Centre for Misfolding Diseases

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  • Currently displaying 881 - 900 of 2453 publications
Author(s)
Publication title
Journal Name
Publication year
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
Chemical science
(2019)
10
(doi: 10.1039/c8sc05627g)
Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells.
LJ Alcock, BL Oliveira, MJ Deery, TL Pukala, MV Perkins, GJL Bernardes, JM Chalker
ACS chemical biology
(2019)
14
(doi: 10.1021/acschembio.8b01104)
Azabicyclic vinyl sulfones for residue-specific dual protein labelling
E Gil de Montes, E Jiménez-Moreno, BL Oliveira, CD Navo, PMSD Cal, G Jiménez-Osés, I Robina, AJ Moreno-Vargas, GJL Bernardes
Chem Sci
(2019)
10
(doi: 10.1039/c9sc00125e)
Natural product-drug conjugates for modulation of TRPV1-expressing tumors.
C Baker, T Rodrigues, BP de Almeida, NL Barbosa-Morais, GJL Bernardes
Bioorganic & Medicinal Chemistry
(2019)
27
(doi: 10.1016/j.bmc.2019.03.025)
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia
P Akkapeddi, R Fragoso, JA Hixon, AS Ramalho, ML Oliveira, T Carvalho, A Gloger, M Matasci, F Corzana, SK Durum, D Neri, GJL Bernardes, JT Barata
Leukemia
(2019)
33
(doi: 10.1038/s41375-019-0434-8)
Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer's-associated amyloid beta peptide
JH Cater, JR Kumita, R Zeineddine Abdallah, G Zhao, A Bernardo-Gancedo, A Henry, W Winata, M Chi, BSF Grenyer, ML Townsend, M Ranson, CS Buhimschi, DS Charnock-Jones, CM Dobson, MR Wilson, IA Buhimschi, AR Wyatt
Proceedings of the National Academy of Sciences of the United States of America
(2019)
116
(doi: 10.1073/pnas.1817298116)
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles
Macromol Rapid Commun
(2019)
40
(doi: 10.1002/marc.201800898)
A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli
K Sanagavarapu, E Nüske, I Nasir, G Meisl, JN Immink, P Sormanni, M Vendruscolo, TPJ Knowles, A Malmendal, C Cabaleiro-Lago, S Linse
Scientific Reports
(2019)
9
(doi: 10.1038/s41598-019-39216-z)
Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis.
P Sormanni, M Vendruscolo
Cold Spring Harbor Perspectives in Biology
(2019)
11
(doi: 10.1101/cshperspect.a033845)
Contemporary approaches to site-selective protein modification
EA Hoyt, PMSD Cal, BL Oliveira, GJL Bernardes
Nature Reviews Chemistry
(2019)
3
(doi: 10.1038/s41570-019-0079-1)
A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism
VE Zwicker, BL Oliveira, JH Yeo, ST Fraser, GJL Bernardes, EJ New, KA Jolliffe
Angewandte Chemie
(2019)
131
(doi: 10.1002/ange.201812489)
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
ACS chemical neuroscience
(2019)
10
(doi: 10.1021/acschemneuro.8b00676)
Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage
I Compañón, A Guerreiro, V Mangini, J Castro-López, M Escudero-Casao, A Avenoza, JH Busto, S Castillón, J Jiménez-Barbero, JL Asensio, G Jiménez-Osés, O Boutureira, JM Peregrina, R Hurtado-Guerrero, R Fiammengo, GJL Bernardes, F Corzana
Journal of the American Chemical Society
(2019)
141
(doi: 10.1021/jacs.8b13503)
Atomic force microscopy for single molecule characterisation of protein aggregation
FS Ruggeri, T Šneideris, M Vendruscolo, TPJ Knowles
Archives of Biochemistry and Biophysics
(2019)
664
(doi: 10.1016/j.abb.2019.02.001)
A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone
AM da Silva Neto, SR Silva, M Vendruscolo, C Camilloni, RW Montalvão
Proteins: Structure, Function, and Bioinformatics
(2019)
87
(doi: 10.1002/prot.25652)
Targeting the Formation of Amyloid Oligomers using Rationally Designed Antibodies
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TP Knowles, CM Dobson, M Vendruscolo
Biophysical Journal
(2019)
116
(doi: 10.1016/j.bpj.2018.11.196)
Structure and Dynamics of Alzheimer's Associated Amyloid-Beta Peptide
T Löhr, K Kohlhoff, G Heller, M Vendruscolo
Biophysical Journal
(2019)
116
(doi: 10.1016/j.bpj.2018.11.2352)
Probing Specificity in Disordered Protein Interactions with Small Molecules using Integrative Methods
GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, M Vendruscolo
Biophysical Journal
(2019)
116
(doi: 10.1016/j.bpj.2018.11.998)
In vitro and in silico assessment of the developability of a designed monoclonal antibody library.
A-M Wolf Pérez, P Sormanni, JS Andersen, LI Sakhnini, I Rodriguez-Leon, JR Bjelke, AJ Gajhede, L De Maria, DE Otzen, M Vendruscolo, N Lorenzen
Mabs
(2019)
11
(doi: 10.1080/19420862.2018.1556082)
Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation.
M Ahn, BI Lee, S Chia, J Habchi, JR Kumita, M Vendruscolo, CM Dobson, CB Park
Chemical Communications
(2019)
55
(doi: 10.1039/c8cc09288e)
Yusuf Hamied Department of Chemistry
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