Centre for Misfolding Diseases

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  • Currently displaying 701 - 720 of 2486 publications
Author(s)
Publication title
Journal Name
Publication year
Construction of a liquid-liquid phase separation system from the gel-sol transition of elongated protein microgels in a crowding agent
Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
(2020)
(doi: 10.1101/2020.12.08.416867)
In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry.
VFC Ferreira, BL Oliveira, A D'Onofrio, CM Farinha, L Gano, A Paulo, GJL Bernardes, F Mendes
Bioconjugate chemistry
(2020)
32
(doi: 10.1021/acs.bioconjchem.0c00551)
Sequence determinants of the aggregation of proteins within condensates generated by liquid-liquid phase separation
M Vendruscolo, M Fuxreiter
(2020)
(doi: 10.1101/2020.12.07.414409)
Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis.
PR Lindstedt, FA Aprile, P Sormanni, R Rakoto, CM Dobson, GJL Bernardes, M Vendruscolo
Cell Chem Biol
(2020)
28
(doi: 10.1016/j.chembiol.2020.11.002)
Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases (vol 53, 1, 2020)
T Sinnige, K Stroobants, CM Dobson, M Vendruscolo
Quarterly reviews of biophysics
(2020)
53
(doi: 10.1017/s0033583520000104)
Adaptive Optimization of Chemical Reactions with Minimal Experimental Information
D Reker, EA Hoyt, GJL Bernardes, T Rodrigues
Cell Reports Physical Science
(2020)
1
(doi: 10.1016/j.xcrp.2020.100247)
Perphenazine-macrocycle conjugates rapidly sequester the Aβ42 monomer and inhibit amyloid formation
SR Ball, JSP Adamson, MA Sullivan, MR Zimmermann, V Lo, M Sanz-Hernandez, F Jiang, AH Kwan, EL Werry, TPJ Knowles, M Kassiou, G Meisl, MH Todd, PJ Rutledge, M Sunde
(2020)
(doi: 10.1101/2020.11.16.384248)
Amplification, not spreading limits rate of tau aggregate accumulation in Alzheimer’s disease
G Meisl, Y Zuo, K Allinson, T Rittman, S DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles, D Klenerman
(2020)
(doi: 10.1101/2020.11.16.384727)
Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers
RP Kreiser, AK Wright, NR Block, JE Hollows, LT Nguyen, K LeForte, B Mannini, M Vendruscolo, R Limbocker
Int J Mol Sci
(2020)
21
(doi: 10.3390/ijms21228651)
Machine learning aided top-down proteomics on a microfluidic platform
Y Zhang, MA Wright, KL Saar, P Challa, AS Morgunov, QAE Peter, S Devenish, CM Dobson, TPJ Knowles
(2020)
(doi: 10.1101/2020.11.14.381376)
Hamiltonian Dynamics of Saturated Elongation in Amyloid Fiber Formation
L Hong, X Liu, TCT Michaels, TPJ Knowles
(2020)
(doi: 10.48550/arxiv.2011.06222)
On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide.
GA Braun, BE Ary, AJ Dear, MCH Rohn, AM Payson, DSM Lee, RC Parry, C Friedman, TPJ Knowles, S Linse, KS Åkerfeldt
Biomacromolecules
(2020)
21
(doi: 10.1021/acs.biomac.0c00989)
Structural Characterization of an Unprecedented Lectin-like Antitumoral anti-MUC1 Antibody
J Macías-León, IA Bermejo, A Asín, A García-García, I Compañón, E Jiménez-Moreno, H Coelho, V Mangini, IS Albuquerque, F Marcelo, JL Asensio, GJL Bernardes, HJ Joshi, R Fiammengo, O Blixt, R Hurtado-Guerrero, F Corzana
Chemical Communications
(2020)
56
(doi: 10.1039/d0cc06349e)
A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms
ZF Brotzakis, PR Lindstedt, R Taylor, GJL Bernardes, M Vendruscolo
biorxiv
(2020)
(doi: 10.1101/2020.11.10.376285)
Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide
P Henriques, L Dello Iacono, A Gimeno, A Biolchi, MR Romano, A Arda, GJL Bernardes, J Jimenez-Barbero, F Berti, R Rappuoli, R Adamo
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
(doi: 10.1073/pnas.2011385117)
Amyloid precipitation in biofluids using a structure-specific chemical antibody
M Rodrigues, P Bhattacharjee, A Brinkmalm, D Do, C Pearson, S De, A Ponjavic, J Varela, F Ruggeri, I Baudrexel, J Lee, A Carr, K Kulenkampff, T Knowles, H Zetterberg, T Snaddon, S Gandhi, S Lee, D Klenerman
(2020)
(doi: 10.21203/rs.3.rs-81521/v1)
Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage <i>in vitro</i>.
D Frankel, M Davies, B Bhushan, Y Kulaberoglu, P Urriola-Munoz, J Bertrand-Michel, MR Pergande, AA Smith, S Preet, TJ Park, M Vendruscolo, KS Rankin, SM Cologna, JR Kumita, N Cenac, E St John Smith
Aging
(2020)
12
(doi: 10.18632/aging.202138)
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, IC Felli, R Pierattelli, TPJ Knowles, CM Dobson, M Vendruscolo
Science advances
(2020)
6
(doi: 10.1126/sciadv.abb5924)
The Hsc70 Disaggregation Machinery Removes Monomer Units Directly from α-Synuclein Fibril Ends
MM Schneider, S Gautam, TW Herling, E Andrzejewska, G Krainer, AM Miller, QAE Peter, FS Ruggeri, M Vendruscolo, A Bracher, CM Dobson, FU Hartl, TPJ Knowles
(2020)
(doi: 10.1101/2020.11.02.365825)
Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates
N Ahmed, UA Friedrich, P Sormanni, P Ciryam, NS Altman, B Bukau, G Kramer, EP O'Brien
Journal of molecular biology
(2020)
432
(doi: 10.1016/j.jmb.2020.10.030)
Yusuf Hamied Department of Chemistry
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