Centre for Misfolding Diseases

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  • Currently displaying 821 - 840 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
Biophysical Techniques in Structural Biology
CM Dobson
Annu Rev Biochem
(2019)
88
(doi: 10.1146/annurev-biochem-013118-111947)
3D Microfluidics Spray Nozzle for Sample Processing and Materials Deposition
T Kartanas, R Rodrigues, T Müller, T Herling, T Knowles, J Charmet
AIP Conference Proceedings
(2019)
2096
(doi: 10.1063/1.5096675)
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions.
P Kukic, GM Lo Piccolo, MO Nogueira, DI Svergun, M Vendruscolo, IC Felli, R Pierattelli
Sci Rep
(2019)
9
(doi: 10.1038/s41598-019-41925-4)
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez‐Osés, GJL Bernardes
Angewandte Chemie
(2019)
131
(doi: 10.1002/ange.201901405)
ADSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
(2019)
(doi: 10.1101/600346)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
Nat Commun
(2019)
10
(doi: 10.1038/s41467-019-09477-3)
The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS.
JJ Yerbury, L Ooi, IP Blair, P Ciryam, CM Dobson, M Vendruscolo
Neuroscience Letters
(2019)
704
(doi: 10.1016/j.neulet.2019.04.001)
The Amyloid Phenomenon and Its Significance in Biology and Medicine.
CM Dobson, TPJ Knowles, M Vendruscolo
Cold Spring Harb Perspect Biol
(2019)
12
(doi: 10.1101/cshperspect.a033878)
Synthesis, Characterization and Biological Evaluation of New Manganese Metal Carbonyl Compounds That Contain Sulfur and Selenium Ligands as a Promising New Class of CORMs
AL Amorim, MM Peterle, A Guerreiro, DF Coimbra, RS Heying, GF Caramori, AL Braga, AJ Bortoluzzi, A Neves, GJL Bernardes, R Peralta
Dalton Transactions
(2019)
48
(doi: 10.1039/c9dt00616h)
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species.
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
Chem Sci
(2019)
10
(doi: 10.1039/c8sc05627g)
Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells
LJ Alcock, BL Oliveira, MJ Deery, TL Pukala, MV Perkins, GJL Bernardes, JM Chalker
ACS Chem Biol
(2019)
14
(doi: 10.1021/acschembio.8b01104)
Azabicyclic vinyl sulfones for residue-specific dual protein labelling.
E Gil de Montes, E Jiménez-Moreno, BL Oliveira, CD Navo, PMSD Cal, G Jiménez-Osés, I Robina, AJ Moreno-Vargas, GJL Bernardes
Chemical Science
(2019)
10
(doi: 10.1039/c9sc00125e)
Natural product-drug conjugates for modulation of TRPV1-expressing tumors.
C Baker, T Rodrigues, BP de Almeida, NL Barbosa-Morais, GJL Bernardes
Bioorg Med Chem
(2019)
27
(doi: 10.1016/j.bmc.2019.03.025)
Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide
JH Cater, JR Kumita, R Zeineddine Abdallah, G Zhao, A Bernardo-Gancedo, A Henry, W Winata, M Chi, BSF Grenyer, ML Townsend, M Ranson, CS Buhimschi, DS Charnock-Jones, CM Dobson, MR Wilson, IA Buhimschi, AR Wyatt
Proc Natl Acad Sci U S A
(2019)
116
(doi: 10.1073/pnas.1817298116)
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia
P Akkapeddi, R Fragoso, JA Hixon, AS Ramalho, ML Oliveira, T Carvalho, A Gloger, M Matasci, F Corzana, SK Durum, D Neri, GJL Bernardes, JT Barata
Leukemia
(2019)
33
(doi: 10.1038/s41375-019-0434-8)
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles
Macromolecular Rapid Communications
(2019)
40
(doi: 10.1002/marc.201800898)
A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli
K Sanagavarapu, E Nüske, I Nasir, G Meisl, JN Immink, P Sormanni, M Vendruscolo, TPJ Knowles, A Malmendal, C Cabaleiro-Lago, S Linse
Scientific reports
(2019)
9
(doi: 10.1038/s41598-019-39216-z)
Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis.
P Sormanni, M Vendruscolo
Cold Spring Harb Perspect Biol
(2019)
11
(doi: 10.1101/cshperspect.a033845)
Contemporary approaches to site-selective protein modification
EA Hoyt, PMSD Cal, BL Oliveira, GJL Bernardes
Nature Reviews Chemistry
(2019)
3
(doi: 10.1038/s41570-019-0079-1)
A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism
VE Zwicker, BL Oliveira, JH Yeo, ST Fraser, GJL Bernardes, EJ New, KA Jolliffe
Angewandte Chemie
(2019)
131
(doi: 10.1002/ange.201812489)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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