Centre for Misfolding Diseases

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  • Currently displaying 161 - 180 of 2393 publications
Author(s)
Publication title
Journal Name
Publication year
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
T Knowles, Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, M Schneider, C Fischer, E Schoenmakers, N Schoenmakers
(2024)
(doi: 10.21203/rs.3.rs-5139555/v1)
Assessment of fine-tuned large language models for real-world chemistry and material science applications †
J Van Herck, MV Gil, KM Jablonka, A Abrudan, AS Anker, M Asgari, B Blaiszik, A Buffo, L Choudhury, C Corminboeuf, H Daglar, AM Elahi, IT Foster, S Garcia, M Garvin, G Godin, LL Good, J Gu, N Xiao Hu, X Jin, T Junkers, S Keskin, TPJ Knowles, R Laplaza, M Lessona, S Majumdar, H Mashhadimoslem, RD McIntosh, SM Moosavi, B Mouriño, F Nerli, C Pevida, N Poudineh, M Rajabi-Kochi, KL Saar, F Hooriabad Saboor, M Sagharichiha, KJ Schmidt, J Shi, E Simone, D Svatunek, M Taddei, I Tetko, D Tolnai, S Vahdatifar, J Whitmer, DCF Wieland, R Willumeit-Römer, A Züttel, B Smit
Chemical science
(2024)
16
(doi: 10.1039/d4sc04401k)
The inhibitory action of the chaperone BRICHOS against the α-Synuclein secondary nucleation pathway
D Ghosh, F Torres, MM Schneider, D Ashkinadze, H Kadavath, Y Fleischmann, S Mergenthal, P Güntert, G Krainer, EA Andrzejewska, L Lin, J Wei, E Klotzsch, T Knowles, R Riek
Nat Commun
(2024)
15
(doi: 10.1038/s41467-024-54212-2)
A scale-invariant log-normal droplet size distribution below the transition concentration for protein phase separation
T Amico, S Dada, A Lazzari, A Trovato, M Vendruscolo, M Fuxreiter, A Maritan
eLife
(2024)
13
(doi: 10.7554/eLife.94214.3)
A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation
T Amico, ST Dada, A Lazzari, M Brezinova, A Trovato, M Vendruscolo, M Fuxreiter, A Maritan
Elife
(2024)
13
(doi: 10.7554/elife.94214)
Dynamically arrested condensate fusion creates complex structures with varying material properties
NA Erkamp, I Sanchez-Burgos, A Zhou, TJ Krug, S Qamar, T Sneideris, E Zhang, K Nakajima, A Chen, R Collepardo-Guevara, J van Hest, P St George-Hyslop, DA Weitz, JR Espinosa, TPJ Knowles
(2024)
(doi: 10.1101/2024.11.15.623768)
Organization of the Proteostasis Network of Membraneless Organelles
CM Lim, Y Bian, AG Díaz, F Pun, A Zhavoronkov, RI Morimoto, M Vendruscolo
(2024)
(doi: 10.1101/2024.11.12.623332)
AlphaFold-Metainference: Prediction of Structural Ensembles of Disordered Proteins
ZF Brotzakis, S Zhang, MH Murtada, M Vendruscolo
(2024)
(doi: 10.1101/2024.11.09.622758)
Learning the rules of peptide self-assembly through data mining with large language models
Z Yang, SK Yorke, TPJ Knowles, MJ Buehler
(2024)
(doi: 10.48550/arxiv.2411.05421)
Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules
A Stevenson, R Staats, AJ Dear, D Voderholzer, G Meisl, R Guido, C Galvagnion, AK Buell, TPJ Knowles, M Vendruscolo, TCT Michaels
(2024)
(doi: 10.1101/2024.11.07.622437)
Selective Inhibition of the m6a RNA Reader, YTHDC1, As a Novel Therapeutic Strategy for MYC-Driven Acute Myeloid Leukemia
M Arora, R Centore, M Charles, Y Chen, M Watson, M Czekalska, M Rebmann, M Ghandi, J Cattin, N Bharatham, P Radhakrishnan, A Howarth, WE Arter, S Qamar, L Andraghetti, K Saar, A Seeber, MG Kharas, M Kulander, T Knowles, S Arora
Blood
(2024)
144
(doi: 10.1182/blood-2024-207561)
Technologies for Targeted RNA Degradation and Induced RNA Decay.
S Mikutis, GJL Bernardes
Chem Rev
(2024)
124
(doi: 10.1021/acs.chemrev.4c00472)
AIntibody: an experimentally validated in silico antibody discovery design challenge
MF Erasmus, L Spector, F Ferrara, R DiNiro, TJ Pohl, K Perea-Schmittle, W Wang, PM Tessier, C Richardson, L Turner, S Kumar, D Bedinger, P Sormanni, ML Fernández-Quintero, AB Ward, JR Loeffler, OM Swanson, CM Deane, MIJ Raybould, A Evers, C Sellmann, S Bachas, J Ruffolo, HG Nastri, K Ramesh, J Sørensen, R Croasdale-Wood, O Hijano, C Leal-Lopes, M Shahsavarian, Y Qiu, P Marcatili, E Vernet, R Akbar, S Friedensohn, R Wagner, VB Kurella, S Malhotra, S Kumar, P Kidger, JC Almagro, E Furfine, M Stanton, CP Graff, SD Villalba, F Tomszak, AAR Teixeira, E Hopkins, M Dovner, S D'Angelo, ARM Bradbury
Nature Biotechnology
(2024)
42
(doi: 10.1038/s41587-024-02469-9)
Non‐Natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity
A Guerreiro, I Compañón, FS Lazaris, C Labão-Almeida, P Oroz, M Ghirardello, MC Marques, F Corzana, GJL Bernardes
Angewandte Chemie International Edition
(2024)
63
(doi: 10.1002/anie.202411009)
Oxidation-sensitive cysteines drive IL-38 amyloid formation
A Diaz-Barreiro, G Cereghetti, FG Ortega Sánchez, J Tonacini, D Talabot-Ayer, S Kieffer-Jaquinod, VM Kissling, A Huard, C Swale, TPJ Knowles, Y Couté, M Peter, A Francés-Monerris, G Palmer
Cell reports
(2024)
43
(doi: 10.1016/j.celrep.2024.114940)
Synapsin condensation is governed by sequence-encoded molecular grammars.
C Hoffmann, KM Ruff, I Edu, M Kyung Shinn, J Tromm, M King, A Pant, H Ausserwoeger, J Morgan, T Knowles, RV Pappu, D Milovanovic
(2024)
(doi: 10.1101/2024.08.03.606464)
Small Molecule RNA Degraders.
J Bonet-Aleta, T Maehara, BA Craig, GJL Bernardes
Angew Chem Int Ed Engl
(2024)
63
(doi: 10.1002/anie.202412925)
Serine phosphorylation mimics of Aβ form distinct, non-cross-seeding fibril morphs.
K Sanagavarapu, G Meisl, V Lattanzi, K Bernfur, B Frohm, U Olsson, TPJ Knowles, A Malmendal, S Linse
Chemical science
(2024)
15
(doi: 10.1039/d3sc06343g)
Biomolecular Condensates are Characterized by Interphase Electric Potentials
AE Posey, A Bremer, NA Erkamp, A Pant, TPJ Knowles, Y Dai, T Mittag, RV Pappu
Journal of the American Chemical Society
(2024)
146
(doi: 10.1021/jacs.4c08946)
Pharmacologic inhibition of YTHDC1 biomolecular condensates as a novel approach to targeting L-MYC driven small cell lung cancer
R Centore, M Charles, M Arora, Y Chen, M Watson, C Kelley, M Czekalska, M Rebmann, M Ghandi, J Cattin, N Bharatham, P Radhakrishnan, A Howarth, W Arter, S Qamar, K Saar, A Seeber, M Kulander, T Knowles, S Arora
European Journal of Cancer
(2024)
211
(doi: 10.1016/j.ejca.2024.114762)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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