Centre for Misfolding Diseases

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  • Currently displaying 481 - 500 of 2456 publications
Author(s)
Publication title
Journal Name
Publication year
Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation.
J West, S Satapathy, DR Whiten, M Kelly, NJ Geraghty, E-J Proctor, P Sormanni, M Vendruscolo, JN Buxbaum, M Ranson, MR Wilson
Sci Adv
(2021)
7
(doi: 10.1126/sciadv.abf7606)
A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms.
ZF Brotzakis, PR Lindstedt, RJ Taylor, DJ Rinauro, NCT Gallagher, GJL Bernardes, M Vendruscolo
ACS Cent Sci
(2021)
7
(doi: 10.1021/acscentsci.1c00585)
Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates
S Chia, ZF Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
(2021)
(doi: 10.1101/2021.12.05.471256)
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
MM Schneider, M Emmenegger, CK Xu, I Condado Morales, G Meisl, P Turelli, C Zografou, MR Zimmermann, BM Frey, S Fiedler, V Denninger, RP Jacquat, L Madrigal, A Ilsley, V Kosmoliaptsis, H Fiegler, D Trono, TP Knowles, A Aguzzi
Life science alliance
(2021)
5
(doi: 10.26508/lsa.202101270)
2-photon-fabricated nano-fluidic traps for extended detection of single macromolecules and colloids in solution
O Vanderpoorten, AN Babar, G Krainer, RPB Jacquat, PK Challa, Q Peter, Z Toprakcioglu, CK Xu, UF Keyser, J Baumberg, CF Kaminski, TPJ Knowles
(2021)
(doi: 10.1101/2021.11.17.468989)
Proliferation of Tau 304–380 Fragment Aggregates through Autocatalytic Secondary Nucleation
DC Rodriguez Camargo, E Sileikis, S Chia, E Axell, K Bernfur, RL Cataldi, SIA Cohen, G Meisl, J Habchi, TPJ Knowles, M Vendruscolo, S Linse
ACS Chemical Neuroscience
(2021)
12
(doi: 10.1021/acschemneuro.1c00454)
A small molecule stabilises the disordered native state of the Alzheimer’s Aβ peptide
T Löhr, K Kohlhoff, GT Heller, C Camilloni, M Vendruscolo
(2021)
(doi: 10.1101/2021.11.10.468059)
Discovery of Potent Inhibitors of α-Synuclein Aggregation Using Structure-Based Iterative Learning
RI Horne, E Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
(2021)
(doi: 10.1101/2021.11.10.468009)
An open-source automated PEG precipitation assay to measure the relative solubility of proteins with low material requirement.
M Vendruscolo, M Oeller, P Sormanni
Scientific Reports
(2021)
11
(doi: 10.1038/s41598-021-01126-4)
Controlled In‐Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging
J Konč, V Sabatino, E Jiménez-Moreno, E Latocheski, LR Pérez, J Day, JB Domingos, GJL Bernardes
Angewandte Chemie (International ed. in English)
(2021)
61
(doi: 10.1002/anie.202113519)
Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates*.
JPM António, JI Carvalho, AS André, JNR Dias, SI Aguiar, H Faustino, RMRM Lopes, LF Veiros, GJL Bernardes, FA da Silva, PMP Gois
Angew Chem Int Ed Engl
(2021)
60
(doi: 10.1002/anie.202109835)
A Platform for Site-Specific DNA-Antibody Bioconjugation by Using Benzoylacrylic-Labelled Oligonucleotides.
J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes
Angew Chem Int Ed Engl
(2021)
60
(doi: 10.1002/anie.202109713)
Vitamin A and vitamin E metabolites comodulate amyloid-β aggregation
P Joshi, S Chia, X Yang, M Perni, J Habchi, M Vendruscolo
(2021)
(doi: 10.1101/2021.10.30.466561)
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides
J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes
Angewandte Chemie
(2021)
133
(doi: 10.1002/ange.202109713)
Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates
DC Rodriguez Camargo, S Chia, J Menzies, B Mannini, G Meisl, M Lundqvist, C Pohl, K Bernfur, V Lattanzi, J Habchi, SI Cohen, TPJ Knowles, M Vendruscolo, S Linse
Front Mol Biosci
(2021)
8
(doi: 10.3389/fmolb.2021.757425)
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease
G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles, D Klenerman
Science advances
(2021)
7
(doi: 10.1126/sciadv.abh1448)
Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation.
X Ferhati, M Salas-Cubero, P Garrido, J García-Sanmartín, A Guerreiro, A Avenoza, JH Busto, JM Peregrina, A Martínez, E Jiménez-Moreno, GJL Bernardes, F Corzana
Organic letters
(2021)
23
(doi: 10.1021/acs.orglett.1c03299)
Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules
D Zaguri, MR Zimmermann, G Meisl, A Levin, S Rencus-Lazar, TPJ Knowles, E Gazit
ACS nano
(2021)
15
(doi: 10.1021/acsnano.1c07537)
From Protein Building Blocks to Functional Materials
Y Shen, T Knowles, A Levin, Z Toprakcioglu, M Rodriguez-Garcia, A Kamada, Y Xu
ACS Nano
(2021)
15
(doi: 10.1021/acsnano.0c08510)
The signal peptide of the amyloid precursor protein forms amyloid-like aggregates and enhances Aβ42 aggregation
K Gadhave, T Bhardwaj, VN Uversky, M Vendruscolo, R Giri
Cell Reports Physical Science
(2021)
2
(doi: 10.1016/j.xcrp.2021.100599)
Yusuf Hamied Department of Chemistry
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