Centre for Misfolding Diseases

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  • Currently displaying 541 - 560 of 2486 publications
Author(s)
Publication title
Journal Name
Publication year
Sequence-based prediction and measurement of pH-dependent protein solubility
M Oeller, P Sormanni, M Vendruscolo
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.989)
Kinetic analysis of tau aggregation for drug discovery
DJ Rinauro, M Vendruscolo
BIOPHYSICAL JOURNAL
(2022)
121
Mechanism of secondary nucleation from the direct observation of Aβ42 aggregation at the single fibril level
MR Zimmermann, SC Bera, G Meisl, S Dasadhikari, S Ghosh, S Linse, K Garai, TPJ Knowles
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.556)
Hsc70 mediated disaggregation of α-synuclein fibrils
MM Schneider, S Gautam, TW Herling, G Krainer, E Andrzejewska, A Bracher, CM Dobson, U Hartl, TP Knowles
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.2605)
Small molecule and antibody mediated inhibition of the aggregation of a tau fragment implicit in Alzheimer's disease
TL McKenzie, RP Kreiser, RA Limbocker, DJ Rinauro, M Vendruscolo
BIOPHYSICAL JOURNAL
(2022)
121
Therapeutic drug targeting in Alzheimer's disease
R Geiser, M Sanguanini, R Staats, D Rinauro, M Metrick, P Ciryam, S Casford, E Zhao, J Fleming, S Hunter, C Brayne, M Vendruscolo
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.1785)
Using microscopy techniques to structurally characterise TDP-43 inclusions present in mammalian cell models
NS Matharu, CW Chung, JR Kumita, GS Kaminski, TP Knowles
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.1401)
Counteraction of amyloid-β aggregation by vitamin A and E metabolites in a crowded environment
P Joshi, S Chia, X Yang, M Perni, J Habchi, M Vendruscolo
BIOPHYSICAL JOURNAL
(2022)
121
Universal lab-on-a-chip microfluidic spray deposition for bulk and single-molecule analytical methods on surfaces
AM Miller, SKR Chia, T Hakala, Z Toprakcioglu, M Vendruscolo, FS Ruggeri, TPJ Knowles
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.993)
Modulators of the plasma membrane protect cells from diverse toxic agents, ranging from protein misfolded oligomers to pore forming agents
R Limbocker, RP Kreiser, LR Sasser, AK Wright, DJ Rinauro, M Vendruscolo
BIOPHYSICAL JOURNAL
(2022)
121
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates
F Carboni, A Kitowski, C Sorieul, D Veggi, MC Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, MR Romano, GJL Bernardes, R Adamo
Chem Sci
(2022)
13
(doi: 10.1039/d1sc01928g)
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization.
A Farzadfard, JN Pedersen, G Meisl, AK Somavarapu, P Alam, L Goksøyr, MA Nielsen, AF Sander, TPJ Knowles, JS Pedersen, DE Otzen
Communications biology
(2022)
5
(doi: 10.1038/s42003-022-03059-8)
Multiphase condensates from a kinetically arrested phase transition
NA Erkamp, T Sneideris, H Ausserwöger, D Qian, S Qamar, J Nixon-Abell, P St George-Hyslop, JD Schmit, DA Weitz, TPJ Knowles
(2022)
(doi: 10.1101/2022.02.09.479538)
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for effectiveness of glycoconjugate vaccine candidates
G Lopes Bernardes, F carboni, A kitowski, C Sorieul, D Veggi, M Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, M Romano, R Adamo
Chemical Science
(2022)
(doi: 10.1039/D1SC01928G)
Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration
S Fiedler, SRA Devenish, AS Morgunov, A Ilsley, F Ricci, M Emmenegger, V Kosmoliaptsis, ES Theel, JR Mills, AM Sholukh, A Aguzzi, A Iwasaki, AK Lynn, TPJ Knowles
(2022)
(doi: 10.1101/2022.02.03.478946)
Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions
M Kar, F Dar, TJ Welsh, L Vogel, R Kühnemuth, A Majumdar, G Krainer, TM Franzmann, S Alberti, CAM Seidel, TPJ Knowles, AA Hyman, RV Pappu
(2022)
(doi: 10.1101/2022.02.03.478969)
Nanofluidic Traps by Two-Photon Fabrication for Extended Detection of Single Macromolecules and Colloids in Solution
O Vanderpoorten, AN Babar, G Krainer, RPB Jacquat, PK Challa, Q Peter, Z Toprakcioglu, CK Xu, UF Keyser, JJ Baumberg, CF Kaminski, TPJ Knowles
ACS Applied Nano Materials
(2022)
5
(doi: 10.1021/acsanm.1c03691)
Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics
R Khetan, R Curtis, CM Deane, JT Hadsund, U Kar, K Krawczyk, D Kuroda, SA Robinson, P Sormanni, K Tsumoto, J Warwicker, ACR Martin
Mabs
(2022)
14
(doi: 10.1080/19420862.2021.2020082)
Rate‐limiting processes of tau aggregate accumulation in Alzheimer's disease
G Meisl, Y Zuo, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, T Knowles, D Klenerman
Alzheimer's & Dementia
(2022)
17
(doi: 10.1002/alz.051680)
Transition metal mediated bioorthogonal release
V Sabatino, VB Unnikrishnan, GJL Bernardes
Chem Catalysis
(2022)
2
(doi: 10.1016/j.checat.2021.12.007)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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