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Currently displaying 441 - 460 of 2473 publications

Adsorption of RNA to interfaces of biomolecular condensates enables wetting transitions

NA Erkamp, M Farag, D Qian, T Sneideris, TJ Welsh, H Ausserwöger, DA Weitz, RV Pappu, TPJ Knowles

(2023)

(doi: 10.1101/2023.01.12.523837)

Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties.

HL Svilenov, P Arosio, T Menzen, P Tessier, P Sormanni

MAbs

(2023)

2164459

(doi: 10.1080/19420862.2022.2164459)

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region

M Emmenegger, E De Cecco, D Lamparter, RPB Jacquat, J Riou, D Menges, T Ballouz, D Ebner, MM Schneider, IC Morales, B Doğançay, J Guo, A Wiedmer, J Domange, M Imeri, R Moos, C Zografou, L Batkitar, L Madrigal, D Schneider, C Trevisan, A Gonzalez-Guerra, A Carrella, IL Dubach, CK Xu, G Meisl, V Kosmoliaptsis, T Malinauskas, N Burgess-Brown, R Owens, S Hatch, J Mongkolsapaya, GR Screaton, K Schubert, JD Huck, F Liu, F Pojer, K Lau, D Hacker, E Probst-Müller, C Cervia, J Nilsson, O Boyman, L Saleh, K Spanaus, A von Eckardstein, DJ Schaer, N Ban, C-J Tsai, J Marino, GFX Schertler, N Ebert, V Thiel, J Gottschalk, BM Frey, RR Reimann, S Hornemann, AM Ring, TPJ Knowles, MA Puhan, CL Althaus, I Xenarios, DI Stuart, A Aguzzi

Iscience

(2023)

105928

(doi: 10.1016/j.isci.2023.105928)

Probing the effects of N-terminal acetylation on α-synuclein structure, aggregation and cytotoxicity

R Bell, M Vendruscolo, JR Kumita

Methods in Enzymology

(2023)

686

(doi: 10.1016/bs.mie.2022.09.003)

Tie-Line Analysis Reveals Interactions Driving Heteromolecular Condensate Formation

D Qian, T Welsh, N Erkamp, S Qamar, J Nixon-Abell, G Krainer, P St George-Hyslop, T Michaels, T Knowles

Physical Review X

(2022)

041038

(doi: 10.1103/PhysRevX.12.041038)

A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ42 Aggregation.

KN Baumann, G Šneiderienė, M Sanguanini, M Schneider, O Rimon, A González Díaz, H Greer, D Thacker, S Linse, TPJ Knowles, M Vendruscolo

ACS chemical neuroscience

(2022)

323

(doi: 10.1021/acschemneuro.2c00765)

Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.

WE Arter, R Qi, NA Erkamp, G Krainer, K Didi, TJ Welsh, J Acker, J Nixon-Abell, S Qamar, J Guillén-Boixet, TM Franzmann, D Kuster, AA Hyman, A Borodavka, PS George-Hyslop, S Alberti, TPJ Knowles

Nature communications

(2022)

7845

(doi: 10.1038/s41467-022-35265-7)

Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid

SR Ball, JSP Adamson, MA Sullivan, MR Zimmermann, V Lo, M Sanz-Hernandez, X Jiang, AH Kwan, ADJ McKenzie, EL Werry, TPJ Knowles, M Kassiou, G Meisl, MH Todd, PJ Rutledge, M Sunde

ACS chemical neuroscience

(2022)

(doi: 10.1021/acschemneuro.2c00498)

Microfluidics for multiscale studies of biomolecular condensates.

NA Erkamp, R Qi, TJ Welsh, TPJ Knowles

Lab on a Chip

(2022)

(doi: 10.1039/d2lc00622g)

Selenium Silk Nanostructured Films for Antifungal and Antibacterial Treatments

Z Toprakcioglu, EG Wiita, AK Jayaram, RC Gregory, TPJ Knowles

(2022)

(doi: 10.1101/2022.12.18.520325)

EGCG inactivates a pore-forming toxin by promoting its oligomerization and decreasing its solvent-exposed hydrophobicity

JM Gabriel, T Tan, DJ Rinauro, CM Hsu, CJ Buettner, M Gilmer, A Kaur, TL McKenzie, M Park, S Cohen, S Errico, AK Wright, F Chiti, M Vendruscolo, R Limbocker

Chemico-Biological Interactions

(2022)

371

110307

(doi: 10.1016/j.cbi.2022.110307)

The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus**

H Zhu, M Narita, JA Joseph, G Krainer, WE Arter, I Olan, KL Saar, N Ermann, JR Espinosa, Y Shen, MA Kuri, R Qi, TJ Welsh, R Collepardo-Guevara, M Narita, TPJ Knowles

ChemBioChem

(2022)

e202200450

(doi: 10.1002/cbic.202200450)

Core-Shell Spheroid-Laden Microgels Crosslinked under Biocompatible Conditions for Probing Cancer-Stromal Communication

H Zhu, LWY Roode, AJ Parry, NA Erkamp, M Rodriguez-Garcia, M Narita, Y Shen, Y Ou, Z Toprakcioglu, M Narita, TPJ Knowles

Advanced NanoBiomed Research

(2022)

2200138

(doi: 10.1002/anbr.202200138)

Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration.

S Fiedler, SRA Devenish, AS Morgunov, A Ilsley, F Ricci, M Emmenegger, V Kosmoliaptsis, ES Theel, JR Mills, AM Sholukh, A Aguzzi, A Iwasaki, AK Lynn, TPJ Knowles

Sci Rep

(2022)

19791

(doi: 10.1038/s41598-022-22214-z)

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates

S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo

Molecular Pharmaceutics

(2022)

183

(doi: 10.1021/acs.molpharmaceut.2c00548)

Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones

CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes

Angewandte Chemie

(2022)

134

(doi: 10.1002/ange.202208543)

Non-specificity as the sticky problem in therapeutic antibody development.

H Ausserwöger, MM Schneider, TW Herling, P Arosio, G Invernizzi, TPJ Knowles, N Lorenzen

Nat Rev Chem

(2022)

844

(doi: 10.1038/s41570-022-00438-x)

Fragment-based computational design of antibodies targeting structured epitopes.

M Aguilar Rangel, A Bedwell, E Costanzi, RJ Taylor, R Russo, GJL Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni

Science advances

(2022)

eabp9540

(doi: 10.1126/sciadv.abp9540)

Sequence-based Prediction of the Cellular Toxicity Associated with Amyloid Aggregation within Protein Condensates

A Horvath, M Vendruscolo, M Fuxreiter

Biochemistry

(2022)

2461

(doi: 10.1021/acs.biochem.2c00499)

Selective Inhibition of Bruton's Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors.

BB Sousa, CR de Almeida, AF Barahona, R Lopes, A Martins-Logrado, M Cavaco, V Neves, LAR Carvalho, C Labão-Almeida, AR Coelho, M Leal Bento, RMRM Lopes, BL Oliveira, MARB Castanho, P Neumeister, A Deutsch, GI Vladimer, N Krall, C João, F Corzana, JD Seixas, R Fior, GJL Bernardes

ACS Pharmacology & Translational Science

(2022)

1156

(doi: 10.1021/acsptsci.2c00163)

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