Centre for Misfolding Diseases

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  • Currently displaying 541 - 560 of 2450 publications
Author(s)
Publication title
Journal Name
Publication year
A small molecule stabilises the disordered native state of the Alzheimer’s Aβ peptide
T Löhr, K Kohlhoff, GT Heller, C Camilloni, M Vendruscolo
(2021)
(doi: 10.1101/2021.11.10.468059)
Discovery of Potent Inhibitors of α-Synuclein Aggregation Using Structure-Based Iterative Learning
RI Horne, E Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
(2021)
(doi: 10.1101/2021.11.10.468009)
An open-source automated PEG precipitation assay to measure the relative solubility of proteins with low material requirement.
M Vendruscolo, M Oeller, P Sormanni
Scientific reports
(2021)
11
(doi: 10.1038/s41598-021-01126-4)
Controlled In-Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging
J Konč, V Sabatino, E Jiménez-Moreno, E Latocheski, LR Pérez, J Day, JB Domingos, GJL Bernardes
Angewandte Chemie International Edition
(2021)
61
(doi: 10.1002/anie.202113519)
Diazaborines are a Versatile Platform to Develop ROS Responsive Antibody Drug Conjugates
JPM António, JI Carvalho, AS André, JNR Dias, SI Aguiar, H Faustino, RMRM Lopes, LF Veiros, GJL Bernardes, FA da Silva, PMP Gois
Angewandte Chemie (International ed. in English)
(2021)
60
(doi: 10.1002/anie.202109835)
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides
J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes
Angewandte Chemie International Edition
(2021)
60
(doi: 10.1002/anie.202109713)
Vitamin A and vitamin E metabolites comodulate amyloid-β aggregation
P Joshi, S Chia, X Yang, M Perni, J Habchi, M Vendruscolo
(2021)
(doi: 10.1101/2021.10.30.466561)
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides
J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes
Angewandte Chemie
(2021)
133
(doi: 10.1002/ange.202109713)
Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates.
DC Rodriguez Camargo, S Chia, J Menzies, B Mannini, G Meisl, M Lundqvist, C Pohl, K Bernfur, V Lattanzi, J Habchi, SI Cohen, TPJ Knowles, M Vendruscolo, S Linse
Frontiers in molecular biosciences
(2021)
8
(doi: 10.3389/fmolb.2021.757425)
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease
G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles, D Klenerman
Science Advances
(2021)
7
(doi: 10.1126/sciadv.abh1448)
Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation.
X Ferhati, M Salas-Cubero, P Garrido, J García-Sanmartín, A Guerreiro, A Avenoza, JH Busto, JM Peregrina, A Martínez, E Jiménez-Moreno, GJL Bernardes, F Corzana
Organic letters
(2021)
23
(doi: 10.1021/acs.orglett.1c03299)
Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules
D Zaguri, MR Zimmermann, G Meisl, A Levin, S Rencus-Lazar, TPJ Knowles, E Gazit
ACS nano
(2021)
15
(doi: 10.1021/acsnano.1c07537)
From Protein Building Blocks to Functional Materials
Y Shen, T Knowles, A Levin, Z Toprakcioglu, M Rodriguez-Garcia, A Kamada, Y Xu
ACS Nano
(2021)
15
(doi: 10.1021/acsnano.0c08510)
The signal peptide of the amyloid precursor protein forms amyloid-like aggregates and enhances Aβ42 aggregation
K Gadhave, T Bhardwaj, VN Uversky, M Vendruscolo, R Giri
Cell Reports Physical Science
(2021)
2
(doi: 10.1016/j.xcrp.2021.100599)
The chromatin regulator HMGA1a undergoes phase separation in the nucleus
H Zhu, M Narita, JA Joseph, G Krainer, WE Arter, I Olan, KL Saar, N Ermann, JR Espinosa, Y Shen, MA Kuri, R Qi, TJ Welsh, Y Xu, R Collepardo-Guevara, M Narita, TPJ Knowles
(2021)
(doi: 10.1101/2021.10.14.464384)
The Hsc70 Disaggregation Machinery Removes Monomer Units Directly from α-Synuclein Fibril ends
MM Schneider, S Gautam, TW Herling, E Andrzejewska, G Krainer, AM Miller, VA Trinkaus, QAE Peter, FS Ruggeri, M Vendruscolo, A Bracher, CM Dobson, FU Hartl, TPJ Knowles
Nature communications
(2021)
12
(doi: 10.1038/s41467-021-25966-w)
Can single-component protein condensates form multiphase architectures?
A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
(2021)
(doi: 10.1101/2021.10.09.463670)
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation
A Pras, B Houben, FA Aprile, R Seinstra, R Gallardo, L Janssen, W Hogewerf, C Gallrein, M De Vleeschouwer, A Mata-Cabana, M Koopman, E Stroo, M de Vries, S Louise Edwards, J Kirstein, M Vendruscolo, SF Falsone, F Rousseau, J Schymkowitz, EAA Nollen
EMBO Journal
(2021)
40
(doi: 10.15252/embj.2020107568)
Computational maturation of a single-domain antibody against Aβ42 aggregation
J Lin, C Figazzolo, MA Metrick, P Sormanni, M Vendruscolo
Chem Sci
(2021)
12
(doi: 10.1039/d1sc03898b)
Accelerating reaction rates of biomolecules by using shear stress in artificial capillary systems
TA Hakala, EV Yates, PK Challa, Z Toprakcioglu, K Nadendla, D Matak-Vinkovic, CM Dobson, R Martínez, F Corzana, TPJ Knowles, GJL Bernardes
J Am Chem Soc
(2021)
143
(doi: 10.1021/jacs.1c03681)
Yusuf Hamied Department of Chemistry
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