Centre for Misfolding Diseases

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  • Currently displaying 381 - 400 of 2396 publications
Author(s)
Publication title
Journal Name
Publication year
Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones
CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes
Angewandte Chemie
(2022)
134
(doi: 10.1002/ange.202208543)
Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α‑Synuclein Aggregates
S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
Molecular Pharmaceutics
(2022)
20
(doi: 10.1021/acs.molpharmaceut.2c00548)
Fragment-based computational design of antibodies targeting structured epitopes
M Aguilar Rangel, A Bedwell, E Costanzi, RJ Taylor, R Russo, GJL Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni
Sci Adv
(2022)
8
(doi: 10.1126/sciadv.abp9540)
Sequence-based Prediction of the Cellular Toxicity Associated with Amyloid Aggregation within Protein Condensates.
A Horvath, M Vendruscolo, M Fuxreiter
Biochemistry
(2022)
61
(doi: 10.1021/acs.biochem.2c00499)
Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors
BB Sousa, CR de Almeida, AF Barahona, R Lopes, A Martins-Logrado, M Cavaco, V Neves, LAR Carvalho, C Labão-Almeida, AR Coelho, M Leal Bento, RMRM Lopes, BL Oliveira, MARB Castanho, P Neumeister, A Deutsch, GI Vladimer, N Krall, C João, F Corzana, JD Seixas, R Fior, GJL Bernardes
ACS Pharmacol Transl Sci
(2022)
5
(doi: 10.1021/acsptsci.2c00163)
Microscale Diffusiophoresis of Proteins.
QAE Peter, RPB Jacquat, TW Herling, PK Challa, T Kartanas, TPJ Knowles
J Phys Chem B
(2022)
126
(doi: 10.1021/acs.jpcb.2c04029)
Multi-dimensional protein solubility optimization with an ultra-high-throughput microfluidic platform
NA Erkamp, M Oeller, T Sneideris, H Ausserwӧger, A Levin, T Welsh, R Qi, D Qian, H Zhu, P Sormanni, M Vendruscolo, TPJ Knowles
(2022)
(doi: 10.1101/2022.10.21.513267)
Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones
CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes
Angewandte Chemie (International ed. in English)
(2022)
61
(doi: 10.1002/anie.202208543)
Characterization of full-length p53 aggregates and their kinetics of formation.
L Julian, JC Sang, Y Wu, G Meisl, JH Brelstaff, A Miller, MR Cheetham, M Vendruscolo, TPJ Knowles, FS Ruggeri, C Bryant, S Ros, KM Brindle, D Klenerman
Biophysical Journal
(2022)
121
(doi: 10.1016/j.bpj.2022.10.013)
Intracellular FUS protein accumulation leads to cytoskeletal, organelle and cellular homeostasis perturbations
CW Chung, AJ Zhou, I Mela, AD Stephens, A Miyashita, PH St George-Hyslop, CF Kaminski, TPJ Knowles, GSK Schierle
(2022)
(doi: 10.1101/2022.10.04.510756)
Hydrodynamics of Droplet Sorting in Asymmetric Acute Junctions
H Yang, TPJ Knowles
Micromachines (Basel)
(2022)
13
(doi: 10.3390/mi13101640)
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients.
K Kulenkampff, D Emin, R Staats, YP Zhang, L Sakhnini, A Kouli, O Rimon, E Lobanova, CH Williams-Gray, FA Aprile, P Sormanni, D Klenerman, M Vendruscolo
Chemical Science
(2022)
13
(doi: 10.1039/d2sc00066k)
Protein condensation diseases: therapeutic opportunities.
M Vendruscolo, M Fuxreiter
Nature Communications
(2022)
13
(doi: 10.1038/s41467-022-32940-7)
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman
Nature Communications
(2022)
13
(doi: 10.1038/s41467-022-33252-6)
Influence of denaturants on amyloid β42 aggregation kinetics
T Weiffert, G Meisl, S Curk, R Cukalevski, A Šarić, TPJ Knowles, S Linse
Front Neurosci
(2022)
16
(doi: 10.3389/fnins.2022.943355)
Label-free monitoring of proteins in optofluidic hollow-core photonic crystal fibres.
J Heck, E Miele, R Mouthaan, M Frosz, T Knowles, T Euser
Methods and Applications in Fluorescence
(2022)
10
(doi: 10.1088/2050-6120/ac9113)
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains
AM Miller, S Meehan, CM Dobson, ME Welland, D Klenerman, M Vendruscolo, FS Ruggeri, TPJ Knowles
(2022)
(doi: 10.1101/2022.09.13.507729)
Effects of N-terminal Acetylation on the Aggregation of Disease-related α-synuclein Variants
R Bell, M Castellana-Cruz, A Nene, RJ Thrush, CK Xu, JR Kumita, M Vendruscolo
J Mol Biol
(2022)
435
(doi: 10.1016/j.jmb.2022.167825)
A chip-based supersonic microfluidic nebulizer for efficient sample introduction into inductively coupled plasma - Mass spectrometry.
E Mavrakis, Z Toprakcioglu, N Lydakis-Simantiris, TPJ Knowles, SA Pergantis
Anal Chim Acta
(2022)
1229
(doi: 10.1016/j.aca.2022.340342)
Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species.
G Fani, CE La Torre, R Cascella, C Cecchi, M Vendruscolo, F Chiti
Cell Mol Life Sci
(2022)
79
(doi: 10.1007/s00018-022-04513-w)
Yusuf Hamied Department of Chemistry
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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