Centre for Misfolding Diseases

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  • Currently displaying 661 - 680 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
Spatially-segmented single-cell transcriptomics by diffusional accessibility to a small-molecule dye
DB Morse, M Ceribelli, J De Jonghe, A Michalowski, C Muus, M Vias, S Boyle, DA Weitz, J Brenton, JD Buenrostro, C Thomas, TP Knowles
Cancer Research
(2020)
80
(doi: 10.1158/1538-7445.AM2020-5879)
Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils
J Yang, AJ Dear, Q-Q Yao, Z Liu, CM Dobson, TPJ Knowles, S Wu, S Perrett
Nanoscale
(2020)
12
(doi: 10.1039/d0nr01481h)
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
R Limbocker, B Mannini, FS Ruggeri, R Cascella, CK Xu, M Perni, S Chia, SW Chen, J Habchi, A Bigi, RP Kreiser, AK Wright, JA Albright, T Kartanas, JR Kumita, N Cremades, M Zasloff, C Cecchi, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
Communications Biology
(2020)
3
(doi: 10.1038/s42003-020-01140-8)
Kinetic analysis reveals the rates and mechanisms of protein aggregation in a multicellular organism
T Sinnige, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, RI Morimoto
(2020)
(doi: 10.1101/2020.08.13.249862)
Microfluidic Templating: Microfluidic Templating of Spatially Inhomogeneous Protein Microgels (Small 32/2020)
Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles
Small
(2020)
16
(doi: 10.1002/smll.202070178)
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation.
P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, M Vendruscolo, S Linse, D Klenerman, TPJ Knowles, CM Dobson
Nature Structural & Molecular Biology
(2020)
27
(doi: 10.1038/s41594-020-0471-z)
Tetrazine Carbon Nanotubes for Pretargeted In Vivo “Click‐to‐Release” Bioorthogonal Tumour Imaging
H Li, J Conde, A Guerreiro, GJL Bernardes
Angewandte Chemie International Edition
(2020)
59
(doi: 10.1002/anie.202008012)
Tetrazine Carbon Nanotubes for Pretargeted In Vivo “Click‐to‐Release” Bioorthogonal Tumour Imaging
H Li, J Conde, A Guerreiro, GJL Bernardes
Angewandte Chemie International Edition
(2020)
59
(doi: 10.1002/ange.202008012)
Tetrazine Carbon Nanotubes for Pretargeted In Vivo “Click‐to‐Release” Bioorthogonal Tumour Imaging
H Li, J Conde, A Guerreiro, GJL Bernardes
Angewandte Chemie
(2020)
132
(doi: 10.1002/ange.202010067)
Back Cover: Tetrazine Carbon Nanotubes for Pretargeted In Vivo “Click‐to‐Release” Bioorthogonal Tumour Imaging (Angew. Chem. Int. Ed. 37/2020)
H Li, J Conde, A Guerreiro, GJL Bernardes
Angewandte Chemie International Edition
(2020)
59
(doi: 10.1002/anie.202010067)
Phase Transition and Crystallization Kinetics of a Supramolecular System in a Microfluidic Platform
D Cohen-Gerassi, ZA Arnon, T Guterman, A Levin, M Ghosh, M Aviv, D Levy, TPJ Knowles, Y Shacham-Diamand, L Adler-Abramovich
Chemistry of Materials
(2020)
32
(doi: 10.1021/acs.chemmater.0c02187)
Real-Time Highly-Sensitive Protein Quantification Through On-Chip Chemiluminescence
HK Chiu, T Kartanas, S R. A. Devenish, K Saar, C Mouritsen Luxhøj, T Knowles
(2020)
(doi: 10.26434/chemrxiv.12646376.v1)
Half a century of amyloids: past, present and future
PC Ke, R Zhou, LC Serpell, R Riek, TPJ Knowles, HA Lashuel, E Gazit, IW Hamley, TP Davis, M Fändrich, DE Otzen, MR Chapman, CM Dobson, DS Eisenberg, R Mezzenga
Chemical Society reviews
(2020)
49
(doi: 10.1039/c9cs00199a)
Continuous Flow Reactors from Microfluidic Compartmentalization of Enzymes within Inorganic Microparticles
TA Hakala, F Bialas, Z Toprakcioglu, B Bräuer, KN Baumann, A Levin, GJL Bernardes, CFW Becker, TPJ Knowles
ACS Applied Materials and Interfaces
(2020)
12
(doi: 10.1021/acsami.0c09226)
Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers
R Limbocker, B Mannini, R Cataldi, S Chhangur, AK Wright, RP Kreiser, JA Albright, S Chia, J Habchi, P Sormanni, JR Kumita, FS Ruggeri, CM Dobson, F Chiti, FA Aprile, M Vendruscolo
International Journal of Molecular Sciences
(2020)
21
(doi: 10.3390/ijms21124542)
Multidimensional protein characterisation using microfluidic post-column analysis.
T Scheidt, T Kartanas, Q Peter, MM Schneider, KL Saar, T Müller, PK Challa, A Levin, S Devenish, TPJ Knowles
Lab Chip
(2020)
20
(doi: 10.1039/d0lc00219d)
Infrared Nanospectroscopy Reveals the Molecular Interaction Fingerprint of an Aggregation Inhibitor with Single Aβ42 Oligomers
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles
(2020)
(doi: 10.1101/2020.06.24.168997)
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.
E Kelmer Sacramento, JM Kirkpatrick, M Mazzetto, M Baumgart, A Bartolome, S Di Sanzo, C Caterino, M Sanguanini, N Papaevgeniou, M Lefaki, D Childs, S Bagnoli, E Terzibasi Tozzini, D Di Fraia, N Romanov, PH Sudmant, W Huber, N Chondrogianni, M Vendruscolo, A Cellerino, A Ori
Molecular Systems Biology
(2020)
16
(doi: 10.15252/msb.20209596)
Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses.
J Pansieri, IA Iashchishyn, H Fakhouri, L Ostojić, M Malisauskas, G Musteikyte, V Smirnovas, MM Schneider, T Scheidt, CK Xu, G Meisl, TPJ Knowles, E Gazit, R Antoine, LA Morozova-Roche
Chemical Science
(2020)
11
(doi: 10.1039/c9sc05905a)
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.
FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo
Proceedings of the National Academy of Sciences
(2020)
117
(doi: 10.1073/pnas.1919464117)
Yusuf Hamied Department of Chemistry
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