Centre for Misfolding Diseases

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  • Currently displaying 421 - 440 of 2450 publications
Author(s)
Publication title
Journal Name
Publication year
Tie-Line Analysis Reveals Interactions Driving Heteromolecular Condensate Formation
D Qian, T Welsh, N Erkamp, S Qamar, J Nixon-Abell, G Krainer, P St George-Hyslop, T Michaels, T Knowles
Physical Review X
(2022)
12
(doi: 10.1103/PhysRevX.12.041038)
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ42 Aggregation.
KN Baumann, G Šneiderienė, M Sanguanini, M Schneider, O Rimon, A González Díaz, H Greer, D Thacker, S Linse, TPJ Knowles, M Vendruscolo
ACS Chem Neurosci
(2022)
14
(doi: 10.1021/acschemneuro.2c00765)
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform
WE Arter, R Qi, NA Erkamp, G Krainer, K Didi, TJ Welsh, J Acker, J Nixon-Abell, S Qamar, J Guillén-Boixet, TM Franzmann, D Kuster, AA Hyman, A Borodavka, PS George-Hyslop, S Alberti, TPJ Knowles
Nature Communications
(2022)
13
(doi: 10.1038/s41467-022-35265-7)
Perphenazine–Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid
SR Ball, JSP Adamson, MA Sullivan, MR Zimmermann, V Lo, M Sanz-Hernandez, X Jiang, AH Kwan, ADJ McKenzie, EL Werry, TPJ Knowles, M Kassiou, G Meisl, MH Todd, PJ Rutledge, M Sunde
ACS Chem Neurosci
(2022)
14
(doi: 10.1021/acschemneuro.2c00498)
Microfluidics for multiscale studies of biomolecular condensates
NA Erkamp, R Qi, TJ Welsh, TPJ Knowles
Lab Chip
(2022)
23
(doi: 10.1039/d2lc00622g)
Selenium Silk Nanostructured Films for Antifungal and Antibacterial Treatments
Z Toprakcioglu, EG Wiita, AK Jayaram, RC Gregory, TPJ Knowles
(2022)
(doi: 10.1101/2022.12.18.520325)
EGCG inactivates a pore-forming toxin by promoting its oligomerization and decreasing its solvent-exposed hydrophobicity.
JM Gabriel, T Tan, DJ Rinauro, CM Hsu, CJ Buettner, M Gilmer, A Kaur, TL McKenzie, M Park, S Cohen, S Errico, AK Wright, F Chiti, M Vendruscolo, R Limbocker
Chemico Biological Interactions
(2022)
371
(doi: 10.1016/j.cbi.2022.110307)
The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus
H Zhu, M Narita, JA Joseph, G Krainer, WE Arter, I Olan, KL Saar, N Ermann, JR Espinosa, Y Shen, MA Kuri, R Qi, TJ Welsh, R Collepardo-Guevara, M Narita, TPJ Knowles
Chembiochem
(2022)
24
(doi: 10.1002/cbic.202200450)
Core–Shell Spheroid-Laden Microgels Crosslinked under Biocompatible Conditions for Probing Cancer-Stromal Communication
H Zhu, LWY Roode, AJ Parry, NA Erkamp, M Rodriguez-Garcia, M Narita, Y Shen, Y Ou, Z Toprakcioglu, M Narita, TPJ Knowles
Advanced Nanobiomed Research
(2022)
2
(doi: 10.1002/anbr.202200138)
Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration
S Fiedler, SRA Devenish, AS Morgunov, A Ilsley, F Ricci, M Emmenegger, V Kosmoliaptsis, ES Theel, JR Mills, AM Sholukh, A Aguzzi, A Iwasaki, AK Lynn, TPJ Knowles
Scientific Reports
(2022)
12
(doi: 10.1038/s41598-022-22214-z)
Non-specificity as the sticky problem in therapeutic antibody development
H Ausserwöger, MM Schneider, TW Herling, P Arosio, G Invernizzi, TPJ Knowles, N Lorenzen
Nat Rev Chem
(2022)
6
(doi: 10.1038/s41570-022-00438-x)
Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones
CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes
Angewandte Chemie
(2022)
134
(doi: 10.1002/ange.202208543)
Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates.
S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
Mol Pharm
(2022)
20
(doi: 10.1021/acs.molpharmaceut.2c00548)
Fragment-based computational design of antibodies targeting structured epitopes
M Aguilar Rangel, A Bedwell, E Costanzi, RJ Taylor, R Russo, GJL Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni
Sci Adv
(2022)
8
(doi: 10.1126/sciadv.abp9540)
Sequence-based Prediction of the Cellular Toxicity Associated with Amyloid Aggregation within Protein Condensates.
A Horvath, M Vendruscolo, M Fuxreiter
Biochemistry
(2022)
61
(doi: 10.1021/acs.biochem.2c00499)
Selective Inhibition of Bruton's Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors.
BB Sousa, CR de Almeida, AF Barahona, R Lopes, A Martins-Logrado, M Cavaco, V Neves, LAR Carvalho, C Labão-Almeida, AR Coelho, M Leal Bento, RMRM Lopes, BL Oliveira, MARB Castanho, P Neumeister, A Deutsch, GI Vladimer, N Krall, C João, F Corzana, JD Seixas, R Fior, GJL Bernardes
ACS Pharmacology & Translational Science
(2022)
5
(doi: 10.1021/acsptsci.2c00163)
Microscale Diffusiophoresis of Proteins.
QAE Peter, RPB Jacquat, TW Herling, PK Challa, T Kartanas, TPJ Knowles
Journal of Physical Chemistry B
(2022)
126
(doi: 10.1021/acs.jpcb.2c04029)
Multi-dimensional protein solubility optimization with an ultra-high-throughput microfluidic platform
NA Erkamp, M Oeller, T Sneideris, H Ausserwӧger, A Levin, T Welsh, R Qi, D Qian, H Zhu, P Sormanni, M Vendruscolo, TPJ Knowles
(2022)
(doi: 10.1101/2022.10.21.513267)
Cysteine-Assisted Click-Chemistry for Proximity-Driven, Site-Specific Acetylation of Histones.
CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes
Angewandte Chemie International Edition
(2022)
61
(doi: 10.1002/anie.202208543)
Characterization of full-length p53 aggregates and their kinetics of formation
L Julian, JC Sang, Y Wu, G Meisl, JH Brelstaff, A Miller, MR Cheetham, M Vendruscolo, TPJ Knowles, FS Ruggeri, C Bryant, S Ros, KM Brindle, D Klenerman
Biophysical journal
(2022)
121
(doi: 10.1016/j.bpj.2022.10.013)
Yusuf Hamied Department of Chemistry
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