Centre for Misfolding Diseases

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  • Currently displaying 421 - 440 of 2396 publications
Author(s)
Publication title
Journal Name
Publication year
Aging can transform single-component protein condensates into multiphase architectures.
A Garaizar, JR Espinosa, JA Joseph, G Krainer, Y Shen, TPJ Knowles, R Collepardo-Guevara
Proceedings of the National Academy of Sciences of USA
(2022)
119
(doi: 10.1073/pnas.2119800119)
Uncovering the universality of self-replication in protein aggregation and its link to disease
G Meisl, CK Xu, JD Taylor, TCT Michaels, A Levin, D Otzen, D Klenerman, S Matthews, S Linse, M Andreasen, TPJ Knowles
(2022)
(doi: 10.1101/2022.06.08.495339)
Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents.
A Istrate, MB Geeson, CD Navo, BB Sousa, MC Marques, RJ Taylor, T Journeaux, SR Oehler, MR Mortensen, MJ Deery, AD Bond, F Corzana, G Jiménez-Osés, GJL Bernardes
J Am Chem Soc
(2022)
144
(doi: 10.1021/jacs.2c02185)
A Small Molecule Stabilizes the Disordered Native State of the Alzheimer's Aβ Peptide
T Löhr, K Kohlhoff, GT Heller, C Camilloni, M Vendruscolo
ACS Chemical Neuroscience
(2022)
13
(doi: 10.1021/acschemneuro.2c00116)
Determination of the structure and dynamics of the fuzzy coat of an amyloid fibril of IAPP using cryo-electron microscopy
ZF Brotzakis, T Löhr, S Truong, SE Hoff, M Bonomi, M Vendruscolo
(2022)
(doi: 10.1101/2022.05.29.493873)
FuzDrop on AlphaFold: visualizing the sequence-dependent propensity of liquid-liquid phase separation and aggregation of proteins
A Hatos, SCE Tosatto, M Vendruscolo, M Fuxreiter
Nucleic Acids Res
(2022)
50
(doi: 10.1093/nar/gkac386)
Automated optimisation of solubility and conformational stability of antibodies and proteins
A Rosace, A Bennett, M Oeller, MM Mortensen, L Sakhnini, N Lorenzen, C Poulsen, P Sormanni
(2022)
(doi: 10.1101/2022.05.20.492798)
The Impact of Activity-based Protein Profiling in Malaria Drug Discovery.
LAR Carvalho, GJL Bernardes
ChemMedChem
(2022)
17
(doi: 10.1002/cmdc.202200174)
Conformational Entropy as a Potential Liability of Computationally Designed Antibodies
T Löhr, P Sormanni, M Vendruscolo
Biomolecules
(2022)
12
(doi: 10.3390/biom12050718)
An aggregation inhibitor specific to oligomeric intermediates of Aβ42 derived from phage display libraries of stable, small proteins.
S Linse, P Sormanni, DJ O'Connell
Proc Natl Acad Sci U S A
(2022)
119
(doi: 10.1073/pnas.2121966119)
Sequence-based pH-dependent prediction of protein solubility using CamSol
M Oeller, R Kang, P Sormanni, M Vendruscolo
(2022)
(doi: 10.1101/2022.05.09.491135)
Adsorption Free Energy Predicts Amyloid Protein Nucleation Rates
Z Toprakcioglu, A Kamada, T Michaels, M Xie, J Krausser, J Wei, A Saric, M Vendruscolo, T Knowles
(2022)
(doi: 10.26434/chemrxiv-2022-tjrtf)
Bioprinting microporous functional living materials from protein-based core-shell microgels
Y Ou, S Cao, Y Zhang, H Zhu, C Guo, W Yan, F Xin, W Dong, Y Zhang, M Narita, Z Yu, T Knowles
(2022)
(doi: 10.1101/2022.05.03.490444)
Structural insights into TRPV2 activation by small molecules
RA Pumroy, AD Protopopova, TC Fricke, IU Lange, FM Haug, PT Nguyen, PN Gallo, BB Sousa, G Lopes Bernardes, V Yarov-Yarovoy, A Leffler, VY Moiseenkova-Bell
Nature Communications
(2022)
13
(doi: 10.1038/s41467-022-30083-3)
Kinetic profiling of therapeutic strategies for inhibiting the formation of amyloid oligomers.
TCT Michaels, AJ Dear, SIA Cohen, M Vendruscolo, TPJ Knowles
Journal of Chemical Physics
(2022)
156
(doi: 10.1063/5.0077609)
Analytical solution to the Flory-Huggins model
D Qian, TCT Michaels, TPJ Knowles
(2022)
(doi: 10.1101/2022.04.23.489256)
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic.
R Limbocker, S Errico, D Barbut, TPJ Knowles, M Vendruscolo, F Chiti, M Zasloff
Natural Product Reports
(2022)
39
(doi: 10.1039/d1np00042j)
Ibrutinib Inhibits BMX-Dependent Endothelial VCAM-1 Expression In Vitro and Pro-Atherosclerotic Endothelial Activation and Platelet Adhesion In Vivo.
TCL Kohs, SR Olson, J Pang, KR Jordan, TJ Zheng, A Xie, J Hodovan, M Muller, C McArthur, J Johnson, BB Sousa, M Wallisch, P Kievit, JE Aslan, JD Seixas, GJL Bernardes, MT Hinds, JR Lindner, OJT McCarty, C Puy, JJ Shatzel
Cellular and molecular bioengineering
(2022)
15
(doi: 10.1007/s12195-022-00723-1)
A Kinetic Map of the Influence of Biomimetic Lipid Membrane Models on Aβ42 Aggregation
KN Baumann, M Sanguanini, O Rimon, G Šneiderienė, H Greer, D Thacker, M Schneider, S Linse, TPJ Knowles, M Vendruscolo
(2022)
(doi: 10.1101/2022.04.16.488542)
A Brain-Permeable Aminosterol Regulates Cell Membranes toMitigate the Toxicity of Diverse Pore-Forming Agents
RP Kreiser, AK Wright, LR Sasser, DJ Rinauro, JM Gabriel, CM Hsu, JA Hurtado, TL McKenzie, S Errico, JA Albright, L Richardson, VA Jaffett, DE Riegner, LT Nguyen, K LeForte, M Zasloff, JE Hollows, F Chiti, M Vendruscolo, R Limbocker
ACS Chemical Neuroscience
(2022)
13
(doi: 10.1021/acschemneuro.1c00840)
Yusuf Hamied Department of Chemistry
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