Centre for Misfolding Diseases

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  • Currently displaying 561 - 580 of 2456 publications
Author(s)
Publication title
Journal Name
Publication year
Learning the molecular grammar of protein condensates from sequence determinants and embeddings
KL Saar, AS Morgunov, R Qi, WE Arter, G Krainer, AA Lee, TPJ Knowles
Proc Natl Acad Sci U S A
(2021)
118
(doi: 10.1073/pnas.2019053118)
The role of reversible and irreversible covalent chemistry in targeted protein degradation
H Kiely-Collins, GE Winter, GJL Bernardes
Cell chemical biology
(2021)
28
(doi: 10.1016/j.chembiol.2021.03.005)
Scaling analysis reveals the mechanism and rates of prion replication in vivo.
G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Hornemann, A Aguzzi, CM Dobson, CJ Sigurdson, TPJ Knowles
Nature Structural & Molecular Biology
(2021)
28
(doi: 10.1038/s41594-021-00565-x)
From Protein Building Blocks to Functional Materials.
Y Shen, A Levin, A Kamada, Z Toprakcioglu, M Rodriguez-Garcia, Y Xu, TPJ Knowles
ACS nano
(2021)
15
(doi: 10.1021/acsnano.0c08510)
The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases
TB Thompson, G Meisl, TPJ Knowles, A Goriely
The Journal of Chemical Physics
(2021)
154
(doi: 10.1063/5.0031650)
Shear-mediated sol-gel transition of regenerated silk allows the formation of Janus-like microgels
Z Toprakcioglu, TPJ Knowles
Sci Rep
(2021)
11
(doi: 10.1038/s41598-021-85199-1)
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease
M Perni, A van der Goot, R Limbocker, TJ van Ham, FA Aprile, CK Xu, P Flagmeier, K Thijssen, P Sormanni, G Fusco, SW Chen, PK Challa, JB Kirkegaard, RF Laine, KY Ma, MBD Müller, T Sinnige, JR Kumita, SIA Cohen, R Seinstra, GS Kaminski Schierle, CF Kaminski, D Barbut, A De Simone, TPJ Knowles, M Zasloff, EAA Nollen, M Vendruscolo, CM Dobson
Frontiers in cell and developmental biology
(2021)
9
(doi: 10.3389/fcell.2021.552549)
Precise Protein Conjugation Technology for the Construction of Homogenous Glycovaccines
A Kitowski, F Corzana, GJL Bernardes
Drug Discovery Today: Technologies
(2021)
38
(doi: 10.1016/j.ddtec.2020.11.007)
Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans
T Sinnige, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, RI Morimoto
Proc Natl Acad Sci U S A
(2021)
118
(doi: 10.1073/pnas.2021888118)
Fragment-based computational design of antibodies targeting structured epitopes
MA Rangel, A Bedwell, E Costanzi, R Taylor, R Russo, GJL Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni
(2021)
(doi: 10.1101/2021.03.02.433360)
Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures
T Ikenoue, FA Aprile, P Sormanni, M Vendruscolo
Front Neurosci
(2021)
15
(doi: 10.3389/fnins.2021.623097)
Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction
S Sieste, T Mack, E Lump, M Hayn, D Schütz, A Röcker, C Meier, K Kaygisiz, F Kirchhoff, TPJ Knowles, FS Ruggeri, CV Synatschke, J Münch, T Weil
Advanced Functional Materials
(2021)
31
(doi: 10.1002/adfm.202009382)
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
G Krainer, TJ Welsh, JA Joseph, JR Espinosa, S Wittmann, E de Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, MA Czekalska, WE Arter, J Guillén-Boixet, TM Franzmann, S Qamar, PS George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
Nature Communications
(2021)
12
(doi: 10.1038/s41467-021-21181-9)
A structural ensemble of a tau-microtubule complex reveals regulatory tau phosphorylation and acetylation mechanisms
ZF Brotzakis, P Lindstedt, R Taylor, G Bernardes, M Vendruscolo
ACS Central Science
(2021)
(doi: 10.21203/rs.3.rs-215084/v1)
Shear-Mediated Sol-Gel Transition of Regenerated Silk Allows the Formation of Janus-like Microgels
Z Toprakcioglu, T Knowles
(2021)
(doi: 10.26434/chemrxiv.13909250.v1)
Shear-Mediated Sol-Gel Transition of Regenerated Silk Allows the Formation of Janus-like Microgels
Z Toprakcioglu, T Knowles
(2021)
(doi: 10.26434/chemrxiv.13909250)
Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases
K Kulenkampff, A-M Wolf Perez, P Sormanni, J Habchi, M Vendruscolo
Nat Rev Chem
(2021)
5
(doi: 10.1038/s41570-021-00254-9)
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition
WK Man, B Tahirbegi, MD Vrettas, S Preet, L Ying, M Vendruscolo, A De Simone, G Fusco
Nature communications
(2021)
12
(doi: 10.1038/s41467-021-21027-4)
Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors
G Fani, B Mannini, G Vecchi, R Cascella, C Cecchi, CM Dobson, M Vendruscolo, F Chiti
ACS chemical neuroscience
(2021)
12
(doi: 10.1021/acschemneuro.0c00811)
One-Step Generation of Multisomes from Lipid-Stabilized Double Emulsions
MA Czekalska, AMJ Jacobs, Z Toprakcioglu, L Kong, KN Baumann, H Gang, G Zubaite, R Ye, B Mu, A Levin, WTS Huck, TPJ Knowles
ACS applied materials & interfaces
(2021)
13
(doi: 10.1021/acsami.0c16019)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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