Centre for Misfolding Diseases

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  • Currently displaying 921 - 940 of 2508 publications
Author(s)
Publication title
Journal Name
Publication year
The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure
M Vivoli Vega, R Cascella, SW Chen, G Fusco, A De Simone, CM Dobson, C Cecchi, F Chiti
ACS Chemical Biology
(2019)
14
(doi: 10.1021/acschembio.9b00324)
Effects of α-tubulin acetylation on microtubule structure and stability
L Eshun-Wilson, R Zhang, D Portran, MV Nachury, DB Toso, T Löhr, M Vendruscolo, M Bonomi, JS Fraser, E Nogales
Proceedings of the National Academy of Sciences
(2019)
116
(doi: 10.1073/pnas.1900441116)
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez-Osés, GJL Bernardes
Angewandte Chemie International Edition
(2019)
58
(doi: 10.1002/anie.201901405)
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies.
R Cascella, M Perni, SW Chen, G Fusco, C Cecchi, M Vendruscolo, F Chiti, CM Dobson, A De Simone
ACS Chem Biol
(2019)
14
(doi: 10.1021/acschembio.9b00312)
Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans
C Huang, S Wagner-Valladolid, AD Stephens, R Jung, C Poudel, T Sinnige, MC Lechler, N Schlörit, M Lu, RF Laine, CH Michel, M Vendruscolo, CF Kaminski, GS Kaminski Schierle, DC David
eLife
(2019)
8
(doi: 10.7554/eLife.43059)
Dissecting celastrol with machine learning to unveil dark pharmacology.
T Rodrigues, BP de Almeida, NL Barbosa-Morais, GJL Bernardes
Chemical communications (Cambridge, England)
(2019)
55
(doi: 10.1039/c9cc03116b)
Computational advances in combating colloidal aggregation in drug discovery.
D Reker, GJL Bernardes, T Rodrigues
Nature chemistry
(2019)
11
(doi: 10.1038/s41557-019-0234-9)
Potassium Arylethynyltrifluoroborate as an Unstrained Dienophile for Ultrafast and On Demand Activation of Bioorthogonal IEDDA Reactions
Z Guo, B Oliveira, CD Navo, P M. S. D. Cal, F Corzana, G Jiménez-Osés, G Bernardes
(2019)
(doi: 10.26434/chemrxiv.8038685.v1)
Determination of the structural ensemble of the molten globule state of a protein by computer simulations
M Shimizu, Y Kajikawa, K Kuwajima, CM Dobson, Y Okamoto
Proteins: Structure, Function, and Bioinformatics
(2019)
87
(doi: 10.1002/prot.25688)
Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming
N Ahmed, P Sormanni, P Ciryam, M Vendruscolo, CM Dobson, EP O'Brien
Scientific reports
(2019)
9
(doi: 10.1038/s41598-019-42348-x)
Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-b aggregates
T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio
Science Advances
(2019)
5
(doi: 10.1126/sciadv.aau3112)
Biophysical Techniques in Structural Biology.
CM Dobson
Annu Rev Biochem
(2019)
88
(doi: 10.1146/annurev-biochem-013118-111947)
Sequence-Optimized Peptide Nanofibers as Growth Stimulators for Regeneration of Peripheral Neurons
C Schilling, T Mack, S Lickfett, S Sieste, FS Ruggeri, T Sneideris, A Dutta, T Bereau, R Naraghi, D Sinske, TPJ Knowles, CV Synatschke, T Weil, B Knöll
Advanced Functional Materials
(2019)
29
(doi: 10.1002/adfm.201809112)
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions.
P Kukic, GM Lo Piccolo, MO Nogueira, DI Svergun, M Vendruscolo, IC Felli, R Pierattelli
Scientific reports
(2019)
9
(doi: 10.1038/s41598-019-41925-4)
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez‐Osés, GJL Bernardes
Angewandte Chemie
(2019)
131
(doi: 10.1002/ange.201901405)
3D Microfluidics Spray Nozzle for Sample Processing and Materials Deposition
T Kartanas, R Rodrigues, T Müller, T Herling, T Knowles, J Charmet
3RD BIOMEDICAL ENGINEERING'S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES
(2019)
2096
(doi: 10.1063/1.5096675)
ADSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
(2019)
(doi: 10.1101/600346)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
Nature Communications
(2019)
10
(doi: 10.1038/s41467-019-09477-3)
The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS.
JJ Yerbury, L Ooi, IP Blair, P Ciryam, CM Dobson, M Vendruscolo
Neuroscience letters
(2019)
704
(doi: 10.1016/j.neulet.2019.04.001)
The Amyloid Phenomenon and Its Significance in Biology and Medicine
CM Dobson, TPJ Knowles, M Vendruscolo
Cold Spring Harbor perspectives in biology
(2019)
12
(doi: 10.1101/cshperspect.a033878)
Yusuf Hamied Department of Chemistry
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