Centre for Misfolding Diseases

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  • Currently displaying 481 - 500 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
Small molecule and antibody mediated inhibition of the aggregation of a tau fragment implicit in Alzheimer's disease
TL McKenzie, RP Kreiser, RA Limbocker, DJ Rinauro, M Vendruscolo
BIOPHYSICAL JOURNAL
(2022)
121
Kinetic analysis of tau aggregation for drug discovery
DJ Rinauro, M Vendruscolo
BIOPHYSICAL JOURNAL
(2022)
121
Counteraction of amyloid-β aggregation by vitamin A and E metabolites in a crowded environment
P Joshi, S Chia, X Yang, M Perni, J Habchi, M Vendruscolo
BIOPHYSICAL JOURNAL
(2022)
121
Sequence-Based Prediction of Ph-Dependent Protein Solubility Using Camsol
M Oeller, R Kang, R Bell, H Ausserwoger, P Sormanni, M Vendruscolo
SSRN Electronic Journal
(2022)
(doi: 10.2139/ssrn.4189397)
Improving safety in regional anaesthesia with a novel, yet simple intervention. A staff survey of the impact of the intervention
R Thomas, S Jigajinni, S Green, T Knowles, R McCartney, A Williams
ANAESTHESIA
(2022)
77
Common sequence motifs of nascent chains engage the ribosome surface and trigger factor
A Deckert, AME Cassaignau, X Wang, T Włodarski, SHS Chan, CA Waudby, JP Kirkpatrick, M Vendruscolo, LD Cabrita, J Christodoulou
Proceedings of the National Academy of Sciences of the United States of America
(2021)
118
(doi: 10.1073/pnas.2103015118)
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease
M Runfola, M Perni, X Yang, M Marchese, A Bacci, S Mero, FM Santorelli, B Polini, G Chiellini, D Giuliani, A Vilella, M Bodria, E Daini, E Vandini, S Rudge, S Gul, MOJ Wakelam, M Vendruscolo, S Rapposelli
Pharmaceuticals (Basel, Switzerland)
(2021)
14
(doi: 10.3390/ph14121330)
Single-molecule sizing through nano-cavity confinement
RPB Jacquat, G Krainer, QAE Peter, AN Babar, O Vanderpoorten, CK Xu, TJ Welsh, CF Kaminski, UF Keyser, JJ Baumberg, TPJ Knowles
(2021)
(doi: 10.1101/2021.12.13.472369)
Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation.
J West, S Satapathy, DR Whiten, M Kelly, NJ Geraghty, E-J Proctor, P Sormanni, M Vendruscolo, JN Buxbaum, M Ranson, MR Wilson
Science Advances
(2021)
7
(doi: 10.1126/sciadv.abf7606)
A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms.
ZF Brotzakis, PR Lindstedt, RJ Taylor, DJ Rinauro, NCT Gallagher, GJL Bernardes, M Vendruscolo
ACS central science
(2021)
7
(doi: 10.1021/acscentsci.1c00585)
Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates
S Chia, ZF Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
(2021)
(doi: 10.1101/2021.12.05.471256)
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
MM Schneider, M Emmenegger, CK Xu, I Condado Morales, G Meisl, P Turelli, C Zografou, MR Zimmermann, BM Frey, S Fiedler, V Denninger, RP Jacquat, L Madrigal, A Ilsley, V Kosmoliaptsis, H Fiegler, D Trono, TP Knowles, A Aguzzi
Life science alliance
(2021)
5
(doi: 10.26508/lsa.202101270)
2-photon-fabricated nano-fluidic traps for extended detection of single macromolecules and colloids in solution
O Vanderpoorten, AN Babar, G Krainer, RPB Jacquat, PK Challa, Q Peter, Z Toprakcioglu, CK Xu, UF Keyser, J Baumberg, CF Kaminski, TPJ Knowles
(2021)
(doi: 10.1101/2021.11.17.468989)
Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation
DC Rodriguez Camargo, E Sileikis, S Chia, E Axell, K Bernfur, RL Cataldi, SIA Cohen, G Meisl, J Habchi, TPJ Knowles, M Vendruscolo, S Linse
ACS chemical neuroscience
(2021)
12
(doi: 10.1021/acschemneuro.1c00454)
Discovery of Potent Inhibitors of α-Synuclein Aggregation Using Structure-Based Iterative Learning
RI Horne, E Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
(2021)
(doi: 10.1101/2021.11.10.468009)
A small molecule stabilises the disordered native state of the Alzheimer’s Aβ peptide
T Löhr, K Kohlhoff, GT Heller, C Camilloni, M Vendruscolo
(2021)
(doi: 10.1101/2021.11.10.468059)
An open-source automated PEG precipitation assay to measure the relative solubility of proteins with low material requirement
M Vendruscolo, M Oeller, P Sormanni
Sci Rep
(2021)
11
(doi: 10.1038/s41598-021-01126-4)
Controlled In‐Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging
J Konč, V Sabatino, E Jiménez-Moreno, E Latocheski, LR Pérez, J Day, JB Domingos, GJL Bernardes
Angewandte Chemie International Edition
(2021)
61
(doi: 10.1002/anie.202113519)
Diazaborines Are a Versatile Platform to Develop ROS‐Responsive Antibody Drug Conjugates**
JPM António, JI Carvalho, AS André, JNR Dias, SI Aguiar, H Faustino, RMRM Lopes, LF Veiros, GJL Bernardes, FA da Silva, PMP Gois
Angewandte Chemie International Edition
(2021)
60
(doi: 10.1002/anie.202109835)
A Platform for Site-Specific DNA-Antibody Bioconjugation by Using Benzoylacrylic-Labelled Oligonucleotides
J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes
Angewandte Chemie International Edition
(2021)
60
(doi: 10.1002/anie.202109713)
Yusuf Hamied Department of Chemistry
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