Centre for Misfolding Diseases

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  • Currently displaying 621 - 640 of 2398 publications
Author(s)
Publication title
Journal Name
Publication year
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
E Kelmer Sacramento, JM Kirkpatrick, M Mazzetto, M Baumgart, A Bartolome, S Di Sanzo, C Caterino, M Sanguanini, N Papaevgeniou, M Lefaki, D Childs, S Bagnoli, E Terzibasi Tozzini, D Di Fraia, N Romanov, PH Sudmant, W Huber, N Chondrogianni, M Vendruscolo, A Cellerino, A Ori
Molecular Systems Biology
(2020)
16
(doi: 10.15252/msb.20209596)
Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses.
J Pansieri, IA Iashchishyn, H Fakhouri, L Ostojić, M Malisauskas, G Musteikyte, V Smirnovas, MM Schneider, T Scheidt, CK Xu, G Meisl, TPJ Knowles, E Gazit, R Antoine, LA Morozova-Roche
Chem Sci
(2020)
11
(doi: 10.1039/c9sc05905a)
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.
FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
(doi: 10.1073/pnas.1919464117)
Microfluidic Templating of Spatially Inhomogeneous Protein Microgels.
Y Xu, RPB Jacquat, Y Shen, D Vigolo, D Morse, S Zhang, TPJ Knowles
Small (Weinheim an der Bergstrasse, Germany)
(2020)
16
(doi: 10.1002/smll.202000432)
Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy.
FS Ruggeri, B Mannini, R Schmid, M Vendruscolo, TPJ Knowles
Nat Commun
(2020)
11
(doi: 10.1038/s41467-020-16728-1)
Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation.
BL Oliveira, BJ Stenton, VB Unnikrishnan, CR de Almeida, J Conde, M Negrão, FSS Schneider, C Cordeiro, MG Ferreira, GF Caramori, JB Domingos, R Fior, GJL Bernardes
Journal of the American Chemical Society
(2020)
142
(doi: 10.1021/jacs.0c01622)
Identification of on- And off-pathway oligomers in amyloid fibril formation
AJ Dear, G Meisl, A Šarić, TCT Michaels, M Kjaergaard, S Linse, TPJ Knowles
Chemical Science
(2020)
11
(doi: 10.1039/c9sc06501f)
High Resolution Biomolecular Condensate Phase Diagrams with a Combinatorial Microdroplet Platform
W Arter, R Qi, N Erkamp, G Krainer, K Didi, T Welsh, J Acker, J Nixon-Abell, J Nixon-Abell, S Qamar, J Guillén-Boixet, T Franzmann, D Kuster, A Hyman, A Borodavka, P St George-Hyslop, S Alberti, TPJ Knowles
(2020)
(doi: 10.1101/2020.06.04.132308)
Lipid membranes from naked mole-rat brain lipids are cholesterol-rich, highly phase-separated, and sensitive to amyloid-induced damage
D Frankel, M Davies, B Bhushan, Y Kulaberoglu, P Urriola-Munoz, J Bertrand-Michel, MR Pergande, AA Smith, S Preet, TJ Park, M Vendruscolo, K Rankin, SM Cologna, JR Kumita, N Cenac, ES John Smith
(2020)
(doi: 10.1101/2020.06.05.134973)
Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases
T Sinnige, K Stroobants, CM Dobson, M Vendruscolo
Q Rev Biophys
(2020)
49
(doi: 10.1017/s0033583520000025)
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors
K McAulay, EA Hoyt, M Thomas, M Schimpl, MS Bodnarchuk, HJ Lewis, D Barratt, D Bhavsar, DM Robinson, MJ Deery, DJ Ogg, GJL Bernardes, RA Ward, MJ Waring, JG Kettle
Journal of the American Chemical Society
(2020)
142
(doi: 10.1021/jacs.9b13391)
Synthesis, characterization and photoinduced CO-release by manganese( i ) complexes
AL Amorim, A Guerreiro, VA Glitz, DF Coimbra, AJ Bortoluzzi, GF Caramori, AL Braga, A Neves, GJL Bernardes, RA Peralta
New Journal of Chemistry
(2020)
44
(doi: 10.1039/d0nj02260h)
Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses
J Pansieri, I Iashchishyn, H Fakhouri, L Ostojić, M Malisauskas, G Musteikyte, V Smirnovas, M Schneider, T Scheidt, C Xu, G Meisl, T Knowles, E Gazit, R Antoine, L Morozova-Roche
(2020)
(doi: 10.1101/2020.05.26.116400)
Direct digital sensing of protein biomarkers in solution
G Krainer, K Saar, W Arter, T Welsh, M Czekalska, RPB Jacquat, Q Peter, W Traberg, W Traberg, A Pujari, A Jayaram, P Challa, C Taylor, L-M van der Linden, T Franzmann, R Owens, S Alberti, D Klenerman, TPJ Knowles
BIOPHYSICAL JOURNAL
(2020)
120
(doi: 10.1101/2020.05.24.113498)
Sequence-based prediction of protein binding mode landscapes
A Horvath, M Miskei, V Ambrus, M Vendruscolo, M Fuxreiter
PLoS computational biology
(2020)
16
(doi: 10.1371/journal.pcbi.1007864)
Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit.
WE Arter, Y Yusim, Q Peter, CG Taylor, D Klenerman, UF Keyser, TPJ Knowles
ACS nano
(2020)
14
(doi: 10.1021/acsnano.0c00628)
Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils
M Törnquist, R Cukalevski, U Weininger, G Meisl, TPJ Knowles, T Leiding, A Malmendal, M Akke, S Linse
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
(doi: 10.1073/pnas.1918481117)
Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform
M Koopman, Q Peter, RI Seinstra, M Perni, M Vendruscolo, CM Dobson, TPJ Knowles, EAA Nollen
Nature protocols
(2020)
15
(doi: 10.1038/s41596-020-0321-9)
Precise installation of diazo-tagged side-chains on proteins to enable in vitro and in-cell site-specific labelling
B Bernardim, L Dunsmore, H Li, B Hocking, R Nuñez-Franco, CD Navo, G Jiménez-Osés, ACB Burtoloso, GJL Bernardes
Bioconjug Chem
(2020)
31
(doi: 10.1021/acs.bioconjchem.0c00232)
Kinetic diversity of amyloid oligomers
AJ Dear, TCT Michaels, G Meisl, D Klenerman, S Wu, S Perrett, S Linse, CM Dobson, TPJ Knowles
Proceedings of the National Academy of Sciences
(2020)
117
(doi: 10.1073/pnas.1922267117)
Yusuf Hamied Department of Chemistry
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