Centre for Misfolding Diseases

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  • Currently displaying 521 - 540 of 2473 publications
Author(s)
Publication title
Journal Name
Publication year
Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV‑2
V Denninger, CK Xu, G Meisl, AS Morgunov, S Fiedler, A Ilsley, M Emmenegger, AY Malik, MA Piziorska, MM Schneider, SRA Devenish, V Kosmoliaptsis, A Aguzzi, H Fiegler, TPJ Knowles
ACS Infectious Diseases
(2022)
8
(doi: 10.1021/acsinfecdis.1c00486)
Lipid Homeostasis and Its Links With Protein Misfolding Diseases
M Vendruscolo
Frontiers in molecular neuroscience
(2022)
15
(doi: 10.3389/fnmol.2022.829291)
A Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates built using Acetal-based Linkers and Thiol-maleimide Chemistry
X Ferhati, E Jiménez-Moreno, EA Hoyt, G Salluce, M Cabeza-Cabrerizo, CD Navo, I Compañón, P Akkapeddi, MJ Matos, N Salaverri, P Garrido, A Martínez, V Laserna, TV Murray, G Jiménez-Osés, P Ravn, GJL Bernardes, F Corzana
Journal of the American Chemical Society
(2022)
144
(doi: 10.1021/jacs.1c07675)
Surface interaction patches link non-specific binding and phase separation of antibodies
H Ausserwöger, G Krainer, TJ Welsh, T Sneideris, MM Schneider, G Invernizzi, TW Herling, N Lorenzen, TPJ Knowles
(2022)
(doi: 10.1101/2022.03.07.483238)
Tie-lines reveal interactions driving heteromolecular condensate formation
D Qian, TJ Welsh, NA Erkamp, S Qamar, J Nixon-Abell, G Krainer, P St George-Hyslop, TCT Michaels, TPJ Knowles
(2022)
(doi: 10.1101/2022.02.22.481401)
Universal lab-on-a-chip microfluidic spray deposition for bulk and single-molecule analytical methods on surfaces
AM Miller, SKR Chia, T Hakala, Z Toprakcioglu, M Vendruscolo, FS Ruggeri, TPJ Knowles
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.993)
Modulators of the plasma membrane protect cells from diverse toxic agents, ranging from protein misfolded oligomers to pore forming agents
R Limbocker, RP Kreiser, LR Sasser, AK Wright, DJ Rinauro, M Vendruscolo
BIOPHYSICAL JOURNAL
(2022)
121
Hsc70 mediated disaggregation of α-synuclein fibrils
MM Schneider, S Gautam, TW Herling, G Krainer, E Andrzejewska, A Bracher, CM Dobson, U Hartl, TP Knowles
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.2605)
Simultaneous fractionation and characterization of pre-fibrillar aggregates in solution with single-molecule microfluidics
EA Andrzejewska, G Krainer, CK Xu, R Jacquat, MM Schneider, W Arter, TPJ Knowles
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.1003)
Mechanism of secondary nucleation from the direct observation of Aβ42 aggregation at the single fibril level
MR Zimmermann, SC Bera, G Meisl, S Dasadhikari, S Ghosh, S Linse, K Garai, TPJ Knowles
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.556)
Using microscopy techniques to structurally characterise TDP-43 inclusions present in mammalian cell models
NS Matharu, CW Chung, JR Kumita, GS Kaminski, TP Knowles
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.1401)
Therapeutic drug targeting in Alzheimer's disease
R Geiser, M Sanguanini, R Staats, D Rinauro, M Metrick, P Ciryam, S Casford, E Zhao, J Fleming, S Hunter, C Brayne, M Vendruscolo
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.1785)
Kinetic analysis of tau aggregation for drug discovery
DJ Rinauro, M Vendruscolo
BIOPHYSICAL JOURNAL
(2022)
121
Counteraction of amyloid-β aggregation by vitamin A and E metabolites in a crowded environment
P Joshi, S Chia, X Yang, M Perni, J Habchi, M Vendruscolo
BIOPHYSICAL JOURNAL
(2022)
121
Sequence-based prediction and measurement of pH-dependent protein solubility
M Oeller, P Sormanni, M Vendruscolo
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.989)
Small molecule and antibody mediated inhibition of the aggregation of a tau fragment implicit in Alzheimer's disease
TL McKenzie, RP Kreiser, RA Limbocker, DJ Rinauro, M Vendruscolo
BIOPHYSICAL JOURNAL
(2022)
121
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization
A Farzadfard, JN Pedersen, G Meisl, AK Somavarapu, P Alam, L Goksøyr, MA Nielsen, AF Sander, TPJ Knowles, JS Pedersen, DE Otzen
Commun Biol
(2022)
5
(doi: 10.1038/s42003-022-03059-8)
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for effectiveness of glycoconjugate vaccine candidates
G Lopes Bernardes, F carboni, A kitowski, C Sorieul, D Veggi, M Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, M Romano, R Adamo
Chemical Science
(2022)
(doi: 10.1039/D1SC01928G)
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates.
F Carboni, A Kitowski, C Sorieul, D Veggi, MC Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, MR Romano, GJL Bernardes, R Adamo
Chemical science
(2022)
13
(doi: 10.1039/d1sc01928g)
Multiphase condensates from a kinetically arrested phase transition
NA Erkamp, T Sneideris, H Ausserwöger, D Qian, S Qamar, J Nixon-Abell, P St George-Hyslop, JD Schmit, DA Weitz, TPJ Knowles
(2022)
(doi: 10.1101/2022.02.09.479538)
Yusuf Hamied Department of Chemistry
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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