Centre for Misfolding Diseases

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  • Currently displaying 381 - 400 of 2473 publications
Author(s)
Publication title
Journal Name
Publication year
Formation of Protein Nanoparticles in Microdroplet Flow Reactors
Q Zhang, Z Toprakcioglu, AK Jayaram, G Guo, X Wang, TPJ Knowles
ACS Nano
(2023)
17
(doi: 10.1021/acsnano.3c00107)
Understanding and controlling the molecular mechanisms of protein aggregation in mAb therapeutics.
KT Pang, YS Yang, W Zhang, YS Ho, P Sormanni, TCT Michaels, I Walsh, S Chia
Biotechnology advances
(2023)
67
(doi: 10.1016/j.biotechadv.2023.108192)
De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
M Rebelo, C Tang, AR Coelho, C Labão-Almeida, MM Schneider, L Tatalick, P Ruivo, MP de Miranda, A Gomes, T Carvalho, MJ Walker, H Ausserwoeger, J Pedro Simas, M Veldhoen, TPJ Knowles, D-A Silva, D Shoultz, GJL Bernardes
Journal of Infectious Diseases
(2023)
228
(doi: 10.1093/infdis/jiad135)
Thermodynamic and kinetic approaches for drug discovery to target protein misfolding and aggregation
M Vendruscolo
Expert opinion on drug discovery
(2023)
18
(doi: 10.1080/17460441.2023.2221024)
Quantifying collective interactions in biomolecular phase separation
H Ausserwöger, D Qian, G Krainer, E de Csilléry, TJ Welsh, T Sneideris, TM Franzmann, S Qamar, NA Erkamp, J Nixon-Abell, M Kar, P St George-Hyslop, AA Hyman, S Alberti, RV Pappu, TPJ Knowles
(2023)
(doi: 10.1101/2023.05.31.543137)
Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration
S Koga, MA Metrick, LI Golbe, A Santambrogio, M Kim, AI Soto-Beasley, RL Walton, MC Baker, CF De Castro, M DeTure, D Russell, BA Navia, C Sandiego, OA Ross, M Vendruscolo, B Caughey, DW Dickson
Acta Neuropathologica Communications
(2023)
11
(doi: 10.1186/s40478-023-01584-z)
Unlocking the Potential of Bio-Based Nitrogen-Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
Angewandte Chemie International Edition
(2023)
62
(doi: 10.1002/anie.202304449)
Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
Angewandte Chemie
(2023)
135
(doi: 10.1002/ange.202304449)
CAID prediction portal: a comprehensive service for predicting intrinsic disorder and binding regions in proteins.
A Del Conte, A Bouhraoua, M Mehdiabadi, D Clementel, AM Monzon, CAID predictors, SCE Tosatto, D Piovesan
Nucleic acids research
(2023)
51
(doi: 10.1093/nar/gkad430)
α-Synuclein oligomers form by secondary nucleation
CK Xu, G Meisl, E Andrzejewska, G Krainer, AJ Dear, MC Cruz, S Turi, R Jacquat, WE Arter, M Vendruscolo, S Linse, TP Knowles
(2023)
(doi: 10.1101/2023.05.28.542651)
Label-free detection of proteins with optofluidic hollow-core photonic crystal fibre sensors
JR Heck, E Miele, R Mouthaan, MH Frosz, TPJ Knowles, TG Euser
Proceedings of SPIE--the International Society for Optical Engineering
(2023)
12327
(doi: 10.1117/12.2643905)
Towards sequence-based principles for protein phase separation predictions.
M Vendruscolo, M Fuxreiter
Curr Opin Chem Biol
(2023)
75
(doi: 10.1016/j.cbpa.2023.102317)
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains.
A Miller, J Wei, S Meehan, CM Dobson, ME Welland, D Klenerman, M Vendruscolo, FS Ruggeri, TPJ Knowles
Proceedings of the National Academy of Sciences
(2023)
120
(doi: 10.1073/pnas.2216234120)
Theoretical and Data-Driven Approaches for Biomolecular Condensates
KL Saar, D Qian, LL Good, AS Morgunov, R Collepardo-Guevara, RB Best, TPJ Knowles
Chem Rev
(2023)
123
(doi: 10.1021/acs.chemrev.2c00586)
A novel microfluidic immunoassay for in-solution quantification of alloantibody affinity and concentration in transplantation and beyond
A Priddey, G Karahan, M Schneider, G Meisl, T Scheidt, C Xu, S Peacock, R Buchli, A Mulder, S Heidt, F Class, T Knowles, V Kosmolipaptsis
British Journal of Surgery
(2023)
110
(doi: 10.1093/bjs/znad101.010)
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions
GM Dal Forno, E Latocheski, A Beatriz Machado, J Becher, L Dunsmore, AL St John, BL Oliveira, CD Navo, G Jiménez-Osés, R Fior, JB Domingos, GJL Bernardes
J Am Chem Soc
(2023)
145
(doi: 10.1021/jacs.3c01960)
AbNatiV: VQ-VAE-based assessment of antibody and nanobody nativeness for hit selection, humanisation, and engineering
A Ramon, M Ali, M Atkinson, A Saturnino, K Didi, C Visentin, S Ricagno, X Xu, M Greenig, P Sormanni
(2023)
(doi: 10.1101/2023.04.28.538712)
Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules.
S Mikutis, M Rebelo, E Yankova, M Gu, C Tang, AR Coelho, M Yang, ME Hazemi, M Pires de Miranda, M Eleftheriou, M Robertson, GS Vassiliou, DJ Adams, JP Simas, F Corzana, JS Schneekloth, K Tzelepis, GJL Bernardes
ACS Cent Sci
(2023)
9
(doi: 10.1021/acscentsci.3c00015)
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases
R Limbocker, N Cremades, R Cascella, PM Tessier, M Vendruscolo, F Chiti
Accounts of chemical research
(2023)
56
(doi: 10.1021/acs.accounts.3c00045)
A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation
T Amico, S Dada, A Lazzari, M Brezinova, A Trovato, M Vendruscolo, M Fuxreiter, A Maritan
(2023)
(doi: 10.1101/2023.04.11.536478)
Yusuf Hamied Department of Chemistry
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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