Centre for Misfolding Diseases

Publications

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  • Currently displaying 741 - 760 of 2403 publications
Author(s)
Publication title
Journal Name
Publication year
Widespread remodeling of proteome solubility in response to different protein homeostasis stresses
X Sui, DEV Pires, AR Ormsby, D Cox, S Nie, G Vecchi, M Vendruscolo, DB Ascher, GE Reid, DM Hatters
Proceedings of the National Academy of Sciences
(2020)
117
(doi: 10.1073/pnas.1912897117)
The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State.
M Runfola, A De Simone, M Vendruscolo, CM Dobson, G Fusco
Scientific reports
(2020)
10
(doi: 10.1038/s41598-019-57023-4)
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, SIA Cohen, M Vendruscolo, CM Dobson, S Linse, TPJ Knowles
(2020)
(doi: 10.1101/2020.01.08.897488)
A microfluidic strategy for the detection of membrane protein interactions.
Y Zhang, TW Herling, S Kreida, QAE Peter, T Kartanas, S Törnroth-Horsefield, S Linse, TPJ Knowles
Lab on a chip
(2020)
20
(doi: 10.1039/d0lc00205d)
Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine
S Errico, G Lucchesi, D Odino, S Muscat, C Capitini, C Bugelli, C Canale, R Ferrando, G Grasso, D Barbut, M Calamai, A Danani, M Zasloff, A Relini, G Caminati, M Vendruscolo, F Chiti
Nanoscale
(2020)
12
(doi: 10.1039/d0nr05285j)
Polyglutamine Aggregation in a Living Animal is Governed by Biophysical Parameters
T Sinnige, T Michaels, M Vendruscolo, RI Morimoto
BIOPHYSICAL JOURNAL
(2020)
118
Rational Design of Conformation-Specific Antibodies for Tau Oligomers
K Kulenkampff, FA Aprile, P Sormanni, RT Ranasinghe, D Klenerman, M Vendruscolo
BIOPHYSICAL JOURNAL
(2020)
118
Local micro and nano patterning of microfluidic devices using the solid on liquid deposition process
J Charmet, A Homsy, M Wood, J Covington, L Isa, M Textor, TPJ Knowles, H Keppner
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2017
(2020)
Proteome-wide observation of the phenomenon of life on the edge of solubility.
G Vecchi, P Sormanni, B Mannini, A Vandelli, GG Tartaglia, CM Dobson, FU Hartl, M Vendruscolo
Proc Natl Acad Sci U S A
(2019)
117
(doi: 10.1073/pnas.1910444117)
Physical mechanisms of amyloid nucleation on fluid membranes
J Krausser, TPJ Knowles, A Šarić
(2019)
(doi: 10.1101/2019.12.22.886267)
Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains
M Maritan, M Romeo, L Oberti, P Sormanni, M Tasaki, R Russo, A Ambrosetti, P Motta, P Rognoni, G Mazzini, A Barbiroli, G Palladini, M Vendruscolo, L Diomede, M Bolognesi, G Merlini, F Lavatelli, S Ricagno
Journal of molecular biology
(2019)
432
(doi: 10.1016/j.jmb.2019.12.015)
Homage to Chris Dobson
J Baum, F Chiti, A De Simone, TPJ Knowles, JR Kumita, SE Radford, CV Robinson, X Salvatella, K Valelli, M Vendruscolo, A Pastore, GG Tartaglia
Front Mol Biosci
(2019)
6
(doi: 10.3389/fmolb.2019.00137)
Determination of a Structural Ensemble Representing the Dynamics of a G‑Quadruplex DNA
G Portella, M Orozco, M Vendruscolo
Biochemistry
(2019)
59
(doi: 10.1021/acs.biochem.9b00493)
Proteome-Wide Survey of Cysteine Oxidation by Using a Norbornene Probe
LJ Alcock, M Langini, K Stühler, M Remke, MV Perkins, GJL Bernardes, JM Chalker
ChemBioChem
(2019)
21
(doi: 10.1002/cbic.201900729)
A metastable subproteome underlies inclusion formation in muscle proteinopathies
P Ciryam, M Antalek, F Cid, GG Tartaglia, CM Dobson, A-K Guettsches, B Eggers, M Vorgerd, K Marcus, RA Kley, RI Morimoto, M Vendruscolo, CC Weihl
Acta neuropathologica communications
(2019)
7
(doi: 10.1186/s40478-019-0853-9)
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
Nature communications
(2019)
10
(doi: 10.1038/s41467-018-07699-5)
Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease.
R Freer, P Sormanni, P Ciryam, B Rammner, SO Rizzoli, CM Dobson, M Vendruscolo
Heliyon
(2019)
5
(doi: 10.1016/j.heliyon.2019.e02589)
Label-Free Analysis of Protein Aggregation and Phase Behavior
Z Toprakcioglu, P Challa, C Xu, TPJ Knowles
ACS Nano
(2019)
13
(doi: 10.1021/acsnano.9b05552)
Machine learning for target discovery in drug development.
T Rodrigues, GJL Bernardes
Curr Opin Chem Biol
(2019)
56
(doi: 10.1016/j.cbpa.2019.10.003)
Dynamics and Control of Peptide Self-Assembly and Aggregation.
G Meisl, TCT Michaels, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Adv Exp Med Biol
(2019)
1174
(doi: 10.1007/978-981-13-9791-2_1)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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