Centre for Misfolding Diseases

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  • Currently displaying 701 - 720 of 2336 publications
Author(s)
Publication title
Journal Name
Publication year
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez‐Osés, GJL Bernardes
Angewandte Chemie
(2019)
131
(doi: 10.1002/ange.201901405)
ADSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
S De, D Whiten, F Ruggeri, C Hughes, M Rodrigues, D Sideris, C Taylor, F Aprile, S Muyldermans, T Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
(2019)
(doi: 10.1101/600346)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
Nat Commun
(2019)
10
(doi: 10.1038/s41467-019-09477-3)
The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS.
JJ Yerbury, L Ooi, IP Blair, P Ciryam, CM Dobson, M Vendruscolo
Neuroscience letters
(2019)
704
(doi: 10.1016/j.neulet.2019.04.001)
Synthesis, characterization and biological evaluation of new manganese metal carbonyl compounds that contain sulfur and selenium ligands as a promising new class of CORMs.
AL Amorim, MM Peterle, A Guerreiro, DF Coimbra, RS Heying, GF Caramori, AL Braga, AJ Bortoluzzi, A Neves, GJL Bernardes, R Peralta
Dalton transactions (Cambridge, England : 2003)
(2019)
48
(doi: 10.1039/c9dt00616h)
Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells
LJ Alcock, BL Oliveira, MJ Deery, TL Pukala, MV Perkins, GJL Bernardes, JM Chalker
ACS Chemical Biology
(2019)
14
(doi: 10.1021/acschembio.8b01104)
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
Chemical Science
(2019)
10
(doi: 10.1039/c8sc05627g)
Azabicyclic vinyl sulfones for residue-specific dual protein labelling Electronic supplementary information (ESI) available: Detailed methods and additional characterisation. See DOI: 10.1039/c9sc00125e
E Gil de Montes, E Jiménez-Moreno, BL Oliveira, CD Navo, PMSD Cal, G Jiménez-Osés, I Robina, AJ Moreno-Vargas, GJL Bernardes
Chemical Science
(2019)
10
(doi: 10.1039/c9sc00125e)
Natural product-drug conjugates for modulation of TRPV1-expressing tumors
C Baker, T Rodrigues, BP de Almeida, NL Barbosa-Morais, GJL Bernardes
Bioorg Med Chem
(2019)
27
(doi: 10.1016/j.bmc.2019.03.025)
Human pregnancy zone protein stabilises misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide
JH Cater, JR Kumita, R Zeineddine Abdallah, G Zhao, A Bernardo-Gancedo, A Henry, W Winata, M Chi, BSF Grenyer, ML Townsend, M Ranson, CS Buhimschi, DS Charnock-Jones, CM Dobson, MR Wilson, IA Buhimschi, AR Wyatt
Proceedings of the National Academy of Sciences
(2019)
116
(doi: 10.1073/pnas.1817298116)
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.
P Akkapeddi, R Fragoso, JA Hixon, AS Ramalho, ML Oliveira, T Carvalho, A Gloger, M Matasci, F Corzana, SK Durum, D Neri, GJL Bernardes, JT Barata
Leukemia
(2019)
33
(doi: 10.1038/s41375-019-0434-8)
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N‑Terminally Truncated Aβ42 Species Aβ5–42
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
ACS Chem Neurosci
(2019)
10
(doi: 10.1021/acschemneuro.8b00676)
A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli.
K Sanagavarapu, E Nüske, I Nasir, G Meisl, JN Immink, P Sormanni, M Vendruscolo, TPJ Knowles, A Malmendal, C Cabaleiro-Lago, S Linse
Scientific Reports
(2019)
9
(doi: 10.1038/s41598-019-39216-z)
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles
Macromolecular Rapid Communications
(2019)
40
(doi: 10.1002/marc.201800898)
Contemporary approaches to site-selective protein modification
EA Hoyt, PMSD Cal, BL Oliveira, GJL Bernardes
Nature Reviews Chemistry
(2019)
3
(doi: 10.1038/s41570-019-0079-1)
A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism
VE Zwicker, BL Oliveira, JH Yeo, ST Fraser, GJL Bernardes, EJ New, KA Jolliffe
Angewandte Chemie
(2019)
131
(doi: 10.1002/ange.201812489)
Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage.
I Compañón, A Guerreiro, V Mangini, J Castro-López, M Escudero-Casao, A Avenoza, JH Busto, S Castillón, J Jiménez-Barbero, JL Asensio, G Jiménez-Osés, O Boutureira, JM Peregrina, R Hurtado-Guerrero, R Fiammengo, GJL Bernardes, F Corzana
J Am Chem Soc
(2019)
141
(doi: 10.1021/jacs.8b13503)
Atomic force microscopy for single molecule characterisation of protein aggregation
FS Ruggeri, T Šneideris, M Vendruscolo, TPJ Knowles
Archives of biochemistry and biophysics
(2019)
664
(doi: 10.1016/j.abb.2019.02.001)
A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone
AM da Silva Neto, SR Silva, M Vendruscolo, C Camilloni, RW Montalvão
Proteins
(2019)
87
(doi: 10.1002/prot.25652)
Structure and Dynamics of Alzheimer's Associated Amyloid-Beta Peptide
T Lohr, K Kohlhoff, G Heller, M Vendruscolo
Biophysical Journal
(2019)
116
(doi: 10.1016/j.bpj.2018.11.2352)
Yusuf Hamied Department of Chemistry
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