Centre for Misfolding Diseases

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  • Currently displaying 921 - 940 of 2489 publications
Author(s)
Publication title
Journal Name
Publication year
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez‐Osés, GJL Bernardes
Angewandte Chemie
(2019)
131
(doi: 10.1002/ange.201901405)
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions
P Kukic, GM Lo Piccolo, MO Nogueira, DI Svergun, M Vendruscolo, IC Felli, R Pierattelli
Scientific reports
(2019)
9
(doi: 10.1038/s41598-019-41925-4)
ADSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
(2019)
(doi: 10.1101/600346)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
Nature communications
(2019)
10
(doi: 10.1038/s41467-019-09477-3)
The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS
JJ Yerbury, L Ooi, IP Blair, P Ciryam, CM Dobson, M Vendruscolo
Neuroscience Letters
(2019)
704
(doi: 10.1016/j.neulet.2019.04.001)
The Amyloid Phenomenon and Its Significance in Biology and Medicine
CM Dobson, TPJ Knowles, M Vendruscolo
Cold Spring Harb Perspect Biol
(2019)
12
(doi: 10.1101/cshperspect.a033878)
Synthesis, characterization and biological evaluation of new manganese metal carbonyl compounds that contain sulfur and selenium ligands as a promising new class of CORMs.
AL Amorim, MM Peterle, A Guerreiro, DF Coimbra, RS Heying, GF Caramori, AL Braga, AJ Bortoluzzi, A Neves, GJL Bernardes, R Peralta
Dalton Transactions
(2019)
48
(doi: 10.1039/c9dt00616h)
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species.
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
Chem Sci
(2019)
10
(doi: 10.1039/c8sc05627g)
Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells.
LJ Alcock, BL Oliveira, MJ Deery, TL Pukala, MV Perkins, GJL Bernardes, JM Chalker
ACS Chem Biol
(2019)
14
(doi: 10.1021/acschembio.8b01104)
Azabicyclic vinyl sulfones for residue-specific dual protein labelling Electronic supplementary information (ESI) available: Detailed methods and additional characterisation. See DOI: 10.1039/c9sc00125e
E Gil de Montes, E Jiménez-Moreno, BL Oliveira, CD Navo, PMSD Cal, G Jiménez-Osés, I Robina, AJ Moreno-Vargas, GJL Bernardes
Chem Sci
(2019)
10
(doi: 10.1039/c9sc00125e)
Natural product-drug conjugates for modulation of TRPV1-expressing tumors
C Baker, T Rodrigues, BP de Almeida, NL Barbosa-Morais, GJL Bernardes
Bioorganic & Medicinal Chemistry
(2019)
27
(doi: 10.1016/j.bmc.2019.03.025)
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.
P Akkapeddi, R Fragoso, JA Hixon, AS Ramalho, ML Oliveira, T Carvalho, A Gloger, M Matasci, F Corzana, SK Durum, D Neri, GJL Bernardes, JT Barata
Leukemia
(2019)
33
(doi: 10.1038/s41375-019-0434-8)
Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer'sassociated amyloid beta peptide
JH Cater, JR Kumita, R Zeineddine Abdallah, G Zhao, A Bernardo-Gancedo, A Henry, W Winata, M Chi, BSF Grenyer, ML Townsend, M Ranson, CS Buhimschi, DS Charnock-Jones, CM Dobson, MR Wilson, IA Buhimschi, AR Wyatt
Proceedings of the National Academy of Sciences of the United States of America
(2019)
116
(doi: 10.1073/pnas.1817298116)
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles
Macromol Rapid Commun
(2019)
40
(doi: 10.1002/marc.201800898)
A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli.
K Sanagavarapu, E Nüske, I Nasir, G Meisl, JN Immink, P Sormanni, M Vendruscolo, TPJ Knowles, A Malmendal, C Cabaleiro-Lago, S Linse
Scientific reports
(2019)
9
(doi: 10.1038/s41598-019-39216-z)
Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis.
P Sormanni, M Vendruscolo
Cold Spring Harbor Perspectives in Biology
(2019)
11
(doi: 10.1101/cshperspect.a033845)
Contemporary approaches to site-selective protein modification
EA Hoyt, PMSD Cal, BL Oliveira, GJL Bernardes
Nature Reviews Chemistry
(2019)
3
(doi: 10.1038/s41570-019-0079-1)
A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism
VE Zwicker, BL Oliveira, JH Yeo, ST Fraser, GJL Bernardes, EJ New, KA Jolliffe
Angewandte Chemie
(2019)
131
(doi: 10.1002/ange.201812489)
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N‑Terminally Truncated Aβ42 Species Aβ5–42
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
ACS chemical neuroscience
(2019)
10
(doi: 10.1021/acschemneuro.8b00676)
Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage
I Compañón, A Guerreiro, V Mangini, J Castro-López, M Escudero-Casao, A Avenoza, JH Busto, S Castillón, J Jiménez-Barbero, JL Asensio, G Jiménez-Osés, O Boutureira, JM Peregrina, R Hurtado-Guerrero, R Fiammengo, GJL Bernardes, F Corzana
Journal of the American Chemical Society
(2019)
141
(doi: 10.1021/jacs.8b13503)
Yusuf Hamied Department of Chemistry
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