Centre for Misfolding Diseases

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  • Currently displaying 841 - 860 of 2401 publications
Author(s)
Publication title
Journal Name
Publication year
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
ACS Chem Neurosci
(2019)
10
(doi: 10.1021/acschemneuro.8b00676)
Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage
I Compañón, A Guerreiro, V Mangini, J Castro-López, M Escudero-Casao, A Avenoza, JH Busto, S Castillón, J Jiménez-Barbero, JL Asensio, G Jiménez-Osés, O Boutureira, JM Peregrina, R Hurtado-Guerrero, R Fiammengo, GJL Bernardes, F Corzana
Journal of the American Chemical Society
(2019)
141
(doi: 10.1021/jacs.8b13503)
Atomic force microscopy for single molecule characterisation of protein aggregation.
FS Ruggeri, T Šneideris, M Vendruscolo, TPJ Knowles
Archives of Biochemistry and Biophysics
(2019)
664
(doi: 10.1016/j.abb.2019.02.001)
A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone.
AM da Silva Neto, SR Silva, M Vendruscolo, C Camilloni, RW Montalvão
Proteins Structure Function and Bioinformatics
(2019)
87
(doi: 10.1002/prot.25652)
Targeting the Formation of Amyloid Oligomers using Rationally Designed Antibodies
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TP Knowles, CM Dobson, M Vendruscolo
Biophysical Journal
(2019)
116
(doi: 10.1016/j.bpj.2018.11.196)
Structure and Dynamics of Alzheimer's Associated Amyloid-Beta Peptide
T Löhr, K Kohlhoff, G Heller, M Vendruscolo
Biophysical Journal
(2019)
116
(doi: 10.1016/j.bpj.2018.11.2352)
Probing Specificity in Disordered Protein Interactions with Small Molecules using Integrative Methods
GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, M Vendruscolo
Biophysical Journal
(2019)
116
(doi: 10.1016/j.bpj.2018.11.998)
In vitro and in silico assessment of the developability of a designed monoclonal antibody library.
A-M Wolf Pérez, P Sormanni, JS Andersen, LI Sakhnini, I Rodriguez-Leon, JR Bjelke, AJ Gajhede, L De Maria, DE Otzen, M Vendruscolo, N Lorenzen
mAbs
(2019)
11
(doi: 10.1080/19420862.2018.1556082)
Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation.
M Ahn, BI Lee, S Chia, J Habchi, JR Kumita, M Vendruscolo, CM Dobson, CB Park
Chemical communications (Cambridge, England)
(2019)
55
(doi: 10.1039/c8cc09288e)
De novo design of potent and selective mimics of IL-2 and IL-15.
D-A Silva, S Yu, UY Ulge, JB Spangler, KM Jude, C Labão-Almeida, LR Ali, A Quijano-Rubio, M Ruterbusch, I Leung, T Biary, SJ Crowley, E Marcos, CD Walkey, BD Weitzner, F Pardo-Avila, J Castellanos, L Carter, L Stewart, SR Riddell, M Pepper, GJL Bernardes, M Dougan, KC Garcia, D Baker
Nature
(2019)
565
(doi: 10.1038/s41586-018-0830-7)
Effects of α-tubulin acetylation on microtubule structure and stability
L Eshun-Wilson, R Zhang, D Portran, M Nachury, D Toso, T Lohr, M Vendruscolo, M Bonomi, JS Fraser, E Nogales
(2019)
(doi: 10.1101/516591)
Physical Determinants of Amyloid Assembly in Biofilm Formation.
M Andreasen, G Meisl, JD Taylor, TCT Michaels, A Levin, DE Otzen, MR Chapman, CM Dobson, SJ Matthews, TPJ Knowles
mBio
(2019)
10
(doi: 10.1128/mBio.02279-18)
Efficient and irreversible antibody-cysteine bioconjugation using carbonylacrylic reagents
B Bernardim, MJ Matos, X Ferhati, I Compañón, A Guerreiro, P Akkapeddi, ACB Burtoloso, G Jiménez-Osés, F Corzana, GJL Bernardes
Nat Protoc
(2019)
14
(doi: 10.1038/s41596-018-0083-9)
Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis
MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles
Analyst
(2019)
144
(doi: 10.1039/C9AN00382G)
Lysine Bioconjugation on Native Albumin with a Sulfonyl Acrylate Reagent.
MJ Matos, G Jiménez-Osés, GJL Bernardes
Methods Mol Biol
(2019)
2033
(doi: 10.1007/978-1-4939-9654-4_3)
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Y-C Liao, M Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, T Knowles, M Nelson, M Czekalska, G Musteikyte, R Patel, C Stephens, A Pasolli, L Forrest, P St George-Hyslop, J Lippincott-Schwartz, ME Ward
(2019)
(doi: 10.2139/ssrn.3312723)
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
JM Kirkpatrick, EK Sacramento, M Mazzetto, S Di Sanzo, C Caterino, A Bartolome, M Sanguanini, N Papaevgeniou, M Lefaki, D Childs, E Terzibasi-Tozzini, N Romanov, M Baumgart, W Huber, N Chondrogianni, M Vendruscolo, A Cellerino, A Ori
MOLECULAR & CELLULAR PROTEOMICS
(2019)
18
The presence of autoantibodies against the prion protein is independent of PRNP mutations
K Frontzek, M Carta, M Losa, M Epskamp, G Meisl, U Camenisch, T Knowles, S Hornemann, A Aguzzi
PRION
(2019)
13
General sol to gel transition of liquid-liqud phase separated protein under shear
Y Shen, S Qamar, D Vigolo, A Kamada, S Zhang, P St George-Hyslop, T Knowles
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2019)
48
Cytosolic aggregation of mitochondrial precursor proteins stimulates degeneration of cellular homeostasis
U Nowicka, P Chroscicki, K Stroobants, M Sladowska, M Turek, B Uszczynska-Ratajczak, R Kundra, T Goral, M Vendruscolo, A Chacinska
FEBS OPEN BIO
(2019)
9
Yusuf Hamied Department of Chemistry
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