Centre for Misfolding Diseases

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  • Currently displaying 941 - 960 of 2474 publications
Author(s)
Publication title
Journal Name
Publication year
Oligomer Diversity during the Aggregation of the Repeat Region of Tau
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman
ACS Chem Neurosci
(2018)
9
(doi: 10.1021/acschemneuro.8b00250)
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
ACS Chem Neurosci
(2018)
9
(doi: 10.1021/acschemneuro.8b00141)
Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism
C Bortolini, T Kartanas, D Copic, I Condado Morales, Y Zhang, PK Challa, Q Peter, T Jávorfi, R Hussain, M Dong, G Siligardi, TPJ Knowles, J Charmet
Lab on A Chip
(2018)
19
(doi: 10.1039/c8lc00757h)
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology
H Fu, A Possenti, R Freer, Y Nakano, NC Hernandez Villegas, M Tang, PVM Cauhy, BA Lassus, S Chen, SL Fowler, HY Figueroa, ED Huey, GVW Johnson, M Vendruscolo, KE Duff
Nature neuroscience
(2018)
22
(doi: 10.1038/s41593-018-0298-7)
Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming
N Ahmed, P Sormanni, P Ciryam, M Vendruscolo, CM Dobson, EP O’Brien
(2018)
(doi: 10.1101/490755)
One-pot stapling of interchain disulfides of antibodies using an isobutylene motif
S Sun, P Akkapeddi, MC Marques, N Martínez-Sáez, VM Torres, C Cordeiro, O Boutureira, GJL Bernardes
Organic & biomolecular chemistry
(2018)
17
(doi: 10.1039/c8ob02877j)
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale
J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman
Nano Letters
(2018)
18
(doi: 10.1021/acs.nanolett.8b02916)
Protein engineering through chemical, genetic and computational manipulation
I Hamachi, GJL Bernardes
Chem Soc Rev
(2018)
47
(doi: 10.1039/c8cs90125b)
Attentive Cross-Modal Paratope Prediction
A Deac, P VeliČković, P Sormanni
J Comput Biol
(2018)
26
(doi: 10.1089/cmb.2018.0175)
Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics.
C Bertulli, M Gerigk, N Piano, Y Liu, D Zhang, T Müller, TJ Knowles, YYS Huang
Sci Rep
(2018)
8
(doi: 10.1038/s41598-018-30776-0)
Bioorthogonal Decaging Reactions for Targeted Drug Activation
S Davies, BJ Stenton, GJL Bernardes
Chimia
(2018)
72
(doi: 10.2533/chimia.2018.771)
Mechanobiology of Protein Droplets: Force Arises from Disorder.
TJ Welsh, Y Shen, A Levin, TPJ Knowles
Cell
(2018)
175
(doi: 10.1016/j.cell.2018.11.020)
Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform
M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson
Journal of Visualized Experiments
(2018)
(doi: 10.3791/58643-v)
Quantifying Co-Oligomer Formation by Alpha-Synuclein
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman
ACS nano
(2018)
12
(doi: 10.1021/acsnano.8b03575)
Radical-mediated thiol-ene strategy for photoactivation of thiol-containing drugs in cancer cells
GJ Lopes Bernardes
Angew Chem Int Ed Engl
(2018)
130
(doi: 10.1002/anie.201811338)
Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution
NL Mutter, M Soskine, G Huang, IS Albuquerque, GJL Bernardes, G Maglia
ACS Chemical Biology
(2018)
13
(doi: 10.1021/acschembio.8b00720)
Determination of Structural Ensembles of Proteins: Restraining vs Reweighting.
R Rangan, M Bonomi, GT Heller, A Cesari, G Bussi, M Vendruscolo
J Chem Theory Comput
(2018)
14
(doi: 10.1021/acs.jctc.8b00738)
Cisplatin-Triggered Bioorthogonal Decaging of Amide Bonds for Targeted-Drug Activation in vivo
B Stenton, B Oliveira, J Conde, M Negrão, M Godinho Ferreira, R Fior, G Bernardes
(2018)
(doi: 10.26434/chemrxiv.7327904.v1)
Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools.
L Shan, N Mody, P Sormani, KL Rosenthal, MM Damschroder, R Esfandiary
Molecular pharmaceutics
(2018)
15
(doi: 10.1021/acs.molpharmaceut.8b00867)
Microfluidic Diffusional Sizing Enables Characterisation of Protein-Protein Interactions Under Native Conditions
S Devenish, C Thorne, T Scheidt, J Carozza, P Arosio, Y Zhang, A Buell, T Mueller, A Lynn, J Faherty, M Wright, M Butz, T Knowles
PROTEIN SCIENCE
(2018)
27
Yusuf Hamied Department of Chemistry
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