Centre for Misfolding Diseases

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  • Currently displaying 621 - 640 of 2487 publications
Author(s)
Publication title
Journal Name
Publication year
Feedback control of protein aggregation.
AJ Dear, TCT Michaels, TPJ Knowles, L Mahadevan
Journal of Chemical Physics
(2021)
155
(doi: 10.1063/5.0055925)
METTL1-mediated m<sup>7</sup>G modification of Arg-TCT tRNA drives oncogenic transformation.
EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, J Lim, D Aspris, E Sendinc, DA Garyfallos, M Gu, R Ali, A Gutierrez, S Mikutis, GJL Bernardes, ES Fischer, A Bradley, GS Vassiliou, FJ Slack, K Tzelepis, RI Gregory
Molecular cell
(2021)
81
(doi: 10.1016/j.molcel.2021.06.031)
DETECTION AND QUANTIFICATION OF IMMUNOLOGICALLY RELEVANT ALLOANTIBODY-HLA INTERACTIONS USING MICROFLUIDIC ANTIBODY AFFINITY PROFILING
A Priddey, M Schneider, G Karahan, T Scheidt, C Xu, G Meisl, H Copley, F Claas, R Buchli, A Mulder, S Heidt, T Knowles, V Kosmoliaptsis
TRANSPLANT INTERNATIONAL
(2021)
34
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response (vol 4, 843, 2021)
P Joshi, M Perni, R Limbocker, B Mannini, S Casford, S Chia, J Habchi, J Labbadia, CM Dobson, M Vendruscolo
Commun Biol
(2021)
4
(doi: 10.17863/CAM.74787)
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies
M Emmenegger, E De Cecco, M Hruska-Plochan, T Eninger, MM Schneider, M Barth, E Tantardini, P de Rossi, M Bacioglu, RG Langston, A Kaganovich, N Bengoa-Vergniory, A Gonzalez-Guerra, M Avar, D Heinzer, R Reimann, LM Häsler, TW Herling, NS Matharu, N Landeck, K Luk, R Melki, PJ Kahle, S Hornemann, TPJ Knowles, MR Cookson, M Polymenidou, M Jucker, A Aguzzi
EMBO molecular medicine
(2021)
13
(doi: 10.15252/emmm.202114745)
Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape
S Fiedler, V Denninger, AS Morgunov, A Ilsley, R Worth, G Meisl, CK Xu, MA Piziorska, F Ricci, AY Malik, SRA Devenish, MM Schneider, V Kosmoliaptsis, A Aguzzi, A Iwasaki, H Fiegler, TPJ Knowles
(2021)
(doi: 10.1101/2021.07.23.453327)
Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2
V Denninger, CK Xu, G Meisl, AS Morgunov, S Fiedler, A Ilsley, M Emmenegger, AY Malik, MA Piziorska, MM Schneider, SRA Devenish, V Kosmoliaptsis, A Aguzzi, H Fiegler, TPJ Knowles
(2021)
(doi: 10.1101/2021.07.23.453352)
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins.
U Nowicka, P Chroscicki, K Stroobants, M Sladowska, M Turek, B Uszczynska-Ratajczak, R Kundra, T Goral, M Perni, CM Dobson, M Vendruscolo, A Chacinska
Elife
(2021)
10
(doi: 10.7554/elife.65484)
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.
K Neukirch, K Alsabil, C-P Dinh, R Bilancia, M Raasch, A Ville, I Cerqua, G Viault, D Bréard, S Pace, V Temml, E Brunner, PM Jordan, MC Marques, K Loeser, A Gollowitzer, S Permann, J Gerstmeier, S Lorkowski, H Stuppner, U Garscha, T Rodrigues, GJL Bernardes, D Schuster, D Séraphin, P Richomme, A Rossi, AS Mosig, F Roviezzo, O Werz, J-J Helesbeux, A Koeberle
J Med Chem
(2021)
64
(doi: 10.1021/acs.jmedchem.1c00806)
Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions
Z Zawada, Z Guo, BL Oliveira, CD Navo, H Li, PMSD Cal, F Corzana, G Jiménez-Osés, GJL Bernardes
Bioconjugate chemistry
(2021)
32
(doi: 10.1021/acs.bioconjchem.1c00276)
Modulation of the Interactions Between α-Synuclein and Lipid Membranes by Post-translational Modifications.
R Bell, M Vendruscolo
Front Neurol
(2021)
12
(doi: 10.3389/fneur.2021.661117)
Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans
M Perni, B Mannini, CK Xu, JR Kumita, CM Dobson, F Chiti, M Vendruscolo
Scientific reports
(2021)
11
(doi: 10.1038/s41598-021-93527-8)
Liquid–Liquid Phase‐Separated Systems from Reversible Gel–Sol Transition of Protein Microgels
Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
Advanced Materials
(2021)
33
(doi: 10.1002/adma.202008670)
The unhappy chaperone
S Linse, K Thalberg, TPJ Knowles
QRB discovery
(2021)
2
(doi: 10.1017/qrd.2021.5)
Protein Conjugation by Electrophilic Alkynylation Using 5-(Alkynyl)dibenzothiophenium Triflates.
V Laserna, A Istrate, K Kafuta, TA Hakala, TPJ Knowles, M Alcarazo, GJL Bernardes
Bioconjugate chemistry
(2021)
32
(doi: 10.1021/acs.bioconjchem.1c00317)
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response
P Joshi, M Perni, R Limbocker, B Mannini, S Casford, S Chia, J Habchi, J Labbadia, CM Dobson, M Vendruscolo
Commun Biol
(2021)
4
(doi: 10.1038/s42003-021-02218-7)
Biomembranes in Bioelectronic Sensing
AK Jayaram, AM Pappa, S Ghosh, ZA Manzer, WC Traberg, TPJ Knowles, S Daniel, RM Owens
Trends Biotechnol
(2021)
40
(doi: 10.1016/j.tibtech.2021.06.001)
Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease.
DI Sideris, JSH Danial, D Emin, FS Ruggeri, Z Xia, YP Zhang, E Lobanova, H Dakin, S De, A Miller, JC Sang, TPJ Knowles, M Vendruscolo, G Fraser, D Crowther, D Klenerman
Brain Commun
(2021)
3
(doi: 10.1093/braincomms/fcab147)
Rational design of oligomer-specific antibodies as diagnostic tools for Alzheimer's and Parkinson's diseases
M Vendruscolo
FEBS OPEN BIO
(2021)
11
Microfluidic diffusional sizing for studying protein-protein interactions
MM Schneider, CM Dobson, A Aguzzi, FU Hartl, TPJ Knowles
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2021)
50
Yusuf Hamied Department of Chemistry
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