Centre for Misfolding Diseases

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  • Currently displaying 901 - 920 of 2456 publications
Author(s)
Publication title
Journal Name
Publication year
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal of neuroscience methods
(2018)
306
(doi: 10.1016/j.jneumeth.2018.02.005)
Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation.
C Månsson, RTP van Cruchten, U Weininger, X Yang, R Cukalevski, P Arosio, CM Dobson, T Knowles, M Akke, S Linse, C Emanuelsson
Biochemistry
(2018)
57
(doi: 10.1021/acs.biochem.8b00353)
Structural differences between toxic and nontoxic HypF-N oligomers.
C Capitini, JR Patel, A Natalello, C D'Andrea, A Relini, JA Jarvis, L Birolo, A Peduzzo, M Vendruscolo, P Matteini, CM Dobson, A De Simone, F Chiti
Chemical Communications
(2018)
54
(doi: 10.1039/c8cc03446j)
Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
T Rodrigues, M Werner, J Roth, EHG da Cruz, MC Marques, P Akkapeddi, SA Lobo, A Koeberle, F Corzana, EN da Silva Júnior, O Werz, GJL Bernardes
Chemical Science
(2018)
9
(doi: 10.1039/c8sc02634c)
Site-selective installation of an electrophilic handle on proteins for bioconjugation.
B Lee, S Sun, E Jiménez-Moreno, AA Neves, GJL Bernardes
Bioorganic & Medicinal Chemistry
(2018)
26
(doi: 10.1016/j.bmc.2018.02.028)
Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs
E Papaleo, C Camilloni, K Teilum, M Vendruscolo, K Lindorff-Larsen
Peerj
(2018)
6
(doi: 10.7717/peerj.5125)
O2‐02‐02: TARGETING AMYLOID FORMATION USING RATIONALLY DESIGNED ANTIBODIES
FA Aprile, P Sormanni, M Perni, P Arosio, R Limbocker, S Chhangur, B Mannini, S Linse, T Knowles, CM Dobson, M Vendruscolo
Alzheimer's & Dementia
(2018)
14
(doi: 10.1016/j.jalz.2018.06.2646)
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding
F El Turk, E De Genst, T Guilliams, B Fauvet, M Hejjaoui, J Di Trani, A Chiki, A Mittermaier, M Vendruscolo, HA Lashuel, CM Dobson
Protein Science
(2018)
27
(doi: 10.1002/pro.3412)
Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson
ACS Chem Biol
(2018)
13
(doi: 10.1021/acschembio.8b00466)
Reversible inhibition of the ClpP protease via an N-terminal conformational switch
S Vahidi, ZA Ripstein, M Bonomi, T Yuwen, MF Mabanglo, JB Juravsky, K Rizzolo, A Velyvis, WA Houry, M Vendruscolo, JL Rubinstein, LE Kay
Proceedings of the National Academy of Sciences
(2018)
115
(doi: 10.1073/pnas.1805125115)
Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection
KL Saar, T Müller, J Charmet, PK Challa, TPJ Knowles
Analytical Chemistry
(2018)
90
(doi: 10.1021/acs.analchem.8b01205)
Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils
FS Ruggeri, F Benedetti, TPJ Knowles, HA Lashuel, S Sekatskii, G Dietler
Proceedings of the National Academy of Sciences of the United States of America
(2018)
115
(doi: 10.1073/pnas.1721220115)
Determination of Polypeptide Conformation with Nanoscale Resolution in Water.
G Ramer, FS Ruggeri, A Levin, TPJ Knowles, A Centrone
ACS nano
(2018)
12
(doi: 10.1021/acsnano.8b01425)
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers
DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, JR Kumita, H Ecroyd, CM Dobson, D Klenerman, MR Wilson
Cell Reports
(2018)
23
(doi: 10.1016/j.celrep.2018.05.074)
Origin of metastable oligomers and their effects on amyloid fibril self- assembly
F Hasecke, T Miti, C Perez, J Barton, D Schölzel, L Gremer, CSR Grüning, G Matthews, G Meisl, TPJ Knowles, D Willbold, P Neudecker, H Heise, G Ullah, W Hoyer, M Muschol
Chemical science
(2018)
9
(doi: 10.1039/c8sc01479e)
On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations
X Yang, G Meisl, B Frohm, E Thulin, TPJ Knowles, S Linse
Proc Natl Acad Sci U S A
(2018)
115
(doi: 10.1073/pnas.1803539115)
Kinetic analysis of amyloid formation
G Meisl, TCT Michaels, S Linse, TPJ Knowles
Methods in Molecular Biology
(2018)
1779
(doi: 10.1007/978-1-4939-7816-8_12)
Cooperative Assembly of Hsp70 Subdomain Clusters.
MA Wright, FA Aprile, MMJ Bellaiche, TCT Michaels, T Müller, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Biochemistry
(2018)
57
(doi: 10.1021/acs.biochem.8b00151)
Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.
Y Song, TCT Michaels, Q Ma, Z Liu, H Yuan, S Takayama, TPJ Knowles, HC Shum
Nature Communications
(2018)
9
(doi: 10.1038/s41467-018-04510-3)
C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH
IM van der Wateren, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion
Chemical Science
(2018)
9
(doi: 10.1039/c8sc01109e)
Yusuf Hamied Department of Chemistry
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