Centre for Misfolding Diseases

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  • Currently displaying 941 - 960 of 2456 publications
Author(s)
Publication title
Journal Name
Publication year
Optical Structural Analysis of Individual α‐Synuclein Oligomers
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
Angewandte Chemie
(2018)
130
(doi: 10.1002/ange.201710779)
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, D Klenerman, AM van Oijen, H Ecroyd
Journal of Biological Chemistry
(2018)
293
(doi: 10.1074/jbc.m117.813865)
Chemo- and Regioselective Lysine Modification on Native Proteins
MJ Matos, BL Oliveira, N Martínez-Sáez, A Guerreiro, PMSD Cal, J Bertoldo, M Maneiro, E Perkins, J Howard, MJ Deery, JM Chalker, F Corzana, G Jiménez-Osés, GJL Bernardes
Journal of the American Chemical Society
(2018)
140
(doi: 10.1021/jacs.7b12874)
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.
F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, SE Jackson, CM Dobson, D Klenerman
ACS chemical biology
(2018)
13
(doi: 10.1021/acschembio.7b01039)
Reaction rate theory for supramolecular kinetics: application to protein aggregation
TCT Michaels, LX Liu, S Curk, PG Bolhuis, A Saric, TPJ Knowles
(2018)
(doi: 10.48550/arxiv.1803.04851)
Corneal Dystrophy Mutations Drive Pathogenesis by Targeting TGFBIp Stability and Solubility in a Latent Amyloid-forming Domain.
M Stenvang, NP Schafer, KG Malmos, A-MW Pérez, O Niembro, P Sormanni, RV Basaiawmoit, G Christiansen, M Andreasen, DE Otzen
Journal of Molecular Biology
(2018)
430
(doi: 10.1016/j.jmb.2018.03.001)
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 69
(2018)
69
(doi: 10.1146/annurev-physchem-050317-021322)
Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs
E Papaleo, C Camilloni, K Teilum, M Vendruscolo, K Lindorff-Larsen
(2018)
(doi: 10.1101/273714)
Additional contributions from: Nobel Symposium 162 - Microfluidics
S Löfås, AE Herr, J Qin, T Knowles, T Kitamori, H Lu, DJ Beebe, J Han, J Landers, A Manz, R Zengerle, DA Weitz, J Elf, T Laurell
(2018)
(doi: 10.48550/arxiv.1802.08565)
Antikörpergerichtete Therapien: Quo vadis?
T Rodrigues, GJL Bernardes
Angewandte Chemie
(2018)
130
(doi: 10.1002/ange.201712185)
Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices.
PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, JLP Benesch, TPJ Knowles
Analytical Chemistry
(2018)
90
(doi: 10.1021/acs.analchem.7b04523)
Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2.
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, S Perrett
J Am Chem Soc
(2018)
140
(doi: 10.1021/jacs.7b10439)
Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Amyloid-Beta42 Aggregation in Alzheimer's Disease
S Chia, J Habchi, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, P Arosio, JR Kumita, PK Challa, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1253)
2-Photon Lithography for Nanofluidic Lab-on-Chip Devices
O Vanderpoorten, PK Challa, Q Peter, J Charmet, N Curry, TPJ Knowles, CF Kaminski
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.3716)
Modulating Amyloid-Beta Aggregation to Reduce the Toxicity of its Oligomeric Aggregates
R Limbocker, B Mannini, S Chia, FS Ruggeri, M Perni, R Cascella, C Xu, J Habchi, JR Kumita, F Chiti, TPJ Knowles, M Vendruscolo, CM Dobson
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.2382)
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species
L-M Needham, J Weber, JWB Fyfe, OM Kabia, DT Do, E Klimont, Y Zhang, M Rodrigues, CM Dobson, S Ghandi, SE Bohndiek, TN Snaddon, SF Lee
Royal Society open science
(2018)
5
(doi: 10.1098/rsos.171399)
Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Perrett, S Wu
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.3693)
Principles of Protein Structural Ensemble Determination
M Vendruscolo
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.2149)
Molecular Mechanism of AB42 Peptide-Fibril Adsorption
MMJ Bellaiche, TPJ Knowles, RB Best
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1165)
Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2017.11.1246)
Yusuf Hamied Department of Chemistry
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