Centre for Misfolding Diseases

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  • Currently displaying 641 - 660 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase
AE Conicella, R Huang, ZA Ripstein, A Nguyen, E Wang, T Löhr, P Schuck, M Vendruscolo, JL Rubinstein, LE Kay
Proceedings of the National Academy of Sciences
(2020)
117
(doi: 10.1073/pnas.2013920117)
The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils.
D Thacker, K Sanagavarapu, B Frohm, G Meisl, TPJ Knowles, S Linse
Proceedings of the National Academy of Sciences
(2020)
117
(doi: 10.1073/pnas.2002956117)
The role of clearance mechanisms in the kinetics of toxic protein aggregates involved in neurodegenerative diseases
TB Thompson, G Meisl, T Knowles, A Goriely
(2020)
(doi: 10.48550/arxiv.2009.14135)
Deformable and robust core-shell protein microcapsules templated by liquid-liquid phase separated microdroplets
Y Xu, Y Shen, TCT Michaels, KN Baumann, D Vigolo, Q Peter, Y Lu, KL Saar, D Vella, H Zhu, B Li, H Yang, APM Guttenplan, M Rodriguez-Garcia, D Klenerman, TPJ Knowles
(2020)
(doi: 10.48550/arxiv.2009.13413)
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies.
S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, E Sileikis, M Lundqvist, F Qian, T O'Malley, T Bussiere, PH Weinreb, CK Xu, G Meisl, SRA Devenish, TPJ Knowles, O Hansson
Nature Structural & Molecular Biology
(2020)
27
(doi: 10.1038/s41594-020-0505-6)
Sequential dual site-selective protein labelling enabled by lysine modification.
MJ Matos, L Brown, B Bernardim, A Guerreiro, G Jiménez-Osés, GJL Bernardes
Bioorganic & Medicinal Chemistry
(2020)
28
(doi: 10.1016/j.bmc.2020.115783)
Serine-Selective Bioconjugation.
JC Vantourout, SR Adusumalli, KW Knouse, DT Flood, A Ramirez, NM Padial, A Istrate, K Maziarz, JN deGruyter, RR Merchant, JX Qiao, MA Schmidt, MJ Deery, MD Eastgate, PE Dawson, GJL Bernardes, PS Baran
Journal of the American Chemical Society
(2020)
142
(doi: 10.1021/jacs.0c05595)
Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of COVID-19 Survivors
MM Schneider, M Emmenegger, CK Xu, IC Morales, G Meisl, P Turelli, C Zografou, MR Zimmermann, BM Frey, S Fiedler, V Denninger, RPB Jacquat, L Madrigal, A Ilsley, V Kosmoliaptsis, H Fiegler, D Trono, TPJ Knowles, A Aguzzi
medRxiv
(2020)
(doi: 10.1101/2020.09.20.20196907)
Converting lateral scanning into axial focusing to speed up three-dimensional microscopy.
T Chakraborty, B Chen, S Daetwyler, B-J Chang, O Vanderpoorten, E Sapoznik, CF Kaminski, TPJ Knowles, KM Dean, R Fiolka
Light Sci Appl
(2020)
9
(doi: 10.1038/s41377-020-00401-9)
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition.
Y Shen, FS Ruggeri, D Vigolo, A Kamada, S Qamar, A Levin, C Iserman, S Alberti, PS George-Hyslop, TPJ Knowles
Nature Nanotechnology
(2020)
15
(doi: 10.1038/s41565-020-0731-4)
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease
T Ikenoue, FA Aprile, P Sormanni, FS Ruggeri, M Perni, GT Heller, CP Haas, C Middel, R Limbocker, B Mannini, TCT Michaels, TPJ Knowles, CM Dobson, M Vendruscolo
Sci Rep
(2020)
10
(doi: 10.1038/s41598-020-69626-3)
Biomimetic peptide self-assembly for functional materials
A Levin, TA Hakala, L Schnaider, GJL Bernardes, E Gazit, TPJ Knowles
Nature Reviews Chemistry
(2020)
4
(doi: 10.1038/s41570-020-0215-y)
Microfluidic Antibody Affinity Profiling for In-Solution Characterisation of Alloantibody - HLA Interactions in Human Serum
MM Schneider, T Scheidt, AJ Priddey, CK Xu, M Hu, SRA Devenish, G Meisl, CM Dobson, V Kosmoliaptsis, TPJ Knowles
bioRxiv
(2020)
(doi: 10.1101/2020.09.14.296442)
Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
TCT Michaels, A Šarić, G Meisl, GT Heller, S Curk, P Arosio, S Linse, CM Dobson, M Vendruscolo, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
(doi: 10.1073/pnas.2006684117)
Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors
JD Seixas, BB Sousa, MC Marques, A Guerreiro, R Traquete, T Rodrigues, IS Albuquerque, MFQ Sousa, AR Lemos, PMF Sousa, TM Bandeiras, D Wu, SK Doyle, CV Robinson, AN Koehler, F Corzana, PM Matias, GJL Bernardes
Rsc Chemical Biology
(2020)
1
(doi: 10.1039/d0cb00033g)
Selective N-Terminal Cysteine Protein Modification with Cyclopropenones
A Istrate, CD Navo, BB Sousa, MC Marques, M Deery, A Bond, F Corzana, G Jiménez-Osés, G Bernardes
(2020)
(doi: 10.26434/chemrxiv.12866873.v1)
Selective N-Terminal Cysteine Protein Modification with Cyclopropenones
A Istrate, CD Navo, BB Sousa, MC Marques, M Deery, A Bond, F Corzana, G Jiménez-Osés, G Bernardes
(2020)
(doi: 10.26434/chemrxiv.12866873)
Protein–Protein Conjugates: Tyrosine Delivers
MB Geeson, GJL Bernardes
ACS Cent Sci
(2020)
6
(doi: 10.1021/acscentsci.0c01008)
Mechanism, scaling and rates of protein aggregation from in vivo measurements
G Meisl, AJ Dear, TC Michaels, TP Knowles
(2020)
(doi: 10.48550/arxiv.2008.09699)
A scalable insect cell-based production process of the human recombinant BMX for in-vitro covalent ligand high-throughput screening
BB Sousa, MFQ Sousa, MC Marques, JD Seixas, JA Brito, PM Matias, GJL Bernardes, A Roldão
Bioprocess Biosyst Eng
(2020)
44
(doi: 10.1007/s00449-020-02421-6)
Yusuf Hamied Department of Chemistry
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