Centre for Misfolding Diseases

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  • Currently displaying 561 - 580 of 2398 publications
Author(s)
Publication title
Journal Name
Publication year
In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry.
VFC Ferreira, BL Oliveira, A D'Onofrio, CM Farinha, L Gano, A Paulo, GJL Bernardes, F Mendes
Bioconjugate chemistry
(2020)
32
(doi: 10.1021/acs.bioconjchem.0c00551)
Sequence determinants of the aggregation of proteins within condensates generated by liquid-liquid phase separation
M Vendruscolo, M Fuxreiter
(2020)
(doi: 10.1101/2020.12.07.414409)
Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis.
PR Lindstedt, FA Aprile, P Sormanni, R Rakoto, CM Dobson, GJL Bernardes, M Vendruscolo
Cell Chemical Biology
(2020)
28
(doi: 10.1016/j.chembiol.2020.11.002)
Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases (vol 53, 1, 2020)
T Sinnige, K Stroobants, CM Dobson, M Vendruscolo
Quarterly reviews of biophysics
(2020)
53
(doi: 10.1017/S0033583520000104)
Adaptive Optimization of Chemical Reactions with Minimal Experimental Information
D Reker, EA Hoyt, GJL Bernardes, T Rodrigues
Cell Reports Physical Science
(2020)
1
(doi: 10.1016/j.xcrp.2020.100247)
Adaptive Optimization of Chemical Reactions with Minimal Experimental Information
G Lopes Bernardes
Cell Reports Physical Science
(2020)
(doi: 10.1016/j.xcrp.2020.100247)
Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers
RP Kreiser, AK Wright, NR Block, JE Hollows, LT Nguyen, K LeForte, B Mannini, M Vendruscolo, R Limbocker
Int J Mol Sci
(2020)
21
(doi: 10.3390/ijms21228651)
Machine learning aided top-down proteomics on a microfluidic platform
Y Zhang, M Wright, K Saar, P Challa, A Morgunov, Q Peter, S Devenish, C Dobson, TPJ Knowles
(2020)
(doi: 10.1101/2020.11.14.381376)
On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide
GA Braun, BE Ary, AJ Dear, MCH Rohn, AM Payson, DSM Lee, RC Parry, C Friedman, TPJ Knowles, S Linse, KS Åkerfeldt
Biomacromolecules
(2020)
21
(doi: 10.1021/acs.biomac.0c00989)
Structural Characterization of an Unprecedented Lectin-like Antitumoral anti-MUC1 Antibody
J Macías-León, IA Bermejo, A Asín, A García-García, I Compañón, E Jiménez-Moreno, H Coelho, V Mangini, IS Albuquerque, F Marcelo, JL Asensio, GJL Bernardes, HJ Joshi, R Fiammengo, O Blixt, R Hurtado-Guerrero, F Corzana
Chemical Communications
(2020)
56
(doi: 10.1039/d0cc06349e)
A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms
F Brotzakis, P Lindstedt, R Taylor, G Bernardes, M Vendruscolo
biorxiv
(2020)
(doi: 10.1101/2020.11.10.376285)
Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide.
P Henriques, L Dello Iacono, A Gimeno, A Biolchi, MR Romano, A Arda, GJL Bernardes, J Jimenez-Barbero, F Berti, R Rappuoli, R Adamo
Proceedings of the National Academy of Sciences
(2020)
117
(doi: 10.1073/pnas.2011385117)
Amyloid precipitation in biofluids using a structure-specific chemical antibody
M Rodrigues, P Bhattacharjee, A Brinkmalm, D Do, C Pearson, S De, A Ponjavic, J Varela, F Ruggeri, I Baudrexel, J Lee, A Carr, K Kulenkampff, T Knowles, H Zetterberg, T Snaddon, S Gandhi, S Lee, D Klenerman
(2020)
(doi: 10.21203/rs.3.rs-81521/v1)
Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro.
D Frankel, M Davies, B Bhushan, Y Kulaberoglu, P Urriola-Munoz, J Bertrand-Michel, MR Pergande, AA Smith, S Preet, TJ Park, M Vendruscolo, KS Rankin, SM Cologna, JR Kumita, N Cenac, E St John Smith
Aging
(2020)
12
(doi: 10.18632/aging.202138)
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease.
GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, IC Felli, R Pierattelli, TPJ Knowles, CM Dobson, M Vendruscolo
Science Advances
(2020)
6
(doi: 10.1126/sciadv.abb5924)
Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates.
N Ahmed, UA Friedrich, P Sormanni, P Ciryam, NS Altman, B Bukau, G Kramer, EP O'Brien
J Mol Biol
(2020)
432
(doi: 10.1016/j.jmb.2020.10.030)
The Hsc70 Disaggregation Machinery Removes Monomer Units Directly from α-Synuclein Fibril Ends
M Schneider, S Gautam, T Herling, E Andrzejewska, G Krainer, A Miller, Q Peter, FS Ruggeri, M Vendruscolo, A Bracher, C Dobson, U Hartl, T Knowles
(2020)
(doi: 10.1101/2020.11.02.365825)
MeCLICK-Seq, a Substrate-Hijacking and RNA Degradation Strategy for the Study of RNA Methylation
S Mikutis, M Gu, E Sendinc, ME Hazemi, H Kiely-Collins, D Aspris, GS Vassiliou, Y Shi, K Tzelepis, GJL Bernardes
ACS Cent Sci
(2020)
6
(doi: 10.1021/acscentsci.0c01094)
Machine learning models for predicting protein condensate formation from sequence determinants and embeddings
K Saar, A Morgunov, R Qi, W Arter, G Krainer, A Lee, T Knowles
(2020)
(doi: 10.1101/2020.10.26.354753)
Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction
S Sieste, T Mack, E Lump, M Hayn, D Schütz, A Röcker, C Meier, F Kirchhoff, T Knowles, FS Ruggeri, C Synatschke, J Münch, T Weil
(2020)
(doi: 10.26434/chemrxiv.13129709)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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