Centre for Misfolding Diseases

Publications

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  • Currently displaying 861 - 880 of 2393 publications
Author(s)
Publication title
Journal Name
Publication year
One-pot stapling of interchain disulfides of antibodies using an isobutylene motif
S Sun, P Akkapeddi, MC Marques, N Martínez-Sáez, VM Torres, C Cordeiro, O Boutureira, GJL Bernardes
Organic and Biomolecular Chemistry
(2018)
17
(doi: 10.1039/c8ob02877j)
Protein engineering through chemical, genetic and computational manipulation
I Hamachi, GJL Bernardes
Chemical Society reviews
(2018)
47
(doi: 10.1039/c8cs90125b)
Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics
C Bertulli, M Gerigk, N Piano, Y Liu, D Zhang, T Müller, TJ Knowles, YYS Huang
Scientific Reports
(2018)
8
(doi: 10.1038/s41598-018-30776-0)
Attentive Cross-Modal Paratope Prediction.
A Deac, P VeliČković, P Sormanni
Journal of Computational Biology
(2018)
26
(doi: 10.1089/cmb.2018.0175)
Bioorthogonal Decaging Reactions for Targeted Drug Activation.
S Davies, BJ Stenton, GJL Bernardes
Chimia (Aarau)
(2018)
72
(doi: 10.2533/chimia.2018.771)
Mechanobiology of Protein Droplets: Force Arises from Disorder.
TJ Welsh, Y Shen, A Levin, TPJ Knowles
Cell
(2018)
175
(doi: 10.1016/j.cell.2018.11.020)
Automated Behavioral Analysis of Large <em>C. elegans</em> Populations Using a Wide Field-of-view Tracking Platform
M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson
Journal of Visualized Experiments
(2018)
(doi: 10.3791/58643-v)
Quantifying Co-Oligomer Formation by α-Synuclein.
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, TCT Michaels, D Frenkel, CM Dobson, TPJ Knowles, D Klenerman
ACS Nano
(2018)
12
(doi: 10.1021/acsnano.8b03575)
Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution
NL Mutter, M Soskine, G Huang, IS Albuquerque, GJL Bernardes, G Maglia
ACS Chemical Biology
(2018)
13
(doi: 10.1021/acschembio.8b00720)
Determination of Structural Ensembles of Proteins: Restraining vs Reweighting
R Rangan, M Bonomi, GT Heller, A Cesari, G Bussi, M Vendruscolo
Journal of chemical theory and computation
(2018)
14
(doi: 10.1021/acs.jctc.8b00738)
Cisplatin-Triggered Bioorthogonal Decaging of Amide Bonds for Targeted-Drug Activation in vivo
B Stenton, B Oliveira, J Conde, M Negrão, M Godinho Ferreira, R Fior, G Bernardes
(2018)
(doi: 10.26434/chemrxiv.7327904.v1)
Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools
L Shan, N Mody, P Sormani, KL Rosenthal, MM Damschroder, R Esfandiary
Mol Pharm
(2018)
15
(doi: 10.1021/acs.molpharmaceut.8b00867)
Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform
M Perni, S Casford, FA Aprile, EA Nollen, TPJ Knowles, M Vendruscolo, CM Dobson
J Vis Exp
(2018)
2018
(doi: 10.3791/58643)
Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling.
M Bonomi, S Hanot, CH Greenberg, A Sali, M Nilges, M Vendruscolo, R Pellarin
Structure (London, England : 1993)
(2018)
27
(doi: 10.1016/j.str.2018.09.011)
Posttranslational chemical mutagenesis: to reveal the role of non-catalytic cysteine residues in pathogenic bacterial phosphatases
JB Bertoldo, H Terenzi, S Hüttelmaier, GJL Bernardes
Biochemistry
(2018)
57
(doi: 10.1021/acs.biochem.8b00639)
Statistical Mechanics of Globular Oligomer Formation by Protein Molecules
AJ Dear, A Šarić, TCT Michaels, CM Dobson, TPJ Knowles
The journal of physical chemistry. B
(2018)
122
(doi: 10.1021/acs.jpcb.8b07805)
Direct observation of murine prion protein replication in vitro
JC Sang, G Meisl, AM Thackray, L Hong, A Ponjavic, TPJ Knowles, R Bujdoso, D Klenerman
J Am Chem Soc
(2018)
140
(doi: 10.1021/jacs.8b08311)
¬Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells
DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, RT Ranasinghe, SE Sanchez, D Athauda, SF Lee, CM Dobson, S Gandhi, M-G Spillantini, D Klenerman, MH Horrocks
ChemBioChem
(2018)
19
(doi: 10.1002/cbic.201800209)
A bioinformatics approach to define the aggregation capacity of the myofiber proteome in inclusion body myositis
C Weihl, P Ciryam, A Guttsches, K Marcus, R Morimoto, M Vendruscolo, R Kley
Neuromuscular Disorders
(2018)
28
(doi: 10.1016/j.nmd.2018.06.188)
SAR by kinetics for drug discovery in protein misfolding diseases.
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
Proceedings of the National Academy of Sciences
(2018)
115
(doi: 10.1073/pnas.1807884115)
Yusuf Hamied Department of Chemistry
Lensfield Road
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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