Centre for Misfolding Diseases

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  • Currently displaying 441 - 460 of 2450 publications
Author(s)
Publication title
Journal Name
Publication year
Intracellular FUS protein accumulation leads to cytoskeletal, organelle and cellular homeostasis perturbations
CW Chung, AJ Zhou, I Mela, AD Stephens, A Miyashita, PH St George-Hyslop, CF Kaminski, TPJ Knowles, GSK Schierle
(2022)
(doi: 10.1101/2022.10.04.510756)
Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions.
H Yang, TPJ Knowles
Micromachines
(2022)
13
(doi: 10.3390/mi13101640)
Protein condensation diseases: therapeutic opportunities
M Vendruscolo, M Fuxreiter
Nature Communications
(2022)
13
(doi: 10.1038/s41467-022-32940-7)
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients
K Kulenkampff, D Emin, R Staats, YP Zhang, L Sakhnini, A Kouli, O Rimon, E Lobanova, CH Williams-Gray, FA Aprile, P Sormanni, D Klenerman, M Vendruscolo
Chem Sci
(2022)
13
(doi: 10.1039/d2sc00066k)
Influence of denaturants on amyloid β42 aggregation kinetics
T Weiffert, G Meisl, S Curk, R Cukalevski, A Šarić, TPJ Knowles, S Linse
Frontiers in Neuroscience
(2022)
16
(doi: 10.3389/fnins.2022.943355)
Label-free monitoring of proteins in optofluidic hollow-core photonic crystal fibres
J Heck, E Miele, R Mouthaan, M Frosz, T Knowles, T Euser
Methods Appl Fluoresc
(2022)
10
(doi: 10.1088/2050-6120/ac9113)
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman
Nature Communications
(2022)
13
(doi: 10.1038/s41467-022-33252-6)
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains
AM Miller, S Meehan, CM Dobson, ME Welland, D Klenerman, M Vendruscolo, FS Ruggeri, TPJ Knowles
(2022)
(doi: 10.1101/2022.09.13.507729)
Effects of N-terminal Acetylation on the Aggregation of Disease-related α-synuclein Variants: N-terminal acetylation of α-synuclein variants
R Bell, M Castellana-Cruz, A Nene, RJ Thrush, CK Xu, JR Kumita, M Vendruscolo
Journal of molecular biology
(2022)
435
(doi: 10.1016/j.jmb.2022.167825)
A chip-based supersonic microfluidic nebulizer for efficient sample introduction into inductively coupled plasma- Mass spectrometry
E Mavrakis, Z Toprakcioglu, N Lydakis-Simantiris, TPJ Knowles, SA Pergantis
Anal Chim Acta
(2022)
1229
(doi: 10.1016/j.aca.2022.340342)
Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species.
G Fani, CE La Torre, R Cascella, C Cecchi, M Vendruscolo, F Chiti
Cell Mol Life Sci
(2022)
79
(doi: 10.1007/s00018-022-04513-w)
Analytical Solution to the Flory-Huggins Model.
D Qian, TCT Michaels, TPJ Knowles
The journal of physical chemistry letters
(2022)
13
(doi: 10.1021/acs.jpclett.2c01986)
Solid/liquid coexistence during aging of FUS condensates
Y Shen, A Chen, W Wang, Y Shen, FS Ruggeri, S Aime, Z Wang, S Qamar, JR Espinosa, A Garaizar, P St George-Hyslop, R Collepardo-Guevara, DA Weitz, D Vigolo, TPJ Knowles
(2022)
(doi: 10.1101/2022.08.15.503964)
Uncovering the universality of self-replication in protein aggregation and its link to disease.
G Meisl, CK Xu, JD Taylor, TCT Michaels, A Levin, D Otzen, D Klenerman, S Matthews, S Linse, M Andreasen, TPJ Knowles
Sci Adv
(2022)
8
(doi: 10.1126/sciadv.abn6831)
A conformational switch controlling the toxicity of the prion protein.
K Frontzek, M Bardelli, A Senatore, A Henzi, RR Reimann, S Bedir, M Marino, R Hussain, S Jurt, G Meisl, M Pedotti, F Mazzola, G Siligardi, O Zerbe, M Losa, T Knowles, A Lakkaraju, C Zhu, P Schwarz, S Hornemann, MG Holt, L Simonelli, L Varani, A Aguzzi
Nature Structural & Molecular Biology
(2022)
29
(doi: 10.1038/s41594-022-00814-7)
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates.
R Bell, RJ Thrush, M Castellana-Cruz, M Oeller, R Staats, A Nene, P Flagmeier, CK Xu, S Satapathy, C Galvagnion, MR Wilson, CM Dobson, JR Kumita, M Vendruscolo
Biochemistry
(2022)
61
(doi: 10.1021/acs.biochem.2c00104)
Chemical and Enzymatic Methods for Post-Translational Protein–Protein Conjugation
RJ Taylor, MB Geeson, T Journeaux, GJL Bernardes
J Am Chem Soc
(2022)
144
(doi: 10.1021/jacs.2c00129)
ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy
C Olivieri, GC Li, Y Wang, M V S, C Walker, J Kim, C Camilloni, A De Simone, M Vendruscolo, DA Bernlohr, SS Taylor, G Veglia
Science Advances
(2022)
8
(doi: 10.1126/sciadv.abo0696)
Adsorption free energy predicts amyloid protein nucleation rates.
Z Toprakcioglu, A Kamada, TCT Michaels, M Xie, J Krausser, J Wei, A Saric, M Vendruscolo, TPJ Knowles
Proceedings of the National Academy of Sciences of USA
(2022)
119
(doi: 10.1073/pnas.2109718119)
Enhanced surface nano-analytics of transient biomolecular processes
A Miller, S Chia, Z Toprakcioglu, T Hakala, R Schmid, Y Feng, T Kartanas, A Kamada, M Vendruscolo, FS Ruggeri, TPJ Knowles
(2022)
(doi: 10.1101/2022.07.25.501379)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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