Centre for Misfolding Diseases

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  • Currently displaying 521 - 540 of 2399 publications
Author(s)
Publication title
Journal Name
Publication year
Sequential Storage and Release of Microdroplets for On and Off-chip Analysis
Z Toprakcioglu, T Knowles
(2021)
(doi: 10.33774/chemrxiv-2021-66zrn)
A conformational switch controlling the toxicity of the prion protein
K Frontzek, M Bardelli, A Senatore, A Henzi, RR Reimann, S Bedir, M Marino, R Hussain, S Jurt, G Meisl, M Pedotti, F Mazzola, G Siligardi, O Zerbe, M Losa, T Knowles, A Lakkaraju, C Zhu, P Schwarz, S Hornemann, MG Holt, L Simonelli, L Varani, A Aguzzi
(2021)
(doi: 10.1101/2021.09.20.460912)
Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses
F Geiger, J Acker, G Papa, X Wang, WE Arter, KL Saar, N Erkamp, R Qi, J Bravo, S Strauss, G Krainer, OR Burrone, R Jungmann, TPJ Knowles, H Engelke, A Borodavka
The EMBO journal
(2021)
40
(doi: 10.15252/embj.2021107711)
Deformable and Robust Core–Shell Protein Microcapsules Templated by Liquid–Liquid Phase‐Separated Microdroplets
Y Xu, Y Shen, TCT Michaels, KN Baumann, D Vigolo, Q Peter, Y Lu, KL Saar, D Vella, H Zhu, B Li, H Yang, APM Guttenplan, M Rodriguez‐Garcia, D Klenerman, TPJ Knowles
Advanced Materials Interfaces
(2021)
8
(doi: 10.1002/admi.202101071)
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces
T Scheidt, JA Carozza, CC Kolbe, FA Aprile, O Tkachenko, MMJ Bellaiche, G Meisl, QAE Peter, TW Herling, S Ness, M Castellana-Cruz, JLP Benesch, M Vendruscolo, CM Dobson, P Arosio, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2021)
118
(doi: 10.1073/pnas.2108790118|1of8)
Combating small-molecule aggregation with machine learning
K Lee, A Yang, Y-C Lin, D Reker, GJL Bernardes, T Rodrigues
Cell Reports Physical Science
(2021)
2
(doi: 10.1016/j.xcrp.2021.100573)
New Frontiers for Machine Learning in Protein Science
AS Morgunov, KL Saar, M Vendruscolo, TPJ Knowles
Journal of molecular biology
(2021)
433
(doi: 10.1016/j.jmb.2021.167232)
Assessment of Therapeutic Antibody Developability by Combinations of In Vitro and In Silico Methods
A-M Wolf Pérez, N Lorenzen, M Vendruscolo, P Sormanni
Methods in molecular biology (Clifton, N.J.)
(2021)
2313
(doi: 10.1007/978-1-0716-1450-1_4)
The Amyloid-β Pathway in Alzheimer’s Disease
H Hampel, J Hardy, K Blennow, C Chen, G Perry, SH Kim, VL Villemagne, P Aisen, M Vendruscolo, T Iwatsubo, CL Masters, M Cho, L Lannfelt, JL Cummings, A Vergallo
Molecular Psychiatry
(2021)
26
(doi: 10.1038/s41380-021-01249-0)
Unraveling the Physicochemical Determinants of Protein Liquid-liquid Phase Separation by Nanoscale Infrared Vibrational Spectroscopy
FS Ruggeri, AM Miller, M Vendruscolo, TPJ Knowles
Bio Protocol
(2021)
11
(doi: 10.21769/bioprotoc.4122)
Liquid–Liquid Phase‐Separated Systems from Reversible Gel–Sol Transition of Protein Microgels (Adv. Mater. 33/2021)
Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
Advanced Materials
(2021)
33
(doi: 10.1002/adma.202170258)
Sequence Determinants of the Aggregation of Proteins Within Condensates Generated by Liquid-liquid Phase Separation: Sequence code of aggregation in protein condensates
M Vendruscolo, M Fuxreiter
J Mol Biol
(2021)
434
(doi: 10.1016/j.jmb.2021.167201)
Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine
S Errico, H Ramshini, C Capitini, C Canale, M Spaziano, D Barbut, M Calamai, M Zasloff, R Oropesa-Nuñez, M Vendruscolo, F Chiti
ACS chemical neuroscience
(2021)
12
(doi: 10.1021/acschemneuro.1c00327)
Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation.
J Wen, L Hong, G Krainer, Q-Q Yao, TPJ Knowles, S Wu, S Perrett
Journal of the American Chemical Society
(2021)
143
(doi: 10.1021/jacs.1c03078)
Feedback control of protein aggregation.
AJ Dear, TCT Michaels, TPJ Knowles, L Mahadevan
The Journal of Chemical Physics
(2021)
155
(doi: 10.1063/5.0055925)
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, J Lim, D Aspris, E Sendinc, DA Garyfallos, M Gu, R Ali, A Gutierrez, S Mikutis, GJL Bernardes, ES Fischer, A Bradley, GS Vassiliou, FJ Slack, K Tzelepis, RI Gregory
Mol Cell
(2021)
81
(doi: 10.1016/j.molcel.2021.06.031)
Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape
S Fiedler, V Denninger, AS Morgunov, A Ilsley, R Worth, G Meisl, CK Xu, MA Piziorska, F Ricci, AY Malik, SRA Devenish, MM Schneider, V Kosmoliaptsis, A Aguzzi, A Iwasaki, H Fiegler, TPJ Knowles
(2021)
(doi: 10.1101/2021.07.23.453327)
Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response.
P Joshi, M Perni, R Limbocker, B Mannini, S Casford, S Chia, J Habchi, J Labbadia, CM Dobson, M Vendruscolo
Communications biology
(2021)
4
(doi: 10.17863/CAM.74787)
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
M Emmenegger, E De Cecco, M Hruska-Plochan, T Eninger, MM Schneider, M Barth, E Tantardini, P de Rossi, M Bacioglu, RG Langston, A Kaganovich, N Bengoa-Vergniory, A Gonzalez-Guerra, M Avar, D Heinzer, R Reimann, LM Häsler, TW Herling, NS Matharu, N Landeck, K Luk, R Melki, PJ Kahle, S Hornemann, TPJ Knowles, MR Cookson, M Polymenidou, M Jucker, A Aguzzi
EMBO Mol Med
(2021)
13
(doi: 10.15252/emmm.202114745)
Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2
V Denninger, CK Xu, G Meisl, AS Morgunov, S Fiedler, A Ilsley, M Emmenegger, AY Malik, MA Piziorska, MM Schneider, SRA Devenish, V Kosmoliaptsis, A Aguzzi, H Fiegler, TPJ Knowles
(2021)
(doi: 10.1101/2021.07.23.453352)
Yusuf Hamied Department of Chemistry
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