 10.1038/s41586-024-07948-2)
Mechanical Profiling of Biopolymer Condensates through Acoustic Trapping.
K Nakajima, T Sneideris, LL Good, NA Erkamp, H Ogi, TPJ Knowles
(2024)
(doi: 10.1101/2024.09.16.613217)
Single-molecule digital sizing of proteins in solution.
G Krainer, RPB Jacquat, MM Schneider, TJ Welsh, J Fan, QAE Peter, EA Andrzejewska, G Šneiderienė, MA Czekalska, H Ausserwoeger, L Chai, WE Arter, KL Saar, TW Herling, TM Franzmann, V Kosmoliaptsis, S Alberti, FU Hartl, SF Lee, TPJ Knowles
Nat Commun
(2024)
15
(doi: 10.1038/s41467-024-50825-9)
A human neuronal model of sporadic Alzheimer’s disease induced by FBXO2 downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairment
AG Díaz, A Possenti, GA Urrutia, Y Bian, S Kedia, D Boeken, C Lim, D Licastro, B Mannini, D Klenerman, M Vendruscolo
(2024)
(doi: 10.1101/2024.09.01.610673)
TNF⍺-driven Aβ aggregation, synaptic dysfunction and hypermetabolism in human iPSC-derived cortical neurons
AG Díaz, E Belli, B Mannini, GA Urrutia, M Vendruscolo
(2024)
(doi: 10.1101/2024.08.30.610594)
Unraveling the Structure and Dynamics of Ac-PHF6-NH<sub>2</sub> Tau Segment Oligomers.
I Stroganova, Z Toprakcioglu, H Willenberg, TPJ Knowles, AM Rijs
ACS Chemical Neuroscience
(2024)
15
(doi: 10.1021/acschemneuro.4c00404)
Surface effects on functional amyloid formation
AJ Dear, G Meisl, CG Taylor, UC Palmiero, SN Stubbe, Q Liu, P Arosio, S Linse, TPJ Knowles, M Andreasen
Nanoscale
(2024)
16
(doi: 10.1039/d4nr01496k)
Proximity-driven site-specific cyclization of phage-displayed peptides.
L Brown, AV Vidal, AL Dias, T Rodrigues, A Sigurdardottir, T Journeaux, S O'Brien, TV Murray, P Ravn, M Papworth, GJL Bernardes
Nat Commun
(2024)
15
(doi: 10.1038/s41467-024-51610-4)
Formation of Nanofibrillar Self-Healing Hydrogels Using Antimicrobial Peptides.
EG Wiita, Z Toprakcioglu, AK Jayaram, TPJ Knowles
ACS Applied Materials and Interfaces
(2024)
16
(doi: 10.1021/acsami.4c11542)
Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates
NA Erkamp, M Farag, Y Qiu, D Qian, T Sneideris, T Wu, TJ Welsh, H Ausserwӧger, TJ Krug, DA Weitz, M Lew, TPJ Knowles, RV Pappu
(2024)
(doi: 10.1101/2024.08.19.608662)
α-Synuclein oligomers form by secondary nucleation
CK Xu, G Meisl, EA Andrzejewska, G Krainer, AJ Dear, M Castellana-Cruz, S Turi, IA Edu, G Vivacqua, RPB Jacquat, WE Arter, MG Spillantini, M Vendruscolo, S Linse, TPJ Knowles
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-50692-4)
Competing addition processes give distinct growth regimes in the assembly of 1D filaments
SA Akram, T Brown, S Whitelam, G Meisl, TPJ Knowles, JD Schmit
(2024)
(doi: 10.48550/arxiv.2408.07257)
AlphaFold2-based prediction of the co-condensation propensity of proteins
S Zhang, CM Lim, M Occhetta, M Vendruscolo
Proceedings of the National Academy of Sciences
(2024)
121
(doi: 10.1073/pnas.2315005121)
Gold (III)-Induced Amide Bond Cleavage In Vivo: A Dual Release Strategy via π-acid Mediated Allyl Substitution
VB Unnikrishnan, V Sabatino, F Amorim, MF Estrada, CD Navo, G Jimenez-Oses, R Fior, GJL Bernardes
J Am Chem Soc
(2024)
146
(doi: 10.1021/jacs.4c05582)
Dominance analysis to assess solute contributions to multicomponent phase equilibria
D Qian, H Ausserwoger, T Sneideris, M Farag, RV Pappu, TPJ Knowles
Proceedings of the National Academy of Sciences
(2024)
121
(doi: 10.1073/pnas.2407453121)
Yusuf Hamied Department of Chemistry
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