Centre for Misfolding Diseases

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  • Currently displaying 501 - 520 of 2486 publications
Author(s)
Publication title
Journal Name
Publication year
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes
H Mikolajek, M Weckener, ZF Brotzakis, J Huo, EV Dalietou, A Le Bas, P Sormanni, PJ Harrison, PN Ward, S Truong, L Moynie, DK Clare, M Dumoux, J Dormon, C Norman, N Hussain, V Vogirala, RJ Owens, M Vendruscolo, JH Naismith
Proceedings of the National Academy of Sciences
(2022)
119
(doi: 10.1073/pnas.2205412119)
DNA-Liposome Hybrid Carriers for Triggered Cargo Release
KN Baumann, T Schröder, PS Ciryam, D Morzy, P Tinnefeld, TPJ Knowles, S Hernández-Ainsa
ACS applied bio materials
(2022)
5
(doi: 10.1021/acsabm.2c00225)
π-Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation.
RJ Taylor, M Aguilar Rangel, MB Geeson, P Sormanni, M Vendruscolo, GJL Bernardes
J Am Chem Soc
(2022)
144
(doi: 10.1021/jacs.2c04747)
Structure-specific amyloid precipitation in biofluids
M Rodrigues, P Bhattacharjee, A Brinkmalm, DT Do, CM Pearson, S De, A Ponjavic, JA Varela, K Kulenkampff, I Baudrexel, D Emin, FS Ruggeri, JE Lee, AR Carr, TPJ Knowles, H Zetterberg, TN Snaddon, S Gandhi, SF Lee, D Klenerman
Nat Chem
(2022)
14
(doi: 10.1038/s41557-022-00976-3)
Editorial: Intrinsically Disordered Proteins and Regions: The Challenge to the Structure-Function Relationship.
A Toto, P Sormanni, C Paissoni, VN Uversky
Front Mol Biosci
(2022)
9
(doi: 10.3389/fmolb.2022.962643)
Recent advances in microgels: from biomolecules to functionality
Y Xu, H Zhu, A Denduluri, Y Ou, NA Erkamp, R Qi, Y Shen, TPJ Knowles
Small
(2022)
18
(doi: 10.1002/smll.202200180)
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.
M Kar, F Dar, TJ Welsh, LT Vogel, R Kühnemuth, A Majumdar, G Krainer, TM Franzmann, S Alberti, CAM Seidel, TPJ Knowles, AA Hyman, RV Pappu
Proceedings of the National Academy of Sciences
(2022)
119
(doi: 10.1073/pnas.2202222119)
Comparative study of the affinities of natural aminosterols for lipid membranes and their relation with protection from misfolded protein oligomers
S Errico, L Neri, G Lucchesi, D Odino, G Caminati, A Relini, M Zasloff, M Vendruscolo, F Chiti
FEBS OPEN BIO
(2022)
12
Thermodynamics of oligomeric alph-asynuclein-membrane interactions
G Musteikyte, C Xu, M Czekalska, Q Peter, G Krainer, S Devenish, T Knowles
FEBS OPEN BIO
(2022)
12
Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease.
G Meisl, TPJ Knowles, D Klenerman
Frontiers in Neuroscience
(2022)
16
(doi: 10.3389/fnins.2022.909861)
Controlled masking and targeted release of redox-cycling ortho-quinones via a C-C bond-cleaving 1,6-elimination
L Dunsmore, CD Navo, J Becher, EG de Montes, A Guerreiro, E Hoyt, L Brown, V Zelenay, S Mikutis, J Cooper, I Barbieri, S Lawrinowitz, E Siouve, E Martin, PR Ruivo, T Rodrigues, FP da Cruz, O Werz, G Vassiliou, P Ravn, G Jiménez-Osés, GJL Bernardes
Nature chemistry
(2022)
14
(doi: 10.1038/s41557-022-00964-7)
Aging can transform single-component protein condensates into multiphase architectures
A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
Proceedings of the National Academy of Sciences of the United States of America
(2022)
119
(doi: 10.1073/pnas.2119800119)
Uncovering the universality of self-replication in protein aggregation and its link to disease
G Meisl, CK Xu, JD Taylor, TCT Michaels, A Levin, D Otzen, D Klenerman, S Matthews, S Linse, M Andreasen, TPJ Knowles
(2022)
(doi: 10.1101/2022.06.08.495339)
Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents.
A Istrate, MB Geeson, CD Navo, BB Sousa, MC Marques, RJ Taylor, T Journeaux, SR Oehler, MR Mortensen, MJ Deery, AD Bond, F Corzana, G Jiménez-Osés, GJL Bernardes
J Am Chem Soc
(2022)
144
(doi: 10.1021/jacs.2c02185)
A Small Molecule Stabilizes the Disordered Native State of the Alzheimer’s Aβ Peptide
T Löhr, K Kohlhoff, GT Heller, C Camilloni, M Vendruscolo
ACS Chemical Neuroscience
(2022)
13
(doi: 10.1021/acschemneuro.2c00116)
Determination of the structure and dynamics of the fuzzy coat of an amyloid fibril of IAPP using cryo-electron microscopy
ZF Brotzakis, T Löhr, S Truong, SE Hoff, M Bonomi, M Vendruscolo
(2022)
(doi: 10.1101/2022.05.29.493873)
FuzDrop on AlphaFold: visualizing the sequence-dependent propensity of liquid-liquid phase separation and aggregation of proteins.
A Hatos, SCE Tosatto, M Vendruscolo, M Fuxreiter
Nucleic Acids Research
(2022)
50
(doi: 10.1093/nar/gkac386)
Automated optimisation of solubility and conformational stability of antibodies and proteins
A Rosace, A Bennett, M Oeller, MM Mortensen, L Sakhnini, N Lorenzen, C Poulsen, P Sormanni
(2022)
(doi: 10.1101/2022.05.20.492798)
The Impact of Activity‐Based Protein Profiling in Malaria Drug Discovery
LAR Carvalho, GJL Bernardes
ChemMedChem
(2022)
17
(doi: 10.1002/cmdc.202200174)
Conformational Entropy as a Potential Liability of Computationally Designed Antibodies.
T Löhr, P Sormanni, M Vendruscolo
Biomolecules
(2022)
12
(doi: 10.3390/biom12050718)
Yusuf Hamied Department of Chemistry
Lensfield Road
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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