Centre for Misfolding Diseases

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  • Currently displaying 441 - 460 of 2396 publications
Author(s)
Publication title
Journal Name
Publication year
A Brain-Permeable Aminosterol Regulates Cell Membranes toMitigate the Toxicity of Diverse Pore-Forming Agents
RP Kreiser, AK Wright, LR Sasser, DJ Rinauro, JM Gabriel, CM Hsu, JA Hurtado, TL McKenzie, S Errico, JA Albright, L Richardson, VA Jaffett, DE Riegner, LT Nguyen, K LeForte, M Zasloff, JE Hollows, F Chiti, M Vendruscolo, R Limbocker
ACS Chemical Neuroscience
(2022)
13
(doi: 10.1021/acschemneuro.1c00840)
Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants
M Emmenegger, S Fiedler, SD Brugger, SRA Devenish, AS Morgunov, A Ilsley, F Ricci, AY Malik, T Scheier, L Batkitar, L Madrigal, M Rossi, AK Lynn, L Saleh, A von Eckardstein, TPJ Knowles, A Aguzzi
(2022)
(doi: 10.1101/2022.04.07.22273545)
Vulnerability of the spinal motor neuron presynaptic terminal sub-proteome in ALS
JS Lum, T Berg, CG Chisholm, M Vendruscolo, JJ Yerbury
Neuroscience letters
(2022)
778
(doi: 10.1016/j.neulet.2022.136614)
Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV‑2
V Denninger, CK Xu, G Meisl, AS Morgunov, S Fiedler, A Ilsley, M Emmenegger, AY Malik, MA Piziorska, MM Schneider, SRA Devenish, V Kosmoliaptsis, A Aguzzi, H Fiegler, TPJ Knowles
ACS Infect Dis
(2022)
8
(doi: 10.1021/acsinfecdis.1c00486)
Lipid Homeostasis and Its Links With Protein Misfolding Diseases
M Vendruscolo
Frontiers in molecular neuroscience
(2022)
15
(doi: 10.3389/fnmol.2022.829291)
Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry.
X Ferhati, E Jiménez-Moreno, EA Hoyt, G Salluce, M Cabeza-Cabrerizo, CD Navo, I Compañón, P Akkapeddi, MJ Matos, N Salaverri, P Garrido, A Martínez, V Laserna, TV Murray, G Jiménez-Osés, P Ravn, GJL Bernardes, F Corzana
Journal of the American Chemical Society
(2022)
144
(doi: 10.1021/jacs.1c07675)
Surface interaction patches link non-specific binding and phase separation of antibodies
H Ausserwöger, G Krainer, TJ Welsh, T Sneideris, MM Schneider, G Invernizzi, TW Herling, N Lorenzen, TPJ Knowles
(2022)
(doi: 10.1101/2022.03.07.483238)
Tie-lines reveal interactions driving heteromolecular condensate formation
D Qian, TJ Welsh, NA Erkamp, S Qamar, J Nixon-Abell, G Krainer, P St George-Hyslop, TCT Michaels, TPJ Knowles
(2022)
(doi: 10.1101/2022.02.22.481401)
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for effectiveness of glycoconjugate vaccine candidates
G Lopes Bernardes, F carboni, A kitowski, C Sorieul, D Veggi, M Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, M Romano, R Adamo
Chemical Science
(2022)
(doi: 10.1039/D1SC01928G)
Multiphase condensates from a kinetically arrested phase transition
NA Erkamp, T Sneideris, H Ausserwöger, D Qian, S Qamar, J Nixon-Abell, P St George-Hyslop, JD Schmit, DA Weitz, TPJ Knowles
(2022)
(doi: 10.1101/2022.02.09.479538)
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates
F Carboni, A Kitowski, C Sorieul, D Veggi, MC Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, MR Romano, GJL Bernardes, R Adamo
Chemical Science
(2022)
13
(doi: 10.1039/d1sc01928g)
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization.
A Farzadfard, JN Pedersen, G Meisl, AK Somavarapu, P Alam, L Goksøyr, MA Nielsen, AF Sander, TPJ Knowles, JS Pedersen, DE Otzen
Communications Biology
(2022)
5
(doi: 10.1038/s42003-022-03059-8)
Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration
S Fiedler, SRA Devenish, AS Morgunov, A Ilsley, F Ricci, M Emmenegger, V Kosmoliaptsis, ES Theel, JR Mills, AM Sholukh, A Aguzzi, A Iwasaki, AK Lynn, TPJ Knowles
(2022)
(doi: 10.1101/2022.02.03.478946)
Nanofluidic Traps by Two-Photon Fabrication for Extended Detection of Single Macromolecules and Colloids in Solution
O Vanderpoorten, AN Babar, G Krainer, RPB Jacquat, PK Challa, Q Peter, Z Toprakcioglu, CK Xu, UF Keyser, JJ Baumberg, CF Kaminski, TPJ Knowles
ACS Applied Nano Materials
(2022)
5
(doi: 10.1021/acsanm.1c03691)
Phase separating RNA binding proteins form heterogeneous distributions of clusters in subsaturated solutions
M Kar, F Dar, TJ Welsh, L Vogel, R Kühnemuth, A Majumdar, G Krainer, TM Franzmann, S Alberti, CAM Seidel, TPJ Knowles, AA Hyman, RV Pappu
(2022)
(doi: 10.1101/2022.02.03.478969)
Sequence-based prediction and measurement of pH-dependent protein solubility
M Oeller, P Sormanni, M Vendruscolo
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.989)
Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics
R Khetan, R Curtis, CM Deane, JT Hadsund, U Kar, K Krawczyk, D Kuroda, SA Robinson, P Sormanni, K Tsumoto, J Warwicker, ACR Martin
mAbs
(2022)
14
(doi: 10.1080/19420862.2021.2020082)
Hsc70 mediated disaggregation of α-synuclein fibrils
MM Schneider, S Gautam, TW Herling, G Krainer, E Andrzejewska, A Bracher, CM Dobson, U Hartl, TP Knowles
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.2605)
Rate‐limiting processes of tau aggregate accumulation in Alzheimer's disease
G Meisl, Y Zuo, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, T Knowles, D Klenerman
Alzheimer's & Dementia
(2022)
17
(doi: 10.1002/alz.051680)
Universal lab-on-a-chip microfluidic spray deposition for bulk and single-molecule analytical methods on surfaces
AM Miller, SKR Chia, T Hakala, Z Toprakcioglu, M Vendruscolo, FS Ruggeri, TPJ Knowles
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2021.11.993)
Yusuf Hamied Department of Chemistry
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