Centre for Misfolding Diseases

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  • Currently displaying 361 - 380 of 2456 publications
Author(s)
Publication title
Journal Name
Publication year
Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties.
HL Svilenov, P Arosio, T Menzen, P Tessier, P Sormanni
Mabs
(2023)
15
(doi: 10.1080/19420862.2022.2164459)
Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.
M Emmenegger, E De Cecco, D Lamparter, RPB Jacquat, J Riou, D Menges, T Ballouz, D Ebner, MM Schneider, IC Morales, B Doğançay, J Guo, A Wiedmer, J Domange, M Imeri, R Moos, C Zografou, L Batkitar, L Madrigal, D Schneider, C Trevisan, A Gonzalez-Guerra, A Carrella, IL Dubach, CK Xu, G Meisl, V Kosmoliaptsis, T Malinauskas, N Burgess-Brown, R Owens, S Hatch, J Mongkolsapaya, GR Screaton, K Schubert, JD Huck, F Liu, F Pojer, K Lau, D Hacker, E Probst-Müller, C Cervia, J Nilsson, O Boyman, L Saleh, K Spanaus, A von Eckardstein, DJ Schaer, N Ban, C-J Tsai, J Marino, GFX Schertler, N Ebert, V Thiel, J Gottschalk, BM Frey, RR Reimann, S Hornemann, AM Ring, TPJ Knowles, MA Puhan, CL Althaus, I Xenarios, DI Stuart, A Aguzzi
iScience
(2023)
26
(doi: 10.1016/j.isci.2023.105928)
Probing the effects of N-terminal acetylation on α-synuclein structure, aggregation and cytotoxicity.
R Bell, M Vendruscolo, JR Kumita
Methods in Enzymology
(2023)
686
(doi: 10.1016/bs.mie.2022.09.003)
Invited speaker Kinetics of protein phase transitions
T Knowles
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2023)
52
Development of machine learning models for prediction of antibody non-specificity
L Sakhnini, N Lorenzen, P Sormanni, M Vendruscolo, D Granata
BIOPHYSICAL JOURNAL
(2023)
122
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Y Liao, M Fernandopulle, G Wang, H Choi, L Hao, C Drerup, R Patel, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, T Knowles, N Matthew, M Czekalska, G Musteikyte, M Gachechiladze, C Stephens, H Pasolli, L Forrest, P St George-Hyslop, J Lippincott-Schwartz, ME Ward
MOLECULAR BIOLOGY OF THE CELL
(2023)
34
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ42 Aggregation.
KN Baumann, G Šneiderienė, M Sanguanini, M Schneider, O Rimon, A González Díaz, H Greer, D Thacker, S Linse, TPJ Knowles, M Vendruscolo
ACS Chemical Neuroscience
(2022)
14
(doi: 10.1021/acschemneuro.2c00765)
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.
WE Arter, R Qi, NA Erkamp, G Krainer, K Didi, TJ Welsh, J Acker, J Nixon-Abell, S Qamar, J Guillén-Boixet, TM Franzmann, D Kuster, AA Hyman, A Borodavka, PS George-Hyslop, S Alberti, TPJ Knowles
Nature communications
(2022)
13
(doi: 10.1038/s41467-022-35265-7)
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid
SR Ball, JSP Adamson, MA Sullivan, MR Zimmermann, V Lo, M Sanz-Hernandez, X Jiang, AH Kwan, ADJ McKenzie, EL Werry, TPJ Knowles, M Kassiou, G Meisl, MH Todd, PJ Rutledge, M Sunde
ACS Chemical Neuroscience
(2022)
14
(doi: 10.1021/acschemneuro.2c00498)
Microfluidics for multiscale studies of biomolecular condensates
NA Erkamp, R Qi, TJ Welsh, TPJ Knowles
Lab on A Chip
(2022)
23
(doi: 10.1039/d2lc00622g)
Selenium Silk Nanostructured Films for Antifungal and Antibacterial Treatments
Z Toprakcioglu, EG Wiita, AK Jayaram, RC Gregory, TPJ Knowles
(2022)
(doi: 10.1101/2022.12.18.520325)
EGCG inactivates a pore-forming toxin by promoting its oligomerization and decreasing its solvent-exposed hydrophobicity?
JM Gabriel, T Tan, DJ Rinauro, CM Hsu, CJ Buettner, M Gilmer, A Kaur, TL McKenzie, M Park, S Cohen, S Errico, AK Wright, F Chiti, M Vendruscolo, R Limbocker
Chem Biol Interact
(2022)
371
(doi: 10.1016/j.cbi.2022.110307)
The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus**
H Zhu, M Narita, JA Joseph, G Krainer, WE Arter, I Olan, KL Saar, N Ermann, JR Espinosa, Y Shen, MA Kuri, R Qi, TJ Welsh, R Collepardo-Guevara, M Narita, TPJ Knowles
Chembiochem : a European journal of chemical biology
(2022)
24
(doi: 10.1002/cbic.202200450)
Core-Shell Spheroid-Laden Microgels Crosslinked under Biocompatible Conditions for Probing Cancer-Stromal Communication
H Zhu, LWY Roode, AJ Parry, NA Erkamp, M Rodriguez-Garcia, M Narita, Y Shen, Y Ou, Z Toprakcioglu, M Narita, TPJ Knowles
Advanced Nanobiomed Research
(2022)
2
(doi: 10.1002/anbr.202200138)
Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration
S Fiedler, SRA Devenish, AS Morgunov, A Ilsley, F Ricci, M Emmenegger, V Kosmoliaptsis, ES Theel, JR Mills, AM Sholukh, A Aguzzi, A Iwasaki, AK Lynn, TPJ Knowles
Sci Rep
(2022)
12
(doi: 10.1038/s41598-022-22214-z)
Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones
CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes
Angewandte Chemie
(2022)
134
(doi: 10.1002/ange.202208543)
Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates
S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
Molecular Pharmaceutics
(2022)
20
(doi: 10.1021/acs.molpharmaceut.2c00548)
Non-specificity as the sticky problem in therapeutic antibody development
H Ausserwöger, MM Schneider, TW Herling, P Arosio, G Invernizzi, TPJ Knowles, N Lorenzen
Nat Rev Chem
(2022)
6
(doi: 10.1038/s41570-022-00438-x)
Fragment-based computational design of antibodies targeting structured epitopes
M Aguilar Rangel, A Bedwell, E Costanzi, RJ Taylor, R Russo, GJL Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni
Sci Adv
(2022)
8
(doi: 10.1126/sciadv.abp9540)
Sequence-based Prediction of the Cellular Toxicity Associated with Amyloid Aggregation within Protein Condensates.
A Horvath, M Vendruscolo, M Fuxreiter
Biochemistry
(2022)
61
(doi: 10.1021/acs.biochem.2c00499)
Yusuf Hamied Department of Chemistry
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